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View Full Version : Offerings in Anti-aging, anti-inflammatory supplements



FGC Corp
09-23-2017, 12:41 AM
Any interest in the group in anti-aging or anti-inflammatory supplements? I'm looking into that as an additional offering.

Example:
NAD

From a recent paper: Rejuvenation Res. 2017
"NAD+ levels decline with age in diverse animals from Caenorhabditis elegans to mice. Raising NAD+ levels by dietary supplementation with NAD+ precursors, nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), improves mitochondrial function and muscle and neural and melanocyte stem cell function in mice, as well as increases murine life span. "

https://www.ncbi.nlm.nih.gov/pubmed/28537485

RobertCasey
09-23-2017, 06:20 AM
I guess most of the genetic genealogy testers need investigate this NAD research so FGC and FTDNA do not lose their loyal customer base too soon :)

FGC Corp
09-23-2017, 07:33 AM
More info:
https://www.ncbi.nlm.nih.gov/pubmed/28330719

Neurosci Lett. 2017 Apr 24;647:133-140. doi: 10.1016/j.neulet.2017.03.027. Epub 2017 Mar 19.

Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease.
Yao Z1, Yang W1, Gao Z2, Jia P3.
Author information

Abstract
Amyloid-β (Aβ) oligomers have been accepted as major neurotoxic agents in the therapy of Alzheimer's disease (AD). It has been shown that the activity of nicotinamide adenine dinucleotide (NAD+) is related with the decline of Aβ toxicity in AD. Nicotinamide mononucleotide (NMN), the important precursor of NAD+, is produced during the reaction of nicotinamide phosphoribosyl transferase (Nampt). This study aimed to figure out the potential therapeutic effects of NMN and its underlying mechanisms in APPswe/PS1dE9 (AD-Tg) mice. We found that NMN gave rise to a substantial improvement in behavioral measures of cognitive impairments compared to control AD-Tg mice. In addition, NMN treatment significantly decreased β-amyloid production, amyloid plaque burden, synaptic loss, and inflammatory responses in transgenic animals. Mechanistically, NMN effectively controlled JNK activation. Furthermore, NMN potently progressed nonamyloidogenic amyloid precursor protein (APP) and suppressed amyloidogenic APP by mediating the expression of APP cleavage secretase in AD-Tg mice. Based on our findings, it was suggested that NMN substantially decreases multiple AD-associated pathological characteristically at least partially by the inhibition of JNK activation.

pauleug
04-19-2019, 03:02 AM
Anti-aging or anti-inflammatory supplements are, in most cases, a snake oil