Bone Strength Calculator

[Sangarius]

A PLOS Genetics paper from 2012 found genes for bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.

Paper: "WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk"
Link: http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002745

Some people build a calculator based on the paper. The app is based on the 23andme api. So it only works for 23andme customers.
Link: http://bones.herokuapp.com/

My results:

http://img843.imageshack.us/img843/2379/wye4.png

Kavkaz bone structure hehe :P

[leonardo]

Not quite as good as yours Sangarius
9/14
High Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 3/4
Lower Forearm Fracture Risk 4/6

[DMXX]

Very close to yours Sangarius!



11/14
Superhuman Bone Strength

Higher Cortical Bone Strength 3/4
Higher Forearm Bone Mineral Density 3/4
Lower Forearm Fracture Risk 5/6


Must be something in the (Black + Caspian sea) water, eh?

[MikeWhalen]

just plain regular Irish boy I guess
I am a bit surprised because my bones are thick and dense and have never broken...that's not the good thing you might think because it means I have had alot of much worse soft tissue damage in sports...instead of a bone breaking, my ligaments, tendons and whatnot would get ripped up and torn and take way longer to heal

Results from SNPs rs9525638, rs2908004, rs2707466, and rs7776725 on genes WNT16 and FAM3C. "Higher/Lower" compares to those with mutations. Check out the PLoS paper.
MICHAEL WHALEN
8/14
High Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

Mike

[Sangarius]

Must be something in the (Black + Caspian sea) water, eh?

I guess so. :P The grandpa of orangepulp (North-Eastern Turkey) scored 14/14. Another Turkish guy from that region scored 13/14.


For those of you did not test with 23andme, check the following SNPs (thanks to MfA):

Higher Cortical Bone Strength
rs9525638
TT = 2 pts
CT = 1 pts
CC = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

Higher Forearm Bone Mineral Density
rs2908004
NA = 2 pts
AA = 2 pts
AG = 1 pts
GG = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

Lower Forearm Fracture Risk
rs2908004
NA = 2 pts
AA = 2 pts
AG = 1 pts
GG = 0 pts

rs7776725
TT = 2 pts
CT = 1 pts
CC = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

[J Man]

Everyone in my family including myself get 8/14 High Bone Strength except for my mother who has 7/14 and my great uncle who has 10/14. None of us are frail though.

[Humanist]

It appears I am more like Mr. Glass. :) At least compared to some of you fellas.


Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 3/4
Lower Forearm Fracture Risk 4/6

8/14

[MikeWhalen]

btw Sangarius...very cool topic, being able to check this stuff out is fun
thx for posting

Mike

[QUOTE=Sangarius;11705]A PLOS Genetics paper from 2012 found genes for bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.

[Calamus]

Mine is the same as Mike:

8/14
High Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

[rod]

Oh well..
630

[ilmari]

Ilmari
3/14
weak Bone Strength

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 0/4
Lower Forearm Fracture Risk 2/6

I have never broken a bone, and I've had many opportunities to have done so with some major traumas. I'm not certain I believe this app is working properly.

[Clinton P]

I suppose this explains how I broke the neck of my right femur 8 years ago.

Clinton P


631

[N21163]

Anyone know how to access these calculators without a 23andme account (probably not possible). I have tested with FTDNA and have converted my results to 23and me format.

[MikeWhalen]

jeez Ilmari, sounds like the test results are missing something as that sure seems a low score for you...maybe the score shows a predilection or just one of several factors that ultimately give bone strength


Ilmari
3/14
weak Bone Strength

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 0/4
Lower Forearm Fracture Risk 2/6

I have never broken a bone, and I've had many opportunities to have done so with some major traumas. I'm not certain I believe this app is working properly.

[Sangarius]

Anyone know how to access these calculators without a 23andme account (probably not possible). I have tested with FTDNA and have converted my results to 23and me format.

Check my post on the first page. I listed the SNPs to check. http://www.anthrogenica.com/showthread.php?1230-Bone-Strength-Calculator&p=11727&viewfull=1#post11727

[Dr_McNinja]

I got 11/14 (3/4, 3/4, 5/6)

[basque]

Ilmari
3/14
weak Bone Strength

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 0/4
Lower Forearm Fracture Risk 2/6

I have never broken a bone, and I've had many opportunities to have done so with some major traumas. I'm not certain I believe this app is working properly.

Ilmari we must be twins B) my score was exactly the same as yours. Considering I have spent most of my life dancing, gymnastics, running, weight training eta.. and have fallen from great heights and other accidents. I have never broken a bone in my body and consider my self very strong I expected to be super human :confused:

It cant possibly be working properly. I better wrap myself in cotton wool.

basque :rolleyes:

[Kaido]

Noice.

http://i.gyazo.com/dab28c4fd8000569c588c89a9a40e141.png

[BalkanKiwi]

http://i.imgur.com/OikWrkF.png

[anglesqueville]

Ilmari
3/14
weak Bone Strength

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 0/4
Lower Forearm Fracture Risk 2/6

I have never broken a bone, and I've had many opportunities to have done so with some major traumas. I'm not certain I believe this app is working properly.

Definitly, there is something true with the calculators that tell I have finnish/saami ancestors:
5076
My wife now: do you think I must tell her she is superhuman? Don't know......
5077

[Passa]

8/14

5078

[Reith]

11/14

[Gray Fox]

3/14... Not sure I believe that. I've broken a few bones in my day, but they were traumatic incidents and a lot of force was involved.

[anglesqueville]

3/14... Not sure I believe that. I've broken a few bones in my day, but they were traumatic incidents and a lot of force was involved.

I agree, that looks rather odd for me and my mother. But conversely, when my wife had a bone scanning, before a chemo, she was said to have the bones of a teenager, while she was 55. Therefore she is perhaps actually "superhuman". I don't know what to think about this, regardless of the fact that I am suspicious about the health oriented reports of 23.

[Cofgene]

12/14. My father came in at 13/14.

[icebreaker]

13/14

[Arslan]

http://i.imgur.com/rRkGMJo.png

[can't_lurk_no_mo']

9/14
high Bone Strength

Higher Cortical Bone Strength 3/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

[ashwinb]

7/14,

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

[surbakhunWeesste]

http://i.imgur.com/2pA2smb.png

[Caspian]

A calculator that doesn't support raw data based on FTDNA again.
https://d304k3mn1nwj0a.cloudfront.net/meme/facepalm-captain.png

[can't_lurk_no_mo']

Throughout life, bone density is affected by heredity, diet, sex hormones, physical activity, lifestyle choices and the use of certain medications.

http://www.wernermd.com/testosterone-bone-health.php

[Varun R]

9/14- high bone strength. Works for me :)

[MonkeyDLuffy]

3/14

Yeah totally :doh:

[tamilgangster]

Is their a correlation between population groups and bone strength, or is their greater variation within populations

[MonkeyDLuffy]

According to these results i should wear a gundum suit everywhere, as a normal blow of air can crush me into pieces. Totally going to stay in my bed from now on.

[John Doe]

9/14
High Bone Strength

Higher Cortical Bone Strength 3/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

[Táltos]

I'm apparently Superhuman! I've only chipped my talus (ankle bone) once. Won't admit to what I was doing to have that happen! :biggrin1:
12/14
Superhuman Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 4/4
Lower Forearm Fracture Risk 6/6

[MfA]

Is their a correlation between population groups and bone strength, or is their greater variation within populations

Not enough data so far, fwiw here's regional breakdown of Anthrogenicians.

http://abload.de/img/hestikkqko.png


I'm 2/4 3/4 5/6 10/14 untermensch btw
Ezidi Kurd 3/4 4/4 5/6 12/14


RISE423 MBA Armenia only 1 call: rs7776725 TT 2 pts

didn't take ashwinb and surbakhunWeesste in consideration since I don't know where they're from.

[Stellaritic]

Stellaritic
13/14
Superhuman Bone Strength

Higher Cortical Bone Strength 3/4
Higher Forearm Bone Mineral Density 4/4
Lower Forearm Fracture Risk 6/6


:biggrin1:

[MfA]

Stuttgart LBK
3/4 2/4 3/6 - 8/14

RISE395 Sintastha
4/4 4/4 4/6 - 12/14

RISE98 Battle Axe/Nordic LN
3/4 4/4 5/6 - 13/14

RISE495 Karasuk
2/4 2/4 4/6 - 8/14

[Passa]

Would be interesting to see Oase 1's results

[MfA]

Kostenki K14
1/4 1/4 3/4 - 5/14

Ust'-Ishim
1/4 0/4 2/4 - 3/14

Mal’ta
4/4 4/4 6/6 - 14/14


Would be interesting to see Oase 1's results

Couldn't see Felix converted his genome.


RISE505 Andronovo
2/4 4/4 4/6 - 10/14

RISE500 Andronovo
2/4 2/4 4/6 - 8/14

RISE523 Meshovskaya
3/4 3/4 5/6 - 11/14

RISE552 Yamnaya
3/4 4/4 6/6 - 13/14

RISE174 IA Sweden
4/4 3/4 5/6 - 12/14

RISE150 Unetice
4/4 3/4 5/6 - 12/14

RISE511 Afanasievo
4/4 3/4 4/6 - 11/14

Loschbour
3/4 2/4 3/6 - 8/14

K01
2/4 0/4 2/6 - 4/14

NE7
3/4 3/4 3/6 - 9/14

Motala-12
4/4 4/4 4/6 - 12/14

[MfA]

IR1
4/4 4/4 6/6 - 14/14

BR2
1/4 0/4 2/6 - 3/14

CO1
2/4 0/4 2/6 - 4/14

Hinxton4
2/4 2/4 2/6 - 6/14

NE1
3/4 4/4 5/6 - 12/14

[bol_nat]

:P

https://scontent-mad1-1.xx.fbcdn.net/hphotos-xpt1/v/t1.0-9/11822661_1682743561944149_8613506938327867311_n.jp g?oh=63b41d4d9a908d29e186499406733003&oe=5654618E

[fil]

7/14

Higher Cortical Bone Strength 1/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

[BalkanKiwi]

Its interesting to see all the variation among everyone who has posted. Those of us who get 14/14 don't seem to be too common. I should mention applying load can improve bone density (osteoblast activity in particular), so therefore if you get a low score, it isn't a representation of potential biological change over time.

[bored]

http://i.imgur.com/Ux8gnFj.png

[bored]

3/14

Yeah totally :doh:

How is that even possible? Lol.

[Sapporo]

http://oi58.tinypic.com/j7ddn9.jpg

[MonkeyDLuffy]

How is that even possible? Lol.

No idea mahn. Good thing because of this calculator i am enjoying my metal armor.

Life is not same anymore. I am glad i ran my data on it.

[Sein]

5351

Good enough for me.

[khanabadoshi]

I was expecting to break the calculator and cause their servers to crash -- I've fallen off a roof onto cement; got beaten the living sh*t out of by some 20 y/o when I was 14; and crashed into a brick wall at 30mph on a motorcycle with my shin behind the peg/footrest. I broke/fractured nothing. The footrest dug into shin due to the force, I still have a "dent" there.

So relax all you 8s -- I've been battle tested.


8/14
high Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

[Awale]

http://oi58.tinypic.com/2enypl3.jpg

Not bad... Always knew I was a bad ass. Good to have genetic confirmation.

[Rukha]

12/14
Superhuman Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 4/4
Lower Forearm Fracture Risk 6/6

[Arbogan]

10/14

A better indication is joint size. If you have larger wrists you're less likely to get a fracture.

[surbakhunWeesste]

Too many Super-humans. I wonder about their costumes now!

[Stellaritic]

Too many Super-humans. I wonder about their costumes now!

https://d1vuqpxfeed0st.cloudfront.net/media/catalog/product/cache/3/image/450x/9df78eab33525d08d6e5fb8d27136e95/t/h/the-skull-and-bones-morphsuit-1.jpg

[Arbogan]

Proof that even supermen can havr their bones broken.


http://youtu.be/BrHm5XeN-dQ

The strongman who has his arm broken literally look's like guile from street fighter.

[Volat]

For those of you did not test with 23andme, check the following SNPs (thanks to MfA):

Higher Cortical Bone Strength
rs9525638
TT = 2 pts
CT = 1 pts
CC = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

Higher Forearm Bone Mineral Density
rs2908004
NA = 2 pts
AA = 2 pts
AG = 1 pts
GG = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

Lower Forearm Fracture Risk
rs2908004
NA = 2 pts
AA = 2 pts
AG = 1 pts
GG = 0 pts

rs7776725
TT = 2 pts
CT = 1 pts
CC = 0 pts

rs2707466
TT = 2 pts
CT = 1 pts
CC = 0 pts

Two SNPs (rs2908004 , rs2908004) were not found . Not tested? So 8 /10.

[Mellifluous]

8/14 higher bone strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

[Mellifluous]

I was expecting to break the calculator and cause their servers to crash -- I've fallen off a roof onto cement; got beaten the living sh*t out of by some 20 y/o when I was 14; and crashed into a brick wall at 30mph on a motorcycle with my shin behind the peg/footrest. I broke/fractured nothing. The footrest dug into shin due to the force, I still have a "dent" there.

So relax all you 8s -- I've been battle tested.


8/14
high Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

phew! Fellow 8 here.

[MonkeyDLuffy]

I was expecting to break the calculator and cause their servers to crash -- I've fallen off a roof onto cement; got beaten the living sh*t out of by some 20 y/o when I was 14; and crashed into a brick wall at 30mph on a motorcycle with my shin behind the peg/footrest. I broke/fractured nothing. The footrest dug into shin due to the force, I still have a "dent" there.

So relax all you 8s -- I've been battle tested.


8/14
high Bone Strength

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

I feel you brah, on same boat, but mine are worse than yours. I guess there might be more genes responsible for that too. I have heavy bones, solid as Tarkhan's hammer.

[bored]

phew! Fellow 8 here.

Maybe your weak bones made you lactose intolerant?

[Dorkymon]

It's 8/14 for me.

Higher Cortical Bone Strength 2/4
Higher Forearm Bone Mineral Density 2/4
Lower Forearm Fracture Risk 4/6

[MfA]

Iran Iron Age F38

10/14
High Bone Strength

Higher Cortical Bone Strength
2/4

Higher Forearm Bone Mineral Density
3/4

Lower Forearm Fracture Risk
5/6

[firemonkey]

Can't do this as rs7776725 is not found in the data from my chip.

[Shaikorth]

Some 1000genomes data bits, the important caveat about Africans here is that these pops are West Africans or West African-derived:

Derived rs9525638 is more common in Eurasians than in Africans, and slightly rarer in South Eurasia than elsewhere in Eurasia.

http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=13:43128077-43129077;v=rs9525638;vdb=variation;vf=5200338

Derived rs2908004 is much more common in Eurasia than in Africa, and particularly common in East Eurasia

http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=7:120969269-120970269;v=rs2908004;vdb=variation;vf=2163981

Derived rs2707466 same story

http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=7:120978589-120979589;v=rs2707466;vdb=variation;vf=2000980

Derived rs7776725 is more common in Africa than in Eurasia, and rarest in East Eurasia

http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=7:121032621-121033621;v=rs7776725;vdb=variation;vf=4642043