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View Full Version : Y-chromosomal analysis identifies skeletal remains of Swiss national hero Jenatsch



RCO
09-06-2013, 11:28 AM
C. Haas, N. Shved, F. R¨uhli, C. Papageorgopoulou, J. Purps,
M. Geppert, S.Willuweit, L. Roewer,M. Krawczak, Y-chromosomal analysis identifies
the skeletal remains of Swiss national hero J¨org Jenatsch (1596-1639), Forensic Science
International: Genetics (2013), http://dx.doi.org/10.1016/j.fsigen.2013.08.006

Abstract

Jörg Jenatsch was a Swiss defender of independence and a fighter for liberty in the 17th century. With the help of three living male members of the Jenatsch family, we successfully identified a skeleton exhumed from Chur cathedral as the remains of Jörg Jenatsch. Our conclusion was based upon complete Y-STR and Y-SNP profiles that could be generated by replicate analyses of a bone sample available to us. The skeleton and the three living family members carried the same Y-SNP-haplogroup, but were discordant at three of 23 Y-STR loci. This notwithstanding, conservative biostatistical evaluation of the data suggests that the Chur skeleton is at least 20 times more likely than not to be Jörg Jenatsch.

http://www.sciencedirect.com/science/article/pii/S1872497313001804

The skeleton and the three living family members carried the same Y-SNPhaplogroup,
R1b1b2a2g. In YHRD, R1b1b2a2g occurs in 132 of 2357 Western- or
Middle-Europeans (frequency: 5.610-2), meaning that this haplotype is quite
common in the target area. Therefore the match on its own did not provide sufficient
evidence to allow reliable identification of the skeleton. Comparison of the PowerPlex
Y23 profiles of the skeleton and the three living family members revealed three
discrepancies and 20 matches. Bearing in mind that, under the hypothesis that the
skeleton is that of Jörg Jenatsch, each of these mutations would have occurred in
one of 12 meioses, such an observation may well have been compatible with the
presumed identity. Indeed, conservative biostatistical evaluation of the data
suggested that it was at least 20 times more likely than not that the Chur skeleton is
Jörg Jenatsch. In addition, our calculations were based upon the 17 loci of the Yfiler
kit only, due to the scarcity of population data, and did not allow for the fact that the
profiles under study matched for six additional STRs. If the conservative assumption
was made that the probability of observing exactly three mismatches between two
unrelated Western-European Y-chromosomal haplotypes is the same for the
PowerPlex Y23 kit as for the 17 Yfiler loci, a likelihood ratio of 36 would emerge.
Finally, two of the additional markers, DYS570 and DYS576, are rapidly mutating
with mutation rates >10-2 [24, 25]. The fact that we did not find a mutation at any of
these loci argues further for the presumed relationship. Since no other male relative
has ever been connected to the find, our analysis therefore strongly suggests that the
Chur skeleton is that of Jörg Jenatsch.
Our study highlights the power of Y-chromosomal

rms2
09-06-2013, 11:34 AM
"R1b1b2a2g" is an old longhand for U152, correct?

RCO
09-06-2013, 12:52 PM
Yes, I think so ! It's a nice little article.