PDA

View Full Version : DF49 Big Y Results



jdean
04-15-2014, 06:24 PM
There are now eight DF49 x DF23 Big Y results

Six of these share a novel SNP at 24079397 G to A

Three of these also share 22469685 C to A and a forth would most definitely have had this mutation as well if it was covered in his results.

The maximum GD @ 67 over the entire 24079397 G to A group is 34 and the minimum (excluding the two clearly related individuals) is 22

The maximum GD over the 22469685 C to A group is 32 with the same minimum as above.


The last two (one of which being myself) have a GD of 19 @ 67 loci and belong to a cluster I identified in 2009, we share eight novel SNPs and one deletion

3851946 G to A
6108926 G to A
16367410 T to C
16456423 T to C
16551277 G to T
17807641 C to A
19109590 A to C
21052738 T to G
17079776 AG to A

jdean
04-16-2014, 07:32 PM
I've just received the FGC results for Bill Harrison who represents the large Hopkins McCabe Cluster that L302 was found in, they are now a branch of 22469685 C to A

BTW If any moderators are following this could they do me a favour and edit the ancestral value for 24079397 from G to C

One day I might actually manage to make a post without including stupid mistakes !!

GoldenHind
04-16-2014, 10:44 PM
One day I might actually manage to make a post without including stupid mistakes !!

I know the feeling. I'm afraid I could never keep a job as a typist or a proof reader. Fortunately I usually catch my typos before the time to edit my posts expires. Unfortunately I cannot edit emails after they are sent!

jdean
04-16-2014, 10:55 PM
I know the feeling. I'm afraid I could never keep a job as a typist or a proof reader. Fortunately I usually catch my typos before the time to edit my posts expires. Unfortunately I cannot edit emails after they are sent!

My fave, sending emails to the wrong person : )

However in this case I can't edit the message because it's the start of the thread, apparently ?

jdean
04-17-2014, 04:46 PM
Bum I'm making a mess of this, scrub the comment about mixing up the ancestral value of 24079397 and thank you to Bill Harrison for letting me know !!!

Roll on getting these mutations recognized on Ybrower I say, and SNP tested of course : )

jdean
04-19-2014, 11:36 AM
We have another branching mutation to announce in DF49*.

Both Allison (kit no. B3231) and Harrison (kit no. 129036) share 19121014 C to A

Both these kits are also part of the 24079397 G to A & 22469685 C to A group.

Also Harrison is part of the large Hopkins McCabe Cluster that L302 was found in.


I've decided to opt for reporting mutations in the same format as MtDNA for the time being on the project results page otherwise it going to start getting very confusing.

So the ancestral value is followed by the position and ends with the derived value of the new mutation.

https://www.familytreedna.com/public/R-df49/default.aspx?section=yresults

jdean
04-28-2014, 11:36 PM
The last known DF49* result's just rolled in and it's a double six !!!!

too late to expand much but we've got a DF23- Z2976+ plus Z2983+ (apparently, only medium quality)

I feel I should drink to this this but I think I need go to bed instead (unfortunately) as I've work in the morning : ))


Anyhow hopefully participant will be sending me the RAW data shortly, us admin are no longer trusted to access this stuff willy nilly ????

jdean
06-10-2014, 06:46 PM
Wow, An order for Z2976 just came in for the DF49 project !!!

I've looked at Y-browser and there's still no primers mentioned for it there so is this the first DF49 SNP to be made available because of Big Y ?

Anyhow, best of luck to the participant with this one : )

jdean
06-10-2014, 06:59 PM
Oh my god !!!!!

I think I may be in need of a valium !!!!!


ZP21, 23, 41,42,43 & 44 are available from FTDNA : )))))))))))))))))))))))))))))))))))))))))))))))))) )))))))))))))))))))))))))))))))))))

Dubhthach
09-04-2014, 10:36 PM
With regards to DF49 and BigY, did anyone from the WSW (Wales-Southwest England) cluster do BigY. I was looking at the diagram on DF49 project and I see that they are DF23+/Z2986+/Z2961- (going off Vaughan result)

https://dl.dropboxusercontent.com/u/10258680/Draft%20DF49%20x%20M222%20Tree%20v12.png

jdean
09-04-2014, 10:57 PM
Off the top of my head I'm not sure of the name for it but Vaughn belongs to a large cluster containing a lot of Welsh names, I expect it's the one you're referring to though : )

We didn't find any connecting SNPs with Calwell unfortunately, we could really do with a good few more DF23 NGS results, I'm sure we'd start seeing a very different picture then !!!

jdean
09-04-2014, 11:51 PM
BTW we've now got Sanger tests confirming all testable SNP levels (only ZP41 & Z2976 tested at those levels) with the exception of the connection between ZP20 & ZP21, and we potentially only need one more test to confirm that.

I'll be emailing a couple of folk over the weekend to see about tying up that lose end : )

MJost
09-11-2015, 12:31 AM
Paul,

I also was interested in the large number of SNPs in the M222 block. 42 of them to see if these could have any physical location clustering in over lapping 1000bp range? I did not find any at all. I am not saying that some could have mutated in short spurts of generations but I look at the average. Not counting DF49, there are 51 total SNPs to the end of the M222 Block. A large number in just these when I compare to my 800+ NGS kits used in a previous exercise of counting BigTree SNPs DF13 and below which averaged 47 +- 10 (SD). So I removed the seven SNPs that are in repeat and looped sections leaving 44 to the end of the M222 block. FYI, of those 51, there are 20 positions that are not found in any of the 857 CombBED (CB) regions. My next post will show the data.

MJost

MJost
09-11-2015, 12:34 AM
I have shown the DF49 to end M222 Block's SNP's positions with a '#' leading left end of the position that are within the CB regions. Has someone found a more recent average number of SNPs for below M222 to present SNPs?

Below is the list I complied. MJost




Branch Counts
Region
CB-POS-REF-ALT
Names
Pos


1-1

4915019-C-A
Y2599 FGC436
4915019


1-2

#22735599-G-A
DF49 S474
22735599


2-1
P7_Gap
17997565-T-C
Z2980 S6154
17997565


3-1

#15994422-C-G
S476 Z2976
15994422


3-2

#19391822-T-G
Z2983 S6146 S475
19391822


4-1

#17774409-G-A
DF23 S193
17774409


4-2
DYZ19
22440517-A-C
Z2985 S7068
22440517


4-3
DYZ19
22477109-G-C
Z2986 S6137
22477109


5-1

4915019-C-A
Y2599 FGC436
4915019


5-2

#7855252-C-T
Z2961
7855252


6-1

#2767791-T-C
S653 Z2955
2767791


6-2

#2793166-GATT-G
Y2606
2793166


6-3

#2822914-T-G
Z2956
2822914


6-4

3045441-T-A
Y2597 FGC439
3045441


6-5

3090830-C-G
FGC7512
3090830


6-6

3331464-T-A
FGC435
3331464


6-7

5004912-A-T
Z2958
5004912


6-8

5288847-T-C
Y2600 FGC437
5288847


6-9

6977103-A-T
S656 Z2959
6977103


6-10

#7243731-C-T
Z2960
7243731


6-11

#8157356-A-G
FGC449 Y2596 S7072
8157356


6-12

#8180494-T-C
Z2962
8180494


6-13

#8224850-C-A
Z2963
8224850


6-14

#8343779-A-G
Z2964
8343779


6-15

8909149-A-C
S6155 Z2965
8909149


6-16

#9149547-GA-G
Z2966
9149547


6-17
IR3_Prx
9574554-A-C
Y2601
9574554


6-18

13953551-C-T
S634 Z2967
13953551


6-19

#14010329-A-G
S635 Z2968
14010329


6-20

#14055503-G-A
Z2969 A1
14055503


6-21

#14365440-G-C
S637 Z2970
14365440


6-22

#14372339-A-G
Z2971
14372339


6-23

#14902414-G-A
M222 PAGES00084
14902414


6-24

#15172051-G-A
S640 Z2972
15172051


6-25

#15344019-A-C
S641 Z2973
15344019


6-26

15399507-A-C
S642 Z2974
15399507


6-27

#15658215-GTA-G
Z16322
15658215


6-28

#15731346-T-C
Z2975 S643
15731346


6-29

#16419368-C-T
S645 Z2977
16419368


6-30

18988316-G-A
Z2982 S648
18988316


6-31

#19522057-T-G
Z2984
19522057


6-32

#21691570-A-T
M2626 S629
21691570


6-33
DYZ19
22507531-A-G
S7815 FGC8023
22507531


6-34

#22884954-T-A
M11666 CTS11001
22884954


6-35

#23295679-C-T
S651 Z2988
23295679


6-36

#23480728-A-G
S652 Z2989
23480728


6-37

#23581931-A-C
S6152 Z2990
23581931


6-38

#23856771-A-C
S6149 Y2602 FGC438
23856771


6-39

#23959290-C-T
S6141 Z2991
23959290


6-40
P3_t1
24293374-G-C
Z16323
24293374


6-41
P1_Y1
26078887-T-C
FGC462 S7073
26078887


6-42

28648166-T-C
S655 Z2992
28648166

Dubhthach
09-11-2015, 08:38 AM
I'll admit I haven't kept up with the terminology, are the Combed regions the same as the "Gold region SNP's" (or whatever FTDNA were calling them). If 20 of the SNP's are in areas that have high risk of recombination or anything, it would make sense that large number of SNP's would arise in very short period.

From point of view of downstream SNP's of the "Mega-Block" the most dominant in numbers so far appears to be DF105 (under S658) which is shaping up to be the "DF13 of M222 land".

miiser
09-14-2015, 12:43 AM
Paul,

I also was interested in the large number of SNPs in the M222 block. 42 of them to see if these could have any physical location clustering in over lapping 1000bp range? I did not find any at all. I am not saying that some could have mutated in short spurts of generations but I look at the average. Not counting DF49, there are 51 total SNPs to the end of the M222 Block. A large number in just these when I compare to my 800+ NGS kits used in a previous exercise of counting BigTree SNPs DF13 and below which averaged 47 +- 10 (SD). So I removed the seven SNPs that are in repeat and looped sections leaving 44 to the end of the M222 block. FYI, of those 51, there are 20 positions that are not found in any of the 857 CombBED (CB) regions. My next post will show the data.

MJost

A binomial distribution of 227 trials, with a probability of .21, gives an average of 47 and a standard deviation of 6. Your standard deviation of 10 >> 6. This suggests that the SNPs are not randomly distributed.