PDA

View Full Version : Mitochondrial DNA haplogroup K as a contributor to protection against thyroid cancer



paoloferrari
09-03-2017, 03:44 PM
Mitochondrial DNA haplogroup K as a contributor to protection against thyroid cancer in a population from southeast Europe

http://www.sciencedirect.com/science/article/pii/S1567724916302835

"Highlights



mtDNA haplogroups can constitute susceptibility or protective factors for diseases.


Contribution of mtDNA haplogroups to thyroid cancer risk is investigated.


Our results indicate a protective effect of haplogroup K.

Abstract

We aimed to analyze the contribution of mitochondrial DNA (mtDNA) haplogroups of the mtDNA control region to thyroid cancer risk in a population from southeastern Europe consisting of 235 thyroid tumor patients, including 114 patients with thyroid follicular adenoma, 121 patients with papillary thyroid carcinoma, and 419 healthy controls. Binary logistic regression with adjustment for age and gender revealed that mtDNA haplogroup K was significantly associated with a protective role for thyroid cancer in the combined tumor group versus controls. These results indicate a potential role for mtDNA haplogroups as important candidate susceptibility markers for the patients with thyroid nodules."

Saetro
09-03-2017, 10:22 PM
Mitochondrial DNA haplogroup K as a contributor to protection against thyroid cancer in a population from southeast Europe

http://www.sciencedirect.com/science/article/pii/S1567724916302835

"Highlights



mtDNA haplogroups can constitute susceptibility or protective factors for diseases.


Contribution of mtDNA haplogroups to thyroid cancer risk is investigated.


Our results indicate a protective effect of haplogroup K.

Abstract

We aimed to analyze the contribution of mitochondrial DNA (mtDNA) haplogroups of the mtDNA control region to thyroid cancer risk in a population from southeastern Europe consisting of 235 thyroid tumor patients, including 114 patients with thyroid follicular adenoma, 121 patients with papillary thyroid carcinoma, and 419 healthy controls. Binary logistic regression with adjustment for age and gender revealed that mtDNA haplogroup K was significantly associated with a protective role for thyroid cancer in the combined tumor group versus controls. These results indicate a potential role for mtDNA haplogroups as important candidate susceptibility markers for the patients with thyroid nodules."

Maybe, maybe not.
Most of these associations disappear once more samples come in.
Perhaps this is effectively a call for more funding to run that bigger study.