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rokousa
07-31-2014, 02:40 PM
Malaria is an ancient disease caused by the Plasmodium organism. Evidence shows that P. falciparum causing malignant tertian malaria originated in Central Africa 165 million years ago and migrated towards the Mediterranean at the end of the last Ice Age. P. vivax and P. malariae causing more benign malaria probably originated in South-East Asia. (Retief 2004 (http://reference.sabinet.co.za/document/EJC27191))

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria.
The presence of thalassemia minor (like sickle cell trait in Africa) afforded protection against malaria.

Available calculations suggest that Sickle cell gene has developed between 3000 and 6000 generations, approximately 70000-150000 years ago. (Kurnit1997, Soloman 1997).

Mitochondrial Eve is estimated to have lived around 200,000 years ago. (Soares 2009) Y-chromosomal Adam lived as early as around 142,000 years ago. (Cruciani 2011) The MRCA approximately 100,000 years ago is probably associated with the expansion of early modern humans. It was part of a malaria population which preyed on the human population to which “mitochondrial Eve”, the ancestor of all currently existing human mitochondrial genotypes, belonged. (Sallares 2004 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC547919/))

Thalassaemia major are more serious blood disorders which mean you inherit the defective gene from both your parents.
If both parents have sickle cell trait (each have one normal hemoglobin gene and one sickle cell gene), the child has a 50% chance of inheriting sickle cell trait...

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Humanist
07-31-2014, 02:58 PM
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What is the deal with all of the question marks? What is your question?

Táltos
07-31-2014, 03:04 PM
What is the deal with all of the question marks? What is your question?
They are seriously confused. :P :biggrin1:

rokousa
07-31-2014, 03:07 PM
if Adam i Eve had Malaria, sickle cell traits, beta thalassaemia, why i don't have sickle cell traits or beta thalassaemia?
again...
Thalassaemia major are more serious blood disorders which mean you inherit the defective gene from both your parents.
If both parents have sickle cell trait (each have one normal hemoglobin gene and one sickle cell gene), the child has a 50% chance of inheriting sickle cell trait...

???????????????