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tipirneni
04-08-2021, 03:46 PM
Hello,
Any one posses U2 mutation like 'T11368C' connecting to K N9a3 N9a8 M7a1a4a ? I got that mutation according to Ian Hogan which is not seen among U2a1a mtdna group.

Jatt1
04-08-2021, 07:44 PM
Hello,
Any one posses U2 mutation like 'T11368C' connecting to N9a3 N9a8 M7a1a4a ? I got that mutation according to Ian Hogan which is not seen among U2a1a mtdna group.

Most have such extra mutations. mtDNA have very few mutations and this mutation can be thousands of year old. Do you think it is a new mutation?

tipirneni
04-08-2021, 08:13 PM
Most have such extra mutations. mtDNA have very few mutations and this mutation can be thousands of year old. Do you think it is a new mutation?

I checked on web K shows up as backmutation at that place. 16311 is supposed to be high heteroplasty so things change quickly. Looks like Otzi had it as a extra mutation. This is present widely in N9 and M7 population of Steppe and Far east. Since I have both these admixtures Otzi in copper age and then Steppe/far east coming in multiple waves it is possible it could have come at any time. But U2a1a mtdna having this mutation apparently didn't occur before.

....... K A3480G A10550G T11299C T14798C T16224C T16311C!

A recent study by Rollo et al. (2006) attempted to determine, at a fine level of molecular resolution, the phylogenetic position of the Iceman’s mtDNA by genotyping a set
of conservative coding region markers. The re-examination confirmed the control region signature mutations
T16224C/T16311C characteristic of haplogroup K reported earlier in the study by Handt et al. (1994).

https://www.csueastbay.edu/museum/files/docs/exhibit/dna/dna-unresolved-loc.pdf

tipirneni
04-08-2021, 11:20 PM
From https://www.nature.com/articles/ncomms3599.pdf?origin=ppub
Shows several deep clades > 50k TMRCA such as F1, N9, B4 have this T16311C mutation. Probably prior to peopling of farmers these people existed all over eastern asia

Table 2 | Estimated time to the most recent common
ancestor (TMRCA) of the haplogroups and their haplotype
diversity in Cambodians.
Haplogroup n TMRCA (years)* Haplotype diversityw
425,000 years ago:
M68z 14 82,78222,020y /
F1 192 76,15828,610 0.9162
M69z 13 68,13720,797y 0.4545
B4 59 60,77226,019 0.7434
F1a 188 60,67624,108 0.9129
M78z 7 55,18813,086y /
R9 26 51,95518,766 0.8615
R9b 25 50,69819,345 0.8533
F1a1a 138 47,97721,121 0.8643
B4c2 52 44,90023,405 0.6757
M74 52 39,42019,710 0.5083
F1a1a1 69 36,73815,364 0.7451
N7z 13 36,38811,281 0.7949
M51 21 35,20713,866 0.819
N9a 11 34,87014,463 0.8364
B5a 288 34,22018,389 0.8364
B5 296 34,1401,7899 0.8456
M7b 21 33,35415,276 0.7048
M3dz 14 28,90812,248y /
M59z 2 27,59410,430y /
B5a1a 96 26,23217,043 0.7342
B5a1 287 26,14913,682 0.8361
M21 28 25,73618,007 0.5767
M20 14 25,01615,021 0.7143

tipirneni
04-09-2021, 04:02 AM
https://dash.harvard.edu/bitstream/handle/1/32072021/5325568.pdf?sequence=1

Mitochondrial DNA analysis of Eneolithic Trypillians from Ukraine reveals
neolithic farming genetic roots

The Cucuteni-Trypillia culture complex dominated the cultural landscape of the Carpathian
foothills in eastern Romania, Moldova and the territory of modern-day Ukraine west of the
Dnieper River during the Eneolithic (Copper Age) period in eastern Europe, ca. 5,400–2,700
BCE. It is known as the Cucuteni culture in its western ranges, while in its eastern part it is
known as the Trypillian culture (TC) after the village of Trypillia in what is now central
Ukraine where it was first identified by Vikentij Khvoika in the late 19th century


Specimen ID, radiocarbon age (2σ) Mitochondrial haplogroup SNPs
V1.1.1, 3,700–3,500cal BCE U8b1a2 C7028T, A12308G,T16172C, C16259T, C16266T, T16311C


The sample V1.1.1 found in Trypillian culture is U8b1a2 considered upper paleolithic European mtDNA also carries this T16311C mutation

GailT
04-10-2021, 05:22 AM
Hello,
Any one posses U2 mutation like 'T11368C' connecting to K N9a3 N9a8 M7a1a4a ? I got that mutation according to Ian Hogan which is not seen among U2a1a mtdna group.

Ian Logan has a list of U2a samples at this link (http://www.ianlogan.co.uk/sequences_by_group/u2a_genbank_sequences.htm), and there is a sample with T11368C but it appears to be a partial sequence, perhaps from 23andMe or some other partial test, so it is not very helpful. But you can compare your full sequence results to the other U2a1a samples on that page to see if you match other mutations with those samples.

Marker 16311 is highly variable so I would ignore it.

tipirneni
04-10-2021, 03:42 PM
Ian Logan has a list of U2a samples at this link (http://www.ianlogan.co.uk/sequences_by_group/u2a_genbank_sequences.htm), and there is a sample with T11368C but it appears to be a partial sequence, perhaps from 23andMe or some other partial test, so it is not very helpful. But you can compare your full sequence results to the other U2a1a samples on that page to see if you match other mutations with those samples.

Marker 16311 is highly variable so I would ignore it.

.. ('Shireesh Agrawal'-huD4860C) U2a1 73G 200G 263G 750G 1438G 1811G 2706G 4769G 7028T 11368C 11467G 11719A 12372A 14766T 16051G 16093A 16206G 16311C

seems to lack only few mutations I have. Also looks like the Agrawals and Jains banias are from the same stock of people as me, But they mixed with later MLBA waves whereas we are more unmixed Jain/Buddhist heritage groups.

tipirneni
04-16-2021, 04:07 AM
On YFULL, I am placed under U2a1a* https://www.yfull.com/mtree/U2a1a/

There is a Kashmiri KU178920 person and another from Palanisamy 2006 dataset Uttar Pradesh GQ337552 person sharing the U2a1a* branch. However these two dont have some of the mutations that my kit has