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Mandoos
01-19-2014, 09:08 PM
Finally got around getting tested on 23andme, and figured I have this haplogroup which is quite frequent in Malayali Christians (Indians) on the site. I have very little foreign admixture, even through the HarappaWorld calculator. However, some Europeans and Middle Easterners have U1a3. Anyone have an idea about its origins?

Humanist
01-20-2014, 04:40 AM
Finally got around getting tested on 23andme, and figured I have this haplogroup which is quite frequent in Malayali Christians (Indians) on the site. I have very little foreign admixture, even through the HarappaWorld calculator. However, some Europeans and Middle Easterners have U1a3. Anyone have an idea about its origins?

Thank you for your post. Assyrian Christians also have a few members of U1a3, including board member ZephyrousMandaru.

Humanist
01-20-2014, 05:03 AM
Posted on the 23andMe boards, by user MMaddi (https://www.23andme.com/you/community/thread/4225/):


The cousin is in the maternal line of Rosalia, so this means that Rosalia was also U1a3. This line is Sicilian and documented back into the mid 1700s. The birthplace is a small town about 25 miles from Palermo. It's somewhat remote, about 1,800 feet above sea level. It's quite possible that this maternal line has been there for several hundred or more years.

This was posted by user Shpendo:


I'm U1a3 as well, and I am Albanian.


The Assyrian/Indian/Italian-Sicilian commonality is nothing new.

BMG
01-20-2014, 02:49 PM
Finally got around getting tested on 23andme, and figured I have this haplogroup which is quite frequent in Malayali Christians (Indians) on the site. I have very little foreign admixture, even through the HarappaWorld calculator. However, some Europeans and Middle Easterners have U1a3. Anyone have an idea about its origins?
Are u a malayali christian?
U1 in kerala is not limited to christians.In fact it was found around 70% in a study in 2002 .The samples was taken from the coastal regions from cochin who were hindus .Though predominantly U1a3 other subclades like U1a1 and U1a'c are also found .From an mtdna study about cochin jews they found a few U1b samples too .

BMG
01-20-2014, 02:51 PM
Can you also post the mutation list with reference to CRS

Mandoos
01-20-2014, 02:56 PM
Are u a malayali christian?
U1 in kerala is not limited to christians.In fact it was found around 70% in a study in 2002 .The samples was taken from the coastal regions from cochin who were hindus .Though predominantly U1a3 other subclades like U1a1 and U1a'c are also found .From an mtdna study about cochin jews they found a few U1b samples too .

Yes, I am Christian, and I saw on Harappa that there is a Punjabi Brahmin who has U1a3, which really contradicts the idea that it is restricted to Kerala Christians. Even Hindus from Karnataka and Kerala are reported to have it.

Mandoos
01-20-2014, 03:00 PM
Can you also post the mutation list with reference to CRS

U1a3 defining mutations
variant call rCRS anc
i3002606 15115 T
rs28357686 15115 T
i3001363 15217 G
i5049896 15217 G

BMG
01-20-2014, 03:29 PM
U1a3 defining mutations
variant call rCRS anc
i3002606 15115 T
rs28357686 15115 T
i3001363 15217 G
i5049896 15217 G

Well i meant the mutations in HVR1,HVR2 and Control Regions . I am not sure how 23andme displays their results though

BMG
01-20-2014, 03:34 PM
We also have one tajik person in this forum with mtdna U1a3

BMG
01-20-2014, 03:44 PM
Here are few U1 full sequences including a few U1a3 .You can compare your results with them
http://www.ianlogan.co.uk/sequences_by_group/u1_genbank_sequences.htm

GailT
01-22-2014, 07:54 AM
Finally got around getting tested on 23andme, and figured I have this haplogroup which is quite frequent in Malayali Christians (Indians) on the site. I have very little foreign admixture, even through the HarappaWorld calculator. However, some Europeans and Middle Easterners have U1a3. Anyone have an idea about its origins?

If you upload your 23andMe results to mthap (link (http://dna.jameslick.com/mthap/)), it could identify extra coding region mutations that would show a closer match to samples withing U1a3.

There are 5 new U1a3 samples from Iran recently published by Derenko et al. I have 14 U1a3 samples with an age estimate of about 14,000 years. The 4 Indian samples share an extra mutation at 10253 with 3 of the Derenko Iranian samples, but this group is also quite old, probably more than 10,000 years. The Indian subgroup is also quite old, probably close to 10,000 years, and 3 of the 4 Indian samples also share an extra HVR mutation at 16527, so this group can also be predicted from HVR test results.

Mandoos
01-22-2014, 03:15 PM
Here's the list…so far it shows this U1a3 as the closest match…

1) U1a3

Defining Markers for haplogroup U1a3:
HVR2: 73G 263G 285T
CR: 750G 1438G 2218T 2706G 4769G 4991A 6026A 7028T 7581C 8860G 11467G 11719A 12308G 12372A 12879C 13104G 14070G 14364A 14766T 15115C 15148A 15217A 15326G 15954C
HVR1: 16189C 16249C

Marker path from rCRS to haplogroup U1a3 (plus extra markers):
H2a2a1(rCRS) ⇨ 263G ⇨ H2a2a ⇨ 8860G 15326G ⇨ H2a2 ⇨ 750G ⇨ H2a ⇨ 4769G ⇨ H2 ⇨ 1438G ⇨ H ⇨ 2706G 7028T ⇨ HV ⇨ 14766T ⇨ R0 ⇨ 73G 11719A ⇨ R ⇨ 11467G 12308G 12372A ⇨ U ⇨ 285T 12879C 13104G 14070G 15148A 15954C 16249C ⇨ U1 ⇨ 2218T 14364A 16189C ⇨ U1a'c ⇨ 4991A 6026A 7581C ⇨ U1a ⇨ 15115C 15217A ⇨ U1a3 ⇨ (523G) 4508T 10253C (16519C) 16527T

Imperfect Match. Your results contained differences with this haplogroup:
Matches(24): 73G 263G 285T 750G 1438G 2218T 2706G 4769G 4991A 6026A 7028T 7581C 8860G 11467G 11719A 12308G 12372A 12879C 13104G 14364A 14766T 15115C 15217A 16249C
Flips(1): 15954G
Extras(3): (523G) 4508T 10253C (16519C) 16527T
No-Calls(2): 14070G 15148A
Untested(2): 15326 16189

BMG
01-25-2014, 06:17 PM
All the U1 samples from ftdna kerala project does have 16527T .All of them along with you seems to be part of subgroup GailT mentioned .

GailT
01-25-2014, 11:41 PM
10253C and 16527T are found in three U1a3 FMS samples, and only one of these is in GenBank: AY714042. The other two people tested at FTDNA. You also share 4508T with one of these people. 523G is unique in your results and 16519 is usually ignored. If you want to send me a personal message with you email address, I can forward a message to the project member who most nearly matches you. However, your common maternal ancestor with this person could still be quite distant, perhaps as much as a few thousand years. If you test the full mtDNA sequence at FTDNA, the test would identify any other extra mutations in your results and would give a better estimate of the date of the common maternal ancestor with the project member.

My age estimate of the U1a3 subgroup that shares 10253C and 16527T is about 9000 years, so anyone with HVR test results in this group should also test the full sequence to get a more specific result.

Dr_McNinja
11-03-2014, 06:00 PM
Just adding, a 3rd cousin showed up for me on 23andMe with mtDNA U1a3 (33cM shared over 3 segments). They haven't accepted my invite yet. They would presumably be from Punjab to be that close.

I have 3 other U1a3 people on my share list. Two Punjabis and one Sindhi. Searching 23andMe also turned up a Kurd and an Indian from Kerala.

EDIT: They're Punjabi most likely, Bhatti.