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Sangarius
08-17-2013, 06:23 PM
A PLOS Genetics paper from 2012 found genes for bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.

Paper: "WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk"
Link: http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002745

Some people build a calculator based on the paper. The app is based on the 23andme api. So it only works for 23andme customers.
Link: http://bones.herokuapp.com/

My results:

http://img843.imageshack.us/img843/2379/wye4.png

Kavkaz bone structure hehe :P

leonardo
08-17-2013, 06:35 PM
Not quite as good as yours Sangarius
9/14
High Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 3/4
Lower Forearm Fracture Risk 4/6

DMXX
08-17-2013, 07:10 PM
Very close to yours Sangarius!



11/14
Superhuman Bone Strength

Higher Cortical Bone Strength 3/4
Higher Forearm Bone Mineral Density 3/4
Lower Forearm Fracture Risk 5/6


Must be something in the (Black + Caspian sea) water, eh?

MikeWhalen
08-17-2013, 07:34 PM
just plain regular Irish boy I guess
I am a bit surprised because my bones are thick and dense and have never broken...that's not the good thing you might think because it means I have had alot of much worse soft tissue damage in sports...instead of a bone breaking, my ligaments, tendons and whatnot would get ripped up and torn and take way longer to heal

Results from SNPs rs9525638, rs2908004, rs2707466, and rs7776725 on genes WNT16 and FAM3C. "Higher/Lower" compares to those with mutations. Check out the PLoS paper.
MICHAEL WHALEN
8/14
High Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

Mike

Sangarius
08-17-2013, 08:12 PM
Must be something in the (Black + Caspian sea) water, eh?

I guess so. :P The grandpa of orangepulp (North-Eastern Turkey) scored 14/14. Another Turkish guy from that region scored 13/14.


For those of you did not test with 23andme, check the following SNPs (thanks to MfA):

Higher Cortical Bone Strength
rs9525638
TT = 2 pts
CT = 1 pts
CC = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

Higher Forearm Bone Mineral Density
rs2908004
NA = 2 pts
AA = 2 pts
AG = 1 pts
GG = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

Lower Forearm Fracture Risk
rs2908004
NA = 2 pts
AA = 2 pts
AG = 1 pts
GG = 0 pts

rs7776725
TT = 2 pts
CT = 1 pts
CC = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

J Man
08-17-2013, 09:51 PM
Everyone in my family including myself get 8/14 High Bone Strength except for my mother who has 7/14 and my great uncle who has 10/14. None of us are frail though.

Humanist
08-18-2013, 01:45 AM
It appears I am more like Mr. Glass. :) At least compared to some of you fellas.


Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 3/4
Lower Forearm Fracture Risk 4/6

8/14

MikeWhalen
08-18-2013, 01:46 AM
btw Sangarius...very cool topic, being able to check this stuff out is fun
thx for posting

Mike

[QUOTE=Sangarius;11705]A PLOS Genetics paper from 2012 found genes for bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.

Calamus
08-18-2013, 09:05 AM
Mine is the same as Mike:

8/14
High Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

rod
08-19-2013, 03:21 AM
Oh well..
630

ilmari
08-19-2013, 06:27 AM
Ilmari
3/14
weak Bone Strength

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 0/4
Lower Forearm Fracture Risk 2/6

I have never broken a bone, and I've had many opportunities to have done so with some major traumas. I'm not certain I believe this app is working properly.

Clinton P
08-19-2013, 08:30 AM
I suppose this explains how I broke the neck of my right femur 8 years ago.

Clinton P


631

N21163
08-20-2013, 11:52 PM
Anyone know how to access these calculators without a 23andme account (probably not possible). I have tested with FTDNA and have converted my results to 23and me format.

MikeWhalen
08-21-2013, 03:29 AM
jeez Ilmari, sounds like the test results are missing something as that sure seems a low score for you...maybe the score shows a predilection or just one of several factors that ultimately give bone strength


Ilmari
3/14
weak Bone Strength

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 0/4
Lower Forearm Fracture Risk 2/6

I have never broken a bone, and I've had many opportunities to have done so with some major traumas. I'm not certain I believe this app is working properly.

Sangarius
08-21-2013, 08:50 AM
Anyone know how to access these calculators without a 23andme account (probably not possible). I have tested with FTDNA and have converted my results to 23and me format.

Check my post on the first page. I listed the SNPs to check. http://www.anthrogenica.com/showthread.php?1230-Bone-Strength-Calculator&p=11727&viewfull=1#post11727

Dr_McNinja
09-16-2013, 03:38 PM
I got 11/14 (3/4, 3/4, 5/6)

basque
09-16-2013, 07:51 PM
Ilmari
3/14
weak Bone Strength

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 0/4
Lower Forearm Fracture Risk 2/6

I have never broken a bone, and I've had many opportunities to have done so with some major traumas. I'm not certain I believe this app is working properly.

Ilmari we must be twins B) my score was exactly the same as yours. Considering I have spent most of my life dancing, gymnastics, running, weight training eta.. and have fallen from great heights and other accidents. I have never broken a bone in my body and consider my self very strong I expected to be super human :confused:

It cant possibly be working properly. I better wrap myself in cotton wool.

basque :rolleyes:

Kaido
06-29-2015, 10:17 AM
Noice.

http://i.gyazo.com/dab28c4fd8000569c588c89a9a40e141.png

BalkanKiwi
06-29-2015, 10:22 AM
http://i.imgur.com/OikWrkF.png

anglesqueville
06-29-2015, 11:20 AM
Ilmari
3/14
weak Bone Strength

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 0/4
Lower Forearm Fracture Risk 2/6

I have never broken a bone, and I've had many opportunities to have done so with some major traumas. I'm not certain I believe this app is working properly.

Definitly, there is something true with the calculators that tell I have finnish/saami ancestors:
5076
My wife now: do you think I must tell her she is superhuman? Don't know......
5077

Passa
06-29-2015, 11:38 AM
8/14

5078

Reith
06-29-2015, 01:43 PM
11/14

Gray Fox
06-29-2015, 01:54 PM
3/14... Not sure I believe that. I've broken a few bones in my day, but they were traumatic incidents and a lot of force was involved.

anglesqueville
06-29-2015, 03:38 PM
3/14... Not sure I believe that. I've broken a few bones in my day, but they were traumatic incidents and a lot of force was involved.

I agree, that looks rather odd for me and my mother. But conversely, when my wife had a bone scanning, before a chemo, she was said to have the bones of a teenager, while she was 55. Therefore she is perhaps actually "superhuman". I don't know what to think about this, regardless of the fact that I am suspicious about the health oriented reports of 23.

Cofgene
06-29-2015, 04:18 PM
12/14. My father came in at 13/14.

icebreaker
06-29-2015, 04:20 PM
13/14

Arslan
06-29-2015, 04:38 PM
http://i.imgur.com/rRkGMJo.png

can't_lurk_no_mo'
06-29-2015, 05:18 PM
9/14
high Bone Strength

Higher Cortical Bone Strength 3/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

ashwinb
06-29-2015, 05:26 PM
7/14,

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

surbakhunWeesste
06-29-2015, 05:30 PM
http://i.imgur.com/2pA2smb.png

Caspian
06-29-2015, 05:44 PM
A calculator that doesn't support raw data based on FTDNA again.
https://d304k3mn1nwj0a.cloudfront.net/meme/facepalm-captain.png

can't_lurk_no_mo'
06-29-2015, 08:42 PM
Throughout life, bone density is affected by heredity, diet, sex hormones, physical activity, lifestyle choices and the use of certain medications.

http://www.wernermd.com/testosterone-bone-health.php

Varun R
06-29-2015, 11:51 PM
9/14- high bone strength. Works for me :)

MonkeyDLuffy
06-30-2015, 12:17 AM
3/14

Yeah totally :doh:

tamilgangster
06-30-2015, 08:15 AM
Is their a correlation between population groups and bone strength, or is their greater variation within populations

MonkeyDLuffy
06-30-2015, 08:58 AM
According to these results i should wear a gundum suit everywhere, as a normal blow of air can crush me into pieces. Totally going to stay in my bed from now on.

John Doe
06-30-2015, 09:43 AM
9/14
High Bone Strength

Higher Cortical Bone Strength 3/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

Táltos
06-30-2015, 02:23 PM
I'm apparently Superhuman! I've only chipped my talus (ankle bone) once. Won't admit to what I was doing to have that happen! :biggrin1:
12/14
Superhuman Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 4/4
Lower Forearm Fracture Risk 6/6

MfA
06-30-2015, 06:56 PM
Is their a correlation between population groups and bone strength, or is their greater variation within populations

Not enough data so far, fwiw here's regional breakdown of Anthrogenicians.

http://abload.de/img/hestikkqko.png


I'm 2/4 3/4 5/6 10/14 untermensch btw
Ezidi Kurd 3/4 4/4 5/6 12/14


RISE423 MBA Armenia only 1 call: rs7776725 TT 2 pts

didn't take ashwinb and surbakhunWeesste in consideration since I don't know where they're from.

Stellaritic
06-30-2015, 08:14 PM
Stellaritic
13/14
Superhuman Bone Strength

Higher Cortical Bone Strength 3/4
Higher Forearm Bone Mineral Density 4/4
Lower Forearm Fracture Risk 6/6


:biggrin1:

MfA
06-30-2015, 08:27 PM
Stuttgart LBK
3/4 2/4 3/6 - 8/14

RISE395 Sintastha
4/4 4/4 4/6 - 12/14

RISE98 Battle Axe/Nordic LN
3/4 4/4 5/6 - 13/14

RISE495 Karasuk
2/4 2/4 4/6 - 8/14

Passa
06-30-2015, 09:23 PM
Would be interesting to see Oase 1's results

MfA
06-30-2015, 09:39 PM
Kostenki K14
1/4 1/4 3/4 - 5/14

Ust'-Ishim
1/4 0/4 2/4 - 3/14

Mal’ta
4/4 4/4 6/6 - 14/14


Would be interesting to see Oase 1's results

Couldn't see Felix converted his genome.


RISE505 Andronovo
2/4 4/4 4/6 - 10/14

RISE500 Andronovo
2/4 2/4 4/6 - 8/14

RISE523 Meshovskaya
3/4 3/4 5/6 - 11/14

RISE552 Yamnaya
3/4 4/4 6/6 - 13/14

RISE174 IA Sweden
4/4 3/4 5/6 - 12/14

RISE150 Unetice
4/4 3/4 5/6 - 12/14

RISE511 Afanasievo
4/4 3/4 4/6 - 11/14

Loschbour
3/4 2/4 3/6 - 8/14

K01
2/4 0/4 2/6 - 4/14

NE7
3/4 3/4 3/6 - 9/14

Motala-12
4/4 4/4 4/6 - 12/14

MfA
07-01-2015, 09:42 AM
IR1
4/4 4/4 6/6 - 14/14

BR2
1/4 0/4 2/6 - 3/14

CO1
2/4 0/4 2/6 - 4/14

Hinxton4
2/4 2/4 2/6 - 6/14

NE1
3/4 4/4 5/6 - 12/14

bol_nat
07-29-2015, 03:00 AM
:P

https://scontent-mad1-1.xx.fbcdn.net/hphotos-xpt1/v/t1.0-9/11822661_1682743561944149_8613506938327867311_n.jp g?oh=63b41d4d9a908d29e186499406733003&oe=5654618E

fil
07-29-2015, 10:53 PM
7/14

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

BalkanKiwi
07-30-2015, 07:54 AM
Its interesting to see all the variation among everyone who has posted. Those of us who get 14/14 don't seem to be too common. I should mention applying load can improve bone density (osteoblast activity in particular), so therefore if you get a low score, it isn't a representation of potential biological change over time.

bored
07-30-2015, 08:16 AM
http://i.imgur.com/Ux8gnFj.png

bored
07-30-2015, 08:19 AM
3/14

Yeah totally :doh:

How is that even possible? Lol.

Sapporo
07-30-2015, 08:39 AM
http://oi58.tinypic.com/j7ddn9.jpg

MonkeyDLuffy
07-30-2015, 08:48 AM
How is that even possible? Lol.

No idea mahn. Good thing because of this calculator i am enjoying my metal armor.

Life is not same anymore. I am glad i ran my data on it.

Sein
07-30-2015, 09:10 AM
5351

Good enough for me.

khanabadoshi
07-30-2015, 09:38 AM
I was expecting to break the calculator and cause their servers to crash -- I've fallen off a roof onto cement; got beaten the living sh*t out of by some 20 y/o when I was 14; and crashed into a brick wall at 30mph on a motorcycle with my shin behind the peg/footrest. I broke/fractured nothing. The footrest dug into shin due to the force, I still have a "dent" there.

So relax all you 8s -- I've been battle tested.


8/14
high Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

Awale
07-30-2015, 09:43 AM
http://oi58.tinypic.com/2enypl3.jpg

Not bad... Always knew I was a bad ass. Good to have genetic confirmation.

Rukha
07-30-2015, 12:15 PM
12/14
Superhuman Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 4/4
Lower Forearm Fracture Risk 6/6

Arbogan
07-31-2015, 07:26 AM
10/14

A better indication is joint size. If you have larger wrists you're less likely to get a fracture.

surbakhunWeesste
07-31-2015, 07:43 AM
Too many Super-humans. I wonder about their costumes now!

Stellaritic
07-31-2015, 12:55 PM
Too many Super-humans. I wonder about their costumes now!

https://d1vuqpxfeed0st.cloudfront.net/media/catalog/product/cache/3/image/450x/9df78eab33525d08d6e5fb8d27136e95/t/h/the-skull-and-bones-morphsuit-1.jpg

Arbogan
08-01-2015, 08:59 AM
Proof that even supermen can havr their bones broken.


http://youtu.be/BrHm5XeN-dQ

The strongman who has his arm broken literally look's like guile from street fighter.

Volat
08-01-2015, 09:23 AM
For those of you did not test with 23andme, check the following SNPs (thanks to MfA):

Higher Cortical Bone Strength
rs9525638
TT = 2 pts
CT = 1 pts
CC = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

Higher Forearm Bone Mineral Density
rs2908004
NA = 2 pts
AA = 2 pts
AG = 1 pts
GG = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

Lower Forearm Fracture Risk
rs2908004
NA = 2 pts
AA = 2 pts
AG = 1 pts
GG = 0 pts

rs7776725
TT = 2 pts
CT = 1 pts
CC = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

Two SNPs (rs2908004 , rs2908004) were not found . Not tested? So 8 /10.

Mellifluous
11-11-2015, 06:34 AM
8/14 higher bone strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

Mellifluous
11-11-2015, 06:36 AM
I was expecting to break the calculator and cause their servers to crash -- I've fallen off a roof onto cement; got beaten the living sh*t out of by some 20 y/o when I was 14; and crashed into a brick wall at 30mph on a motorcycle with my shin behind the peg/footrest. I broke/fractured nothing. The footrest dug into shin due to the force, I still have a "dent" there.

So relax all you 8s -- I've been battle tested.


8/14
high Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

phew! Fellow 8 here.

MonkeyDLuffy
11-11-2015, 07:44 AM
I was expecting to break the calculator and cause their servers to crash -- I've fallen off a roof onto cement; got beaten the living sh*t out of by some 20 y/o when I was 14; and crashed into a brick wall at 30mph on a motorcycle with my shin behind the peg/footrest. I broke/fractured nothing. The footrest dug into shin due to the force, I still have a "dent" there.

So relax all you 8s -- I've been battle tested.


8/14
high Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

I feel you brah, on same boat, but mine are worse than yours. I guess there might be more genes responsible for that too. I have heavy bones, solid as Tarkhan's hammer.

bored
11-11-2015, 08:53 AM
phew! Fellow 8 here.

Maybe your weak bones made you lactose intolerant?

Dorkymon
11-11-2015, 03:19 PM
It's 8/14 for me.

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

MfA
10-01-2016, 06:06 PM
Iran Iron Age F38

10/14
High Bone Strength

Higher Cortical Bone Strength
2/4

Higher Forearm Bone Mineral Density
3/4

Lower Forearm Fracture Risk
5/6

firemonkey
10-02-2016, 12:22 AM
Can't do this as rs7776725 is not found in the data from my chip.

Shaikorth
10-07-2016, 06:19 PM
Some 1000genomes data bits, the important caveat about Africans here is that these pops are West Africans or West African-derived:

Derived rs9525638 is more common in Eurasians than in Africans, and slightly rarer in South Eurasia than elsewhere in Eurasia.

http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=13:43128077-43129077;v=rs9525638;vdb=variation;vf=5200338

Derived rs2908004 is much more common in Eurasia than in Africa, and particularly common in East Eurasia

http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=7:120969269-120970269;v=rs2908004;vdb=variation;vf=2163981

Derived rs2707466 same story

http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=7:120978589-120979589;v=rs2707466;vdb=variation;vf=2000980

Derived rs7776725 is more common in Africa than in Eurasia, and rarest in East Eurasia

http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=7:121032621-121033621;v=rs7776725;vdb=variation;vf=4642043