View Full Version : Genetiske analyse av 150 dansker

08-07-2017, 07:12 PM
På engelsk (http://www.nature.com/nature/journal/v548/n7665/full/nature23264.html?foxtrotcallback=true)

08-08-2017, 07:59 PM
På engelsk (http://www.nature.com/nature/journal/v548/n7665/full/nature23264.html?foxtrotcallback=true)
this caught my attention:

Significantly more SNVs than indels were of paternal origin (78% versus 66%, P = 0.002), suggesting that these mutations were less dependent on replication. We found a highly significant effect of maternal age on the number of SNV mutations coming from the mother (Fig. 3b), showing that de novo mutations accumulate over time in the female germ line even in the absence of further cell divisions (see also ref. 24). The CpG mutations had a smaller (and non-significant) correlation to paternal age than non-CpG mutations; consequently, the fraction of CpG mutations was negatively correlated with paternal age (Fig. 3c). We also observed significantly higher mutation rates at CpG sites that tended to be methylated in humans

The highest number of non-matching alleles, of those mutually called, between a parent and their child --tested with the same chip that people have let me compare-- was a mother-son pair. Maybe this study gives an indication why. Maybe her age at his conception is the contributing factor.
Thanks for posting @AJL.
dp :-)