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warwick
05-08-2014, 07:38 PM
Together with a large group of collaborators, Mucke and Dubal examined the question in three separate cohorts of people participating in aging studies of various kinds, adding up to more than 700 people. Their analysis showed that people with one of the life-extending variants of the KLOTHO gene scored better on cognitive tests
Reference: http://www.sciencedaily.com/releases/2014/05/140508121343.htm

Relevant SNP: Rs9536314

http://www.snpedia.com/index.php/Rs9536314

Beneficial variants: GG, GT

My variant: GT

MJost
05-08-2014, 08:06 PM
Dang, I am just TT, Wife's brother is GT and her son is GG.

life-extending variants of the KLOTHO gene scored better on cognitive tests as you get older, right?

MJost

Little bit
05-08-2014, 11:05 PM
In my group of 8:

2 TT
5 GT - including me
1 GG

The Mendel's are both TT

Looking at dbSNP, GG is the least common version, less than 10% in all populations. If the G is so good, why isn't it more favored? Could there be a hidden dark side?
http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=rs9536314

Sangarius
05-09-2014, 08:10 AM
Read about it yesterday. My haplotype is GT.

warwick
05-11-2014, 06:03 AM
Also:

People who have one copy of a variant, or form, of the KLOTHO gene, called KL-VS, tend to live longer and have lower chances of suffering a stroke whereas people who have two copies may live shorter lives and have a higher risk of stroke. In this study, the investigators found that people who had one copy of the KL-VS variant performed better on a battery of cognitive tests than subjects who did not have it, regardless of age, sex or the presence of the apolipoprotein 4 gene, the main genetic risk factor for Alzheimer's disease.



NMDA receptors control communication at many glutamate synapses. GluN2B subunits are components of some NMDA receptors. Previous studies have shown that the presence of GluN2B at synapses is associated with changes in synaptic strength and learning and memory. In this study, the researchers found that synapses in the brains of klotho-enhanced mice had more GluN2B subunits than control mice. Treating klotho mice with a drug that selectively blocks GluN2B-containing NMDA receptors reduced their ability to perform on learning and memory tests. The results suggest that increasing the presence of GluN2B-containing NMDA receptors may be one way that klotho could enhance cognitive skills.

http://www.eurekalert.org/pub_releases/2014-05/nion-lgm050914.php

warwick
05-11-2014, 05:07 PM
http://www.eurekalert.org/pub_releases/2014-05/nion-lgm050914.php

" increasing the production of the GluN2B subunit in aged animals enhances memory and synaptic transmission."

http://www.ncbi.nlm.nih.gov/pubmed/23103326

warwick
05-13-2014, 02:49 AM
Mighty Mouse?

http://www.wired.com/2010/01/mighty-mouse-new-adventures/

Mellifluous
01-31-2016, 08:43 AM
Rs9536314

GG

surbakhunWeesste
01-31-2016, 09:30 AM
rs9536314 G or T
TT
& I thought I was extraordionaire. :doh:

Gray Fox
01-31-2016, 10:05 AM
Rs9536314 T / T

Well fiddlesticks.. :pout:

Mellifluous
01-31-2016, 11:50 AM
rs9536314 G or T
TT
& I thought I was extraordionaire. :doh:

Biology hasn't defined you! That's even more extraordinary :P

DMXX
01-31-2016, 04:23 PM
I'm TT for this one.

Intelligence is a complex trait (though recent evidence suggests environmental boosters, such as a stable family environment or academic enrichment, don't markedly effect the intelligence of individuals once they reach maturity). Last I read, intelligence is estimated to be over 80% heritable.

The longstanding belief (supported by past evidence (http://www.pnas.org/cgi/reprint/0704292104v1)) that breastfeeding raises IQ has been challenged recently by a Kings College London paper (http://www.telegraph.co.uk/news/health/news/11886646/Breastfeeding-does-not-improve-IQ-study-finds.html) (and a good one at that).

With that in mind, TT's are best holding off on wearing a shirt saying this for the time being... :)

http://www.quickmeme.com/img/59/59f784ffb2264858a6fefdf9609489620f7ccc3248afcc1d6a 546b582fa763ba.jpg

bored
01-31-2016, 04:46 PM
Rs9536314

TT :nono:

Shaikorth
01-31-2016, 04:47 PM
Looking at dbSNP, GG is the least common version, less than 10% in all populations. If the G is so good, why isn't it more favored? Could there be a hidden dark side?
http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=rs9536314

Maybe there is some truth to it, as East Asians have become fixed for T, and so have Native Americans (PEL is admixed, Karitiana/Pima/Surui have none) and Oceanians. Among 1kgenomes pops only Mandinka and Finnish samples have >25% G, and neither are huge populations.
http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=13:33627638-33628638;v=rs9536314;vdb=variation;vf=5209807

AnnieD
01-31-2016, 09:04 PM
GT ... does this make me a half-wit? ;)

faulconer
02-01-2016, 02:53 AM
GT

http://www.sciencedaily.com/releases/2015/01/150127121158.htm
http://blog.kittycooper.com/2014/05/klotho-a-gene-for-longevity-and-alzheimers-protection/

Mestace
02-01-2016, 08:21 AM
TT Father
GG Mother

Me GT (surprise !)

jdean
02-01-2016, 08:51 AM
" increasing the production of the GluN2B subunit in aged animals enhances memory and synaptic transmission."

http://www.ncbi.nlm.nih.gov/pubmed/23103326

If it's to do with memory that makes perfect sense, I'm TT : )

reagan
02-01-2016, 02:06 PM
GT...

Asimakidis
02-01-2016, 02:16 PM
...TG

Ashina
02-09-2016, 07:23 PM
GG.

A bad combo apparently.

We're all GT or GG btw. None in my family is TT.

Theramster
08-10-2016, 04:51 AM
Reference: http://www.sciencedaily.com/releases/2014/05/140508121343.htm

Relevant SNP: Rs9536314

http://www.snpedia.com/index.php/Rs9536314

Beneficial variants: GG, GT

My variant: GT

I don't know how reliable these studies are. Chances are there is more at work for longevity and intelligence than what is commonly known and may involve a variety of genes and a variety of triggers.

Browsing through the responses and reading the article I realized most people missed what was being said in the study, whether it's right or wrong.

Only the heterozygous GT is assumed to have beneficial effect while GG, the rarest variety, is assumed to have adverse effect. TT is not assumed to have any effect. Cheers.

cercle
08-10-2016, 06:34 AM
The kl-vs genotype "GT" wasn't not replicated in a study with more participant.

"Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group."
http://www.ncbi.nlm.nih.gov/pubmed/26405063

"We found that heterozygotes for the previously reported KL-VS had poorer cognitive function than noncarriers. "

Too much hype in the mainstream media for that variant. Careful with what snpedia is throwing at you, some pages aren't updated for a while.

The educational attainement loci looks far more robust about cognitive perfomance :

"Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment."
http://www.ncbi.nlm.nih.gov/pubmed/25951819

firemonkey
08-10-2016, 08:38 AM
I am GT for rs9536314 and AC for rs1906252. I would say I fall into the too clever to be stupid but too stupid to be really clever category.

Theramster
08-18-2016, 11:21 AM
The kl-vs genotype "GT" wasn't not replicated in a study with more participant.

"Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group."
http://www.ncbi.nlm.nih.gov/pubmed/26405063

"We found that heterozygotes for the previously reported KL-VS had poorer cognitive function than noncarriers. "

Too much hype in the mainstream media for that variant. Careful with what snpedia is throwing at you, some pages aren't updated for a while.

The educational attainement loci looks far more robust about cognitive perfomance :

"Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment."
http://www.ncbi.nlm.nih.gov/pubmed/25951819

Thanks for sharing the articles.
I turned out to be homozygous for both
rs9536314 GG
rs1906252 AA