View Full Version : FOXO3 gene linked to why short people live longer

05-18-2014, 07:45 AM

Study Objectives:

To determine the relation between height, FOXO3 genotype and age of death in humans.

PLOS ONE article link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0094385

05-19-2014, 10:04 PM
Fascinating, thanks for the study!

05-19-2014, 11:51 PM
Well there goes my chance for a long life, dang darn tall genes.... :D

05-21-2014, 07:36 PM
I am rs2802292 GG, and I am 162.56 cm tacouldn't find the mention I am using a tablet and can't find which variant is longevity positive, is it GG, GT, or TT?

Thank you in advance.

Edit: my current height is 160.02 cm, I couldn't find mention of the age of height measurement.

05-22-2014, 03:25 PM
rs2802292 GG
Height 6'5 196cm

"An analysis of the HHP/HAAS subpopulation described above divided according to median height (161.4 cm) into shorter and taller categories, demonstrated higher prevalence of the T allele of the FOXO3 rs2802292 SNP in the taller subgroup (Table 5A). A phenotype-genotype analysis showed, moreover, that taller baseline height was associated with the T allele, TT subjects being 1.4 cm taller than GG/GT subjects"

09-24-2014, 01:04 PM
Long live me! :)

R. Walker
09-30-2014, 03:04 AM
The study was on Japanese American men in Hawaii.

10-06-2014, 07:27 PM
I wonder if this inverse correlation between height and longevity vanishes if you remove GG individuals. I think there are other factors, too. One could be that larger people have more cells which increases the odds of getting malicious tumors.
I'm 196 cm and GT by the way.

10-06-2014, 07:32 PM
183 cm (6' even) and GT. At least I'll have a while, probably. :)

10-06-2014, 09:32 PM
GG. Height 5'9 (175cm)

10-07-2014, 11:57 AM
TT, height 6'3. I really don't want to live too long. 75 to 80 is good enough...seen too many old people warehoused and suffer. Looks like the odds are in my favor!

12-18-2014, 02:05 PM