View Full Version : Disruption to the gene TOP3B increases susceptibility to schizophrenia and a learning

08-05-2013, 03:58 PM
'A team of researchers have shown that schizophrenia and a disorder associated with autism and learning difficulties share a common biological pathway. This is one of the first times that researchers have uncovered genetic evidence for the underlying causes of schizophrenia.

The team found that a disruption of the gene TOP3B, an exceedingly rare occurrence in most parts of the world, is fairly common in a uniquely genetically distinct founder population from North-eastern Finland. In this population, which has grown in relative isolation for several centuries, the disruption of TOP3B is associated with an increased risk of schizophrenia as well as with impairment in intellectual function and learning.'

This caught my attention and I wonder if someone knows more about the genes and mutations (about 100) which increase to get schizophrenia?