View Full Version : Big Cats (Panthera genus), um, screwing around

07-22-2017, 12:06 AM
This article is really above my knowledge comfort zone but I thought some might like it...

I think it means the several big cats in this genus boinked each other often, back in the day, and you can see it in the modern admixture

...there is some speculation it might help shed light on similar events within the archaic human types and us sapiens....

I think

this into written by Dale E Reddick, posting in an FB genetics group
"This is big cat genomics. This covers the jaguar, leopard, lion, snow leopard, and tiger. The results found indicate a great deal of post-speciation introgression / admixture among the species of the pantherine felid genus Panthera. One can easily think about similar processes among the species and populations of the hominin genus Homo: especially AMH; Neanderthal; and Denisovan populations."


The great cats of the genus Panthera comprise a recent radiation whose evolutionary history is poorly understood. Their rapid diversification poses challenges to resolving their phylogeny while offering opportunities to investigate the historical dynamics of adaptive divergence. We report the sequence, de novo assembly, and annotation of the jaguar (Panthera onca) genome, a novel genome sequence for the leopard (Panthera pardus), and comparative analyses encompassing all living Panthera species. Demographic reconstructions indicated that all of these species have experienced variable episodes of population decline during the Pleistocene, ultimately leading to small effective sizes in present-day genomes. We observed pervasive genealogical discordance across Panthera genomes, caused by both incomplete lineage sorting and complex patterns of historical interspecific hybridization. We identified multiple signatures of species-specific positive selection, affecting genes involved in craniofacial and limb development, protein metabolism, hypoxia, reproduction, pigmentation, and sensory perception. There was remarkable concordance in pathways enriched in genomic segments implicated in interspecies introgression and in positive selection, suggesting that these processes were connected. We tested this hypothesis by developing exome capture probes targeting ~19,000 Panthera genes and applying them to 30 wild-caught jaguars. We found at least two genes (DOCK3 and COL4A5, both related to optic nerve development) bearing significant signatures of interspecies introgression and within-species positive selection. These findings indicate that post-speciation admixture has contributed genetic material that facilitated the adaptive evolution of big cat lineages.

good luck, tell me if I messed up the intro badly