View Full Version : cold adaptation in human evolutionary history

07-17-2017, 10:22 AM
Experimental evidence reveals the UCP1 genotype changes the oxygen consumption attributed to non-shivering thermogenesis in humans



Humans have spread out all over the world adapting to many different cold environments. Recent worldwide genome analyses and animal experiments have reported dozens of genes associated with cold adaptation. The uncoupling protein 1 (UCP1) gene enhances thermogenesis reaction in a physiological process by blocking ATP (adenosine triphosphate) synthesis on a mitochondrial membrane in brown adipose tissues. To our knowledge, no previous studies have shown an association between variants of the UCP1 gene and physiological phenotypes concerning non-shivering thermogenesis (NST) under the condition of low temperature in humans. We showed that the degree of NST for healthy subjects in an artificial climate chamber is significantly different among UCP1 genotypes. Defining the haplotypes covering the UCP1 region (39.4 kb), we found that the frequency of the haplotype with the highest NST was significantly correlated with latitudes and ambient temperature. Thus, the data in this study provide the first evidence that the UCP1 genotype alters the efficiency of NST in humans, and likely supports the hypothesis that the UCP1 gene has been related to cold adaptation in human evolutionary history."

08-13-2017, 01:13 AM
In addition to your interesting post,

OCA 2 or oculocutaneous albinism will change hair color with temperatures.
IIRC oculocutaneous albinism can change the "color" of the whole genome in an individual.

08-13-2017, 05:43 PM
I noticed a long time ago, in written works, that Native Americans were hardier regarding cold than whites. Specifically, I recall reading (I still have the book somewhere) that a captive white man almost died from the chilly climate, while his captors were going around barefoot. This was on Vancouver Island. His life was spared because he was a gunsmith and therefore useful. Otherwise, the rest of them on a trading ship were killed. I hope I remembered that more or less correctly.

08-13-2017, 09:04 PM
I was told by a doctor I had unusually thick skin, ?