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mafe
05-03-2014, 09:33 AM
A274: 21387964 C to T

A275: 13668489 T to C

Found dowstream of U152*.


A274 and A275 are now available at YSEQ. http://shop.yseq.net/advanced_search_result.php?keywords=A274+or+A275


I have ordered both SNPs for vetting as A275 might be an unstable marker.

mafe
05-22-2014, 08:15 PM
The U152 project now shows another Big-Y kit that is "A274+" (21387964 C to T).

Compared to me, he has got a GD of 30, which makes it an old SNP. I had hoped that some of my charactaristic STR markers would be an indicator for this particular subclade, it looks like that is not the case. But they might be an indicator for hopefully more than one novel SNP downstream of A274 > A275.

R.Rocca
05-23-2014, 01:33 PM
The U152 project now shows another Big-Y kit that is "A274+" (21387964 C to T).

Compared to me, he has got a GD of 30, which makes it an old SNP. I had hoped that some of my charactaristic STR markers would be an indicator for this particular subclade, it looks like that is not the case. But they might be an indicator for hopefully more than one novel SNP downstream of A274 > A275.

It is unfortunate this kit belongs to someone who is adopted. Oddly enough, he has a very Spanish last name (although it could be French or Italian), but he lists his paternal origin country as the Netherlands. This of course could have been changed when he saw that he was A274+, but I have no way of knowing.

mafe
05-23-2014, 04:57 PM
It is unfortunate this kit belongs to someone who is adopted. Oddly enough, he has a very Spanish last name (although it could be French or Italian), but he lists his paternal origin country as the Netherlands. This of course could have been changed when he saw that he was A274+, but I have no way of knowing.

I believe this kit used to have Ireland as country of origin, I think this was the location of his closest match. He is still flagged in Ireland on the U152* map.

The Spanish surname is interesting though, at least three out of four grandparents of 1KG NA19720 were born in Mexico. I believe this sample was also used in the International HapMap project, do you know if that project reported haplotypes?, I can't access the database atm.



S19861 is also available at YSEQ, I am positive for this SNP. The haplogroup isn't listed in the description.

R.Rocca
05-24-2014, 01:01 PM
I believe this kit used to have Ireland as country of origin, I think this was the location of his closest match. He is still flagged in Ireland on the U152* map.

The Spanish surname is interesting though, at least three out of four grandparents of 1KG NA19720 were born in Mexico. I believe this sample was also used in the International HapMap project, do you know if that project reported haplotypes?, I can't access the database atm.



S19861 is also available at YSEQ, I am positive for this SNP. The haplogroup isn't listed in the description.

The 1000 Genomes project did eventually provide some STR data for their samples, including NA19720. You can find the file here:

http://ftp.1000genomes.ebi.ac.uk/vol1/ftp/technical/working/20140107_chrY_str_haplotypes/YSTRs_PowerPLexY23_1000Y_QA_20130107.txt

mafe
05-25-2014, 03:57 PM
The 1000 Genomes project did eventually provide some STR data for their samples, including NA19720. You can find the file here:

http://ftp.1000genomes.ebi.ac.uk/vol1/ftp/technical/working/20140107_chrY_str_haplotypes/YSTRs_PowerPLexY23_1000Y_QA_20130107.txt

Thanks Richard!

YSEQ completed my A275 test and I'm reported C+ (positive), so it looks like it is stable enough for individual testing. A274 isn't in yet.

mafe
06-08-2014, 06:33 PM
My A274 result has been posted, T+ (positive). Both SNPs are stable enough for individual testing, and available at YSEQ for the U152*s out there who are willing to take a gamble.

mafe
06-22-2014, 08:21 AM
Good news, S19861 also came back positive at YSEQ!

Additional SNPs tested:

S260 ChrY 13668653 13668653 A-
Z44 ChrY 13668653 13668653 A-
FGC8395 ChrY 17534291 17534291 C-
S4923 ChrY 17534330 17534330 A-
A146 ChrY 17534355 17534356 del-
Z16250 ChrY 17534355 17534356 del-
F2517 ChrY 17534365 17534365 T-
F4239 ChrY 17534380 17534380 T-
F3188 ChrY 21387889 21387889 C-

mafe
10-07-2014, 02:50 PM
Does anyone know if the UK10K project also reports haplotypes? The haplotype of UK10K_ALS5085946 could help me identify other possible A274's and A275's

R.Rocca
10-08-2014, 01:39 AM
Does anyone know if the UK10K project also reports haplotypes? The haplotype of UK10K_ALS5085946 could help me identify other possible A274's and A275's

No, just SNPs.

mafe
10-08-2014, 02:56 PM
No, just SNPs.

Thanks Richard!

mafe
12-26-2014, 10:27 PM
My YFull analysis has been completed:

81 novel SNPs (10 best quality, 15 acceptable, 55 ambiguous, 1 low quality.)

Could this analysis be of help to the U152 project?

Btw I'm still U152* at YFull, which surprises me a bit as 1KG-NA19720 is listed in their Y-tree.

mafe
01-14-2015, 08:50 AM
New shared SNP with NA19720:

Y8424 23579267 G>T

It would be interesting to see if the other A274+ kit in the U152 project is positive for Y8424.

mafe
05-14-2015, 06:52 PM
Dear R-U152*s,

I am offering "all" U152*s in the project a FREE test at YSEQ for SNP "A274".
(regarding you test another SNP ($17,50) if you turn out to be negative for A274.)

Please let me know if you're interested.

Regards, Martijn