View Full Version : H5c2

11-30-2013, 09:57 PM
AFAIK, there are 16 FMS H5c2 results for now, all from FTDNA, represented by these HVR haplotypes:

16213A 16216G 16304C 263G 315.1C 456T
16213A 16216G 263G 315.1C 456T
16213A 263G 315.1C 456T
16207G 16213A 16216G 263G 315.1C 456T
16213A 16216G 16355T 263G 315.1C 456T
16213A 16216G 152C 263G 309.1C 315.1C 456T
16213A 16216G 152Y 263G 315.1C 456T

It's difficult to classify H5c2 unambiguously by HVR mutations, because similar motifs are known for H5a2 and H5a1a.

01-11-2014, 05:01 AM
Most of the people in H5c2 also have 16216 and a back mutation at 16304. I think that anyone with 16213A 16216G is likely to be H5c2. This group appears to be quite, young, perhaps less than 2000 years, and all of the members are from Germany or eastern Europe, and several are Jewish. It is possible that H5c2 represents a Jewish lineage that expanded into Europe, or that it was originally a German group, and that some women in this group converted to the Jewish faith. It would be interesting to survey this group to see how many have Jewish ancestry.

01-29-2014, 11:36 AM
Based on FTDNA data I'm pretty sure that H5c2 with back mutation at 16304 is an Ashkenazi subclade, but any autosomal test (FF, 23andme, Ancestry) can prove I'm wrong. From the same reasons H5c1 looks like North European branch while its subclade H5c1a is restricted to Finland.
Now, the situation with H5c2(16304C) is unclear as its known HVR motif is like much more common H5a2 and H5a1a variants. Not a single H5c2 case is known from populational or forensic publications.
Published phylogenetic trees of H5c are based so far on sequences of FTDNA's customers. Recently, three papers relevant for H5c were published:
a) Derenko et al (2013) "Complete Mitochondrial DNA Diversity in Iranians" - 1 case of H5c* (out of 352), a Persian from South Iranian province of Bushehr with 6 private mutaions.
b) Li et al (2013) "Variation and association to diabetes in 2000 full mtDNA sequences mined from an exome study in a Danish population" - 1 case of H5c1 (out of 2000)
3) Raule et al (2014) "The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific" - no H5c was found among 1292 Europeans.
Unlike Costa et al (2013) I don't see how a phylogeographic argument can be made for any rare line with unknown populational distribution.

My table of HVR haplotypes suspected as H5c2 from academic publications. (https://docs.google.com/spreadsheet/ccc?key=0AttTtNIAL8JMdGZxeVhHX0hPbFdkUktDazZTMzVfT lE&usp=drive_web#gid=1)

04-30-2014, 08:25 AM
New H5c2 haplotype: 16183C, 16189C, 16213A, 16216G, 16304C | 263G, 315.1C, 456T