View Full Version : rs12458349 Neanderthal Straight Hair Gene

J Man
06-08-2017, 04:59 PM
According to my new updated 23andme results I have one copy of the ''Neanderthal'' origin allele at rs12458349 which according to them is associated with straight hair. I am TG at rs12458349. Funny thing is though I have wavy/curly hair (when I had hair lol). I can't find much information about rs12458349 and hair type though. I also see though that according to some studies it is associated with kidney disease. Anyone else have similar results at 23andme or know more about rs12458349 and Neanderthal ancestry?

06-08-2017, 06:36 PM
Before I went bald on top my hair was curly and I'm TT for rs12458349

J Man
06-09-2017, 03:47 AM
Before I went bald on top my hair was curly and I'm TT for rs12458349

Yes the G allele is apparently the Neanderthal version at this SNP.

06-09-2017, 11:23 AM
TT and wavy.

07-15-2018, 08:40 PM
Surprised there's not another Neanderthal thread on the 23 and Me forum. This is the first test I took with the conversation piece about Neanderthal ancestry, so I was kind of looking forward to it.

I don't have the straight hair variant (although I do have very straight hair). Nor do I have the height or less likely to sneeze after eating dark chocolate variants (I'm slightly below average in height and don't think I've ever noticed an association between dark chocolate -- which I like -- and sneezing). I do have the variant for less back hair. For the record, I do not have back hair, thank goodness!

Anyway, I have 298 variants, which is apparently more than 82% of 23 and Me testers.

07-16-2018, 12:15 AM
I have 277 variants which apparently is more than 52% of 23andMe customers. I’m T/T at rs12458349 and have 0 variants for straight hair, chocolate sneezing, back hair and height. I have two Neanderthal variants on 16 markers and only one on 245 marker. Other than that, I feel pretty normal. :-)

07-16-2018, 10:25 AM
I have 324 variants whilst my brother has 277.

For rs12458349 both of us have T/T, we both have slightly curly hair. For the others mentioned in this thread -

For the back hair variant, both of us have G/G although my brother has far more back hair than I do.

For height, we're both A/A and G/G and roughly the same height, 5 foot 9.

For dark chocolate (which I've actually just had some of, incidentally), we're both C/C. Neither of us sneeze after eating dark chocolate, although my brother doesn't like dark chocolate anyway.