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DMXX
07-01-2013, 01:11 AM
As mentioned in J Man's thread on hazel eyes (http://www.anthrogenica.com/showthread.php?1029-Hazel-Eye-Colour), I am pleased to announce my project on eye colour genetics is active once more.

For those who are unfamiliar with it, or wish to learn what happened to the project since its' inception, please view the Spoiler below.


The project began in the Autosomal DNA section of the now defunct DNA-Forums in the first half of 2010. As more users became interested, the general aims of the project took shape. The initial focus was on the HER2 and OCA2 genes, both of which are browsable in a 23andMe customer's raw data. This was expanded to include additional loci, such as SLC45A2.

At its' peak, the project contained 60 distinct genotype strings based on 16 handpicked SNP's taken from the literature of the time. These were stored on an offline spreadsheet on my hard-disk. Unfortunately, a set of computer problems resulted in the data being inaccessible in May 2011. I managed to retrieve most of the data from their original sources (PM's and posts).

The final blow to the project came with the demise of DNA-Forums. The community scattered across various other forums and I have not encountered quite a few of them since online. As the project was entirely derived from DNA-Forums members, it was inappropriate and against my own principles to continue using personal genome data from kind participants without their continued knowledge, regardless of the small number of SNP's used.


Several users here on Anthrogenica were participants in my project. I have listed all previous participants below. If those users could kindly inform me (publicly or privately) whether or not they are interested in remaining in the project, that would be much appreciated. All data belonging to previous users who haven't made contact will remain unused indefinitely and in their entirety.




Aaron1981
AmandaHR
Annihilus
bai_xue
BioGeek
Cacio
Cacio's sister
cilldara
Corey Reece
David F. Reynolds
Delcambre
Drouhin
Drouhin's father
Eekhoorn
gilljo
Giuseppe
Giuseppe's aunt
Giuseppe's brother
hamasen1
Handschar
Handschar's brother
J Man
J Man's Aunt
J Man's Dad
J Man's Mum
JAFarris
Johnserrat
Johnserrat's daughter
Johnserrat's son
Jolson 1
Jolson 2
kvpbf's relative
lalex
lalex's brother
lalex's father
lalex's husband
lalex's maternal grandmother
lalex's mother
lalex's paternal grandfather
lalex's paternal grandmother
Mamluk
Mamluk's father
Mamluk's wife
Mmaddi
mothdust9
Mrwo
Parma
R1a1a
R1a1a's grandfather
Rogers5858
romanms15
Simranjits
Simranjits' son
Simranjits' wife
Solothurn
Solothurn's wife
Stephen1986
Treysl
vadu's contribution



I should also take this opportunity to state that, if sufficient users (at least n=50) are participating by August 15th 2013, it is my intention to formally write up and publish the results and subsequent analysis (for more information on this please view "Project Assurances and Terms" below). Participation in this project is therefore automatically taken as unwritten permission to include your eye colour SNP's for my research. This was stated toward the end of the original project and remains the case now.




Project Aims

Based on the 23andMe chip, ascertain...


Which SNP's predominantly control brown vs. light eye phenotype.
Which SNP's for the cohort are involved in additional variation.
Successfully predict the phenotype from five examples of genotype data.
Contrast with existing conclusions in several studies.
Whether 23andMe's standard v2 chip has the capacity to support more detailed eye colour prediction assays.



How Can Users Participate?


Please inspect the SNP panel below.


rs12913832
rs1800407
rs12896399
rs16891982
rs1393350
rs12203592
rs7495174
rs7183877
rs4778232
rs1408799
rs8024968
rs683
rs4778138
rs4778241
rs1667394
rs26722
rs1015362
rs4911414
rs1540771
rs12821256
rs885479
rs1805008
rs1805005
rs3829241

Search your 23andMe Raw Data for all the SNP's in this panel (currently accessed by logging into your profile, highlighting the cogwheel on the top left hand side, selecting "BROWSE RAW DATA").
List your SNP genotypes in the order shown in the panel.
Information on eye colour phenotype is also crucial to the project. Pictures are ideal, descriptions of phenotype are acceptable. Additional information (i.e. heritage) is welcomed but not mandatory. For a guide on how to describe your eyes, please refer to the image below (add your observations as appropriate):


http://i1084.photobucket.com/albums/j418/DMXX_DNA/Betterchart.png (http://s1084.photobucket.com/user/DMXX_DNA/media/Betterchart.png.html)
Modified and taken from Beleza et al.'s Genetic Architecture of Skin and Eye Color in an African-European Admixed Population and Ruiz et al.'s Further development of forensic eye color predictive tests.

Share the essential data (genotype and phenotype information) with the project creator (myself, DMXX) either publicly on this thread or privately by PM.
Participants are sent a unique ID (IDnnn) by PM to confirm their information is stored on an offline spreadsheet.



How Do Participants Benefit?


Receive deeper analysis into genotype data provided from markers validated in current scientific literature. This will be delivered via an online spreadsheet which differs from the offline hard copy. In it, user ID's are listed alongside the inferences made from their genotypes.
Opportunity to discuss findings or queries concerning the inheritance of eye colour via personal data.
Real-time updates concerning what the project has discovered and how this relates to you.



Project Assurances and Terms


All communications and data between the project creator and participants (user ID's, genotypes, pictures) will remain confidential unless users choose to publicly post these.
At no point will user data of the sort described above be passed onto third parties.
Incomplete participant information (i.e. half of SNP genotypes, no picture/description) will not be included in the project.
If a formal report is composed, no personal genotype data or user ID's will be published. The only planned exception will be of the five predictions from genotype data. If I feel any of the pictures are worth including in the report, I will seek permission from those who provided them.
Updates on findings will be posted in this thread only.
It is worth stating that eye colour genotypes are highly unlikely to convey sensitive information concerning health traits as they tend to come from genes which regulate pigmentation. The first version of the project also revealed that a partial distinction between West Eurasians and other world groups could be gleamed from eye colour genotypes in a rudimentary and non-specific manner. Therefore, it is also highly unlikely any specific information pertaining to ancestry will be inferred.
As unlikely as it is, any changes made to the project's methodology or approach will be announced here.


Updated List of Citations
Will be completed in the next week.

ilmari
07-01-2013, 01:35 AM
Please feel free to use me and my family at your leisure.

EDIT: Hmmm, I thought we were in it, but I don't see the names in your second spoiler. Do you want data?

DMXX
07-05-2013, 08:25 PM
Updated with the SNP panel and a guide to use when giving your phenotype descriptions if a picture cannot be produced.

Clinton P
07-05-2013, 11:53 PM
GG rs12913832
CC rs1800407
TT rs12896399
CG rs16891982
AG rs1393350
CC rs12203592
AA rs7495174
CC rs7183877
CC rs4778232
CC rs1408799
CC rs8024968
AA rs683
AA rs4778138
CC rs4778241
TT rs1667394
CC rs26722
CT rs1015362
TT rs4911414
CT rs1540771
TT rs12821256
GG rs885479
CC rs1805008
GT rs1805005
AA rs3829241


516

Ancestry: British Isles

Clinton P

cavergal
07-06-2013, 06:04 PM
527
American mixed McDonalds 3 top custom
English .3815 Irish .5142 Jewish .1043
Irish .7025 French .2116 Jewish .0858
Irish .8118 Tuscan 0.139 Jewish .0743

rs12913832 HERC2 28365618 rs12913832 A or G GG
rs1800407 OCA2 28230318 rs1800407 C or T CC
rs12896399 intergenic 92773663 rs12896399 G or T TT
rs16891982 SLC45A2 33951693 rs16891982 C or G GG
rs1393350 TYR 89011046 rs1393350 A or G GG
rs12203592 IRF4 396321 rs12203592 C or T CC
rs7495174 OCA2 28344238 rs7495174 A or G AA
rs7183877 HERC2 28365733 rs7183877 A or C CC
rs4778232 OCA2 28281765 rs4778232 C or T TT
rs1408799 intergenic 12672097 rs1408799 C or T CT
rs8024968 OCA2 28283689 rs8024968 C or T CT
rs683 TYRP1, LOC100506267 12709305 rs683 A or C AA
rs4778138 OCA2 28335820 rs4778138 A or G AA
rs4778241 OCA2 28338713 rs4778241 A or C CC
rs1667394 HERC2 28530182 rs1667394 C or T TT
rs26722 SLC45A2 33963870 rs26722 C or T CC
rs1015362 intergenic 32738612 rs1015362 C or T CC
rs4911414 intergenic 32729444 rs4911414 G or T GT
rs1540771 intergenic 466033 rs1540771 C or T CT
rs12821256 intergenic 89328335 rs12821256 C or T CT
rs885479 MC1R 89986154 rs885479 A or G GG
rs1805008 MC1R 89986144 rs1805008 C or T CC
rs1805005 MC1R 89985844 rs1805005 G or T GT
rs3829241 TPCN2 68855363 rs3829241 A or G AG

Scarlet Ibis
07-07-2013, 12:15 AM
rs12913832: AG
rs1800407: CC
rs12896399: GG
rs16891982: CC
rs1393350: AG
rs12203592: CC
rs7495174: AG
rs7183877: AC
rs4778232: CT
rs1408799: CT
rs8024968: CC
rs683: AC
rs4778138: AG
rs4778241: AC
rs1667394: CT
rs26722: TT
rs1015362: CC
rs4911414: GG
rs1540771: CT
rs12821256: CT
rs885479: AG
rs1805008: CC
rs1805005: GG
rs3829241: GG




Heritage: Korean mom, dad of mostly UK ancestry

Eye color: Dark brown, I think. Sorry about the poor quality, but I had to take the pic in the bathroom with my cell phone.

Private_user
07-07-2013, 01:44 AM
For a guide on how to describe your eyes, please refer
to the image below (add your observations as appropriate):
http://i1084.photobucket.com/albums/j418/DMXX_DNA/Betterchart.pngGoing by that color scheme, I guess mine counts as either Inter-light or Green-hazel?
http://imageshack.us/a/img268/8729/i21v.jpg
http://imageshack.us/a/img441/1968/ndak.jpg

rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG




My mother's:
http://imageshack.us/a/img542/9233/zwa3.jpg

rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG



My maternal grandfather (the picture is not very clear but I don't have any better photo at the moment, his eyes are just blue without any yellow flecks)
http://imageshack.us/a/img853/995/rww.png

rs12913832 GG
rs1800407 CC
rs12896399 TT
rs16891982 GG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG


Ancestry: Lithuanians

DMXX
07-07-2013, 02:13 AM
Linkus,

I'd actually say both you and your mother belong to the "Inter-light" category because there's evidently some blue pigmentation which the "Green" category seems to lack. I imagine some of the uncertainty concerning your own eyes stems from differing resolutions; all sorts of interesting patterns can be observed in human eyes up close. Those photos provided in the study, however, clearly aren't as detailed. Even from a distance, however, your maternal grandfather's eyes are clearly a uniform blue. :)

For the fun of it, I might as well post a picture of my own eyes since they provided the impetus all those years back to look into the genetics of eye colour. 23andMe determined from the couple of SNP's they currently employed I had "brown" eyes without any more definition, despite something more evidently going on phenotypically:

http://i1084.photobucket.com/albums/j418/DMXX_DNA/eye.jpg (http://s1084.photobucket.com/user/DMXX_DNA/media/eye.jpg.html)

ilmari
07-07-2013, 03:21 AM
Mine, sorry, I know not how to make the code box like I used to know in the old forums:

rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CT
rs1805005 GG
rs3829241 AG

528

Finnish

ilmari
07-07-2013, 03:46 AM
My mother's data:

rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG

529

Finnish.

basque
07-07-2013, 08:56 PM
My data

AG rs12913832
CC rs1800407
GT rs12896399
GG rs16891982
GG rs1393350
CC rs12203592
AA rs7495174
CC rs7183877
CC rs4778232
CT rs1408799
CC rs8024968
AC rs683
AG rs4778138
CC rs4778241
CT rs1667394
CC rs26722
CC rs1015362
GG rs4911414
CT rs1540771
TT rs12821256
GG rs885479
CC rs1805008
GG rs1805005
AG rs382924

531 Light brown

British

Basque :rolleyes:

Humanist
07-08-2013, 04:55 AM
Please feel free to use me and my family at your leisure.

Same here. :)

History-of-Things
07-08-2013, 01:38 PM
rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 GG
rs12203592 CT
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GT
rs1540771 TT
rs12821256 CT
rs885479 GG
rs1805008 CC
rs1805005 GT
rs3829241 GG

You have my eye photo from the last round? I can't seem to find it, myself.

jeanL
07-08-2013, 02:46 PM
My mother's 23andme data:

rs12913832 AG
rs1800407 CC
rs12896399 GG
rs16891982 CG
rs1393350 AG
rs12203592 CT
rs7495174 AG
rs7183877 CC
rs4778232 TT
rs1408799 CT
rs8024968 CC
rs683 CC
rs4778138 GG
rs4778241 AA
rs1667394 TT
rs26722 CT
rs1015362 CC
rs4911414 GG
rs1540771 TT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

DMXX
07-08-2013, 09:45 PM
Thank you all for your kind contributions.


Same here. :)

Thank you Humanist - Would it be possible to have the genotypes for yourself and your brother from the new SNP panel on the original post? I'm using a (much more) updated one this time round. I do still have both the images as well.


rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 GG
rs12203592 CT
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GT
rs1540771 TT
rs12821256 CT
rs885479 GG
rs1805008 CC
rs1805005 GT
rs3829241 GG

You have my eye photo from the last round? I can't seem to find it, myself.

I do indeed History-of-Things, thank you.


My mother's 23andme data:

rs12913832 AG
rs1800407 CC
rs12896399 GG
rs16891982 CG
rs1393350 AG
rs12203592 CT
rs7495174 AG
rs7183877 CC
rs4778232 TT
rs1408799 CT
rs8024968 CC
rs683 CC
rs4778138 GG
rs4778241 AA
rs1667394 TT
rs26722 CT
rs1015362 CC
rs4911414 GG
rs1540771 TT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

May I please have a description of your mother's eye colour based on the chart I created on the original post?

jeanL
07-08-2013, 10:01 PM
My mother's 23andme data:

rs12913832 AG
rs1800407 CC
rs12896399 GG
rs16891982 CG
rs1393350 AG
rs12203592 CT
rs7495174 AG
rs7183877 CC
rs4778232 TT
rs1408799 CT
rs8024968 CC
rs683 CC
rs4778138 GG
rs4778241 AA
rs1667394 TT
rs26722 CT
rs1015362 CC
rs4911414 GG
rs1540771 TT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

This is her eye color.

535

DMXX
07-08-2013, 10:06 PM
This is her eye color.

535

Thanks, although it's a little hard to make out; is her eye colour in bright lighting the same as the shade of brown next to the Inter-dark choice below?

http://i1084.photobucket.com/albums/j418/DMXX_DNA/Betterchart.png (http://s1084.photobucket.com/user/DMXX_DNA/media/Betterchart.png.html)

jeanL
07-08-2013, 10:19 PM
Thanks, although it's a little hard to make out; is her eye colour in bright lighting the same as the shade of brown next to the Inter-dark choice below?

http://i1084.photobucket.com/albums/j418/DMXX_DNA/Betterchart.png (http://s1084.photobucket.com/user/DMXX_DNA/media/Betterchart.png.html)

Her eye color is in between light brown and medium brown.

AJL
07-09-2013, 03:40 AM
Please feel free to use my data. I can also post my mother's data if you like (this will also phase my data, I guess).

MikeWhalen
07-11-2013, 12:27 AM
I will send in a pic and my info, soon as I get a decent pic of the eye!! thats alot harder that it looks to do, fer cryin out loud!

Mike

AJL
07-11-2013, 01:13 AM
I will send in a pic and my info, soon as I get a decent pic of the eye!! thats alot harder that it looks to do, fer cryin out loud!

Mike

Yup, they should invent a kind of reverse camera that takes a picture of the viewfinder!

Here are mine, DMXX:

A.J.
greyish-hazel

rs12913832 AG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CT
rs1805005 GT
rs3829241 AG


Paternal Grandfather
bluish-grey

rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 TT
rs8024968 CC
rs683 CC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GT
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 TT
rs3829241 AG


Mother
light-to-medium brown

rs12913832 AG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 CC
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CT
rs1805005 GG
rs3829241 GG

MikeWhalen
07-11-2013, 01:15 AM
DMXX-here is my 23&me data, along with a picture.
I give you full permission to use my data in your project/studies as you see fit

...other data you've mentioned is:
-15/16 great great grandparents were from the British Isles and the 16 was from Holland
-mostly Irish, Irish-Scot and a little Scottish on my dads side, Irish and Devenshire English (said to be possibly the reminants of the British Indiginous Celtic) on my moms
-dads eyes were brown-brown-hazel, my moms light and bright blue
-my eyes are blue, lighter than darker but the seem to change color or look lighter/darker without much change in enviroment...I had a devil of a time picking an eye picture as I was mostly getting 2/3's light blue but 1/3 medium to dark blue
-some pics had a dark ring around the outside of the blue, many did not, but I wonder if that is a function of the flash on the camera?

Mikes
HERC2 28365618 rs12913832 A or G GG
OCA2 28230318 rs1800407 C or T CC
intergenic 92773663 rs12896399 G or T GT
SLC45A2 33951693 rs16891982 C or G GG
TYR 89011046 rs1393350 A or G GG
IRF4 396321 rs12203592 C or T CC
OCA2 28344238 rs7495174 A or G AA
HERC2 28365733 rs7183877 A or C CC
OCA2 28281765 rs4778232 C or T CC
intergenic 12672097 rs1408799 C or T CT
OCA2 28283689 rs8024968 C or T CC
TYRP1, LOC100506267 12709305 rs683 A or C AC
OCA2 28335820 rs4778138 A or G AA
OCA2 28338713 rs4778241 A or C CC
HERC2 28530182 rs1667394 C or T TT
SLC45A2 33963870 rs26722 C or T CC
intergenic 32738612 rs1015362 C or T CT
intergenic 32729444 rs4911414 G or T GT
intergenic 466033 rs1540771 C or T CT
intergenic 89328335 rs12821256 C or T TT
MC1R 89986154 rs885479 A or G AG
MC1R 89986144 rs1805008 C or T CC
MC1R 89985844 rs1805005 G or T GG
TPCN2 68855363 rs3829241 A or G GG

I took these two pics within 10 min of each other, same camera, same settings but the 'blue'er' one was outside in natural light-maybe a bit darker than what I really am and the 'lighter' one is a bit too light...so you pick which one seems more likely :)

537
538

DMXX
07-12-2013, 01:15 AM
Fantastic, thank you AJL and Mike for the new additions. I'll be posting the first inferences on the data pretty soon (stretched very thin at the moment with the R1b write-up, this project and some other personal enterprises); expect something substantial here in the next four days!

The response has been pretty impressive so far but I could definitely do with some more samples. The more I receive, the more clarity I'll have concerning the significance of certain SNP's.

ilmari
07-13-2013, 09:20 PM
I'll attempt to get an example of my sister's, nephew's, and one cousin's eyes and then post their SNPs, or are you really alright with just a description?

DMXX
07-13-2013, 09:22 PM
I'll attempt to get an example of my sister's, nephew's, and one cousin's eyes and then post their SNPs, or are you really alright with just a description?

I would be perfectly happy with descriptions, yes. It would be helpful for me if they could be compared against the panel shown below.

http://i1084.photobucket.com/albums/j418/DMXX_DNA/Betterchart.png (http://s1084.photobucket.com/user/DMXX_DNA/media/Betterchart.png.html)

Sangarius
07-13-2013, 10:37 PM
rs12913832 AG
rs1800407 CC
rs12896399 GG
rs16891982 CG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 CT
rs8024968 CC
rs683 CC
rs4778138 AG
rs4778241 CC
rs1667394 CT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CC
rs12821256 TT
rs885479 AG
rs1805008 CC
rs1805005 GT
rs3829241 AG

The color of my eyes lies somewhere in the brown-spectrum.
The photo below is from a professional shooting, I zoomed it to 200%.
541

This one I just did in the bathroom with my mobilephone.
542

I don't have any in natural lighting or daylight handy, but they are brown anyway. :P

---------------------------------

btw this is my gedmatch prediction:
543

geebee
07-14-2013, 12:45 PM
Both my actual eye color and my prediction seem pretty close to those of Sangarius. We're different on a few SNPs, though in (I think) all cases but one we could have at least half matching.

rs12913832 AG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 AC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 AC
rs1667394 CT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 TT
rs12821256 CT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

Here's a shot of my eye versus the prediction (EDIT: I added a third photo which shows the prediction based on my combined 23andMe/FTDNA data. Still has a way to go, but seems slightly closer.):

Humanist
07-14-2013, 03:05 PM
Would it be possible to have the genotypes for yourself and your brother from the new SNP panel on the original post? I'm using a (much more) updated one this time round. I do still have both the images as well.


Please inspect the SNP panel below.

No problem. My genotypes are below. I will post my brother's genotypes later.

rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

alan
07-14-2013, 03:43 PM
I might be being paranoid but be aware that iris identification is used to prove identity etc. I wouldnt want to post my eyes onto the internet without looking into this.

Humanist
07-14-2013, 05:42 PM
No problem. My genotypes are below. I will post my brother's genotypes later.

My brother's genotypes are in red. SNPs where my brother and I differ are in bold. There are four. For those who do not recall, my brother has blue eyes, and I have ~green eyes.

rs12913832 GG GG
rs1800407 CC CC
rs12896399 GG GG
rs16891982 GG CG
rs1393350 GG GG
rs12203592 CC CT
rs7495174 AA AA
rs7183877 CC CC
rs4778232 CC CC
rs1408799 CT CT
rs8024968 CC CC
rs683 AA AA
rs4778138 AA AA
rs4778241 CC CC
rs1667394 TT TT
rs26722 CC CC
rs1015362 CT CT
rs4911414 GT GT
rs1540771 CT TT
rs12821256 TT TT
rs885479 GG GG
rs1805008 CC CC
rs1805005 GG GG
rs3829241 GG AG

If these can be of any use, here are the Gedmatch predictions:

http://i1178.photobucket.com/albums/x372/paulgiva78/passover/eeyes_gedmatch_brother_humanist.jpg


My actual eye color:

http://i1178.photobucket.com/albums/x372/paulgiva78/passover/hum_eyes___.jpg

ilmari
07-14-2013, 10:03 PM
My sister's data, eye color is almost exactly like your inter-light photo. 100% Finnish

rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CT
rs1805005 GG
rs3829241 AG

My sister's son, my nephew = the first brown after the inter-dark. 50% Finnish

rs12913832 AG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 AC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AG
rs4778241 CC
rs1667394 CT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG

We really don't know much about his other ethnic components, here is what the Ancestry Composition shows for him at 23andMe:

99.2%
European

Northern European
49.3% Finnish
2.6% French and German
0.6% British and Irish
34.7% Nonspecific Northern European
0.2% Ashkenazi
11.8% Nonspecific European
0.4% South Asian
0.5% Unassigned

ilmari
07-14-2013, 10:57 PM
My 2nd cousin's data, she has VERY BLUE eyes, deeper than your "blue" on your chart, more cerulean blue and somewhat like MikeWhalen's color. She is 100% Finnish.

rs12913832 GG
rs1800407 CT
rs12896399 GT
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CT
rs1805005 GG
rs3829241 GG

Quite like this:
https://www.google.com/search?q=blue+eyes+images&tbm=isch&tbo=u&source=univ&sa=X&ei=MyvjUbf7JIXEigLQg4H4AQ&sqi=2&ved=0CC0QsAQ&biw=1024&bih=493#facrc=_&imgdii=_&imgrc=WWXZtZL4NEsnYM%3A%3BMpChpiR3FFWiFM%3Bhttp%25 3A%252F%252Ffc06.deviantart.net%252Ffs27%252Ff%252 F2008%252F075%252F7%252F6%252FJunior_blue_eyes_by_ handesengun.jpg%3Bhttp%253A%252F%252Fhandesengun.d eviantart.com%252Fart%252FJunior-blue-eyes-80032865%3B579%3B800

J Man
07-14-2013, 11:18 PM
Mine below. I have hazel (green-brown) eyes.

rs12913832: AG
rs1800407: CC
rs12896399: GT
rs16891982: GG
rs1393350: AG
rs12203592: CC
rs7495174: AA
rs7183877: AC
rs4778232: CC
rs1408799: CT
rs8024968: CC
rs683: AC
rs4778138: AA
rs4778241: AC
rs1667394: CT
rs26722: CC
rs1015362: CT
rs4911414: GT
rs1540771: CT
rs12821256: CT
rs885479: GG
rs1805008: CC
rs1805005: GT
rs3829241: GG

geebee
07-14-2013, 11:29 PM
I might be being paranoid but be aware that iris identification is used to prove identity etc. I wouldnt want to post my eyes onto the internet without looking into this.

I have posted my first and last name on the internet before. This information alone is a unique identifier for me -- that is, so far as I know, no one else on the planet has my first/last name combination. Anyone who wished to could collect a great deal of information about me using Google, I suspect, including where I've lived, where I went to school, etc.

Identity theft is probably one of the greater dangers we face right now, rather than just being recognized ... although I always hope that identity thieves will be smart enough to avoid someone with as "unusual" a surname as mine. (Probably a vain hope.)

In theory, it's possible that I could be out somewhere and an iris scan could be used to recognize me. But, sooner or later (if not already), we will all go places which use iris recognition. And if someone manages to locate my eye photo online, and tie it to my name and identity ... well, I'd guess I'd better not commit any crimes.

Darn, there goes my promising new career as a cat burglar. :(

EDIT: If you watched Minority Report, you might recall uses of iris scanning for commercial purposes, as well as security. (Which is why Tom Cruise's character had to have the eye transplant, after which he was identified as an Asian individual.) I suspect this is actually still a little way off. But when it is used, it probably won't be through self-posted photos on the internet that you wind up in the database. More likely, you'll be using a credit card at a POS and have your iris scanned and entered at that time -- possibly without your ever knowing about it.

ilmari
07-14-2013, 11:33 PM
A friend's data, he has root beer in sunlight brown eyes, probably closest to your example called Brown that is just before Dark Brown. If you have the old montage photo of 26 individuals, it would be closest to the bottom row, third eye from the left.
rs12913832 AG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AG
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AG
rs4778241 AC
rs1667394 CT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 AG
rs1805008 CC
rs1805005 GT
rs3829241 AG


Primarily of pre Revolutionary War American stock with Irish, Alsatian and northern German paper trail, but the eye color is identical to his mother's eye color and she is the one with the Alsatian and northern German paper trail.

99.0%
European

Northern European
20.1% British and Irish
4.5% French and German
62.9% Nonspecific Northern European

Southern European
0.8% Balkan
0.2% Nonspecific Southern European
0.1% Eastern European
10.3% Nonspecific European
0.6% South Asian
0.1% East Asian & Native American
0.1% East Asian
0.2% Unassigned

ilmari
07-15-2013, 12:17 AM
Another friend's data.

A friend's data, she has north sky blue eyes, probably closest to your example called Blue. If you have the old montage photo of 26 individuals, it would be closest to the top row, second eye from the left.
rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 TT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GT
rs1540771 CC
rs12821256 CT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG

Not much know of her heritage, has some potential German and Isles ancestry on her mother's side and then the rumored father has a surname that suggests British.

99.9% European

Northern European

16.3% British and Irish
2.1% French and German
74.1% Nonspecific Northern European
7.4% Nonspecific European
0.1% Unassigned

DMXX
07-15-2013, 01:47 AM
I'm very pleased to see so much data; thank you all for the time you've taken to pass this on to me. I'll be pumping out the first series of results today or tomorrow.

@alan, I can understand your viewpoint, but bear in mind that most of the photos here are nowhere near high enough quality to be used for identity theft.

DMXX
07-15-2013, 06:59 AM
In my first batch of results, I've decided to apply IrisPlex on participant data. IrisPlex is an assay using only 6 SNP's across several genes (not just the HERC2-OCA2 linkage) that was developed in forensics labs to determine eye colour. Another version of this was extended to include hair colour.

The IrisPlex assay has a ~95% accuracy in predicting the eye colour of Europeans, making it less reliable for African, East Asian or South Asian results. This is one of the caveats I was hoping to address using the other SNP's everyone else has sent in. Nevertheless, most users should find this interesting, as the majority of current participants are predominantly West Eurasian.

What the results show is the phenotypic effect of a particular genotype in a person's results. The summation of those phenotypic effects should theoretically result in your eye colour.

The strength of each SNP also counts here. Because of variation in strength, a person who's brown-eyed for SNP1 but light-eyed on SNP2-6 won't have light eyes, but will instead probably have something resembling a light amber or caramel. SNP1 is the strongest one here.

User ID's are shown with inferred results on phenotype from current literature per SNP. Feedback on your experience with the IrisPlex tool is appreciated. Seems very accurate in my case (brown on most important SNP, general picture of the other 5 is towards a hazelish-green - That's essentially what I see in my eyes, brown with some features of hazel-green).


> Spreadsheet: IrisPlex Application on User Data < (https://docs.google.com/spreadsheet/pub?key=0AuedvPON0rv2dGVZcjQzaFIxSUROVFdBZkt3c050b FE&output=html)

I look forward to hearing everyone's experiences with the spreadsheet; surprised by any of the results? Do they explain any variation within your families (for those who've sent in data from relatives)? If anyone needs some help interpreting the results feel free to PM me or message here if you're fine with discussing openly.

MikeWhalen
07-15-2013, 11:06 AM
sorry for being slow DMXX, but how do we tell what user ID is us? I have no clue which one I am

Mike

DMXX
07-15-2013, 11:19 AM
My bad Mike, I checked through my records and realised I hadn't sent yours via PM/rep points yet, will do now. Apologies for that.

MikeWhalen
07-15-2013, 12:32 PM
Thanks DMXX-got it, now I need help understanding it
...I'm not really a science guy and what I did know, its been a while since I've used it, so even a simple refresher would be of great help....
terms such as; Homozygous,Heterozygous, but also it seems to switch using color's as terms like 'Euro' and 'Green' (no+blue)

these were my results...I dont mind them being discussed and here are my eye color pics

552553

Homozygous (light)
Homozygous (dark)
Heterozygous
Euro (light)
Green (No +Blue)
Homozygous (dark)

From your note explaining the six markers studied, I seem to be half and half for light or dark eyes, but you can see in my 2 pics my eyes are really light I think you would say, although they can look like light blue or med dark blue, depending on the light as I noted regarding my pics....do the results from the test show that or does it suggest something else?
thanks for any info or insight

Mike

PS-the ladies at work (where I am right now) all say that the 'lighter' blue eye pic of mine is the genuine representation of my eye color

DMXX
07-15-2013, 12:44 PM
For each SNP, we carry two alleles (G,T,A,C). When a person's carrying two of the same alleles (AA, GG) this is described as homozygosity (homo = same). When a person's carrying two different alleles (AG), this is heterozygosity (hetero = different).

Here, certain allele combinations give certain phenotypic effects. In SNP1, a person who is homozygous for one pair of alleles will be either light or dark eyed. A person who's heterozygous will be in-between; if all the other alleles cancel each other out, I'd expect them to be hazel eyed. This works the same way for SNP2, 3 and 6.

SNP4 is an interesting one; a person with the recessive homozygous allele pair will have a generally fairer pigmentation (not just the eyes). It's been assigned as quintessentially European in at least one study. This is why it's described here as "Euro (light)".

SNP5 seems to only apply to people who're light eyed, where a certain allele combination will increase the likelihood of blue over green.

These different "rules" each SNP has is from inferences made in the studies which analysed thousands of samples. As mentioned before, the strength of the SNP's decrease as you go further down. It might not make sense that two of your results are brown eyed despite yours being blue, but at least one other person in the project so far has the exact same results as you, and also has blue-grey eyes. SNP1 carries the most weight in determining if you have light vs. brown eyes.

Having said this, some of the other folks with the same results as you are also light eyed but have non-blue colouring in addition. Clearly, despite its' accuracy in discerning blue vs. brown, the IrisPlex has problems differentiating lighter colours from one another going by this. This is where the other 20 SNP's I've requested everyone to send in will hopefully shed some light.

Let me know if you need any more clarifying on this, hope that helped!

Clinton P
07-15-2013, 01:09 PM
I’m surprised by the result I get for SNP4, I always thought I had entirely Northern European ancestry. Could this explain the brown ‘flecks’ that I have in my irises?

556
558

Clinton P

DMXX
07-15-2013, 01:18 PM
Yes, I can see why those studies basically assigning it to be a "European" allele were perhaps a little subjective in their labelling. It could well be responsible for the brown spots around an otherwise blue eye. In the previous version of this project, I had more mixed-ethnicity samples and could discern whether or not people had a random brown spot in their eyes.

We must recall that these are only a couple of SNP's out of millions; if SNP4 happens to be the <0.000001% that's not typical of your thoroughly North European genome, then its' (possible) effect on your iris colour's quite something since we can physically see it. Whereas, for instance, the open-source projects show I'm ~4.4% East Eurasian yet I haven't spotted anything relating to this in my phenotype.

Clinton P
07-15-2013, 01:48 PM
SNP4 appears to be not typical of a European genome, here are my 23andMe and FTDNA ancestral make-up:

23andMe’s Ancestry Composition has me down as:

99.8% British and Irish
0.1% Finnish
0.1% Nonspecific Northern European

FamilyTreeDNA FamilyFinder - Population Finder has me down as:

Europe (Western European) 94.92% ± 5.36%
Europe 5.08% ± 5.36%

Clinton P

DMXX
07-15-2013, 01:54 PM
SNP4 here is in fact rs16891982, found on SLC45A2 (MATP). Any C alleles point towards non-specific darker pigmentation (which is why rs16891982's included in both versions of IrisPlex). CC is typically found in non-Euro's for this reason. More info here: http://snpedia.com/index.php/Rs16891982

J Man
07-15-2013, 02:12 PM
Thanks for including me in your eye colour project again DMXX. :)...Sorry but I exited the comment you gave me earlier with my ID and I did not write it down and I do not know how to find that comment again. Could you please tell me what my ID is again for the project? I also can't PM you for some reason.

DMXX
07-15-2013, 02:16 PM
Hello J Man, I sent you a reputation comment with your ID. To view this, please go to User Control Panel on the upper-left of your screen and you'll see my rep comment down the middle somewhere. I'll message it to you again from there.

Not sure what's going on concerning PM's; my inbox has space still. You might want to post in the Help section if this persists.



SNP4 appears to be not typical of a European genome, here are my 23andMe and FTDNA ancestral make-up:

23andMe’s Ancestry Composition has me down as:

99.8% British and Irish
0.1% Finnish
0.1% Nonspecific Northern European

FamilyTreeDNA FamilyFinder - Population Finder has me down as:

Europe (Western European) 94.92% ± 5.36%
Europe 5.08% ± 5.36%

Clinton P

I went through the results and yes, it appears that one SNP genotype/phenotype you have is fairly unusual for Europeans. Most of those with a result other than GG are West Asian or have an ethnic background from elsewhere, such as Africa or East Asia.

Humanist
07-15-2013, 03:14 PM
My actual eye color:

http://i1178.photobucket.com/albums/x372/paulgiva78/passover/hum_eyes___.jpg

I am ID022. Matches, across these 6 SNPS, with ID011, ID012, and ID024.

http://i1178.photobucket.com/albums/x372/paulgiva78/passover/id022_hum.jpg

ilmari
07-15-2013, 04:15 PM
I am ID011, my mom is ID012, and my sister is ID024. :P

Humanist
07-15-2013, 04:27 PM
I am ID011, my mom is ID012, and my sister is ID024. :P

I knew I liked you for some reason. ;)

J Man
07-15-2013, 04:30 PM
Okay got it thank you DMXX! I am ID029.

History-of-Things
07-15-2013, 04:31 PM
Ah, I've finally found my eye pictures (it took me a long while to figure out how to get them and even then they aren't great because of the reflection). I am ID014.

559

560

SNP1 Homozygous (light)
SNP2 Homozygous (dark)
SNP3 Heterozygous
SNP4 Euro (light)
SNP5 Green (No+Blue)
SNP6 Lighter

J Man
07-15-2013, 04:43 PM
My results from the spreadsheet.

SNP1: Heterozygous
SNP2: Homozygous (dark)
SNP3: Heterozygous
SNP4: Euro (light)
SNP5: Blue>Green
SNP6: Homozygous (dark)

I see that I match ID025 and ID016 exactly at these 6 SNPs.

MikeWhalen
07-15-2013, 05:00 PM
Evidently, I have 2 people with the exact same results
....I am ID 19, ID 17 matchs me
....I wonder if our eyes actually have the same colour?

Mike

New note (*fixed my mistake-only 1 match for me)
-Thx DMXX for adding the colour description to your chart, from it I see 17 is blue like me...fascinating!

DMXX
07-15-2013, 05:05 PM
As there's a lot of speculation over everyone's eye colours, I've included them in the spreadsheet now. The descriptions, regardless of whether a picture or self-description was given, were paired alongside the panel shown consistently in this thread.

^ Mike, if you check ID013 you'll see they're actually heterozygous for SNP1 (you're homozygous light on that one), which explains the colour difference adequately.

J Man
07-15-2013, 05:19 PM
Alright I see now that my eye colour in the spreadsheet is listed as being Hazel which is correct I believe. I see that my match ID016 is also listed as being Hazel but my other match who is ID025 is listed as being Brown (1). Interesting stuff.

History-of-Things
07-15-2013, 05:26 PM
Do eye colors change as one ages? I'm just curious because in my memories, my mother's eyes were darker when I was young (by the way, despite being inter-light, I have two brown-eyed parents, though three out of four light eyed grandparents). I also think my eyes were more blue before my teenage years, when I think they acquired the darker inner circle which makes them appear greenish from a distance.

DMXX
07-15-2013, 05:29 PM
Do eye colors change as one ages? I'm just curious because in my memories, my mother's eyes were darker when I was young (by the way, despite being inter-light, I have two brown-eyed parents, though three out of four light eyed grandparents). I also think my eyes were more blue before my teenage years, when they acquired the darker inner circle which makes them appear greenish from a distance.

Now this is an interesting question I've had with quite a few folks recently. I've seen no anthropological (or in fact any other scientific) data concerning this, but anecdotally, I do know a few cases of this. Even without the anecdotes, I didn't see why this wasn't possible, since hair colour changes with age in some too (and I don't mean just white).

The user R. Walker on DNA-Forums, who was a participant in the old version of my project, said that his eyes were brown in childhood but slowly lightened over time to practically blue by the time he reached his early 60's.

As a matter of fact, my own eyes were a medium-dark brown without any sort of non-brown colouring as a child. I first noticed the amber-green colouring at the age of 15. Actually, I should use myself as a case study and take a picture every year over a decade or two. :P

J Man
07-15-2013, 05:33 PM
So DMXX how would you describe my eye colour based on my results and pictures I sent you before? Would you say that my results are truly heterozygous and my eye colour (hazel) is right in the middle between the lightest blue and darkest brown?

DMXX
07-15-2013, 05:37 PM
So DMXX how would you describe my eye colour based on my results and pictures I sent you before? Would you say that my results are truly heterozygous and my eye colour (hazel) is right in the middle between the lightest blue and darkest brown?

I would, actually. Not only is your eye colour made of shades that are neither blue nor pure brown, but both the green-grey and amber-brown are like a transitional pull of both blue and brown towards another.

The other people who're heterozygous for SNP1, but don't have your eye colour, mostly have other SNP's which code for darker eyes. Indeed, most of these participants have shades of brown.

J Man
07-15-2013, 05:45 PM
I would, actually. Not only is your eye colour made of shades that are neither blue nor pure brown, but both the green-grey and amber-brown are like a transitional pull of both blue and brown towards another.

The other people who're heterozygous for SNP1, but don't have your eye colour, mostly have other SNP's which code for darker eyes. Indeed, most of these participants have shades of brown.

So compared to those other people who are heterozygous for SNP1 who do not share my exact same eye colour and mostly have other SNP's which code for darker eyes are different from me in that my other SNP's code for lighter eye colour? That is even though we are heterozygous on SNP1 together my other SNP's results are for a lighter eye colour than their's are?

MikeWhalen
07-15-2013, 06:30 PM
Doh!
your right, good catch, I guess I only have 1 exact match...thx DMXX


As there's a lot of speculation over everyone's eye colours, I've included them in the spreadsheet now. The descriptions, regardless of whether a picture or self-description was given, were paired alongside the panel shown consistently in this thread.

^ Mike, if you check ID013 you'll see they're actually heterozygous for SNP1 (you're homozygous light on that one), which explains the colour difference adequately.

AJL
07-15-2013, 06:53 PM
My results from the spreadsheet.

SNP1: Heterozygous
SNP2: Homozygous (dark)
SNP3: Heterozygous
SNP4: Euro (light)
SNP5: Blue>Green
SNP6: Homozygous (dark)

I see that I match ID025 and ID016 exactly at these 6 SNPs.

Cousin: Makes sense since we have very similar eye colours: I am ID016, my paternal grandfather is ID017, my mother is ID018.

J Man
07-15-2013, 06:58 PM
Cousin: Makes sense since we have very similar eye colours: I am ID016, my paternal grandfather is ID017, my mother is ID018.

I was wondering if ID016 might be you or not. Nice to see you as a match here as well cuz! :)

ilmari
07-15-2013, 08:40 PM
My results from the spreadsheet.

SNP1: Heterozygous
SNP2: Homozygous (dark)
SNP3: Heterozygous
SNP4: Euro (light)
SNP5: Blue>Green
SNP6: Homozygous (dark)

I see that I match ID025 and ID016 exactly at these 6 SNPs.

ID025 is my nephew. Hi again, cuz.

basque
07-15-2013, 09:39 PM
MY Id 1D013

SNP1: Heterozygous
SNP2: Homozygous (dark)
SNP3: Herterozygous
SNP4: Euro light
SNP5: Green (No + Blue)
6SNP: Homozygous dark

I have 1 exact match ID018 AJLs mother.

basque :rolleyes:

J Man
07-15-2013, 09:47 PM
ID025 is my nephew. Hi again, cuz.

Well shit there ya go cuz lol! I also share an IBD chromosome segment with your nephew, sister and mother on 23andme as you know. :D

Clinton P
07-15-2013, 10:28 PM
I'm ID002.

I appear to have no matches (probably due to SNP4). :(

Clinton P

MikeWhalen
07-15-2013, 11:18 PM
sorry Clinton, but I could'nt resist...

lonely boy
http://www.youtube.com/watch?v=KKcCaCgMLBE

:)

M



I'm ID002.

I appear to have no matches (probably due to SNP4). :(

Clinton P

AJL
07-16-2013, 12:56 AM
MY Id 1D013

SNP1: Heterozygous
SNP2: Homozygous (dark)
SNP3: Herterozygous
SNP4: Euro light
SNP5: Green (No + Blue)
6SNP: Homozygous dark

I have 1 exact match ID018 AJLs mother.

basque :rolleyes:

Ah well, that makes sense. Her ancestry is mainly Isles.

DMXX
07-16-2013, 09:05 AM
So compared to those other people who are heterozygous for SNP1 who do not share my exact same eye colour and mostly have other SNP's which code for darker eyes are different from me in that my other SNP's code for lighter eye colour? That is even though we are heterozygous on SNP1 together my other SNP's results are for a lighter eye colour than their's are?

Close; your other SNP's are generally lighter than the others we're speaking of. Your SNP2 and 6 results are both homozygous dark, whereas the others are hetero or lighter.

J Man
07-16-2013, 04:24 PM
Close; your other SNP's are generally lighter than the others we're speaking of. Your SNP2 and 6 results are both homozygous dark, whereas the others are hetero or lighter.

Hmmm from what I can see many perhaps even the majority of participants in this project eve many of the lighter eyed ones are homozygous dark for SNP2 and SNP6.

DMXX
07-16-2013, 05:11 PM
Yes J Man, it's an interesting phenomena, is it not? Particularly as SNP2 is supposed to be one of the more significant ones for eye colour. The more participant data I have, the better platform I have to validate what the studies say.

J Man
07-16-2013, 09:47 PM
Yes J Man, it's an interesting phenomena, is it not? Particularly as SNP2 is supposed to be one of the more significant ones for eye colour. The more participant data I have, the better platform I have to validate what the studies say.

So based on my own results here say that one day I end up having children with a blue eyed woman or a woman who has heterozygous type results like me then my children could pretty much have any eye colour from blue to brown correct?

Calamus
07-16-2013, 10:18 PM
Mine (Green-Hazel, closest to #3 on your scale):

rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 AG
rs12203592 CT
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 CC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AA

Scarlet Ibis
07-17-2013, 04:39 AM
I see the spreadsheet predicts my eye color as Brown 1. Is that the 1st brown, after "inter-dark" on the eye color chart?


Anyway, it seems like the DMXX prediction, and the Gedmatch predictions are relatively consistent, and not too far off from reality. I have always considered my eyes to be plain dark brown, but realistically, I suppose there are different shades I never took into consideration, or thought too much about.

Gedmatch prediction:
http://i40.tinypic.com/152jnfm.jpg

Actual:
http://i44.tinypic.com/2n20dwp.jpg

MikeWhalen
07-17-2013, 11:04 AM
Since I am partially colour blind (mild red green), I am probably the last guy that should comment, but it sure seems to me in the above pic that there is some green in your eyes-
-of course, it could just be the way the light affected the pic as happened with some of mine if not my little genetic flaw kicking in

just wondering

Mike

--PS-DMXX-are there any studies about the genetics of colour blindness? last I heard, many years ago, apox 10-15 % of the male pop has my kind of colour blindness



I see the spreadsheet predicts my eye color as Brown 1. Is that the 1st brown, after "inter-dark" on the eye color chart?


Anyway, it seems like the DMXX prediction, and the Gedmatch predictions are relatively consistent, and not too far off from reality. I have always considered my eyes to be plain dark brown, but realistically, I suppose there are different shades I never took into consideration, or thought too much about.

Gedmatch prediction:
http://i40.tinypic.com/152jnfm.jpg

Actual:
http://i44.tinypic.com/2n20dwp.jpg

Clinton P
07-17-2013, 02:57 PM
For comparison purpose here’s what I get from GEDmatch….

568

The image on the left is my actual left eye.

The image in the middle is my predicted eye colour from GEDmatch using FamilyTreeDNA FamiliyFinder data.

The image on the right is my predicted eye colour from GEDmatch using 23andMe V2 data.

DMXX’s spreadsheet has me down as ‘Inter Light’

Clinton P

utR!
07-17-2013, 06:27 PM
For comparison purpose here’s what I get from GEDmatch….

568

The image on the left is my actual left eye.

The image in the middle is my predicted eye colour from GEDmatch using FamilyTreeDNA FamiliyFinder data.

The image on the right is my predicted eye colour from GEDmatch using 23andMe V2 data.

DMXX’s spreadsheet has me down as ‘Inter Light’




Clinton P

Hi Clinton!

How to use Family Finder data because I understand there are not those rs-numbers?

I can not participate to this ever so interesting topic really but I can only admire nice eye colors ;)

utR! B)

Clinton P
07-17-2013, 08:03 PM
Hi utR!,

You first have to register at GEDmatch, then upload your data (FTDNA FamilyFinder, FTDNA X-DNA, 23andMe, Ancestry.com).

Unfortunately, due to the current processing backlog, DNA uploads have been suspended. It is expected that new uploads will be accepted on about August 15.

Click here (http://gedmatch.com/) to go to GEDmatch.

Once you have uploaded your data, and have been given a kit number, you can then use ‘Predict Eye Colour’ from the ‘Analyse Your Data’ section.

The Eye Colour Predictor will give you a list of the SNPs used to predict your eye colour, your results at those SNPs, and a description of what influence each SNP has on your eye colour/pattern (e.g. TG at: rs8036572 - Amber Sphincter). The predictor will also give you an image of what your eye colour is expected to be, based on your results for the SNPs used to predict your eye colour.

My 23andMe and FTDNA FamilyFinder data give slightly different predictions.

Clinton P

basque
07-17-2013, 08:38 PM
Gedmatch eye colour prediction using my V3 kit

570

Actual eye colour as you know is brown

basque :rolleyes:

Scarlet Ibis
07-18-2013, 02:02 AM
Since I am partially colour blind (mild red green), I am probably the last guy that should comment, but it sure seems to me in the above pic that there is some green in your eyes-
-of course, it could just be the way the light affected the pic as happened with some of mine if not my little genetic flaw kicking in

just wondering

Mike

--PS-DMXX-are there any studies about the genetics of colour blindness? last I heard, many years ago, apox 10-15 % of the male pop has my kind of colour blindness


Hi Mike,

It's probably just the lighting; in real life, they are uniform brown. :)

Scarlet Ibis
07-18-2013, 02:02 AM
For comparison purpose here’s what I get from GEDmatch….

568

The image on the left is my actual left eye.

The image in the middle is my predicted eye colour from GEDmatch using FamilyTreeDNA FamiliyFinder data.

The image on the right is my predicted eye colour from GEDmatch using 23andMe V2 data.

DMXX’s spreadsheet has me down as ‘Inter Light’

Clinton P

Wow....that's quite a difference....

DMXX
07-18-2013, 02:44 PM
Multipost response below:


So based on my own results here say that one day I end up having children with a blue eyed woman or a woman who has heterozygous type results like me then my children could pretty much have any eye colour from blue to brown correct?

If you end up having children with a woman who has blue eyes, your children's eyes will most likely fall in the "inter-light" and "green" eye categories shown on the original chart. This is because, to produce blue eyes, a person must be homozygous light for SNP1 and the majority of their other alleles coding for light eyes. Since your hypothetical wife will have that, whereas yours is a heterozygous picture (esp. on SNP1), your kids will either be heterozygous or homozygous light for all SNP's.

Whereas, if you have a wife whose eyes are hazel/heterozygous (basically SNP1 again, remember that's the most important), your children could plausibly have any eye colour, depending on the sort of alleles she has and chance inheritance from that diversity.


Mine (Green-Hazel, closest to #3 on your scale):


Thank you, Calamus, I'll update your results to the IrisPlex spreadsheet once I have more samples.


I see the spreadsheet predicts my eye color as Brown 1. Is that the 1st brown, after "inter-dark" on the eye color chart?


This is correct, Scarlet.


PS-DMXX-are there any studies about the genetics of colour blindness? last I heard, many years ago, apox 10-15 % of the male pop has my kind of colour blindness

Yes, colour blindness is an X-linked condition that usually expresses in males (similar case with haemophilia). I'm studying opthamology in my own time soon this holiday so I'll have to get back to you on that. :)


I can not participate to this ever so interesting topic really but I can only admire nice eye colors ;)

utR! B)

Well, you certainly can participate if these SNP's are present in FTDNA's chip. :)

utR!
07-18-2013, 02:46 PM
Hi utR!,

You first have to register at GEDmatch, then upload your data (FTDNA FamilyFinder, FTDNA X-DNA, 23andMe, Ancestry.com).

Unfortunately, due to the current processing backlog, DNA uploads have been suspended. It is expected that new uploads will be accepted on about August 15.

Click here (http://gedmatch.com/) to go to GEDmatch.

Once you have uploaded your data, and have been given a kit number, you can then use ‘Predict Eye Colour’ from the ‘Analyse Your Data’ section.

The Eye Colour Predictor will give you a list of the SNPs used to predict your eye colour, your results at those SNPs, and a description of what influence each SNP has on your eye colour/pattern (e.g. TG at: rs8036572 - Amber Sphincter). The predictor will also give you an image of what your eye colour is expected to be, based on your results for the SNPs used to predict your eye colour.

My 23andMe and FTDNA FamilyFinder data give slightly different predictions.

Clinton P

Thanks for information Clinton P. I just wonder if it may give me a color prediction opposite of mine perhaps brown instead of blue-green. Thats what happened to basque.

Does that all cost something?

utR!

Clinton P
07-18-2013, 03:44 PM
Thanks for information Clinton P. I just wonder if it may give me a color prediction opposite of mine perhaps brown instead of blue-green. Thats what happened to basque.

Does that all cost something?

utR!

This is what GEDmatch has to say....


The GEDmatch site and utilities have been developed, maintained, and constantly updated and improved for use by anyone, anywhere, and FOR FREE.
While we do this work voluntarily, it is a full-time job; your donations are greatly appreciated, and will fund continued improvements to this site and to your experience.
Donations can be made easily and securely by clicking on the 'Donate' button below, or can be sent to GEDmatch, c/o Curtis Rogers at 710 First Avenue South, Lake Worth, FL 33460.
Thank you for your generosity!

Clinton P

utR!
07-18-2013, 03:53 PM
This is what GEDmatch has to say....



Clinton P

Ok. Need to think it over how it all techinically is possible (I'm not really a computer expert). But learning all life long.

;)

utr!

utR!
07-18-2013, 04:01 PM
Multipost response below:

Well, you certainly can participate if these SNP's are present in FTDNA's chip. :)

Hi DMXX!

Tha for you!

I gave up ages ago for a hope that FTDNA finder-results has those SNP's. Partly I'm a bit dissapointed in FTDNA Family Finder because it promised more. There were missing quite a bit of SNP's. But I'd like to be optimistic it does not cost much :)

utR!

J Man
07-18-2013, 05:28 PM
Multipost response below:



If you end up having children with a woman who has blue eyes, your children's eyes will most likely fall in the "inter-light" and "green" eye categories shown on the original chart. This is because, to produce blue eyes, a person must be homozygous light for SNP1 and the majority of their other alleles coding for light eyes. Since your hypothetical wife will have that, whereas yours is a heterozygous picture (esp. on SNP1), your kids will either be heterozygous or homozygous light for all SNP's.

Whereas, if you have a wife whose eyes are hazel/heterozygous (basically SNP1 again, remember that's the most important), your children could plausibly have any eye colour, depending on the sort of alleles she has and chance inheritance from that diversity.



Thank you, Calamus, I'll update your results to the IrisPlex spreadsheet once I have more samples.



This is correct, Scarlet.



Yes, colour blindness is an X-linked condition that usually expresses in males (similar case with haemophilia). I'm studying opthamology in my own time soon this holiday so I'll have to get back to you on that. :)



Well, you certainly can participate if these SNP's are present in FTDNA's chip. :)

Thanks for the reply and your thoughts DMXX. In your photo chart I fall into the Hazel group correct?

DMXX
07-18-2013, 06:40 PM
Thanks for the reply and your thoughts DMXX. In your photo chart I fall into the Hazel group correct?

That is correct, yes. I have archived copies of several participant eye pictures (including yours) and I'm sure you'll agree the Hazel description from the panel I've posted here several times matches your own eye colour quite well. If there were some adjustments in contrast and brightness, I imagine it'd match your eye colour exceedingly so.

Clinton P
07-19-2013, 03:22 PM
An interesting presentation....

Eye Color: Arielle Yablonovitch and Ye Henry Li

Click here (http://www.stanford.edu/class/gene210/files/projects/EyeColorPresentation.pdf) to read this presentation [PDF].

Clinton P

utR!
07-19-2013, 04:45 PM
An interesting presentation....

Eye Color: Arielle Yablonovitch and Ye Henry Li

Click here (http://www.stanford.edu/class/gene210/files/projects/EyeColorPresentation.pdf) to read this presentation [PDF].

Clinton P


I think so too, need to read it all tha for you C. P.

Eyes are mirrow of your soul it is said :nod:

But there is that scientifical side too which makes is more significant to know more.



utR!

J Man
07-19-2013, 06:10 PM
That is correct, yes. I have archived copies of several participant eye pictures (including yours) and I'm sure you'll agree the Hazel description from the panel I've posted here several times matches your own eye colour quite well. If there were some adjustments in contrast and brightness, I imagine it'd match your eye colour exceedingly so.

I know that I sound like I am repeating myself here sorry but is there a chance that say if I end up having children with a blue eyed woman or a woman who is heterozygous that my children could end up with pure blue eyes as well based on my results? You mentioned ''inter-light'' and ''green'' before but what about blue?

DMXX
07-19-2013, 06:22 PM
That's a good link Clinton, it covers the main thrust of eye colour genetics pretty darn well. Their emphasis on HERC2-OCA2 is measured, in my opinion, but it isn't the whole story. A lot of those SNP's were found to be statistically insignificant in later studies once linkage disequilibrium (basically "gene coupling" between important SNP's) was minimised. That's partially why I haven't given all the participants a 50+ list of SNP's to provide.


I know that I sound like I am repeating myself here sorry but is there a chance that say if I end up having children with a blue eyed woman or a woman who is heterozygous that my children could end up with pure blue eyes as well based on my results? You mentioned ''inter-light'' and ''green'' before but what about blue?

That's quite alright J Man; inheritance patterns of eye colour are an interesting topic, so I can appreciate the intrigue. :)

Yes, it's absolutely possible. Here's an easier way of looking at it; your alleles are half the picture, whereas your hypothetical future wife is the other. Since you're heterozygous for the main SNP and a couple others, it's basically up to your hypothetical spouse's "set up" to determine whether it's even possible for your kids to have blue or hazel eyes, such as yourself. If you married a woman and had children with her, and her eye colour eye colour was like yours or lighter, then blue eyes are definitely possible.

In fact, if your hypothetical future wife had brown eyes, but was heterozygous for SNP1 and had a couple of light alleles for the others, there still is a chance you can have a blue eyed child.

J Man
07-19-2013, 10:14 PM
^Alright thanks again! :)

utR!
07-20-2013, 01:11 PM
Multipost response below:opthamology in my own time soon this holiday so I'll have to get back to you on that. :)



Well, you certainly can participate if these SNP's are present in FTDNA's chip. :)

Well DMXX, you meant those 23 SNP's? Sent them here; I have only 5 which give me a result, is it enough? This project is mainly for those who has 23andMe results.



:)

utR1

DMXX
07-20-2013, 01:23 PM
With only those five SNP's, one unfortunately cannot get much information on their eye colour genotypes, as a hefty chunk of the ones missing are used in many of the studies currently out there.

utR!
07-20-2013, 02:27 PM
With only those five SNP's, one unfortunately cannot get much information on their eye colour genotypes, as a hefty chunk of the ones missing are used in many of the studies currently out there.

Thanks again!



Best

utR!

J Man
07-20-2013, 05:38 PM
My mother's results below plus a few photos of her eyes.

rs12913832: GG
rs1800407: CC
rs12896399: GG
rs16891982: GG
rs1393350: AG
rs12203592: CC
rs7495174: AA
rs7183877: CC
rs4778232: CC
rs1408799: CT
rs8024968: CC
rs683: CC
rs4778138: AA
rs4778241: CC
rs1667394: TT
rs26722: CC
rs1015362: CC
rs4911414: GT
rs1540771: CT
rs12821256: CT
rs885479: GG
rs1805008: CC
rs1805005: GG
rs3829241: GG

http://imageshack.us/a/img594/3694/1wwb.jpg

http://imageshack.us/a/img543/7606/23su.jpg

ilmari
07-20-2013, 11:30 PM
J Man, what is her heritage?

J Man
07-21-2013, 03:38 PM
J Man, what is her heritage?

Irish/British Isles.

J Man
07-23-2013, 12:52 AM
DMXX what category do my mother's eyes and results fall into?

DMXX
07-25-2013, 03:30 PM
DMXX what category do my mother's eyes and results fall into?

Hello J Man,

Looking at your mother's phenotype I'd say Inter-light given there's a thin light brown ring around her iris.

I'll be updating the IrisPlex results for new participants once I receive more samples (I'm always accepting new ones).

J Man
07-25-2013, 10:45 PM
Ahhh okay thanks my friend. Now I am also curious about the genes behind those of us such as AJL and myself that have true ''Hazel'' eyes. That is our eyes are green/gray like on the outside and amber/light brown near the pupil. This certainly seems to be a distinct eye colour as I have know many people who have it. Are there probably some as of yet undiscovered genes or SNPS that code for true Hazel eye colour such as AJL and myself have?

DMXX
08-04-2013, 03:59 AM
I suspect allele combinations on the other SNP's explain much of the story, if not most of it. IrisPlex was a big step forward and all the other SNP's are shown to have a role in the literature. As I don't have many people with you and AJL's shade participating at this point it's hard to tell.

I'll be sharing another interesting feature with participants soon (as well as updating the IrisPlex results) once I have at least six more new samples.

Lena Frid
08-10-2013, 04:19 PM
One more sample coming up.
These are my data:


rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 TT
rs4911414 TT
rs1540771 TT
rs12821256 CT
rs885479 AG
rs1805008 CC
rs1805005 GG
rs3829241 AG

And pictures, not very good though.

600601

I am Swedish, also with a few ancestors before 1650 from Denmark and northern Germany. My parents and siblings all had/have blue eyes. I am the only one with mixed colours.
Got my results from 23andme some weeks ago.

Please, ask me if you need any more information,

Lena Frid

Joe B
08-11-2013, 05:27 PM
Just got my results this last night!

My eye color is Green.
Eye Color Prediction: Likely Blue
rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 TT
rs4911414 TT
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GT
rs3829241 GG

leonardo
08-11-2013, 10:01 PM
I will participate DMXX.

rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 TT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG

http://img819.imageshack.us/img819/3377/twnr.jpg

I would say my eye resembles the second from the left on your spectrum provided in the opening post.:)

jiraiyaboutthat
08-13-2013, 12:54 AM
My eye color is grey/green/hazel; 23andme said it was likely to be blue.
I'm not entirely sure what my heritage is, but it there is a known concentration of British, German, and NE Euro. More distantly there is a supposed SW Asian and Near East heritage.

rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 TT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG


611

AJL
08-13-2013, 05:54 AM
My eye color is grey/green/hazel; 23andme said it was likely to be blue.
I'm not entirely sure what my heritage is, but it there is a known concentration of British, German, and NE Euro. More distantly there is a supposed SW Asian and Near East heritage.

Welcome to Anthrogenica!

jiraiyaboutthat
08-13-2013, 09:27 PM
Thanks! This thread is what brought me here.

MikeWhalen
08-14-2013, 11:07 AM
would it be inappropriate of me to say, what a pretty green eye?

welcome aboard jir



Thanks! This thread is what brought me here.

jiraiyaboutthat
08-14-2013, 06:09 PM
would it be inappropriate of me to say, what a pretty green eye?

welcome aboard jir

Thank you, Mike, it isn't at all inappropriate. :)

Sangarius
08-20-2013, 06:31 PM
Hi, here are the results of a friend who wants to participate, his nick is MfA. There might come more participants. :)

His results:
rs12913832 AA
rs1800407 CT
rs12896399 GG
rs16891982 CG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 AA
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 CC
rs4778138 AA
rs4778241 AA
rs1667394 CC
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG

Pics of his eyes, with flash
http://abload.de/img/dfgjauap.jpg

and in daylight.
http://abload.de/img/sam_28602mza4u.png

Hanna
08-20-2013, 07:46 PM
Can I be added too?

My SNP results:

rs12913832 AA
rs1800407 CC
rs12896399 GG
rs16891982 CG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 AC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 AC
rs1667394 CT
rs26722 CT
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG


My eyes are medium brown with yellow pigmentation rings.

This is what I got from Gedmatch's eye predictor:

http://imageshack.com/a/img202/3003/l32y.jpg

MikeWhalen
08-21-2013, 03:31 AM
wow, that is a striking eye color...bet the girls like that!

Mike


Hi, here are the results of a friend who wants to participate, his nick is MfA. There might come more participants. :)

His results:
rs12913832 AA
rs1800407 CT
rs12896399 GG
rs16891982 CG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 AA
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 CC
rs4778138 AA
rs4778241 AA
rs1667394 CC
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG

Pics of his eyes, with flash
http://abload.de/img/dfgjauap.jpg

and in daylight.
http://abload.de/img/sam_28602mza4u.png

utR!
08-21-2013, 05:29 PM
Yes you got it right Mike, his eyes are ihanat nice ones indeed. I do not like brown color much but in eyes it makes a big difference. Do not why it is so?


:rolleyes:

Telfermagne
08-23-2013, 02:59 AM
rs12913832 AG
rs1800407 CT
rs12896399 GT
rs16891982 GG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GT
rs3829241 GG

Photographic supplement:

http://i1161.photobucket.com/albums/q506/sar1227/9571856773_c4cf7f66e6_o_zpsef912b66.jpg (http://s1161.photobucket.com/user/sar1227/media/9571856773_c4cf7f66e6_o_zpsef912b66.jpg.html)

Ancestry - Will just use 23andMe's ancestry composition for this part.

99.9% European

95.1% Northern European

United Kingdom of Great Britain and Northern Ireland (Recent immigrants & colonials mix)
Republic of Ireland (Recent immigrants)
Germany, Switzerland & Germany-France border lands (Mennonite families and some more recent immigrants)

2% Southern European (Iberian in AC)
Presumed as Portuguese (surname Carrico, Y-DNA J2a4b)

0.7% Ashkenazi
RF matches are from Germany & Poland (German language surnames though)

0.7% Eastern European (specific region unknown)

0.1% Subsaharan African (via Barbados and Haiti)

Gedmatch comparison:

Predicted Eye Color for Kit M033622 (V3)

Read rules from top to bottom. In some cases, a rule cancels out results from rules above it.

CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CC at: rs4778241 - Low Melanin. Basis for Gray, Blue, Green, or Yellow Eyes if no other pigmentation is present.
CC at: rs9782955 - Blocks some melanin. Often gives light colored eyes.
CT at: rs1800407 - Penetrance Modifier - Blue
CT at: rs1129038 - Adds Yellow.
AA at: rs8033448 - Med Brown on Sphincter
AA at: rs4778138 - Weak Amber Gradient
GT at: rs7713279 - Inhibit weak amber gradient
GG at: rs16891982 - Starburst (Collarette)
TT at: rs1667394 - Starburst (Collarette)
CC at: rs12203592 - No pigmented Collarette.
CC at: rs4779685 - Flecks (Nevi).

sammyjean
08-25-2013, 04:02 PM
Hi there, I'm new there! I followed your link from 23andMe.

My information:

rs12913832: GG
rs1800407: CC
rs12896399: GT
rs16891982: GG
rs1393350: AG
rs12203592: CT
rs7495174: AA
rs7183877: CC
rs4778232: CC
rs1408799: TT
rs8024968: CC
rs683: CC
rs4778138: AA
rs4778241: CC
rs1667394: TT
rs26722: CC
rs1015362: CT
rs4911414: GT
rs1540771: TT
rs12821256: TT
rs885479: GG
rs1805008: CC
rs1805005: GG
rs3829241: AA

Ancestry Composition:

35.7% British and Irish
16.3% French and German
1.1% Scandinavian
41.6% Nonspecific Northern European
1.5% Nonspecific Southern European
0.9% Eastern European
2.8% Nonspecific European
0.1% East Asian

My eyes are inter-light

chiva01
08-31-2013, 04:05 AM
Newby as well :) Here is my info
AC at: rs4778241 - High Melanin. Adds yellow, amber, or brown. Some darkening. Contributes Amber, Brown.
CC at: rs1847134 - Deep Brown
CC at: rs9782955 - Blocks some melanin. Often gives light colored eyes.
AA at: rs1393350 - Brown
CT at: rs1129038 - Adds Yellow.
GT at: rs7713279 - Inhibit weak amber gradient
GG at: rs12906280 - Gray ring around outer edge
TG at: rs1470608 - Medium melanin on Anterior Epithelium. Gives dark eyes.
AG at: rs7174027 - Adds Yellow.
GA at: rs7495174 - Adds melanin. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
TT at: rs1667394 - Starburst (Collarette)
CC at: rs12203592 - No pigmented Collarette.
AG at: rs11634406 - Flecks (Nevi).
TT at: rs35405 - Inhibit weak amber gradient

Ancestry is mixed European

650

It is not as easy as it looks to get a decent picture of your eyeball :)

leonardo
08-31-2013, 11:04 PM
It is not as easy as it looks to get a decent picture of your eyeball :)
I had my wife take the picture. It is much easier that way.:)

alan
09-16-2013, 03:16 PM
Here my eyes

http://24.media.tumblr.com/88ddefbcb897d5bc2d6ba04747cfa5d4/tumblr_mr4ag85zNe1s9pl8ao1_500.jpg

Scarlet Ibis
09-16-2013, 08:15 PM
^ Love your song "No Control."

9thdigit
09-29-2013, 03:38 PM
723

My eyes seem to change color depending on light. They sometimes appear medium grey in dim light; light brown under medium light; & brown/??? in picture (used flash)... to me i see some green on the lower half of iris. What do others see? GEDMATCH predicted less brown around pupil with lighter green surrounding the brown (outer iris).

9thdigit
09-29-2013, 04:44 PM
rs12913832 AA
rs1800407 CC
rs12896399 GT
rs16891982 CG
rs1393350 GG
rs12203592 CT
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 TT
rs8024968 CC
rs683 CC
rs4778138 AA
rs4778241 AC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GT
rs3829241 AA

Ancestry is mixed European/Native American/Berber

DMXX, Please add me to your eye project. Thanks!

9thdigit
09-29-2013, 05:04 PM
724

GEDMATCH prediction using their snps...

MikeWhalen
09-30-2013, 12:15 PM
Hi 9th
I might be the wrong guy to answer since I have a mild case of red-green color blindness, but to my eyes, there sure seems to be a nice medium dark green to your eyes

welcome to the forum

Mike


723

My eyes seem to change color depending on light. They sometimes appear medium grey in dim light; light brown under medium light; & brown/??? in picture (used flash)... to me i see some green on the lower half of iris. What do others see? GEDMATCH predicted less brown around pupil with lighter green surrounding the brown (outer iris).

MikeWhalen
09-30-2013, 12:19 PM
Hi Alan
wish you could have uploaded your eye pics to this site, it allows for a magnification of the pic so you get a nice close look at the eyes

your first pic makes it look like they are green, but the other two seem to be more of a lighter blue-I'm guessing that the middle pic is the most representative of your eyes given it seemed to have the most natural lighting

Mike


Here my eyes

http://24.media.tumblr.com/88ddefbcb897d5bc2d6ba04747cfa5d4/tumblr_mr4ag85zNe1s9pl8ao1_500.jpg

Private_user
09-30-2013, 01:51 PM
Hi 9th
I might be the wrong guy to answer since I have a mild case of red-green color blindness, but to my eyes, there sure seems to be a nice medium dark green to your eyes

welcome to the forum

Mike
To be honest, your case of color blindness doesn't seem to be that mild. 9thdigit's eye is brown and so was that of Scarlet Ibis (http://www.anthrogenica.com/showthread.php?1057-DMXX-s-Eye-Colour-Project-(v-2)&p=10040&viewfull=1#post10040).

My paternal grandfather and one of his grandchildren (my cousins) are color blind too - both are also convinced that their color blindness is mild...

On the bright side, you're probably better at discerning hue patterns than non-color-blind people are :)

9thdigit
09-30-2013, 01:56 PM
Mike, thanks for your comment! I'm glad i found this site, I think eyes are fascinating and tell a story.

MikeWhalen
10-01-2013, 03:03 PM
Ha!
well, I was a bit nervous about giving my opinion out loud on those eye colors, an unusual situation for a nice Irish-Canadian lad, and I guess I was right to be so...she sure looked greenish to me

much like the time I thought I won a game of snooker when I made a hard shot and sank the needed brown ball, only to have all the other guys look at me in amazement as they asked why the hell did you sink the red ball

thx for the feedback Linkus, I shall double check the color of my socks now
:)

Mike


To be honest, your case of color blindness doesn't seem to be that mild. 9thdigit's eye is brown and so was that of Scarlet Ibis (http://www.anthrogenica.com/showthread.php?1057-DMXX-s-Eye-Colour-Project-(v-2)&p=10040&viewfull=1#post10040).

My paternal grandfather and one of his grandchildren (my cousins) are color blind too - both are also convinced that their color blindness is mild...

On the bright side, you're probably better at discerning hue patterns than non-color-blind people are :)

MfA
10-15-2013, 04:16 PM
wow, that is a striking eye color...bet the girls like that!

Mike

Thanks, Is the project still alive? I haven't received any ID and seems that spreadsheet haven't got an update either..

ilmari
10-15-2013, 11:56 PM
Thanks, Is the project still alive? I haven't received any ID and seems that spreadsheet haven't got an update either..

Hello, and welcome to Anthrogenica. While I am not absolutely certain, I'm fairly certain that the project is still alive. The O.P. and Project manager is often quite busy from time to time, but I feel that it's safe to say you'll get an update here as soon as it is possible.

Scarlet Ibis
10-16-2013, 12:09 AM
Thanks, Is the project still alive? I haven't received any ID and seems that spreadsheet haven't got an update either..

Hi MfA, I think I recognize you from other forums. :)

Ilmari is right; DMXX is busy for the time being, but he will be back.

Jean M
10-18-2013, 12:26 PM
This might be of interest to DMXX. I don't have access to the full paper.

Sheila Ulivi, Massimo Mezzavilla and Paolo Gasparini, Genetics of eye colours in different rural populations on the Silk Road, European Journal of Human Genetics (2013) 21, 1320–1323


Eye colour is a highly transmissible and discernible trait in humans. A genome-wide association scan for variants associated to eye pigmentation was carried out on a large group of individuals coming from the Silk Road. Significant associations were detected not only with HERC2 (P-value=4.99 × 10−37) and OCA2 (P-value=4.51 × 10−9) genes but also with CTNNA2 gene (P-value=4.06 × 10−8). Moreover, the multifactor dimensionality reduction analysis clearly showed the effect of HERC2 haplotype over OCA2 mostly associated with SNP, thus enabling a highly accurate eye-colour prediction. Finally, the regression tree analysis showed that individuals carrying a given combination of haplotypes have a significant probability to show a blue or green/grey iris colour as compared with brown, with a gradient from west to east.

http://www.nature.com/ejhg/journal/v21/n11/abs/ejhg201341a.html

Hok
10-21-2013, 12:41 PM
Hello people, here are my results:

rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 CG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CT
rs1015362 TT
rs4911414 TT
rs1540771 CT
rs12821256 CT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG

I have inter-light eyes.

Stephen1986
12-09-2013, 08:24 PM
Not sure if this is too late, but you can still use my data for the project.

DMXX
12-20-2013, 06:17 AM
As some of our staff have kindly stated here, I have been on hiatus from the forum for three months due to my studies. The project is alive and will continue once more in the next few days.

Thank you all for your patience.

vettor
12-20-2013, 06:40 AM
why are companies wrong with my colour eyes.

23andme state mid blue

gedmatch state light blue

others state a different blue

I keep sending them a photo of my mid -green eyes .................are green and blue so very close?.....I though green was closer to hazel eyes

Ponto
12-29-2013, 05:20 AM
rs12913832 AA
rs1800407 CC
rs12896399 GG
rs16891982 CG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 AC
rs4778232 CT
rs1408799 CT
rs8024968 CT
rs683 CC
rs4778138 AA
rs4778241 AC
rs1667394 CT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 TT
rs12821256 TT
rs885479 GG
rs1805008 CT
rs1805005 GG
rs3829241 AG

Mid brown eyes, some grey.

Mamluk
03-23-2014, 11:49 AM
As a matter of fact, my own eyes were a medium-dark brown without any sort of non-brown colouring as a child. I first noticed the amber-green colouring at the age of 15. Actually, I should use myself as a case study and take a picture every year over a decade or two. :P

Hi DMXX,

I noticed this thread a year too late. But you might still have our data from the old forums (?).

Even though you and I have different SNPs from each other, our irises share similar characteristics, with the "greenish rings" and some changing with age. Here's a recent photo of my eye color, taken with an iPhone indoors. The last photo is of my father's (age in his 70's) taken with an iPhone indoors.

1651
1652

DMXX
03-30-2014, 12:47 AM
After a lengthy break due to my studies I've finally found time to update the project. We currently have a total of 40 participants now. I thank all who have been patiently waiting during the interim period.

All of the results shared on this thread have been included in my spreadsheet aside from Telfermagne's (genotype data provided but picture taken down, no description included) and chiva01 (Photo provided, but genotype data from Gedmatch, not the panel I created). As Ponto is no longer with us on the forum, I decided not to include his results.

The updated IrisPlex Spreadsheet can be found here (https://docs.google.com/spreadsheet/pub?key=0AuedvPON0rv2dGVZcjQzaFIxSUROVFdBZkt3c050b FE&output=html).

Aside from this, I'll be fashioning the data into another informative result over the coming week or so. Replying to a couple of messages in the meantime:


why are companies wrong with my colour eyes.

23andme state mid blue

gedmatch state light blue

others state a different blue

I keep sending them a photo of my mid -green eyes .................are green and blue so very close?.....I though green was closer to hazel eyes

Gedmatch do a very good job of predicting eye colours, but it is hard to discern the lighter colours from one another due to the variation brought about by lighting conditions photographically and the greater role played by minor alleles once the GG @ rs12913832 exert their influence.


Hi DMXX,

I noticed this thread a year too late. But you might still have our data from the old forums (?).

Even though you and I have different SNPs from each other, our irises share similar characteristics, with the "greenish rings" and some changing with age.

I do have your original data, but the updated SNP panel I'm using this time is more condensed and validated by the several years of work in forensic science. If you're interested in participating in the new project, please refer to the original post for detailed instructions.

Yes, your greenish rings are very similar to mine. Which is nice. I've only ever seen the pattern we have in three other people ever (an Anglo-Australian, an anonymous contributor's photo shared by JOlson of Gedmatch on DNA-Forums, and a young Central Asian lady).

vettor
03-30-2014, 12:57 AM
After a lengthy break due to my studies I've finally found time to update the project. We currently have a total of 40 participants now. I thank all who have been patiently waiting during the interim period.

All of the results shared on this thread have been included in my spreadsheet aside from Telfermagne's (genotype data provided but picture taken down, no description included) and chiva01 (Photo provided, but genotype data from Gedmatch, not the panel I created).

I'll be updating the IrisPlex spreadsheet (https://docs.google.com/spreadsheet/pub?key=0AuedvPON0rv2dGVZcjQzaFIxSUROVFdBZkt3c050b FE&output=html) with the new samples after this post has been edited.

Aside from this, I'll be fashioning the data into another informative result over the coming week or so.



http://imageshack.com/a/img34/6478/yf2q.jpg

can you add mine as per above

I have 100% green eyes..............23andme say I am mid blue .............gedmatch show me sky blue

DMXX
03-30-2014, 01:03 AM
can you add mine as per above


Please consult with the original post for the SNP panel I'm using. I can't make use of any of the alleles you've shared.

MfA
03-30-2014, 01:15 AM
Thanks for the heads up DMXX.. My ID is #36, light brown or just brown?, My 2 grandparents have brown eyes, my granddad had greyish blue eyes and my grandma has green eyes.

DMXX
03-30-2014, 01:20 AM
Thanks for the heads up DMXX.. My ID is #36, light brown or just brown?, My 2 grandparents have brown eyes, my granddad had greyish blue eyes and my grandma has green eyes.

Your eyes looked medium brown to me; neither light (amber) nor dark. Your results are somewhat similar to ID010's. As you'll note, most of the Brown (II) participants lack alleles which see to code for lighter eyes. Your heterozygosity on my SNP2 is presumably what's responsible for your eyes not being a darker shade. Reasonable to also presume this was inherited from one of your light-eyed grandparents.

Coincidentally, you have the exact same shade and patterning as my brother. Like you, we also have light-eyed recent ancestors. On both my Azeri and Persian sides we have entire branches with fair hair and eyes. Judging by my own IrisPlex results (ID001) and phenotype (http://www.anthrogenica.com/showthread.php?1057-DMXX-s-Eye-Colour-Project-(v-2)&p=9321&viewfull=1#post9321), I just happened to inherit more of those than my brother.

I'm presuming other people from countries with a majority of dark eyed phenotypes that have light eyed relatives somewhere will have a couple of alleles for it floating around (i.e. we're not special in this regard).

Humanist
03-30-2014, 01:22 AM
I am ID022. Matches, across these 6 SNPS, with ID011, ID012, and ID024.

http://i1178.photobucket.com/albums/x372/paulgiva78/passover/id022_hum.jpg


I am ID011, my mom is ID012, and my sister is ID024. :P

Thanks for the update, DMXX. Just checked your spreadsheet again. Two more matches.

ID011 - Green (Finnish)
ID012 - Inter-light (Finnish)
ID022 - Green (Assyrian)
ID024 - Inter-light (Finnish)
ID033 - Green (??)
ID034 - Inter-light (??)

MfA
03-30-2014, 01:29 AM
Your eyes looked medium brown to me; neither light (amber) nor dark. Your results are somewhat similar to ID010's. As you'll note, most of the Brown (II) participants lack alleles which see to code for lighter eyes. Your heterozygosity on my SNP2 is presumably what's responsible for your eyes not being a darker shade. Reasonable to also presume this was inherited from one of your light-eyed grandparents.

Coincidentally, you have the exact same shade and patterning as my brother. Like you, we also have light-eyed recent ancestors. On both my Azeri and Persian sides we have entire branches with fair hair and eyes. Judging by my own IrisPlex results (ID001), I just happened to inherit more of those than my brother.

I see it seems rare being heterozygous on SNP2, only 4/40 of members inherited while 23/40 members have light eyes.

Hanna
03-30-2014, 02:39 AM
Your eyes looked medium brown to me; neither light (amber) nor dark. Your results are somewhat similar to ID010's. As you'll note, most of the Brown (II) participants lack alleles which see to code for lighter eyes. Your heterozygosity on my SNP2 is presumably what's responsible for your eyes not being a darker shade. Reasonable to also presume this was inherited from one of your light-eyed grandparents.

Coincidentally, you have the exact same shade and patterning as my brother. Like you, we also have light-eyed recent ancestors. On both my Azeri and Persian sides we have entire branches with fair hair and eyes. Judging by my own IrisPlex results (ID001) and phenotype (http://www.anthrogenica.com/showthread.php?1057-DMXX-s-Eye-Colour-Project-(v-2)&p=9321&viewfull=1#post9321), I just happened to inherit more of those than my brother.

I'm presuming other people from countries with a majority of dark eyed phenotypes that have light eyed relatives somewhere will have a couple of alleles for it floating around (i.e. we're not special in this regard).

I (037) am listed as brown 1, shouldn't I be brown 2 according to the results? ID 004 got the same results as me but identified as brown 2, why am I brown 1?

escalation
03-30-2014, 07:46 AM
rs12913832 AG
rs1800407 CT
rs12896399 TT
rs16891982 CG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 TT
rs8024968 CT
rs683 CC
rs4778138 AG
rs4778241 AC
rs1667394 CT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GT
rs3829241 AG

I'm 80% Assyrian and 20% Armenian. My eyes are hazel. They have a very dark brown ring around the outside, mostly green with very small brown lines in some areas between the ring and area around the pupil, and very light brown around the pupil. My mom has very light-blue eyes and my dad has super dark-brown eyes.

vettor
03-30-2014, 09:20 AM
Please consult with the original post for the SNP panel I'm using. I can't make use of any of the alleles you've shared.

ok

my Gedmatch results below .....................others will follow

CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CC at: rs4778241 - Low Melanin. Basis for Gray, Blue, Green, or Yellow Eyes if no other pigmentation is present.
CT at: rs989869 - Contrasting sphincter around pupil.
CT at: rs3947367 - Contrasting sphincter around pupil.
AA at: rs4778138 - Weak Amber Gradient
TT at: rs1129038 - Penetrance modifier. Blue.
GT at: rs8036572 - Amber Sphincter
GG at: rs12906280 - Gray ring around outer edge
GG at: rs16891982 - Starburst (Collarette)
TT at: rs1667394 - Starburst (Collarette)
CC at: rs12203592 - No pigmented Collarette.


rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891482 CC
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885478 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

As per your examples....mine would be closest to the 3rd from the left

DMXX
03-30-2014, 11:23 AM
I (037) am listed as brown 1, shouldn't I be brown 2 according to the results? ID 004 got the same results as me but identified as brown 2, why am I brown 1?

Those assignments (Brown I, Inter-light etc.) are based on your phenotype (that is, the physical manifestation of all the genes responsible for a trait, both known and unknown). Everyone is classified independent of their genotype results from IrisPlex.

The IrisPlex SNP array (the six SNPs you see) are a very accurate way of discerning light from dark in Europeans. It's still relatively accurate for people outside Europe, but less so. You aren't the only person who's noticed a disconnect between genotype and phenotype through those SNPs.

I can tell you ID004's eye colour is very dark. The same goes for ID030. Both their shades are definitely darker than yours. Your shade of brown is more medium in colour and closer to, say, MfA's. If I didn't have numerous greenish rings in my eyes, I'd have classed myself as Brown (I) as well regardless of my genotype.

The purpose of this spreadsheet is for everyone to see a real-world application of eye colour genetics through their own genotypes. I haven't formally assessed the results but they seem largely accurate. In your case, it's probable that other alleles (likely a couple in my extended SNP array) that are "lightening" your eyes up to a medium brown despite IrisPlex indicating you should have a shade of dark brown.

On a related topic, I just realised we have our first example of a person with hazel eyes (brown internal colour, grey-green external colour) who doesn't have AG at the very influential rs12913832. Instead, they are AA. Curious to look into that at a later date.

everest59
03-30-2014, 08:33 PM
Interesting thread. Here are mine. My eyes are dark brown.


rs12913832 AA
rs1800407 CC
rs12896399 GT
rs16891982 CC
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 AC
rs4778232 CC
rs1408799 TT
rs8024968 CC
rs683 CC
rs4778138 AG
rs4778241 AC
rs1667394 CT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG


The thing here is, the picture that GEDMATCH has for my eyes looks yellowish brown even though I'm dark brown. Are all South Asians getting the same thing? Here's GEDMATCH results:


AC at: rs4778241 - High Melanin. Adds yellow, amber, or brown. Some darkening. Contributes Amber, Brown.
AG at: rs4778138 - Adds melanin. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
CC at: rs9782955 - Blocks some melanin. Often gives light colored eyes.
CT at: rs4553604 - Blue.
CT at: rs989869 - Contrasting sphincter around pupil.
CC at: rs1129038 - High Melanin production. Brown.
AA at: rs8033448 - Med Brown on Sphincter
CT at: rs3935591 - Heavy melanin on Anterior Epithelium. Brown.
CT at: rs1667394 - Medium melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
CC at: rs3947367 - Penetrance modifier. Blue
CT at: rs916977 - Adds melanin. Adds yellow, amber, or brown.
AG at: rs7174027 - Adds Yellow.
CC at: rs16891982 - Increased melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
AA at: rs12913832 - High melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
CC at: rs12203592 - No pigmented Collarette.
CC at: rs4779685 - Flecks (Nevi).


23andme says brown, so they got it right.
Okay, I attached the GEDMATCH prediction. Nowhere is that close. What I'm wondering is, what do other South Asians get?

leonardo
03-31-2014, 01:14 AM
Thanks for the update, DMXX. Just checked your spreadsheet again. Two more matches.

ID011 - Green (Finnish)
ID012 - Inter-light (Finnish)
ID022 - Green (Assyrian)
ID024 - Inter-light (Finnish)
ID033 - Green (??)
ID034 - Inter-light (??)

I am ID034 Humanist. If you are looking for my ancestral background, I am a mixed American, likely 45% Germanic-Slavic, 37.5% British Isles/Irish, 12.5% Italian and 5% some sort of East Med.

leonardo
03-31-2014, 01:26 AM
After a lengthy break due to my studies I've finally found time to update the project. We currently have a total of 40 participants now. I thank all who have been patiently waiting during the interim period.

All of the results shared on this thread have been included in my spreadsheet aside from Telfermagne's (genotype data provided but picture taken down, no description included) and chiva01 (Photo provided, but genotype data from Gedmatch, not the panel I created). As Ponto is no longer with us on the forum, I decided not to include his results.

The updated IrisPlex Spreadsheet can be found here (https://docs.google.com/spreadsheet/pub?key=0AuedvPON0rv2dGVZcjQzaFIxSUROVFdBZkt3c050b FE&output=html).

Aside from this, I'll be fashioning the data into another informative result over the coming week or so. Replying to a couple of messages in the meantime:



Gedmatch do a very good job of predicting eye colours, but it is hard to discern the lighter colours from one another due to the variation brought about by lighting conditions photographically and the greater role played by minor alleles once the GG @ rs12913832 exert their influence.



I do have your original data, but the updated SNP panel I'm using this time is more condensed and validated by the several years of work in forensic science. If you're interested in participating in the new project, please refer to the original post for detailed instructions.

Yes, your greenish rings are very similar to mine. Which is nice. I've only ever seen the pattern we have in three other people ever (an Anglo-Australian, an anonymous contributor's photo shared by JOlson of Gedmatch on DNA-Forums, and a young Central Asian lady).

Thanks for the research DMXX. May I ask, what does Inter-Light mean in reference to your study?

Joe B
03-31-2014, 01:31 AM
Thanks for the update, DMXX. Just checked your spreadsheet again. Two more matches.

ID011 - Green (Finnish)
ID012 - Inter-light (Finnish)
ID022 - Green (Assyrian)
ID024 - Inter-light (Finnish)
ID033 - Green (??)
ID034 - Inter-light (??)
IDO33 is German, Irish, Italian and unknown

ZephyrousMandaru
03-31-2014, 01:47 AM
My eyes are dark brown, and I am of Assyrian descent.

SNPs


rs12913832 AA
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AG
rs7183877 CC
rs4778232 TT
rs1408799 TT
rs8024968 CT
rs683 CC
rs4778138 GG
rs4778241 AC
rs1667394 CC
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

Humanist
03-31-2014, 01:49 AM
Thanks for the update, DMXX. Just checked your spreadsheet again. Two more matches.

ID011 - Green (Finnish)
ID012 - Inter-light (Finnish)
ID022 - Green (Assyrian)
ID024 - Inter-light (Finnish)
ID033 - Green (N. European / Italian / Unknown)
ID034 - Inter-light (Pred. N. European / Italian / East Med.)



I am ID034 Humanist. If you are looking for my ancestral background, I am a mixed American, likely 45% Germanic-Slavic, 37.5% British Isles/Irish, 12.5% Italian and 5% some sort of East Med.

Thank you very much for the information, leonardo. :)


IDO33 is German, Irish, Italian and unknown

Much appreciated, Joe B.

DMXX
03-31-2014, 02:15 AM
To those interested in participating, please keep sending in your samples. I'll most likely update the spreadsheet next week given my schedule for the coming weekdays (have an MSc degree interview tomorrow afternoon in London...)


What I'm wondering is, what do other South Asians get?

I currently have no idea given the lack of South Asians in the project. Several South Asians participated in my old project on DNA-Forums (a "simranjits" kindly contributed at least three samples from memory). Unfortunately their data is unusable because of scanty SNP overlap.

An interesting feature of a few results was that some were AG @ rs12913832 and appeared to have inter-dark coloured eyes (i.e. brown with some non-brown colouring). In most West Eurasians, AG normally leads to hazel eyes. It is probably the case that their other SNPs coded for brown eyes and reduced the lighter colouring.


Thanks for the research DMXX. May I ask, what does Inter-Light mean in reference to your study?

Inter-light refers to an intermediate between fully blue and mostly green eyes. People with this colour tend to have an eye colour that's mostly light (usually blue), but there's some brown colouring somewhere.

Ignis90
03-31-2014, 03:14 AM
I have brown eyes. Ancestry: Berber



rs12913832 AA
rs1800407 CC
rs12896399 GT
rs16891482 CC
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 TT
rs1408799 CT
rs8024968 CT
rs683 AA
rs4778138 GG
rs4778241 AC
rs1667394 CC
rs26722 CT
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885478 GT
rs1805008 CC
rs1805005 GG
rs3829241 AG

soulblighter
03-31-2014, 03:33 AM
Another south asian to add to your list (click on the links for the pictures):

First here are my Gedmatch results:
Gedmatch Eye (http://i.imgur.com/4cqmsEg.jpg)

TC at: rs17762363 - Increased melanin production. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
TT at: rs916977 - Adds melanin. Some darkening.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CC at: rs9782955 - Blocks some melanin. Often gives light colored eyes.
CT at: rs989869 - Contrasting sphincter around pupil.
TC at: rs3947367 - Contrasting sphincter around pupil.
CC at: rs1129038 - High Melanin production. Brown.
AA at: rs4778138 - Weak Amber Gradient
TG at: rs7713279 - Inhibit weak amber gradient
GG at: rs12906280 - Gray ring around outer edge
AA at: rs4778241 - Medium melanin on Anterior Epithelium. Brown.
TG at: rs1470608 - Medium melanin on Anterior Epithelium. Gives dark eyes.
CC at: rs7403602 - High density on Anterior Stroma. Blocks melanin. Blocks blue. Gives lighter colors.
CC at: rs16891982 - Increased melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
AA at: rs12913832 - High melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
CC at: rs1667394 - Increased melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
CC at: rs12203592 - No pigmented Collarette.
AA at: rs11634406 - Flecks (Nevi).
GT at: rs1448485 - Inhibits weak amber gradient.


And here is the real one and my 23andme results for the SNPs ("me/ my mom" when different):
Real Eye (http://i.imgur.com/OSdVNmz.jpg)

rs12913832 AA
rs1800407 CC
rs12896399 TT
rs16891982 CC
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 AA/AC
rs4778232 CT/CC
rs1408799 CT
rs8024968 CT/CC
rs683 CC/AC
rs4778138 AA
rs4778241 AA/AC
rs1667394 CC/CT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG


Gedmatch got both the Gray ring as well as the Nevi, right in their prediction (although their sample does not seem show it)

Biloo
03-31-2014, 05:04 AM
rs12913832 AG
rs1800407 CT
rs12896399 GG
rs16891982 CG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 AC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 AC
rs1667394 CT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AA

and here's a picture of my eye

1666

Mamluk
04-01-2014, 04:45 PM
Our SNPs:
1673

And my family's "eye chart" :)
1674

DMXX
04-04-2014, 09:04 PM
Spreadsheet updated to include all samples included here (except soulblighter's mother, didn't see any indication of her eye colour, am happy to add at a later date once clarified).


>>View Updated IrisPlex Spreadsheet Here<< (https://docs.google.com/spreadsheet/ccc?key=0AuedvPON0rv2dGVZcjQzaFIxSUROVFdBZkt3c050b FE&usp=drive_web#gid=0)



As promised earlier, I've found another interesting application for the results. Specifically, in the form of the MC1R gene.

The SNPedia (http://snpedia.com/index.php/MC1R) page explains this gene's background and relevance in the context of pigmentation. Summarised, mutations on this gene lead to the absence of eumelanin (brown-black pigment) production, leaving pheomelanin (reddish) to accumulate. It is famously responsible for the copper-coloured hair, light eyes, freckles and very fair skin in the British Isles. According to at least one study, those with mutations on SNPs associated with MC1R has a role in painkiller drug response.

Why is MC1R relevant in the context of eye colour? Although several studies have focused specifically on its' effect on skin and hair colouring, there is some evidence it also has a role in determining eye colour [1]. This shouldn't come as a surprise as melanocytes are responsible for melanin production in the eyes, just as they are elsewhere in the body.

With that being said, I present a spreadsheet of everyone's results on two SNPs in my array that are a part of MC1R:


>>View MC1R Participant Spreadsheet Here (https://docs.google.com/spreadsheet/pub?key=0AuedvPON0rv2dGVZcjQzaFIxSUROVFdBZkt3c050b FE&gid=1)<<

I don't intend to continuously update this spreadsheet as often as the previous one. Chiefly because only two MC1R SNPs were used in my array, minimising the informativeness. I thought it'd be an interesting exercise to practice nonetheless. A few quick observations I made along the way:


The majority of people in the project (35/51, 68.6%) didn't carry any of the alleles which produce some sort of lightening in phenotype via MC1R. This shouldn't come as a surprise, given a larger number of participants aren't of Isles descent.
Over twice as many carried one of these alleles on SNP Y than SNP X. I have no explanation for this other than a sampling issue. If we get more participants from Europe (esp. the British Isles), it'd be interesting to see if this persists.
Only one participant (ID017) had two alleles coding in favour of decreased eumelanin production. I wonder if the rest of their phenotype expresses this?


This is just speculation, but for those individuals with "Mixed" results, I'd imagine they have some form of reddish colouring to supplement (e.g. reddish beard hairs). However, I should reiterate that pigmentation of any sort is polygenetic in nature; not once have I found any mutations for MC1R in my results, but around 10-20% of my beard hairs are red.

Regardless, I hope the community finds this interesting!

1. Duffy DL, Box NF, Chen W, Palmer JS, Montgomery GW, James MR. Interactive effects of MC1R and OCA2 on melanoma risk phenotypes. Hum Mol Genet. 2004;13:447-61

vettor
04-04-2014, 11:27 PM
@DMXX

who is who in the ID numbers?

Hanna
04-05-2014, 10:09 AM
Spreadsheet updated to include all samples included here (except soulblighter's mother, didn't see any indication of her eye colour, am happy to add at a later date once clarified).


>>View Updated IrisPlex Spreadsheet Here<< (https://docs.google.com/spreadsheet/ccc?key=0AuedvPON0rv2dGVZcjQzaFIxSUROVFdBZkt3c050b FE&usp=drive_web#gid=0)



As promised earlier, I've found another interesting application for the results. Specifically, in the form of the MC1R gene.

The SNPedia (http://snpedia.com/index.php/MC1R) page explains this gene's background and relevance in the context of pigmentation. Summarised, mutations on this gene lead to the absence of eumelanin (brown-black pigment) production, leaving pheomelanin (reddish) to accumulate. It is famously responsible for the copper-coloured hair, light eyes, freckles and very fair skin in the British Isles. According to at least one study, those with mutations on SNPs associated with MC1R has a role in painkiller drug response.

Why is MC1R relevant in the context of eye colour? Although several studies have focused specifically on its' effect on skin and hair colouring, there is some evidence it also has a role in determining eye colour [1]. This shouldn't come as a surprise as melanocytes are responsible for melanin production in the eyes, just as they are elsewhere in the body.

With that being said, I present a spreadsheet of everyone's results on two SNPs in my array that are a part of MC1R:


>>View MC1R Participant Spreadsheet Here (https://docs.google.com/spreadsheet/pub?key=0AuedvPON0rv2dGVZcjQzaFIxSUROVFdBZkt3c050b FE&gid=1)<<

I don't intend to continuously update this spreadsheet as often as the previous one. Chiefly because only two MC1R SNPs were used in my array, minimising the informativeness. I thought it'd be an interesting exercise to practice nonetheless. A few quick observations I made along the way:


The majority of people in the project (35/51, 68.6%) didn't carry any of the alleles which produce some sort of lightening in phenotype via MC1R. This shouldn't come as a surprise, given a larger number of participants aren't of Isles descent.
Over twice as many carried one of these alleles on SNP Y than SNP X. I have no explanation for this other than a sampling issue. If we get more participants from Europe (esp. the British Isles), it'd be interesting to see if this persists.
Only one participant (ID017) had two alleles coding in favour of decreased eumelanin production. I wonder if the rest of their phenotype expresses this?


This is just speculation, but for those individuals with "Mixed" results, I'd imagine they have some form of reddish colouring to supplement (e.g. reddish beard hairs).

Regardless, I hope the community finds this interesting!

1. Duffy DL, Box NF, Chen W, Palmer JS, Montgomery GW, James MR. Interactive effects of MC1R and OCA2 on melanoma risk phenotypes. Hum Mol Genet. 2004;13:447-61
My sister's husband got tested via FDTNA, his beard is red and hair is auburn. Is there a way I can find out if he carries the gene for red hair? With 23andme it is possible to browse raw data but I don't think it is possible with FTDNA?

evon
04-05-2014, 02:45 PM
My sister's husband got tested via FDTNA, his beard is red and hair is auburn. Is there a way I can find out if he carries the gene for red hair? With 23andme it is possible to browse raw data but I don't think it is possible with FTDNA?

If he has red hair at all, then he does ;) But there are many variations, its not just one set of DNA..

Volat
04-05-2014, 03:43 PM
Colour: bluish
Ancestry: eastern European


23andme : Likely blue
GG : In Europeans, 72% chance of blue eyes; 27% chance of green eyes; 1% chance of brown eyes



rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891482 CC
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 CT
rs8024968 CT
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 TT
rs12821256 TT
rs885478 GG
rs1805008 CT
rs1805005 GG
rs3829241 AA



Gedmatch




CT at: rs17762363 - Increased melanin production. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CC at: rs4778241 - Low Melanin. Basis for Gray, Blue, Green, or Yellow Eyes if no other pigmentation is present.
CC at: rs9782955 - Blocks some melanin. Often gives light colored eyes.
CT at: rs4553604 - Blue.
CT at: rs989869 - Contrasting sphincter around pupil.
CT at: rs3947367 - Contrasting sphincter around pupil.
AA at: rs4778138 - Weak Amber Gradient
TT at: rs1129038 - Penetrance modifier. Blue.
GT at: rs1470608 - Medium melanin on Anterior Epithelium. Gives dark eyes.
GG at: rs16891982 - Starburst (Collarette)
TT at: rs1667394 - Starburst (Collarette)
CC at: rs12203592 - No pigmented Collarette.
CC at: rs4779685 - Flecks (Nevi).
AG at: rs11634406 - Flecks (Nevi).
GT at: rs1448485 - Inhibits weak amber gradient.

vettor
04-06-2014, 01:54 AM
@DMXX

who is who in the ID numbers?

@DMXX

thanks for info.

9thdigit
04-20-2014, 10:25 PM
DMXX,

The AA at rs12913832 are mine. my dad has light blue/grey eyes, mom has very dark brown eyes.

Gray Fox
08-25-2014, 03:53 AM
Gedmatch has finally given me full access to their admix features and I ran the eye color predictor this evening.

Here is the data..

CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CC at: rs4778241 - Low Melanin. Basis for Gray, Blue, Green, or Yellow Eyes if no other pigmentation is present.
CC at: rs9782955 - Blocks some melanin. Often gives light colored eyes.
TT at: rs1129038 - Penetrance modifier. Blue.
GG at: rs12906280 - Gray ring around outer edge

Here is my actual eye. I'm not sure if the Gray ring is referring to the area directly around the pupil or the outer edge of the cornea? If its referring to the pupil area then it is right on the money.

2431

rod
08-28-2014, 08:26 PM
AG rs12913832
CC rs1800407
GT rs12896399
GG rs16891982
GG rs1393350
CC rs12203592
AA rs7495174
CC rs7183877
CC rs4778232
TT rs1408799
CC rs8024968
CC rs683
AA rs4778138
CC rs4778241
CT rs1667394
CC rs26722
CC rs1015362
GT rs4911414
CT rs1540771
TT rs12821256
GG rs885479
CC rs1805008
GT rs1805005
AG rs382924

GEDMATCH
Predicted Eye Color for Kit M215638 (V3)
Read rules from top to bottom. In some cases, a rule cancels out results from rules above it.

CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CC at: rs4778241 - Low Melanin. Basis for Gray, Blue, Green, or Yellow Eyes if no other pigmentation is present.
CC at: rs9782955 - Blocks some melanin. Often gives light colored eyes.
CT at: rs1129038 - Adds Yellow.
AA at: rs4778138 - Weak Amber Gradient
GG at: rs12906280 - Gray ring around outer edge
CT at: rs1667394 - Medium melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
CC at: rs7403602 - High density on Anterior Stroma. Blocks melanin. Blocks blue. Gives lighter colors.
CT at: rs916977 - Adds melanin. Adds yellow, amber, or brown.
GG at: rs16891982 - Starburst (Collarette)
CC at: rs12203592 - No pigmented Collarette.
AA at: rs11634406 - Flecks (Nevi).

Gedmatch Prediction
2477

Actual Eye Colour
2478

Salkin
08-29-2014, 05:33 PM
Heritage: Swedish (slight Belgian admixture)

rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 AG
rs1805008 CC
rs1805005 GG
rs3829241 AG

My eyes:

2482

GEDMATCH

CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CC at: rs4778241 - Low Melanin. Basis for Gray, Blue, Green, or Yellow Eyes if no other pigmentation is present.
CC at: rs9782955 - Blocks some melanin. Often gives light colored eyes.
CT at: rs989869 - Contrasting sphincter around pupil.
AA at: rs4778138 - Weak Amber Gradient
TT at: rs1129038 - Penetrance modifier. Blue.
GG at: rs12906280 - Gray ring around outer edge
GG at: rs16891982 - Starburst (Collarette)
TT at: rs1667394 - Starburst (Collarette)
CC at: rs12203592 - No pigmented Collarette.

Gedmatch estimate pic: 2483

Salkin
08-31-2014, 06:44 PM
I might add that Gedmatch's prediction pic is a good match for my childhood eyes. But later, they changed a bit, at about the same time (around puberty) that my hair darkened from blond to medium brown.

I don't believe I had that brown sector before the change, either.

vettor
08-31-2014, 06:49 PM
Heritage: Swedish (slight Belgian admixture)

rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 AG
rs1805008 CC
rs1805005 GG
rs3829241 AG

My eyes:

2482

GEDMATCH

CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CC at: rs4778241 - Low Melanin. Basis for Gray, Blue, Green, or Yellow Eyes if no other pigmentation is present.
CC at: rs9782955 - Blocks some melanin. Often gives light colored eyes.
CT at: rs989869 - Contrasting sphincter around pupil.
AA at: rs4778138 - Weak Amber Gradient
TT at: rs1129038 - Penetrance modifier. Blue.
GG at: rs12906280 - Gray ring around outer edge
GG at: rs16891982 - Starburst (Collarette)
TT at: rs1667394 - Starburst (Collarette)
CC at: rs12203592 - No pigmented Collarette.

Gedmatch estimate pic: 2483

we have the exact same colour .........and I get the exact same estimate regardless if I use my ftdna or 23andme account

venetian ancestors ...........but have a very close maternal ancestral match with the gulf of bothnia

Salkin
09-01-2014, 08:58 AM
we have the exact same colour .........and I get the exact same estimate regardless if I use my ftdna or 23andme account

venetian ancestors ...........but have a very close maternal ancestral match with the gulf of bothnia

Interesting! Not the colour one pictures in Venetians. But then my adult eye colour isn't exactly the first associated with Scandinavians, either.

Do you have the brown sector too? It appears to be a trait, possibly generation-skipping, in my family; maternal grandma had it (I'm told - never got to meet her). My mother has brown eyes, so I guess if there was any such tendency in her, it didn't show.

vettor
09-01-2014, 09:57 AM
Interesting! Not the colour one pictures in Venetians. But then my adult eye colour isn't exactly the first associated with Scandinavians, either.

Do you have the brown sector too? It appears to be a trait, possibly generation-skipping, in my family; maternal grandma had it (I'm told - never got to meet her). My mother has brown eyes, so I guess if there was any such tendency in her, it didn't show.

I have a slight hazel sector around the middle in each eye, but majority is green.
some say the brown/hazel sector is an old illness from childhood..........old wives stories IMO

my mother is hazel...father is pale green ( very light)

Jusarius
09-02-2014, 09:08 PM
My genotypes:

rs12913832: GG
rs1800407: CC
rs12896399: GT
rs16891982: GG
rs1393350: GG
rs12203592: CC
rs7495174: AA
rs7183877: CC
rs4778232: CC
rs1408799: CC
rs8024968: CC
rs683: AA
rs4778138: AA
rs4778241: CC
rs1667394: TT
rs26722: CC
rs1015362: CT
rs4911414: GT
rs1540771: CT
rs12821256: CT
rs885479: GG
rs1805008: CT
rs1805005: GG
rs3829241: GG

My eye:

http://i112.photobucket.com/albums/n178/Jusarius/munsilma_zpsb4e8c30f.jpg


Ancestry: East Finnish


Gedmatch prediction:

CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CC at: rs4778241 - Low Melanin. Basis for Gray, Blue, Green, or Yellow Eyes if no other pigmentation is present.
CC at: rs9782955 - Blocks some melanin. Often gives light colored eyes.
AA at: rs4778138 - Weak Amber Gradient
TT at: rs1129038 - Penetrance modifier. Blue.
GG at: rs12906280 - Gray ring around outer edge
GG at: rs16891982 - Starburst (Collarette)
TT at: rs1667394 - Starburst (Collarette)
CC at: rs12203592 - No pigmented Collarette.
AG at: rs11634406 - Flecks (Nevi).

http://i112.photobucket.com/albums/n178/Jusarius/gedmatcheye_zpse184b459.jpg

kenji.aryan
09-16-2014, 08:40 PM
rs12913832 AA
rs1800407 CC
rs12896399 GG
rs16891982 CC
rs1393350 GG
rs12203592 CC
rs7495174 AG
rs7183877 CC
rs4778232 TT
rs1408799 CT
rs8024968 CT
rs683 AC
rs4778138 GG
rs4778241 AC
rs1667394 CC
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
Rs1805005 GG
rs3829241 GG



Gedmatch prediction


AC at: rs4778241 - High Melanin. Adds yellow, amber, or brown. Some darkening. Contributes Amber, Brown.
TT at: rs916977 - Adds melanin. Some darkening.
GG at: rs4778138 - Adds melanin. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
CT at: rs989869 - Contrasting sphincter around pupil.
CT at: rs3947367 - Contrasting sphincter around pupil.
CC at: rs1129038 - High Melanin production. Brown.
AA at: rs8033448 - Med Brown on Sphincter
GT at: rs7713279 - Inhibit weak amber gradient
GG at: rs12906280 - Gray ring around outer edge
TT at: rs1597196 - Large amounts of melanin on Anterior Epithelium. Brown.
GT at: rs1470608 - Medium melanin on Anterior Epithelium. Gives dark eyes.
AG at: rs7174027 - Adds Yellow.
CC at: rs16891982 - Increased melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
AA at: rs12913832 - High melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
CC at: rs1667394 - Increased melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
AG at: rs7495174 - Adds melanin. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
CC at: rs12203592 - No pigmented Collarette.

http://i.imgur.com/9i5f1NO.jpg

bol_nat
09-17-2014, 01:29 AM
Predicted Eye Color for Kit **

Read rules from top to bottom. In some cases, a rule cancels out results from rules above it.

AG at: rs4778138 - Adds melanin. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CC at: rs4778241 - Low Melanin. Basis for Gray, Blue, Green, or Yellow Eyes if no other pigmentation is present.
CT at: rs1129038 - Adds Yellow.
AA at: rs8033448 - Med Brown on Sphincter
AA at: rs1105879 - Weak Amber Gradient
GT at: rs7713279 - Inhibit weak amber gradient
GG at: rs12906280 - Gray ring around outer edge
CT at: rs3935591 - Heavy melanin on Anterior Epithelium. Brown.
GT at: rs1470608 - Medium melanin on Anterior Epithelium. Gives dark eyes.
CT at: rs1667394 - Medium melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
CC at: rs7403602 - High density on Anterior Stroma. Blocks melanin. Blocks blue. Gives lighter colors.
CT at: rs916977 - Adds melanin. Adds yellow, amber, or brown.
CC at: rs16891982 - Increased melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
CC at: rs12203592 - No pigmented Collarette.
CC at: rs4779685 - Flecks (Nevi).
GT at: rs1448485 - Inhibits weak amber gradient.


2619

Well wrong guess because my eyes are light brown. If this colour is kind of ''yellow'' then my uncle family have it.

karen1300
09-26-2014, 07:56 PM
AC at: rs4778241 - High Melanin. Adds yellow, amber, or brown. Some darkening. Contributes Amber, Brown.
CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CT at: rs1800407 - Penetrance Modifier - Blue
CT at: rs1129038 - Adds Yellow.
AA at: rs8033448 - Med Brown on Sphincter
CT at: rs3935591 - Heavy melanin on Anterior Epithelium. Brown.
CT at: rs1667394 - Medium melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
CT at: rs916977 - Adds melanin. Adds yellow, amber, or brown.
CC at: rs12203592 - No pigmented Collarette.
TT at: rs13160471 - Amber Collarette
TT at: rs35405 - Inhibit weak amber gradient

Gedmatch prediction:

2678


Actual eye:

2677

Porter2226
11-19-2014, 12:55 PM
Code: GEDmatch Prediction

AC at: rs4778241 - High Melanin. Adds yellow, amber, or brown. Some darkening. Contributes Amber, Brown.
CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CT at: rs12203592 - Blue
CC at: rs1129038 - High Melanin production. Brown.
GG at: rs12906280 - Gray ring around outer edge
CT at: rs3935591 - Heavy melanin on Anterior Epithelium. Brown.
CT at: rs1667394 - Medium melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
CT at: rs916977 - Adds melanin. Adds yellow, amber, or brown.
AA at: rs12913832 - High melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
AG at: rs11634406 - Flecks (Nevi).


3028
Dutch

jesus
11-19-2014, 01:17 PM
AC at: rs4778241 - High Melanin. Adds yellow, amber, or brown. Some darkening. Contributes Amber, Brown.
TT at: rs916977 - Adds melanin. Some darkening.
AG at: rs4778138 - Adds melanin. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
CT at: rs12203592 - Blue
CT at: rs4553604 - Blue.
CT at: rs989869 - Contrasting sphincter around pupil.
CT at: rs3947367 - Contrasting sphincter around pupil.
CC at: rs1129038 - High Melanin production. Brown.
AG at: rs10467971 - Penetrance Modifier - Blue
GG at: rs12906280 - Gray ring around outer edge
AG at: rs7174027 - Adds Yellow.
CC at: rs16891982 - Increased melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
AA at: rs12913832 - High melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening. Contributes to brown.
CC at: rs1667394 - Increased melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.


http://v2.gedmatch.com/9fcf74_11_.jpg

DMXX
11-19-2014, 04:32 PM
I do not understand why recent posters are only sharing their GEDmatch predictions. Some of the SNPs differ from the tailor-made array I used. Please find these in the original post (http://www.anthrogenica.com/showthread.php?1057-DMXX-s-Eye-Colour-Project-(v-2)&p=8807&viewfull=1#post8807).

The project will be updated fully with a few new additions in a month's time (coursework commitments eating my time up).

J Man
11-19-2014, 05:12 PM
I do not understand why recent posters are only sharing their GEDmatch predictions. Some of the SNPs differ from the tailor-made array I used. Please find these in the original post (http://www.anthrogenica.com/showthread.php?1057-DMXX-s-Eye-Colour-Project-(v-2)&p=8807&viewfull=1#post8807).

The project will be updated fully with a few new additions in a month's time (coursework commitments eating my time up).

I still think this is a great project. :)....I have been with my girlfriend for a while now and the subject of children has come up. She has blue eyes and from what I have seen based on her 23andme results her genes match her eye colour. Would you be able to predict the possibilities for our child's eye colour once we start to have him/her?

Mandoos
11-19-2014, 09:10 PM
AA rs12913832
CC rs1800407
GT rs12896399
CC rs16891982
AG rs1393350
CC rs12203592
AA rs7495174
CC rs7183877
CT rs4778232
CT rs1408799
CT rs8024968
AC rs683
AG rs4778138
CC rs4778241
CT rs1667394
CT rs26722
CC rs1015362
GG rs4911414
CC rs1540771
TT rs12821256
GG rs885479
CC rs1805008
GG rs1805005
GG rs3829241

Took these a couple years ago, they're really dark even in flash.
3030
3031

Krefter
11-19-2014, 11:32 PM
I do not understand why recent posters are only sharing their GEDmatch predictions. Some of the SNPs differ from the tailor-made array I used. Please find these in the original post (http://www.anthrogenica.com/showthread.php?1057-DMXX-s-Eye-Colour-Project-(v-2)&p=8807&viewfull=1#post8807).

The project will be updated fully with a few new additions in a month's time (coursework commitments eating my time up).

I sent you my SNPs and everything. Do you have an ID for me yet?

DMXX
11-20-2014, 05:21 AM
^ Not yet. As mentioned in my previous post, I simply don't have the time right now to furnish the project with new additions. I do appreciate the new additions as they accumulate, hence my early intervention yesterday regarding the GEDmatch SNPs.

Rest assured you'll get your money's worth (metaphorically speaking of course) for kindly contributing to the project outside of term-time.

dp
11-20-2014, 09:26 PM
3037

I don't have a picture. Hope this still can help with the project.
dp :-)

bored
11-23-2014, 07:07 AM
rs12913832 AA
rs1800407 CC
rs12896399 GT
rs16891982 CG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 TT
rs8024968 CC
rs683 CC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG



My eye colour is dark brown.

SwampThing27
12-01-2014, 07:51 PM
My eyes are identical to DMXX's. Gedmatch gave me a yellowish color.

rs12913832 AG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 AG
rs12203592 CC
rs7495174 AG
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AG
rs4778241 AC
rs1667394 CT
rs26722 CC
rs1015362 TT
rs4911414 TT
rs1540771 CT
rs12821256 CT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

surbakhunWeesste
01-23-2015, 01:20 AM
My father's:

rs12913832 AG
rs1800407 CC
rs12896399 GG
rs16891982 CG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 TT
rs8024968 CC
rs683 CC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG

Has hazel green eyes.

Mine:

rs12913832 AG
rs1800407 CC
rs12896399 GG
rs16891982 CG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 TT
rs8024968 CT
rs683 CC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CC
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG


I have sectoral heterochromia.

DMXX
01-30-2015, 05:44 PM
Thanks all for the submissions. Got piled with work during my holiday (as usual these days). I'll update both spreadsheets by Valentine's (if I'm feeling artistic I'll create a romantic infographic for you all while I'm at it)

Please feel free to keep adding your genotypes (see first post for information). At the very least a description based on the diagram there, or an actual picture would be fantastic.

J Man
02-28-2015, 11:38 PM
Thanks all for the submissions. Got piled with work during my holiday (as usual these days). I'll update both spreadsheets by Valentine's (if I'm feeling artistic I'll create a romantic infographic for you all while I'm at it)

Please feel free to keep adding your genotypes (see first post for information). At the very least a description based on the diagram there, or an actual picture would be fantastic.

Have you been able to figure out the genetics behind hazel (green-brown) eyes? We know that hazel eyes people tend to be quite common in areas where blue, green and brown eyed people have mixed together a lot.

vettor
03-01-2015, 12:39 AM
Have you been able to figure out the genetics behind hazel (green-brown) eyes? We know that hazel eyes people tend to be quite common in areas where blue, green and brown eyed people have mixed together a lot.

Hazel eyes are common throughout Caucasoid populations, in particular in regions where blue, green and brown eyed peoples are intermixed.

I see the above comment in many sites

SwampThing27
03-10-2015, 01:17 AM
Does anyone know what rs8033448 actually does? AA says medium brown on sphincter, but what does CC and AC do? Does C produce more melanin or less?

BalkanKiwi
04-06-2015, 06:29 AM
rs12913832 AG
rs1800407 CC
rs12896399 TT
rs16891982 GG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 AC
rs4778232 CT
rs1408799 CC
rs8024968 CT
rs683 AA
rs4778138 AG
rs4778241 AC
rs1667394 CT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 CT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG

Not a great picture but it would be classed as brown.

4272

Passa
05-15-2015, 03:16 PM
4583

rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 AA
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 AG

neuandertal
05-15-2015, 07:37 PM
rs12913832 AG
rs1800407 CC
rs12896399 GG
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AG
rs4778241 CC
rs1667394 CT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GT
rs3829241 GG

Some light:
http://i.imgur.com/c9qdntd.jpg

In brighter light:
http://i.imgur.com/ksgLIFY.jpg

So, I'm guessing they would be inter-dark or somewhere between green-hazel and inter-dark? They're not green/blue enough to be green-hazel, but they do exhibit the central heterochromia of a hazel eye.

Edited to add Gedmatch's prediction:
http://i.imgur.com/bYo4QTF.png

Zionas
08-04-2015, 02:25 AM
My maternal grandfather and some members in his family have grey eyes. They are from the northwest of China. What could this be? On a Chinese forum, one of the members wrote that from what he's observed, grey eyes aren't actually that rare in China, even in some more southern regions.

Reza
10-12-2015, 10:10 PM
Not sure if this is still running, but thought I'd contribute!

rs12913832 AG
rs1800407 CC
rs12896399 GT
rs16891982 CC
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 AC
rs4778232 CC
rs1408799 TT
rs8024968 CC
rs683 CC
rs4778138 AA
rs4778241 AC
rs1667394 CT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 AG
rs1805008 CC
rs1805005 GG
rs3829241 GG

My eye colour below (brown):

6305

Sibling eye colours below:

630663076308

Gedmatch eye predictor:

AC at: rs4778241 - High Melanin. Adds yellow, amber, or brown. Some darkening. Contributes Amber, Brown.
CC at: rs3794604 - Blocks some melanin. Often gives light colored eyes.
GG at: rs7174027 - Blocks some melanin. Often gives light colored eyes.
CT at: rs4553604 - Blue.
CT at: rs1129038 - Adds Yellow.
AA at: rs4778138 - Weak Amber Gradient
GG at: rs12906280 - Gray ring around outer edge
CT at: rs1667394 - Medium melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
CC at: rs3947367 - Penetrance modifier. Blue
CT at: rs916977 - Adds melanin. Adds yellow, amber, or brown.
CC at: rs16891982 - Increased melanin production on Anterior Epithelium. Adds yellow, amber, or brown. Some darkening.
CC at: rs12203592 - No pigmented Collarette.

Predicted eye colour:

6309

Clearly incorrect but matches more some of my siblings ..

vettor
10-17-2015, 07:31 PM
Gedmatch via 23andme data has got my fathers eyes 100% perfect

see below

http://i103.photobucket.com/albums/m153/vicpret/dad%20eyes_zpso5btsgzf.jpg (http://s103.photobucket.com/user/vicpret/media/dad%20eyes_zpso5btsgzf.jpg.html)

DMXX
11-28-2015, 10:43 PM
Apologies to all for the many months of neglect this project has received. Finally found time to resurrect it.

Some new results will be shared here within the hour. :)

J Man
11-28-2015, 10:47 PM
Apologies to all for the many months of neglect this project has received. Finally found time to resurrect it.

Some new results will be shared here within the hour. :)

Awesome! :D

DMXX
11-29-2015, 12:29 AM
As promised, ladies and gents, the two active parts of the project have been updated:



>>View Updated IrisPlex Spreadsheet Here<< (https://docs.google.com/spreadsheets/d/1v85T8Kx9Q92_ePOzqoZp_CBgAOxdTsY0bETaK-3mxcs/pubhtml?gid=0&single=true) (see here (http://www.anthrogenica.com/showthread.php?1057-DMXX-s-Eye-Colour-Project-(v-2)&p=9809&viewfull=1#post9809) for more info)

>>View MC1R Participant Spreadsheet Here<< (https://docs.google.com/spreadsheets/d/1v85T8Kx9Q92_ePOzqoZp_CBgAOxdTsY0bETaK-3mxcs/pubhtml?gid=1&single=true) (see here (http://www.anthrogenica.com/showthread.php?1057-DMXX-s-Eye-Colour-Project-(v-2)&p=36184&viewfull=1#post36184) for more info)


We currently have 64 people participating in the project. I could not include people who didn't share their results for the custom SNP genotype panel I created, or gave no indication regarding their phenotype (see here (http://www.anthrogenica.com/showthread.php?1057-DMXX-s-Eye-Colour-Project-(v-2)&p=8807&viewfull=1#post8807)).

To emphasise it once more, please do not share your GEDmatch results as a substitute for my custom panel. The SNPs used by GEDmatch's prediction tool cover aspects of phenotype that don't involve colour (e.g. patterning). If you had previously shared some data here and did not receive an ID from me via reputation points, then some form of data was missing (please revisit the above link to determine).

I'm continuously receiving data all the time, so please keep the submissions coming in. Some interesting patterns and exceptions are emerging, which you'll be able to view clearly in the IrisPlex spreadsheet.

I'll also be creating a new spreadsheet involving member data in the coming few weeks. Thanks once more to everyone for their patience and continued participation!

J Man
11-29-2015, 12:48 AM
I am quite curious about what colour my baby boys eyes are going to be once he is born. DMXX you have my raw data already and my girlfriend has tested at 23andme so maybe at some point I will be able to send you her raw data as well for the project. She has blue eyes.

DMXX
11-29-2015, 12:56 AM
I am quite curious about what colour my baby boys eyes are going to be once he is born. DMXX you have my raw data already and my girlfriend has tested at 23andme so maybe at some point I will be able to send you her raw data as well for the project. She has blue eyes.

Sure thing. Based on rs12913832 alone (you're AG, she'll be GG), the odds are stronger that J Man jr. will be light eyed than dark eyed.

A very good friend of mine had a child last year and she also asked me to predict the eye colour. Guessed it'd be a shade of blue based on her and the partner's parent's eye colours (they're not fortunate enough to have genotype data, as you do). Their son ended up with steely blue eyes.

Gray Fox
11-29-2015, 09:45 AM
Sorry bout the gedmatch post :brick:, that was all I had at the time!

rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 AG
rs12203592 CT
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CC
rs12821256 CT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

SwampThing27
11-29-2015, 05:28 PM
Sure thing. Based on rs12913832 alone (you're AG, she'll be GG), the odds are stronger that J Man jr. will be light eyed than dark eyed.

A very good friend of mine had a child last year and she also asked me to predict the eye colour. Guessed it'd be a shade of blue based on her and the partner's parent's eye colours (they're not fortunate enough to have genotype data, as you do). Their son ended up with steely blue eyes.

Have you ever used the freiger hereditary calculator website? My fiance is GG and I am AG, which you would expect to produce a child with blue eyes at a higher percentage, but the freiger calculator takes into account a bunch of other eye color SNPs as well and actually pedicted our child to have >50% chance of brown. Will be interesting to see what happens when the time comes.

Edit: just checked again and it actually says 73% chance of a child with brown eyes. It uses 6 snps.

Krefter
11-29-2015, 05:47 PM
AG and GG parents often produce Brown eyed(AG) children.

DMXX
11-29-2015, 06:17 PM
^ Per Mendelian inheritance, there's a 50% chance of AG and a 50% chance of GG. GG is synonymous with light eye colour (blue to green). AG is found in folks with everything from mostly blue eyes to dark brown (the other SNPs influence phenotype quite drastically in their case).

Of course, eye colour is a complex trait and there's varying penetrance rates per SNP, so it's impossible to make an accurate prediction. But odds are his son will probably be somewhere from blue to hazel eyed (and everything in-between) since J Man's eye colour is "classical" hazel and his partner's blue eyed.

SwampThing27
11-29-2015, 06:44 PM
AG and GG parents often produce Brown eyed(AG) children.

I could believe that. My mom has blue eyes and my dad has brown and my brother and I both ended up brown.

Gray Fox
11-29-2015, 10:11 PM
Here's a breakdown of the eye colors of my parents and all of my grandparents. Father- Pale blue eyes. Mother- Medium green eyes. Paternal Grandfather- Pale Blue eyes. Paternal Grandmother- Light green eyes. Maternal Grandfather- Brown eyes. Maternal Grandmother- Medium blue eyes. I have medium blue eyes with central heterochromia, which I've heard described as either very light green or gray.

Lirio100
11-30-2015, 01:57 AM
rs12913832 AG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 AA
rs12203592 CC

rs7495174 AA
rs7183877 AC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AC
rs4778138 AA
rs4778241 AC
rs1667394 CT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

My eyes are a brown inbetween the "Brown" and "Dark Brown" of the initial post. My mother had blues eyes and both of her parents did too. My father had brown eyes, his mother was light brown and his father dark brown. Two of my sisters have brown eyes, a third has green/hazel.

vettor
11-30-2015, 05:16 AM
Gedmatch via 23andme data has got my fathers eyes 100% perfect

see below

http://i103.photobucket.com/albums/m153/vicpret/dad%20eyes_zpso5btsgzf.jpg (http://s103.photobucket.com/user/vicpret/media/dad%20eyes_zpso5btsgzf.jpg.html)

I forgot my ID #, can you tell me which one it is


also below is my fathers numbers...........appreciate if you do his


rs12913832 GG
rs1800407 CC
rs12896399 GG
rs16891482 CC
rs1393350 AG
rs12203592 CT
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CT
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885478 GT
rs1805008 CC
rs1805005 GT
rs3829241 GG

Stellaritic
11-30-2015, 05:07 PM
rs12913832 AG
rs1800407 CC
rs12896399 GG
rs1393350 AG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885478 GG
rs1805005 GG
rs3829241 GG

Volat
12-01-2015, 02:29 PM
ID052 The prediction results are accurate for me.

reagan
12-02-2015, 03:32 AM
What's your prediction


rs12913832 AG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 GG
rs12203592 CC
rs7495174 AA
rs7183877 CC
rs4778232 CC
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CC
rs4911414 GG
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GG
rs3829241 GG

DMXX
12-02-2015, 03:44 AM
What's your prediction



I'm going to predict...

1) You're of West Eurasian background (either mostly or fully), and
2) Based on the Irisplex panel and prior results, your eye colour is most likely somewhere between Inter-Dark to Brown (II) (that's the second-to-last on the right):

http://i1084.photobucket.com/albums/j418/DMXX_DNA/Betterchart.png

There's also a small chance of classical hazel (the one just on the left of "Inter-Dark" there).

I'm very confident your eye colour is neither dark brown, nor a shade of blue.

How far off am I?

reagan
12-02-2015, 04:13 AM
I'm going to predict...

1) You're of West Eurasian background (either mostly or fully), and
2) Based on the Irisplex panel and prior results, your eye colour is most likely somewhere between Inter

what is west Eurasian? west euro or west Asian?

it's green. From your chart it's between light and dark hazel

DMXX
12-02-2015, 04:26 AM
what is west Eurasian? west euro or west Asian?


Per the geographical definition, that would be Europe, West Asia and Southwest Asia.



it's green. From your chart it's between light and dark hazel, pretty close :)

Fantastic, thanks for sharing. The Irisplex panel I'm using consists of only 6 SNPs, so hopefully the others you've kindly shared will account for why your phenotype's a tad lighter than expected. :)

reagan
12-02-2015, 04:27 AM
edit.

SwampThing27
12-02-2015, 04:58 AM
I posted my snps a long time ago, but don't know my ID number or if I even have one?

SwampThing27
12-02-2015, 02:32 PM
Thanks!

Reza
12-02-2015, 10:52 PM
DMXX, what do you think of your 6 SNP irisplex panel?

Accurate in predicting a true phenotype?

DMXX
12-03-2015, 06:06 AM
There's three reasons I used the Irisplex panel here:

1) Determine if six markers can accurately represent most phenotypes
2) Give participants something interesting in return for their contribution (same goes for the MC1R results)
3) It's a popular toolkit produced from the scientific literature and serves as an appropriate starting point for appraising results

It's clear that Irisplex doesn't sufficiently explain phenotype based on the 6 SNPs alone. Using the extended Hirisplex panel won't help in the least, as the number of eye colour related SNPs remains exactly the same (Walsh et al. 2014).

In my opinion, the best it can do confidently is differentiate between blue-green eyes and non-blue-green eyes, and that's largely determined by rs12913832 anyway.

The other 16-odd SNPs I've asked people to contribute will hopefully explain some of the discrepancies further.

As an aside Reza, you and I have the exact same eye colour (please see first page for the picture). I'm ID001. You'll note from Irisplex our results aren't the same at first glance. I'll be tinkering with some statistical measures of correlation and basic modelling sometime over the next few weeks to understand the genotype-phenotype interplay here.

Reza
12-03-2015, 09:43 PM
Fascinating stuff, I look forward to your further analysis. I've always had a particular interest in the genetics of eye colour.

I think my eyes are probably a tad darker than yours but I take your point that our irisplex panel appear rather different for a similar phenotype. Whereas ID060 is quite similar to mine in terms of markers with instead a homozygous SNP 3 , but has lighter, hazel eyes vs interdark.

Having a quick glance through the spreadsheet, SNP 4 - assume that's SLC45A2 / rs16891982, seems to be quite heavily weighted in influencing eye colour?

I imagine alot of these markers are more validated in european / caucasian populations?

Also, have you had any results from siblings for comparison?

SwampThing27
12-04-2015, 04:48 AM
I know i posted that my eyes are the same as yours DMXX(inter-dark), but thought I would post a pic just for accuracy sake. Not the best, but as clear as i could get with my phone.

DMXX
12-04-2015, 08:50 AM
Fascinating stuff, I look forward to your further analysis. I've always had a particular interest in the genetics of eye colour.


I share the same interest. In my case, it was motivated by 23andMe's incredibly basic prediction tool. There is so much diversity in eye colour that simply wasn't represented by their format.



Having a quick glance through the spreadsheet, SNP 4 - assume that's SLC45A2 / rs16891982, seems to be quite heavily weighted in influencing eye colour?


That is correct. Just for the clarification of readers, I have not added my own weighting to the degree of penetrance per SNP. What you see is what you get from a genotype standpoint. :)



I imagine alot of these markers are more validated in european / caucasian populations?


Irisplex is most accurate for Europeans given they were the source population the tool was calibrated towards, yes.

As far as the totality of the eye colour implicated SNPs go, it's a neutral situation. Non-brown eye colour is essentially a "derived"/non-ancestral phenotype. So, any alleles on SNPs demonstrated to have correlation +- causative links to non-brown eye colour will be indicated as such.

The "problem" here is that the interplay between different allele states in different SNPs in non-European populations (or mixed individuals) is indeterminable for now.



Also, have you had any results from siblings for comparison?


I have two sibling pairs. Siblings are very useful for obvious reasons. I accept all data from anyone and everyone. There's always a practical use for more data with this mini-project.


I know i posted that my eyes are the same as yours DMXX(inter-dark), but thought I would post a pic just for accuracy sake. Not the best, but as clear as i could get with my phone.

Yup, very similar to mine, perhaps a touch darker (from a reasonable distance mine are basically a medium honey or hazelnut). I see the off-greenish-amberish exterior in yours as well!

dp
12-04-2015, 06:33 PM
6805
DMXX,
Here's the panel for a different aunt.
dp :-)

surbakhunWeesste
12-11-2015, 07:11 AM
Fascinating stuff, I look forward to your further analysis. I've always had a particular interest in the genetics of eye colour.

I think my eyes are probably a tad darker than yours but I take your point that our irisplex panel appear rather different for a similar phenotype. Whereas ID060 is quite similar to mine in terms of markers with instead a homozygous SNP 3 , but has lighter, hazel eyes vs interdark.


I am ID060, and I have heterochromia.

Reza
12-11-2015, 04:16 PM
I am ID060, and I have heterochromia.

How interesting! Is it sectoral? And which colours? I'm ID064.

surbakhunWeesste
12-12-2015, 05:41 AM
How interesting! Is it sectoral? And which colours? I'm ID064.

Yes,its sectoral heterochromia, bluish/green with amber.

psaglav
12-24-2015, 01:50 PM
Hello all,

I'm not sure if the project is still running and if my posting will be relevant but I've always been interested in eye/hair color genetics, especially since I'd used the calculator on gedmatch which was crazy accurate. I don't have all the SNPs listed, perhaps because I'd tested ftdna and not 23me but here are the ones I do have:

rs1800407 CC
rs7495174 AG
rs7183877 CC
rs4778232 CC
rs8024968 CC
rs4778241 CC
rs26722 CC
rs1015362 TT
rs885479 AG
rs1805008 CC
rs1805005 GG
rs3829241 AG

ps. for some reason the page freezes when I try to attach an image, so I'll post this first and try again to attach the image-perhaps because it's my first post.

psaglav
12-24-2015, 01:52 PM
7032

the quality is not great but it's in natural light.

evon
12-24-2015, 02:18 PM
Could not see my family in the list provided, so here they are:

23andme accounts:

Paternal Aunt/Maternal Uncle/Me/Maternal grandmother:
rs12913832 - GG (all)
rs1800407 - CC (all)
rs12896399 - TT/GT/GT/TT
rs16891982 - GG (all)
rs1393350 - AG/GG/AG/AG
rs12203592 - CC/CC/CT/CC
rs7495174 - AA (all)
rs7183877 - CC (all)
rs4778232 - CT (all)
rs1408799 - CT/CT/CT/TT
rs8024968 - CT/CC/CC/CC
rs683 - CT/CC/CC/CC
rs4778138 - AA (all)
rs4778241 - CC (all)
rs1667394 - TT (all)
rs26722 - CC (all)
rs1015362 - CT/CT/CC/CT
rs4911414 - GT/GT/GG/GT
rs1540771 - CT/CT/CT/CC
rs12821256 - CT/TT/TT/TT
rs885479 - GG (all)
rs1805008 - CT/CC/CC/CC
rs1805005 - GG (all)
rs3829241 - AA/AA/AA/AG

FTDNA accounts:

Mother/Maternal Grand Uncle:
rs1800407 - CC (both)
rs7495174 - AA (both)
rs7183877 - CC (both)
rs4778232 - TC/CC
rs7495174 - AA (both)
rs7183877 - CC (both)
rs4778232 - TC/CC
rs8024968 - CC (both)
rs683 - AC/AA
rs4778241 - CC (both)
rs26722 - CC (both)
rs1015362 - TT (both)
rs885479 - GG (both)
rs1805008 - CC (both)
rs1805005 - GG (both)
rs3829241 - AA/AG

I think me and my aunt both have bright blue eyes, while my grandmother, mother and uncle likely have grayish blue eyes (dont remember my grand uncles eye colour..My sister has Heterochromia, dark and light blue eyes.

Sea Warrior
12-27-2015, 06:00 PM
Here are my SNPs:

rs12913832 GG
rs1800407 CC
rs12896399 GT
rs16891982 GG
rs1393350 AG
rs12203592 CT
rs7495174 AA
rs7183877 CC
rs4778232 CT
rs1408799 CC
rs8024968 CC
rs683 AA
rs4778138 AA
rs4778241 CC
rs1667394 TT
rs26722 CC
rs1015362 CT
rs4911414 GT
rs1540771 CT
rs12821256 TT
rs885479 GG
rs1805008 CC
rs1805005 GT
rs3829241 AG

Please let me know if there is anything else I can do. I'm very curious to see what you say about my pigmentation genetics.

Thanks!

Helgenes50
12-27-2015, 06:27 PM
7032

the quality is not great but it's in natural light.

If the quality of the picture is not great, it is not the case for the beauty of your eyes !

psaglav
12-27-2015, 07:54 PM
If the quality of the picture is not great, it is not the case for the beauty of your eyes !

Why, thank you, Helgenes! :redface:

Helgenes50
12-27-2015, 08:20 PM
Why, thank you, Helgenes! :redface:

you're welcome

Znertu
12-27-2015, 08:44 PM
This is what Gedmatch gives me:
http://v2.gedmatch.com/3a50d9_11_.jpg

Eye in sunlight:
http://i1068.photobucket.com/albums/u441/Znertu/Good3_zpsnwjcd18h.png~original

(the slightly blue hue right of my iris is my lens)

AA rs12913832
CC rs1800407
GG rs12896399
GG rs16891982
GG rs1393350
CT rs12203592
AA rs7495174
CC rs7183877
CC rs4778232
CC rs1408799
CC rs8024968
AC rs683
AG rs4778138
CC rs4778241
CC rs1667394
CC rs26722
CC rs1015362
GG rs4911414
CT rs1540771
TT rs12821256
AG rs885479
CC rs1805008
GG rs1805005
GG rs3829241

SwampThing27
12-28-2015, 05:24 AM
This is what Gedmatch gives me:
http://v2.gedmatch.com/3a50d9_11_.jpg

Eye in sunlight:
http://i1068.photobucket.com/albums/u441/Znertu/Good3_zpsnwjcd18h.png~original

(the slightly blue hue right of my iris is my lens)

AA rs12913832
CC rs1800407
GG rs12896399
GG rs16891982
GG rs1393350
CT rs12203592
AA rs7495174
CC rs7183877
CC rs4778232
CC rs1408799
CC rs8024968
AC rs683
AG rs4778138
CC rs4778241
CC rs1667394
CC rs26722
CC rs1015362
GG rs4911414
CT rs1540771
TT rs12821256
AG rs885479
CC rs1805008
GG rs1805005
GG rs3829241

AA for rs12913832 and not brown eyed? Interesting.

kingjohn
12-28-2015, 10:15 AM
because he have other genes
in oca2 that give some green colour to his eyes for example{i thinking of this AA RS7495174}
http://www.snpedia.com/index.php/Rs7495174
cool photo
regards
adam

psaglav
12-28-2015, 10:28 AM
because he have other genes
in oca2 that give some green colour to his eyes for example{i thinking of this AA RS7495174}


Mine's AG in that location but I still have green eyes; I guess there are other relevant alleles. Gedmatch gives me a pretty accurate guess too re: eye color prediction.

dp
12-29-2015, 11:19 PM
Dear psaglav,
Your eye color is close to my own, but I have a touch more blue I think towards the pupil.
dp :-)

7032

the quality is not great but it's in natural light.

Roaring
01-06-2016, 10:18 PM
rs12913832 A\G
rs1800407 C\C
rs12896399 T\T
rs16891982 G\G
rs1393350 A\G
rs12203592 G\G
rs7495174 A\A
rs7183877 C\C
rs4778232 C\T
rs1408799 C\C
rs8024968 C\T
rs683 A\A
rs4778138 A\G
rs4778241 C\C
rs1667394 C\T
rs26722 C\C
rs1015362 T\T
rs4911414 T\T
rs1540771 C\C
rs12821256 T\T
rs885479 A\G
rs1805008 C\C
rs1805005 G\T
rs3829241 A\G

Eyes are hazel i guess, not the best pic, but all i have.

http://i.imgur.com/qBrDCnA.jpg

psaglav
01-06-2016, 10:38 PM
Dear psaglav,
Your eye color is close to my own, but I have a touch more blue I think towards the pupil.
dp :-)

I get a blue thingie towards the middle too but only when I'm swimming and/or when the weather's a certain way. Light eyes do change color quite a bit, don't they? :) (I also have some gray spots)

Sea Warrior
02-06-2016, 04:48 AM
76407639

Krefter
02-06-2016, 04:55 AM
@Sea Warrior,

WTF, are you? Sometype of alien.
http://memesvault.com/wp-content/uploads/Baby-Happy-Face-Meme-08.jpg