PDA

View Full Version : DNAland inputation files verification using Promethease



Amerijoe
10-11-2017, 06:00 PM
Just received this from Roberta Estes utilizing Promethease to verify inputation files at DNAland.

https://dna-explained.com/2017/10/11/imputation-analysis-utilizing-promethease/

wilhelmhalys
01-30-2018, 11:13 AM
How is possible that an imputed file from DNA.LAND using my 23andme V5 file, in some topics has lost some SNPs when comparing to the same report for the 23andme V5 file?

Promethease 23andme V5
21104

Promethease DNA.LAND Imputed from 23andme V5 file
21105

Capitalis
02-21-2018, 06:55 PM
I accidentally found the answer to this question myself recently! I tested with Living DNA which is the same chip as your 23andme. None of the SNPs from the Living DNA file at Promethease showed up on the imputed file from Gencove (similar imputation process as your DNA Land file).

I found that the Living DNA SNPs have been recorded on the imputed Gencove Promethease report as dubious! So if you view your DNA Land report at Promethease and check the 'Dubious' box hopefully the combined 23andme and DNA Land SNPs will show.