PDA

View Full Version : Living DNA Haplogroups accuracy ?



Melissay122
06-15-2020, 05:14 PM
Hi ,

FT lists my "confirmed" haplogroup as H1AG, However Living DNA lists it as H1ao. Just curious if this has happened to others, or who you would trust in this situation? I am leaning towards FT, but appreciate any input! Thanks! :)

Stefanie
06-15-2020, 07:15 PM
Can’t say about the accuracy of Family Tree mtdna. I haven’t done that yet. But my haplogroup was just “W” at 23andme for years. Still listed that way for my brother. Wegene gave me W5a2 from my uploaded 23 data. My saliva test at Living Dna gave me W5a2b. W5a2 was in Germany 5000 years ago. W5a2b was in Germany 3000 years ago. And that’s all anyone knows about that. But it matches perfectly with where my direct maternal ancestor comes from. Though a few thousand years later. Hopefully someone who has done the Family tree test can chime in.

Táltos
06-15-2020, 07:57 PM
Hi ,

FT lists my "confirmed" haplogroup as H1AG, However Living DNA lists it as H1ao. Just curious if this has happened to others, or who you would trust in this situation? I am leaning towards FT, but appreciate any input! Thanks! :)

If you did the full mtDNA sequence at Family Tree DNA then that is the accurate haplogroup designation. They test 16,569 base pairs for mtDNA. https://learn.familytreedna.com/faq-items/full-mitochondrial-sequence-fms/

Living DNA approx 4,000 positions. https://isogg.org/wiki/MtDNA_testing_comparison_chart

geebee
06-16-2020, 03:15 AM
Hi ,

FT lists my "confirmed" haplogroup as H1AG, However Living DNA lists it as H1ao. Just curious if this has happened to others, or who you would trust in this situation? I am leaning towards FT, but appreciate any input! Thanks! :)

I would also lean toward FTDNA, for several reasons. First, as has been pointed out, FTDNA tests every position within the mtDNA genome. LivingDNA tests fewer than a third. However, this really shouldn't matter in this case since FTDNA's prediction of H1ag is not a subclade of H1ao. So it surely isn't simply an issue of not testing enough of the defining SNPs. H1ao is not a subclade of H1ag either; in fact, the two clades are mutually exclusive and the defining SNP or SNPs of one should not even be present in the other.

A second reason for being dubious of LivingDNA is the failure to show the SNPs for which you've tested positive except in download form -- whereas FTDNA shows them right on their website in terms of both the RSRS ("Reconstructed Sapiens Reference Sequence") and the RCRS ("Revised Cambridge Reference Sequence"). By contrast, even in the LivingDNA download you can see your results only in terms of the RCRS.

https://learn.familytreedna.com/mtdna-testing/differences-rsrs-reconstructed-sapiens-reference-sequence-mean/
https://www.mitomap.org/MITOMAP/HumanMitoSeq

What's bad about this? Well, if you want to compare your results to the defining SNPs of most online phylotrees, those trees will probably show RSRS values.

Fortunately, if you log in to FTDNA, you can click on your mtDNA haplogroup prediction and selected the tab to see the RCRS version of your results. If you also download your mtDNA file at LivingDNA, you can then compare your results at the two companies.

Melissay122
06-18-2020, 03:07 PM
Hey Guys!

Thanks for the responses. After I posted this, I found an mtdna tool by James Lick.( https://dna.jameslick.com/mthap/). It confirmed h1ag. I'm still learning genetic geneaology so I wasn't even thinking that I had a full sequence done and that it would be correct over living dna. On another forum they posted this from Roberta Estes that explains a little between Living DNA and FT:

From Roberta Estes' 2017 post "LivingDNA Product Review," in which she wrote:

Living DNA claims to have a 3-in-1 ancestry test, meaning ethnicity, mitochondrial and Y DNA, which isn’t exactly true, but it’s not entirely false either. It’s a matter of perception.

LivingDNA is a scan test that scans specified locations in your genome. Haplogroups, both Y and mitochondrial, are defined by specific locations that carry mutations. LivingDNA scans for Y and mitochondrial haplogroup mutations at some level, but they do not offer anything more for Y and mitochondrial DNA than the haplogroup designation. In other words, no detail and no matching. The LivingDNA results are in the same ballpark as 23andMe or the Genographic project, but much less detailed than Family Tree DNA."

Thanks for all the help!