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paoloferrari
05-23-2017, 05:03 PM
Association of mitochondrial DNA haplogroups with elite athletic status in Iranian population

http://www.sciencedirect.com/science/article/pii/S2214540016300858

"Abstract

Increasing evidences suggest that certain variations in the control region of mitochondrial DNA (mtDNA) are associated with physical performance levels of individuals. The aim of the present study was to assess whether mitochondrial haplogroups are associated with elite athlete status in Iranian population. The mtDNA haplogroups of 100 Iranian athletes and 100 healthy, non-athletic individuals were genotyped. Significant differences were observed for haplogroups U and J, which were under- and over-represented in the elite athletes group. The results show that mtDNA haplogroups and their related phenotypic expression correlate with the physical performance."

Dewsloth
05-23-2017, 05:16 PM
Not surprising to see J under-represented among the elite athletes: J's are well known to have relatively deficient VO2max. I do 7 hrs of Brazilian Jiu Jitsu a week, and use this as my excuse for being so awful.

paoloferrari
05-23-2017, 06:04 PM
Not surprising to see J under-represented among the elite athletes: J's are well known to have relatively deficient VO2max. I do 7 hrs of Brazilian Jiu Jitsu a week, and use this as my excuse for being so awful.

i haven't read the paper but from the abstract seem the opposite: j over-represented

Dewsloth
05-23-2017, 06:11 PM
i haven't read the paper but from the abstract seem the opposite: j over-represented

It does read that way!

It looks like earlier studies compared J to H. Maybe U is even worse or the word order was garbled? I'd love to read the full paper.


Mitochondrion. 2010 Mar;10(2):102-7. doi: 10.1016/j.mito.2009.11.005. Epub 2009 Nov 10.
Human mitochondrial haplogroup H: the highest VO2max consumer--is it a paradox?

Martínez-Redondo D1, Marcuello A, Casajús JA, Ara I, Dahmani Y, Montoya J, Ruiz-Pesini E, López-Pérez MJ, Díez-Sánchez C.
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Abstract
Mitochondrial background has been demonstrated to influence maximal oxygen uptake (VO(2max), in mLkg(-1)min(-1)), but this genetic influence can be compensated for by regular exercise. A positive correlation among electron transport chain (ETC) coupling, ATP and reactive oxygen species (ROS) production has been established, and mitochondrial variants have been reported to show differences in their ETC performance. In this study, we examined in detail the VO(2max) differences found among mitochondrial haplogroups. We recruited 81 healthy male Spanish Caucasian individuals and determined their mitochondrial haplogroup. Their VO(2max) was determined using incremental cycling exercise (ICE). VO(2max) was lower in J than in non-J haplogroup individuals (P=0.04). The H haplogroup was responsible for this difference (VO(2max); J vs. H; P=0.008) and this group also had significantly higher mitochondrial oxidative damage (mtOD) than the J haplogroup (P=0.04). In agreement with these results, VO(2max) and mtOD were positively correlated (P=0.01). Given that ROS production is the major contributor to mtOD and consumes four times more oxygen per electron than the ETC, our results strongly suggest that ROS production is responsible for the higher VO(2max) found in the H variant. These findings not only contribute to a better understanding of the mechanisms underneath VO(2max), but also help to explain some reported associations between mitochondrial haplogroups and mtOD with longevity, sperm motility, premature aging and susceptibility to different pathologies.


Martínez-Redondo et al. (2010) found that haplogroup J was associated with a lower maximal oxygen uptake (VO2 max) compared to other haplogroups. Another study by Marcuello et al. (2008) also reported that members of haplogroup J had lower VO2 max, as well as lower efficiency of electron transport chain (ETC), diminished ATP and ROS production. This would imply that members of haplogroup J have a reduced physical endurance during prolonged exercise.