PDA

View Full Version : African-origin Mitochondrial DNA Variants as a Contributing Factor to Susceptibiliti



paoloferrari
08-18-2017, 06:38 AM
African-origin Mitochondrial DNA Variants as a Contributing Factor to
Susceptibilities for Diabetes and Age-related Diseases

https://www.researchgate.net/profile/Deepika_Malik2/publication/313316187_African-origin_Mitochondrial_DNA_Variants_as_a_Contributin g_Factor_to_Susceptibilities_for_Diabetes_and_Age-related_Diseases/links/595f83deaca2728c1173859b/African-origin-Mitochondrial-DNA-Variants-as-a-Contributing-Factor-to-Susceptibilities-for-Diabetes-and-Age-related-Diseases.pdf

"Abstract
African-origin populations are more susceptible to diabetes
and other age-related diseases compared to European-origin
populations, but mechanisms for the differential susceptibility
remain unknown. Human mitochondrial (mt) DNA haplogroups are
maternally inherited ancient polymorphisms representing different
geographic origins of populations. Haplogroups are defined by
accumulations of single nucleotide polymorphisms (SNPs), some
of which cause changes in amino acids and rates of mtDNA
replication and transcription. Several studies have shown that age-
related diseases and their complications can be linked to mtDNA
haplogroup subsets. Previous studies report that transmitochondrial
cybrids (cytoplasmic hybrids), which contain identical nuclei but
either European-origin (H) or African-origin (L) haplogroup mtDNA,
have significantly different bioenergetic profiles, production levels
of reactive oxygen species, and expression levels for complement,
inflammation and apoptosis genes, thus suggesting that major
biological pathways can be modulated by mtDNA. Using GeneChip
arrays and Q-PCR, we show that African-origin L cybrids show
significantly different expression levels for three Wnt pathway
genes (DKK3, SFRP1, and KREMEN1) and three diabetes-
related genes (RPS6KA4, ADAMTS9, and VEGFA) compared to
European-origin H cybrids. Our current findings, along with others,
support the hypothesis that an individualís mtDNA can modulate the
expression of important Wnt signaling and diabetes-related genes,
which may contribute to the racial/ethnic disparities associated with
diabetes and other age-related diseases"

Angoliga
08-18-2017, 01:55 PM
Interesting study, I always assumed diet was the major factor in diabetes among Africans/AAs. If this paper holds strong merit, hopefully more comparative genetic population research of this kind will spread awareness and aid with preventative measures.