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MJost
07-11-2013, 03:25 AM
Whats your geno type?

rs4680(A) = Worrier or rs4680(G) = Warrior

https://www.23andme.com/you/explorer/snp/?snp_name=Rs4680

SNP rs4680 is on chromosome 22.

http://www.pnas.org/content/early/2009/01/23/0808376106.full.pdf+html


GG MJost

J Man
07-11-2013, 04:05 AM
AG at rs4680. So I am a worrier/warrior lol. Makes sense I guess. :P...FTDNA says I do not have the Warrior gene though.

DMXX
07-11-2013, 08:27 AM
Pleased to report I'm a hardcore worrier with AA. Feel free to mail me a lifetime supply of stress balls. :D

Worth mentioning I don't perceive myself to be a particularly "worrying" person. SNP's like this should always be accompanied with the nature (+polygenetic coding for traits) vs. nurture tagline.

Jean M
07-11-2013, 10:27 AM
There are a bewildering number of studies of this allele, associating it with lots of things.
http://snpedia.com/index.php/Rs4680
http://blog.23andme.com/news/dna-variation-may-help-us-break-free-from-our-routines/


DNA Variation May Help Us Break Free From Our Routines

And so begins another Friday night. When it comes to choosing where to go to dinner, my husband likes to stick with the tried and true. I like trying out new places. A new study suggests that the roots of this conflict could spring partly from our genes. It suggests that a DNA variation affecting the neurotransmitter dopamine influence a person’s willingness to explore new options instead of sticking with the status quo.

The finding comes from a study by Michael Frank and colleagues from Brown University and the University of Arizona. The researchers focused on how people learn from positive and negative feedback. Subjects were confronted with a clock face that counted down five seconds. Before time was up they had to push a button to receive points. In some trials, the experiment was set up so that the faster they pushed the button, the more points they got. In other trials, waiting longer got more points.

To the researchers’ surprise, people showed wide swings in response speed within each type of trial as they adjusted their timing in an attempt to maximize their scores. Computer models showed that a likely reason for these swings is that people change their strategy (pressing the button faster or slower) in proportion to how uncertain they are that a new strategy (speeding up or slowing down from what they’ve been doing) will yield better results...

Further analysis of the data ... showed that the extent to which a person tried out new strategies correlated with variations in the COMT gene. People who carried the “Met” version of the gene were more exploratory in the face of uncertainty about what strategy to try next than people with two copies of the “Val” version.... People with two copies of the Met version were the most adventurous, but even those with only one copy were statistically different in their exploration of new strategies from the people with two copies of the Val version.

(The different versions of the COMT gene are determined by rs4680... A=Met, G =Val)

MJost
07-11-2013, 03:22 PM
I wonder. FtDNA say something about the X chr. in their test. What did they tell you.

MJost

AJL
07-11-2013, 03:57 PM
Like my cousin J Man, I am a "woarrier" with AG.

I guess that means we really want to club our opponents over their head, but are usually too worried they will club us back? :)

rockman
07-11-2013, 04:15 PM
I am rs4680(G;G), WARRIOR!

The funny thing is I'm a mix of warrior and worrier lol. Whats the difference between this gene and MAO-A?

MJost
07-11-2013, 05:26 PM
Like my cousin J Man, I am a "woarrier" with AG.

I guess that means we really want to club our opponents over their head, but are usually too worried they will club us back? :)

Nice analogy. I sent the result of all my siblings and three of the four paternal siblings have AG too but one went to GG and my two sisters have AA. So did the one GG brother mutate from AG?

He did say that the GG made much sense to him and explained alot about himself. I said, "Me TOO!"

MJost

william0509
02-17-2016, 05:34 PM
I am rs4680(G;G), too. lol

Shaikorth
02-17-2016, 06:22 PM
I am rs4680(G;G), too. lol

The frequency of this SNP suggests Africans and East Asians are "warriors" while Europeans and South Asians are "worriers".

http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=22:19950771-19951771;v=rs4680;vdb=variation;vf=4466

Stephen1986
02-17-2016, 08:00 PM
My brother has GG whilst I have AG.

Gray Fox
02-17-2016, 10:00 PM
Another "woarrier" here! A/G

ashwinb
02-17-2016, 10:15 PM
AG here.

Mellifluous
02-17-2016, 11:07 PM
GG - Warrior!

drobbah
02-17-2016, 11:14 PM
lol AG here

leonardo
02-17-2016, 11:36 PM
GG here.

Deftextra
02-18-2016, 02:06 AM
A\G here. lol was expecting A\A.

XooR
02-18-2016, 02:40 AM
me
rs4680(A;A)

Magnitude: 2.5
Frequency: 24.8%
Repute:Good
References:277



(worrier) advantage in memory and attention tasks Little or no response to modafinil. You are more difficult to hypnotise. Placebo is more effective http://www.nytimes.com/2013/02/10/magazine/why-can-some-kids-handle-pressure-while-others-fall-apart.html?ref=magazine&pagewanted=all

rs4680 (Val158Met) is a well studied SNP in the COMT gene. 23andMe blog summarizes them as *rs4680(A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions *rs4680(G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions Roughly speaking, the predominant wisdom (known colloquially as the warrior/worrier hypothesis; summary at ) posits that people with Val alleles have increased COMT activity and lower prefrontal extracellular dopamine compar...

Wifey

rs4680(G;G)

Magnitude: 2.5
Frequency: 29.2%
Repute:Good
References:277


(warrior) multiple associations, see details You have the VAL/VAL version of the snp discussed in this news article. It is able to perform better in a test where the optimal strategy changes. Placebo is less effective for you http://www.nytimes.com/2013/02/10/magazine/why-can-some-kids-handle-pressure-while-others-fall-apart.html?ref=magazine&pagewanted=all


rs4680 (Val158Met) is a well studied SNP in the COMT gene. 23andMe blog summarizes them as *rs4680(A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions *rs4680(G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions Roughly speaking, the predominant wisdom (known colloquially as the warrior/worrier hypothesis; summary at ) posits that people with Val alleles have increased COMT activity and lower prefrontal extracellular dopamine compar...

SwampThing27
02-18-2016, 03:23 AM
FiancÚ and I are both GG on rs4680

BalkanKiwi
02-18-2016, 04:20 AM
A sneaky GG.

MonkeyDLuffy
02-18-2016, 07:06 AM
AG here. Depends on situation how I'll react.

kerbal
02-18-2016, 09:21 AM
AA for me, what I expected.

Mestace
02-18-2016, 10:11 AM
rs4680 A or G GG

gravetti
02-18-2016, 10:11 AM
GG for me.Not surprised.

thrax
02-18-2016, 01:01 PM
I have AG

Webb
06-06-2016, 02:03 PM
I have AG as well.

firemonkey
06-06-2016, 02:40 PM
I am AA, worrier type. I do suffer from anxiety. I also tend to perform worse cognitively when under stress.

Amerijoe
06-06-2016, 03:40 PM
AG, also. Note from experience, your warrior gene will go full mode in a threat situation.

anglesqueville
06-06-2016, 04:05 PM
Mother and father are AG. I'm AA, bad luck.

Theramster
08-18-2016, 11:49 AM
GG here Warrior

Zoran
08-18-2016, 12:32 PM
AG here

Theconqueror
08-18-2016, 01:21 PM
I am AA. rs4680(A) = Worrier.
Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions.

kikkk
08-18-2016, 02:58 PM
GG yet I think nurture is way more relevant here, I am far from being a warrior

Gaku
08-18-2016, 06:25 PM
Pleased to report I'm a hardcore worrier with AA. Feel free to mail me a lifetime supply of stress balls. :D

Worth mentioning I don't perceive myself to be a particularly "worrying" person. SNP's like this should always be accompanied with the nature (+polygenetic coding for traits) vs. nurture tagline.

AA here too. Would you like some free stress balls? I definitely don't require any as I am a pretty easy-going mellow chap.


I think nature vs. nurture definitely plays a part though.

I have a military background, worked with some dangerous individuals in mental health, and even once had someone poking me in the back with an open switchblade as he and his friend went about robbing the gas station [mr. switchblade ended up with a broken nose & kissing the tiles after he backed off enough for me to turn around]. That's not including the people I work with in the addictions side of medicine. If I was a true AA [hardcore worrier] I'd be wringing my hands, jumping at every little noise, and getting so flustered / anxious I can barely string a sentence together [and this guy's been in addictions treatment for 12 years] like one of my colleagues do. Yet I didn't even flinch when this huge Hells Angel, who looked like he could break an arm without breaking a sweat, started throwing a fit because of a mess up [paperwork] on the part of his daughter's doctor.

One of the patients once joked someone could blow up the building [and that has been a passing threat alongside with patients threatening to kill us all] and I'd merely pick myself up, brush off the dust, and carry on.



But then again

My brother on the other hand - AG - has at the very least the same military background and is, at times, wound up tighter than a two dollar watch.

Bes
08-19-2016, 05:39 AM
GG here.

L1983
08-19-2016, 09:48 AM
AG Big worrier

Cascio
08-19-2016, 01:26 PM
AG here

Neo
08-22-2016, 01:12 AM
For the Warrior Gene:I got A/G.half and half.

COMT rs4680 19951271 A or G A / G

For the MAO gene: I got C

MAOA rs909525 43553202 C or T C

08-22-2016, 08:51 AM
COMT 19951271 rs4680 A or G AG
So I am a worry-full warrior?

Abd.H
09-30-2016, 10:31 PM
I uploaded my raw data on promethease and i got this result


rs4680(A;A)
(worrier) advantage in memory and attention tasks :ranger:

11926

what does worrier exactly mean?
is it the opposite of warrior?

vettor
09-30-2016, 10:39 PM
I uploaded my raw data on promethease and i got this result


rs4680(A;A)
(worrier) advantage in memory and attention tasks :ranger:

11926

what does worrier exactly mean?
is it the opposite of warrior?

a person who could be easily stressed under certain circumstances

Darko
09-30-2016, 10:58 PM
this is my result from promethease (GG):

rs4680(G;G)


(warrior) multiple associations, see details You have the VAL/VAL version of the snp discussed in this news article. It is able to perform better in a test where the optimal strategy changes. Placebo is less effective for you http://www.nytimes.com/2013/02/10/magazine/why-can-some-kids-handle-pressure-while-others-fall-apart.html?ref=magazine&pagewanted=all

rs4680 (Val158Met) is a well studied SNP in the COMT gene. 23andMe blog summarizes them as *rs4680(A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions *rs4680(G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions Roughly speaking, the predominant wisdom (known colloquially as the warrior/worrier hypothesis; summary at ) posits that people with Val alleles have increased COMT activity and lower prefrontal extracellular dopamine compar...
 more info

anglesqueville
10-01-2016, 08:16 AM
rs4680
AG dad
AG mom

--> AA angles

Gheg
11-26-2018, 03:59 PM
Apologize if it's a problem for bringing an old thread back but, within my family, RS4680 seems to be pretty impressive in calling "warriors" and "worriers".

My mom is GG, my dad is AG
I am GG, my wife is AG
My son is GG

My brother and sister are also both GG. We always used to make fun of my dad for panicking and worrying so much now we know why lol. My wife for sure shows signs of this even more so than my dad (probably due to less testosterone?).

Ruderico
11-26-2018, 04:22 PM
Me - rs4680 AA
Missus - rs4680 AG


I didn't even need to see the .txt to know I'm a "worrier" though

Jeep
11-27-2018, 04:42 AM
G/G on rs4680

drobbah
11-27-2018, 12:55 PM
rs4680- A/G

PoxVoldius
11-28-2018, 02:53 PM
AG on rs4680

Grimbold
02-25-2019, 08:01 PM
My genotype is G G (via 23andMe)