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jesus
08-29-2014, 03:15 AM
This is the best proxy for the number of repeats of the MAOA warrior gene. In 105 samples (69 males, 36 females) from the Stanley foundation brain collection, it was always A in people with the 4 or 5 repeat non-Warrior version and always G in people with the 3 repeat Warrior version. The combination rs909525(A) AND rs6323(G) AND rs3027399(G) indicate specifically that it is the 5 repeat version. The 2 repeat version and the 3.5 repeat version weren't mentioned.[PMID 16893905]
[PMID 19028548] mentioned as potentially affecting white matter volume, sample size tiny.

http://www.snpedia.com/index.php/Rs909525

I'm G;G ( Perhaps MAOA 3 repeats: Warrior Gene? )

Post your results please.

Mehrdad
08-29-2014, 03:28 AM
K, am I getting this right because it's on Chromosome X and mine is T

MitchellSince1893
08-29-2014, 04:10 AM
I'm not sure what it means but on 23andme both my parents and I have

Rs909525 Genotype: C (mom is CC)
Rs6323 Genotype: G (mom is GG)

So is that warrior or non warrior results? EDIT: I read that this combo is the warrior gene.

L200
08-29-2014, 04:14 AM
( Perhaps MAOA 3 repeats: Warrior Gene? )



That's what my 2011 FTDNA result said.

jesus
08-29-2014, 04:15 AM
I'm not sure what it means but on 23andme both my parents and I have

Rs909525 Genotype: C

So is that warrior or non warrior results?

I'm C in 23andme, you have the " warrior gene " or at least one Warrior Gene and one non-Warrior Gene.

Little bit
08-30-2014, 12:35 PM
Me and my son are tested for the warrior gene at FTDNA and my son shows the 3 repeat warrior variant and I show 2 copies of the 3 repeat warrior variant.

Son:
rs909525 C
rs6323 G

Me:
rs909525 CC
rs6323 GT

Neither of us are genotyped for rs3027399. It used to be reported by some that rs6323 was a good proxy for the 3 repeat warrior variant but it is not. Since I carry 2 copies of the 3 repeat warrior variant, my mother and daughter must carry at least one copy each, and yet that are both TT for that snp.

Rukha
08-31-2014, 01:05 AM
Rs909525 Genotype-C
Rs6323 Genotype- G

Salkin
08-31-2014, 06:11 PM
I guess I'm no warrior...

rs909525 T
rs6323 T
rs3027399 G

Reith
11-11-2014, 06:43 PM
2 Repeats Warrior Variant
2 and 3 Repeats Two copies of the Warrior Variants
2 and 4 Repeats One copy each of the Warrior and Normal Variants

3 Repeats Warrior Variant your result :argue:

3 and 3.5 Repeats One copy each of the Warrior and Normal Variants
3.5 Repeats Normal Variant
3.5 and 5 Repeats Normal Variants
4 Repeats Normal Variant
4 and 5 Repeats Normal Variants
5 Repeats Normal Variant

Mehrdad
11-11-2014, 08:10 PM
Someone should do a research on the NERD gene, pretty sure there's one..... ;)

MJost
11-11-2014, 09:15 PM
Here is my results via my Promethease Report MJost


Generated: 2014-07-23
Reference Population CEU
21666 genotypes annotated


rs909525 (T)
rs6323 (T)
rs3027399 (C) <My Son has (not shown in my results)

Original 23andme (shown at the bottom)***
[rs4680(G;G)] <23andme Main info

First three SNPs explained
rs909525(-;T)
References:5

This is the best proxy for the number of repeats of the MAOA warrior gene. In 105 samples (69
males, 36 females) from the Stanley foundation brain collection, it was always A in people with
the 4 or 5 repeat non-Warrior version and always G in people with the 3 repeat Warrior version.
The combination rs909525(A) AND rs6323(G) AND rs3027399(G) indicate specifically that it is the
5 repeat version. The 2 repeat version and the 3.5 repeat version weren't mentioned. mentioned
as potentially affecting white matter volume, sample size tiny


rs6323(-;T)
References:13

rs6323 (R297R / Arg297Arg) is a SNP in the MAOA (monoamine oxidase A) gene. Monoamine oxidase A degrades serotonin, dopamine, epineprine, and norepinephrine. The G allele encodes for the higher activity form of the enzyme. Subjects with major depressive disorder with the highest
activity form of the enzyme (G or G/G) had a significantly lower magnitude of placebo response



***23andme My info

rs4680(G;G)
Magnitude: 2.5
Frequency: 29.2%
Repute:Good
References:260

(warrior) multiple associations, see details You have the VAL/VAL version of the snp discussed
in this news article. It is able to perform better in a test where the optimal strategy
changes. Placebo is less effective for you http://www.nytimes.com/2013/02/10/magazine/why-can-some-kids-handle-pressure-while-others-fall-apart.html?ref=magazine&pagewanted=all

rs4680 (Val158Met) is a well studied SNP in the COMT gene. 23andMe blog summarizes them as
*rs4680(A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher
dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more
efficient at processing information under most conditions *rs4680(G) = Warrior. Val, less
exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain
threshold, better stress resiliency, albeit with a modest reduction in executive cognition
performance under most conditions Roughly speaking, the predominant wisdom (known colloquially as the warrior/worrier hypothesis; summary at ) posits that people with Val alleles have increased COMT activity and lower prefrontal extracellular dopamine compar...

Arbogan
12-06-2014, 07:22 PM
I got:

rs909525: G
rs6323: T

I don't buy it, I've been a "warrior" . Aggression is more complex than genes. Conditions and necessity can turn you into as much as a killer as anyone else. Alot of tribes of pish-ti-kuh turned to banditry and raiding as a result of of economic turmoil brought on by the acquisition of their territory by the qajar goverment. Same with neighboring bakhtiaris during the 18-19th century. Same story for some north-Caucasian ethnicities who became abreks and pashtun tribes that became highwaymen.

Erik
12-06-2014, 08:58 PM
I remember that Promethease said that I have this gene under the "good news" section

Petr
12-07-2014, 12:31 AM
I have results for 18 persons and they are:
rs909525: All T or TT
rs6323: All T or TT
rs3027399: All G or GG
rs4680: 3x AA, 11x AG, 4x GG

What does this mean?

MJost
12-07-2014, 03:05 PM
The different versions of the COMT gene are determined by rs4680, which is available to 23andMe customers in the Browse Raw Data feature. A=Met, G =Val.
Read more at http://blog.23andme.com/news/dna-variation-may-help-us-break-free-from-our-routines/#wrw70x0ZH2SvTO4W.99

For rs4680. I and my son have GG.

Here is the overview of MAOA.
http://en.wikipedia.org/wiki/Monoamine_oxidase_A

rs4680(A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions
rs4680(G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions
http://www.snpedia.com/index.php/Rs4680

23andMe blog
http://blog.23andme.com/2008/08/10/snpwatch-genetic-variant-may-increase-risk-for-anxiety-disorders/

The A version of rs4680 appears to boost working memory and cognitive function compared to G but it also hampers emotional control.


"Evil Genes: Why Rome Fell, Hitler Rose, Enron Failed, and My Sister Stole My ..."
By Barbara Oakley
http://books.google.com/books?id=QLnyr5A-YksC&pg=PA79&lpg=PA79&dq=versions+of+the+COMT+gene&source=bl&ots=YFl_RIyEPu&sig=z6GovU_VlsqC8EQkS7b6WbywXPc&hl=en&sa=X&ei=62qEVK-mK5bYoASpsICQBA&ved=0CEwQ6AEwBzgK#v=onepage&q=versions%20of%20the%20COMT%20gene&f=false


MJost

John Doe
12-07-2014, 03:23 PM
The different versions of the COMT gene are determined by rs4680, which is available to 23andMe customers in the Browse Raw Data feature. A=Met, G =Val.
Read more at http://blog.23andme.com/news/dna-variation-may-help-us-break-free-from-our-routines/#wrw70x0ZH2SvTO4W.99

For rs4680. I and my son have GG.

Here is the overview of MAOA.
http://en.wikipedia.org/wiki/Monoamine_oxidase_A

rs4680(A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions
rs4680(G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions
http://www.snpedia.com/index.php/Rs4680

23andMe blog
http://blog.23andme.com/2008/08/10/snpwatch-genetic-variant-may-increase-risk-for-anxiety-disorders/

The A version of rs4680 appears to boost working memory and cognitive function compared to G but it also hampers emotional control.


"Evil Genes: Why Rome Fell, Hitler Rose, Enron Failed, and My Sister Stole My ..."
By Barbara Oakley
http://books.google.com/books?id=QLnyr5A-YksC&pg=PA79&lpg=PA79&dq=versions+of+the+COMT+gene&source=bl&ots=YFl_RIyEPu&sig=z6GovU_VlsqC8EQkS7b6WbywXPc&hl=en&sa=X&ei=62qEVK-mK5bYoASpsICQBA&ved=0CEwQ6AEwBzgK#v=onepage&q=versions%20of%20the%20COMT%20gene&f=false


MJost

I'm GG so I guess I'm a "warrior" rather than a "worrior"

Salkin
12-07-2014, 03:35 PM
AG, so a bit of both, I guess.

Neo
01-15-2015, 11:09 AM
My results for MAOA are :
rs909525 (C)
rs6323 (G or T)


I don't have rs3027399 for MAOA, at best, I have 1 warrior gene for MAOA, but it doesn't even look I do have it since the the genotype is T on rs6323.Maybe someone can verify this.

As for the COMT gene, I have rs4680 in which the genotype reads AG.



I found some info Rs4680 (http://www.snpedia.com/index.php/Rs4680)and COMT (http://www.snpedia.com/index.php/COMT)on SNPedia. It seems the SNP on the COMT gene that determines one being a warrior or worrier is Rs4680.

Petr
01-17-2015, 12:37 AM
Wow. I would not expect this, my test for MAOA shows I have 3 Repeats = "Warrior Variant" Nobody who knows me would say this.
http://i62.tinypic.com/30vnjg4.png

Promethease says:

rs909525(A;A)
Probably MAOA 4 or 5 repeats: not Warrior Gene. People with this SNP usually also have either the 4 or 5 repeat (non-Warrior) version of MAOA which makes them less aggressive and less anti-social. If you are male, you inherited this from your mother. Do not confuse this with the completely different warrior/worrier gene.
This is the best proxy for the number of repeats of the MAOA warrior gene. In 105 samples (69 males, 36 females) from the Stanley foundation brain collection, it was always A in people with the 4 or 5 repeat non-Warrior version and always G in people with the 3 repeat Warrior version. The combination rs909525(A) AND rs6323(G) AND rs3027399(G) indicate specifically that it is the 5 repeat version. The 2 repeat version and the 3.5 repeat version weren't mentioned. mentioned as potentially affecting white matter volume, sample size tinyAnd SNPedia: http://www.snpedia.com/index.php/Rs909525%28A;A%29

So I don't fit in this rule. :confused:

My results of all referenced "warrior" SNPs are:
rs909525 (MAOA gene): 23andMe T, FTDNA TT
rs6323 (MAOA gene): 23andMe T, FTDNA TT
rs3027399 (MAOA gene): 23andMe G
rs4680 (COMT gene): both 23andMe and FTDNA: AG

surbakhunWeesste
01-17-2015, 08:23 PM
rs909525 CT

rs6323 GT

rs3027399 GG

Salkin
02-26-2015, 03:00 PM
FTDNA confirms 4 repeats, "Normal Variant". Not all that surprising.

Petr
02-26-2015, 06:18 PM
The bad thing is that apparently there is no relation between number of repeats and any of MAOA SNP tested by FTDNA or 23andMe.

Afshar
02-27-2015, 11:13 AM
rs909525 CC
rs6323 GG

Half a warrior

Petr
02-27-2015, 09:17 PM
I did FTDNA MAOA test for other members of our family and it is confirmed that people with 3 repeats (warrior variant) and with 4 repeats (normal variant) have exactly the same all SNPs in MAOA gene, including rs909525 (T) and rs6323 (T), both for FTDNA and 23andMe.

In other words, it looks like rs909525 and rs6323 are not related to warrior variant defined by the number of repeats.:suspicious:

Little bit
02-28-2015, 02:32 AM
Rs6323 definitely is not a good proxy for the 3 repeat, at least not in my family group, but rs909525 looks pretty good. I was tested at FTDNA for the MAOA factoid as was my son and I was told I carry 2 copies of the 3 repeat and my son carries the one copy of the 3 repeat. At 23andme, I am CC for rs909525 and GT for rs6323. My son is C for rs909525 and G for rs6323. My mom and daughter are CT for Rs909525 and TT for rs6323, so rs6323 isn't working for them either. I have other family members tested at 23andme and my husband and my mom's dad both carry T for rs909525 so the inheritance looks good for that snp though I don't have any of my other family members tested for FTDNA's MAOA factoid test.

Jessie
03-02-2015, 11:55 AM
The different versions of the COMT gene are determined by rs4680, which is available to 23andMe customers in the Browse Raw Data feature. A=Met, G =Val.
Read more at http://blog.23andme.com/news/dna-variation-may-help-us-break-free-from-our-routines/#wrw70x0ZH2SvTO4W.99

For rs4680. I and my son have GG.

Here is the overview of MAOA.
http://en.wikipedia.org/wiki/Monoamine_oxidase_A

rs4680(A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions
rs4680(G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions
http://www.snpedia.com/index.php/Rs4680

23andMe blog
http://blog.23andme.com/2008/08/10/snpwatch-genetic-variant-may-increase-risk-for-anxiety-disorders/

The A version of rs4680 appears to boost working memory and cognitive function compared to G but it also hampers emotional control.


"Evil Genes: Why Rome Fell, Hitler Rose, Enron Failed, and My Sister Stole My ..."
By Barbara Oakley
http://books.google.com/books?id=QLnyr5A-YksC&pg=PA79&lpg=PA79&dq=versions+of+the+COMT+gene&source=bl&ots=YFl_RIyEPu&sig=z6GovU_VlsqC8EQkS7b6WbywXPc&hl=en&sa=X&ei=62qEVK-mK5bYoASpsICQBA&ved=0CEwQ6AEwBzgK#v=onepage&q=versions%20of%20the%20COMT%20gene&f=false


MJost

Interesting about rs4680 I'm AA and the rest of the members of my family tested are AG. I'm the most laid back and worry the least. They are also a lot more hot tempered.:) My mother is CT for rs909525, brother T and my daughter and myself are TT.

icebreaker
03-02-2015, 12:19 PM
rs909525 C
rs6323 T
rs4680 GG (rs4680(G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions)

Arbogan
03-03-2015, 05:59 PM
I have it confirmed from FTDNA. I think it's right aswell. If your brain shuts off during a conflict. That's MAOMA.

MonkeyDLuffy
03-04-2015, 09:18 AM
I used this tool, it says I have it, but I am T and T on both sides

Although I am pretty aggressive and easy to get into fight person. :boxing:

http://i.imgur.com/7Ep5rdR.png


http://www.y-str.org/2014/12/warrior-gene-test.html

tamilgangster
03-04-2015, 09:32 AM
They should do this test on military families, and so called martial races, to test the validity. Honestly I highly doubt this has much impact on real life warrior qualities, there is more to warrior qualities than genetics. It has alot more do with exposure to violence at a young age, and factors like poverty, etc. Many other factors have a much bigger affect on martial qualities than genetics

Petr
03-04-2015, 12:20 PM
I used this tool, it says I have it, but I am T and T on both sides

Although I am pretty aggressive and easy to get into fight person. :boxing:

http://i.imgur.com/7Ep5rdR.png


http://www.y-str.org/2014/12/warrior-gene-test.html

This test gives wrong results - it's simple, there is no real relation between any MAOA SNP tested by 23andMe or FTDNA and number of repeats.

MonkeyDLuffy
03-04-2015, 12:57 PM
This test gives wrong results - it's simple, there is no real relation between any MAOA SNP tested by 23andMe or FTDNA and number of repeats.

So what does that mean? 23&me is wrong too? Since I got T and T, it means it is absent?

Petr
03-04-2015, 03:11 PM
People with T and T may have either 3 or 4 repeats, maybe even other numbers. So it means nothing.

I have 3 members in my family with FTDNA MAOA test results 3 repeats and and 8 members with 4 repeats. All have both rs6323 and rs909525 T.

Which 23andMe test do you mean? I think there is no test using MAOA gene.

Arbogan
03-04-2015, 07:05 PM
They should do this test on military families, and so called martial races, to test the validity. Honestly I highly doubt this has much impact on real life warrior qualities, there is more to warrior qualities than genetics. It has alot more do with exposure to violence at a young age, and factors like poverty, etc. Many other factors have a much bigger affect on martial qualities than genetics

It does have an impact. If you're more likely to retaliate in a conflict.. you're more likely to shoot back at someone who shoots at you. You're more likely to kill someone in an engagement. You're more likely to end up in a fight if someone provokes you. That quality is useful if you're a soldier.

MfA
03-04-2015, 09:41 PM
rs4680 GG
rs909525 T
rs6323 T

http://abload.de/img/desktop_2015_03_04_22y0uvc.png

Petr
03-04-2015, 09:55 PM
This is really frustrating. I have provided my X-DNA results to Felix Immanuel, author of the Warrior Gene 3R Test. I have confirmed 3R by direct FTDNA test. Then I tested other people in my family and found that despite they have exactly the same mutations (SNPs) on the X Chromosome in MAO-A gene, some of the mave 4 repeats and some of them 3 repeats. So either the FTDNA Warrior Gene Test gives wrong results or this tool has no data to work with.

Little bit
03-04-2015, 10:21 PM
I don't have a lot of faith in those tools from that website 'Genetic Genealogy Tools.' Someone at 23andme posted a thread questioning their mtdna assignment in mtdna L, insisting he was H2a2a1 because of a tool from that website when it was obvious that he was not getting any real data from it:
https://www.23andme.com/you/community/thread/34313/

If you can scroll through the thread, you'll see others get the same exact, false, results. I'm on a Mac and can't run it but I'm fairly convinced either the tool is buggy is or so complicated that people will often run it wrong and get false results.

Petr
03-04-2015, 10:33 PM
Tools from that website 'Genetic Genealogy Tools usually work fine ane 23andMe to FASTA tool works fine for me, in that case I suppose submission of the wrong file.

rock hunter
03-04-2015, 11:32 PM
Ok that is enough about this warrior gene stuff

First I mean to offend no one but actually as a whole ,we real soldiers of I was one and in one of the most powerful forces on earth I might add ,,I prefer not to kill my fellow human or be killed by them or shoot at them no matter what country they are from what race the might be or what god or gods they do or do not believe in and most REAL warriors and by this I mean soldiers today feel this way.

Its usually the politicians ,the leaders who do not have to fight wars themselves who start the fights that we soldiers are then called to end and die in.

As far as this so called "warrior gene" it is a salesman's name for the set of genes that also by the way also can cover criminal and violent tendencies as well as some mental illnesses , just the things we do not want in the armed forces or with you in a bunker, you want a smart stable person next to you, not some nut job.

Of course if they want to call it the frothing at the mouth ,kill them all and let god sort them out gene, I am sure us veterans will not object, but they will not sell as many tests.

giovanni carli
03-05-2015, 04:35 PM
rs909525 C or T C
rs6323 G or T G
rs3027399 C or G G

MitchellSince1893
03-05-2015, 04:38 PM
I think it's mislabeled...instead of "warrior gene", maybe it should be the "quick temper gene" or "fly off the handle gene". Or maybe the "Road rage gene".

giovanni carli
03-05-2015, 08:45 PM
guys the tool sure is a bullshit (works only on V3 chip)
and maybe the entire "warrior gene theory" too..

DMXX
03-05-2015, 09:08 PM
This is an excellent write-up (https://scientiasalon.wordpress.com/2014/07/31/the-extreme-warrior-gene-a-reality-check/) on the much-touted "Warrior Gene".

In summary, the triple repeat (3R) variant of MAOA was the initial form described in literature, but it's the double repeat (2R) variant which displays a strong correlation with aggressive and violent behaviour (authors described it as the "extreme warrior gene"). Said authors also well explain the status of aggression as a complex behaviour with both genetic and environmental predispositions. So, anyone sporting either 2R or 3R isn't prematurely condemned to a life in Gen. Pop.

The article also provides some useful statistics; 3R is carried by a large proportion of humans.

BdCdL
03-19-2015, 02:49 PM
I'm normal variant (A;A) (http://www.snpedia.com/index.php/Rs4680(A;G)) on Rs909525: 4 repeats MAOA (non-Warrior).
http://www.snpedia.com/index.php/Rs909525(A;A)

The Rs4680 is the other one: The warrior/worrier gene.
http://www.snpedia.com/index.php/Rs4680
I'm (A;G) (http://www.snpedia.com/index.php/Rs4680(A;G)) on Rs4680.

basmaci
04-30-2015, 05:43 PM
i have used the app for that, says:\
http://imagizer.imageshack.com/img911/9976/5wttaN.png

paulgill
04-30-2015, 07:21 PM
Ok that is enough about this warrior gene stuff

First I mean to offend no one but actually as a whole ,we real soldiers of I was one and in one of the most powerful forces on earth I might add ,,I prefer not to kill my fellow human or be killed by them or shoot at them no matter what country they are from what race the might be or what god or gods they do or do not believe in and most REAL warriors and by this I mean soldiers today feel this way.

Its usually the politicians ,the leaders who do not have to fight wars themselves who start the fights that we soldiers are then called to end and die in.

As far as this so called "warrior gene" it is a salesman's name for the set of genes that also by the way also can cover criminal and violent tendencies as well as some mental illnesses , just the things we do not want in the armed forces or with you in a bunker, you want a smart stable person next to you, not some nut job.

Of course if they want to call it the frothing at the mouth ,kill them all and let god sort them out gene, I am sure us veterans will not object, but they will not sell as many tests.Well said, but unfortunately I also have it.

MJost
04-30-2015, 08:58 PM
@Rockhunter, Michealsince, all

I would say I would disagree.

Warrior vs Worrier

We all get one COMT gene from our father and one from our mother, about half of all people inherit one of each gene variation, so they have a mix of the enzymes and are somewhere in between the Warriors and the Worriers. About a quarter of people carry Warrior-only genes, and a quarter of people Worrier-only.

The COMT gene gene carries the assembly code for an enzyme that clears dopamine from the prefrontal cortex. There are two variants of the gene. One variant (Worrier) builds enzymes that slowly remove dopamine. The other variant (Warrior) builds enzymes that rapidly clear dopamine. We all carry the genes for one or the other, or a combination of the two.

Under normal conditions, those with slow-acting enzymes have a cognitive advantage. They have superior executive function and all it entails. Those with the other variant, meanwhile, are comparatively lackadaisical. The fast-acting enzymes remove too much dopamine, so the overall level is too low. The prefrontal cortex simply doesn’t work as well.

Having slow-acting enzymes sounds better. There seems to be a trade-off, however, to these slow enzymes, one triggered by stress. In the absence of stress, there is a cognitive advantage. But when under stress, the advantage goes away and in fact reverses itself. Stress floods the prefrontal cortex with dopamine which can not be removed fast enough. Other research has found that those with the slow-acting enzymes have higher I.Q.’ s, on average. Worriers, through training, can learn to manage the particular stress in the specific training.

Those with fast-acting dopamine clearers are the Warriors, ready for threatening environments where maximum performance is required. Those with slow-acting dopamine clearers are the Worriers, capable of more complex planning. Over the course of evolution, both Warriors and Worriers were necessary for human tribes to survive.

http://www.nytimes.com/2013/02/10/magazine/why-can-some-kids-handle-pressure-while-others-fall-apart.html?_r=0


MJost

MJost
04-30-2015, 09:00 PM
My results:

rs4680 (Val158Met) is a well studied SNP in the COMT gene. 23andMe blog summarizes them as *rs4680(A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions *rs4680(G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions.

Roughly speaking, the predominant wisdom (known colloquially as the warrior/worrier hypothesis.

http://www.snpedia.com/index.php/Rs4680


rs909525(-;T)
This is the best proxy for the number of repeats of the MAOA warrior gene. In 105 samples (69 males, 36 females) from the Stanley foundation brain collection, it was always A in people with the 4 or 5 repeat non-Warrior version and always G in people with the 3 repeat Warrior version.

The combination rs909525(A) AND rs6323(G) AND rs3027399(G) indicate specifically that it is the 5 repeat version.

http://www.snpedia.com/index.php/Rs909525

My 3 repeat Warrior version:
rs4680(G;G) <23andme v3
rs909525 (T) 23andm3 v3
rs6323 (T) 23andm3 v3
rs3027399 (C) <My Son's 23andme v4 (mine is unknown)

MJost

MonkeyDLuffy
05-02-2015, 08:56 AM
According to athletigen i am intermediate. What does that mean, i act warrior or worrior depending on situation? Because I am an aggressive and short tempered person myself.


The AA genotype at this marker is associated with “worrier” personality traits, while the GG genotype is more commonly associated with the “warrior”. The heterozygous (AG) genotype is intermediate in terms of personality traits. The AG genotype is also the most common in individuals of European-descent, where this phenotype has been the most extensively studied. The worrier phenotype is associated with increased susceptibility to stress, it is also linked to more efficient information processing (executive cognitive function) under most conditions (including under stress). Individuals with the AA genotype (worriers) have also been shown to exhibit greater attentional focus when aware of having made an error during tests based on learning tasks. Some research has also suggested that this genotype has a lower pain threshold although results are mixed. The warrior phenotype is associated with a lower susceptibility to stress, but it’s also linked to moderately reduced information processing (executive cognitive processing) under most conditions. Warrior genotypes (GG genotype) and heterozygotes (AG) do not exhibit the same increased attentional focus after errors as the worrier genotype (AA). Some studies have indicated greater levels of cooperativity in individuals with the warrior genotype. The COMT gene codes for an enzyme that degrades a family of molecules that includes dopamine, an important neurotransmitter. Dopamine regulation is important for a wide variety of personality traits. The worrier genotype is associated with lower COMT enzyme activity, which leads to higher dopamine levels. The warrior genotype is associated with higher COMT enzyme activity which leads to lower dopamine levels.

paulgill
05-02-2015, 09:55 AM
According to athletigen i am intermediate. What does that mean, i act warrior or worrior depending on situation? Because I am an aggressive and short tempered person myself.I am also a worrier According to athletigen, but it seems to be based on a single SNP.

tamilgangster
05-02-2015, 10:56 AM
I got:

rs909525: G
rs6323: T

I don't buy it, I've been a "warrior" . Aggression is more complex than genes. Conditions and necessity can turn you into as much as a killer as anyone else. Alot of tribes of pish-ti-kuh turned to banditry and raiding as a result of of economic turmoil brought on by the acquisition of their territory by the qajar goverment. Same with neighboring bakhtiaris during the 18-19th century. Same story for some north-Caucasian ethnicities who became abreks and pashtun tribes that became highwaymen.

I believe the warrior gene isn't population specific, but I do agree, that social factors, such as exporsure to violence triggers it. The warrior gene is a minor risk factor in determing proneness to violence at best. The whole Idea of genetics controlling personality is bullshit.

rockman
05-07-2015, 02:54 AM
i have used the app for that, says:\
http://imagizer.imageshack.com/img911/9976/5wttaN.png

Funny thing, I just did this myself. I got "Warrior" but I am far from being one haha. I am a NERD! :D

How accurate is this test?

Piquerobi
05-26-2015, 02:24 PM
My results:


rs6323: G
rs909525: C

According to a study, people with the warrior gene would be better at risky decisions:


People with 'warrior gene' better at risky decisions

It's been called the "warrior gene" – a mutation that seems to make people more aggressive. Now researchers report that people with this gene may not be aggressive, just better at spotting their own interests.

Previous research has found that people with MAOA-L, a gene that controls signalling chemicals in the brain, can be more aggressive. But there is enormous controversy about this, as the gene's effects seem to vary with people's backgrounds.

Cary Frydman and colleagues at the California Institute of Technology in Pasadena have now found that people with MAOA-L "just make better choices", says Frydman. "This isn't the same as aggression."

Raising the stakes

Variants of the gene MAOA produce less or more of an enzyme that degrades several signalling chemicals, known as neurotransmitters. People with MAOA-L, which results in less of the enzyme, sometimes show more aggression or impulsivity – but not always.

To try to dissect these differences, Frydman gave 83 male volunteers 140 hypothetical choices. With 3 minutes for each choice, the men had to decide whether they preferred a sure thing, say being given $2, or a risky option, for example a 50:50 chance of gaining $10 or losing $5.

Previous research has shown that these choices can be used to reveal each person's overall aversion to risk. The team found this did not differ in people with or without MAOA-L.

But the calculation also allowed them to look at how often each person took the risky option that would also do them the most good. At every level of risk aversion among the participants, "the MAOA-L carriers were better at choosing what – for them – was the more beneficial option".

The results are consistent with previous research, says Frydman, but his team could distinguish for the first time between the two components of each decision: deciding how much each option was worth , then comparing them. The MAOA-L carriers were better at the second part.

Pay attention

This edge may look like aggression or impulsivity in some situations, but may simply reflect more focused attention, thinks Frydman. "If two gamblers are counting cards, and one is making a lot of bets, it may look like he's more aggressive or impulsive. But you don't know what cards he's counting – he may just be responding to good opportunities."

"Previous studies that have associated MAOA-L with aggression or impulsivity might have to be interpreted carefully," says Antonio Rangel, who heads the lab where Frydman works. "The key question is whether, in the context of the lives of the subjects, these decisions were optimal or not."

In a study published last year Dominic Johnson of the University of Edinburgh, UK, found that MAOA-L carriers were more aggressive, but only after a large provocation and without apparent impulsiveness. "That could be explained by this new work," he says, because his subjects seemed to be acting in strategic self-interest, the very thing Frydman's MAOA-L carriers were good at. This also suggests how such behaviour – and the gene that shapes it – could be selected by evolution.

The implications go beyond the so-called "warrior gene". As gene sequencing gets cheaper, says Frydman, there will be more efforts to link genes to behaviour. To do that accurately, researchers will need to define the components of behaviour as carefully as they do the DNA.

Journal reference: Proceedings of the Royal Society B, DOI: 10.1098/rspb.2010.2304
http://www.newscientist.com/article/dn19830-people-with-warrior-gene-better-at-risky-decisions.html#.VWRVOs9Viko

Petr
05-26-2015, 05:53 PM
Bad thing is that apparently there is no real correlation between MAOA "warrior gene" and rs6323 and/or rs909525 and the app http://www.y-str.org/2014/12/warrior-gene-test.html also does not work.

Probably the only way how to get this information is to do warrior gene test: https://www.familytreedna.com/landing/warrior-gene.aspx List price is $99, but I was able to buy it for $34 only.

In our family, all members have the same results of SNPs in MAOA gene:
rs909525 = T or TT
rs6323 = T or TT
rs3027399 = G or GG
(men 1 allele, women 2 alleles)
In FTDNA warrior gene test I have 3R (warrior) variant, my sister 3R and 4R and his son 3R. So at least in our case rs6323, rs909525 nor rs3027399 can serve as a proxy.

Does anybody read any article describing how reliable is the relation between MAOA-L and rs909525(G)?

MJost
05-26-2015, 10:17 PM
Discussion of the Warrior Gene genetic variant of MAO-A can be found in the "pay" paper titled

“A functional polymorphism in the monoamine oxidase A gene promoter”
Sabol et al, 1998
http://dx.doi.org/10.1007/s004390050816

MJost

Piquerobi
07-11-2015, 01:51 PM
My results on FamilyTreeDNA are just in:


Your results are below. With one X-chromosome, men with the "Warrior Gene" will show a value of 3. Other men will have normal variants: 3.5, 4, 4.5 or 5. With two X-chromosomes, women will have two results. For example, a woman might have 3 and 3, 3 and 5, or 4.

3 Repeats Warrior Variant

Piquerobi
08-09-2015, 12:46 AM
Tracking its evolutionary history (it seems - according to researchers - it originated 25 million years ago among Old World monkeys)


For males, a bit of aggression and risk-taking can earn rewards—just ask real-estate magnate Donald Trump. But inappropriate aggression can lead to violence, addiction, early death, and, the worst fate of all in evolutionary terms, no offspring. Now, researchers have found signs of this balancing act in the genes of our primate cousins. At the meeting, a team of geneticists traced one genetic variant, an allele that predisposes men to aggressive, impulsive, and even violent behavior, to chimpanzees, gorillas, and other primates. They conclude that this and similar variants arose at least 25 million years ago in a monkey ancestor.

In order to be retained for so long, these variants must have conferred some selective advantage on the monkeys—and humans— who carried them, says author Tim Newman, a biological anthropologist at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in Rockville, Maryland. What we see today as dangerously inappropriate behavior could be “simply out of context,” says Newman. “Bold, aggressive males might have been quicker to catch prey or detect threats.” Others agree: “If this [allele] has been around that long, then it must be maintained by balancing selection,” says biological anthropologist Henry Harpending of the University of Utah in Salt Lake City.

The gene, found on the X chromosome, codes for an enzyme called monoamine oxidase A (MAOA), which breaks down several neurotransmitters in the brain, such as dopamine and serotonin, thus preventing excess neurotransmitters from interfering with communication among neurons. But the gene is polymorphic: A repeat sequence of 30 base pairs has been inserted from three to five times into the promoter region. Fewer repeats mean that less MAOA enzyme is produced and fewer neurotransmitters are removed.

The MAOA gene’s effects have been linked to aggression. Lab mice that lack the enzyme are more aggressive, and one human family whose members do not produce the enzyme at all has been linked with violent behavior (Science, 18 June 1993, p. 1722). Men who carry the short allele, and so presumably produce a limited amount of enzyme, have been shown to be more likely to be aggressive, impulsive, and even violent if they were abused as children or drink alcohol.

Men who had the short variant and were mistreated as boys were four times more likely than other men to have committed violent crimes such as rape, robbery, and assault, according to one study that tracked boys from birth in New Zealand (Science, 2 August 2002, p. 851). (Women also inherit the allele, but the effects are easier to study in men, who have only one X chromosome.) These findings intrigued psychiatrist Klaus-Peter Lesch of the University of Würzburg in Germany, who works with the NIAAA group. His team first found, in macaques, a similar 18-base-pair repeat that also modulates MAOA enzyme activity. And macaques with less enzyme were more aggressive than other macaques when competing for food, says Lesch.

Newman then sampled all apes and many monkeys—almost 600 primates in all—and found the same 30-base-pair repeat seen in humans or the shorter 18-base-pair repeat, among other forms. He noted that apes and Old World (Asian and African) monkeys carried these alleles, whereas New World (South American) monkeys did not. That suggests that the allele arose after New World and Old World monkeys split, but before apes and Old World monkeys diverged about 25 million years ago.

During those 25 million years, aggressive and risk-taking behavior must have had reproductive payoffs for some males, says Newman. But the gene didn’t sweep through populations, because if a male was too violent, he probably died before reproducing. Newman suggests that the MAOA gene may offer a rare example of so-called balancing selection, in which selection favors two or more forms of a gene and maintains all the forms in a population. “The human social environment required the development of all kinds of emotional and cognitive capabilities, and [it] demanded variation in impulsivity in humans,” agrees David Goldman, a member of the NIAAA team. “It’s what I call the warrior vs. the worrier.” In other words, primate politics has long favored more than one route to success.

Chimpanzee gang warfare

Primatologists have long known that chimpanzees can be demonic: Bands of males routinely head to the borders of their territory to seek, and sometimes destroy, foreign chimpanzees. But what triggers these patrols, and why do males of the troop— who compete fiercely with one another most of the time—seem to cooperate while on patrol? The answer, it seems, may be a mob mentality. In a study of a group of 150 chimpanzees at Ngogo in the Kibale National Park in Uganda, researchers found that chimpanzees went on patrol only after they had assembled enough members to have overwhelming force. Patrols require “safety in numbers” because attacking a foreign chimpanzee is dangerous, explains primatologist John Mitani of the University of Michigan, Ann Arbor, co-author of the study with primatologist David Watts of Yale University. Once a patrol formed, its members exhibited frequent displays of male bonding. “Cooperation among males is rare among animals,” says Watts. “It is conspicuous that closely related chimpanzees and humans deindividualize to engage in this coalitional aggression against outsiders.”
http://www.unil.ch/files/live/sites/determinismes/files/shared/document2004/sem1/Warrior_gene_2004.pdf

everest59
08-09-2015, 03:39 PM
I have the warrior gene according to Felix's tool. It says MAOA, 3R, warrior variant.
I just did the Athletigen thingie, and it says I am a "warrior":

The AA genotype at this marker is associated with “worrier” personality traits, while the GG genotype is more commonly associated with the “warrior”. The heterozygous (AG) genotype is intermediate in terms of personality traits. The AG genotype is also the most common in individuals of European-descent, where this phenotype has been the most extensively studied. The worrier phenotype is associated with increased susceptibility to stress, it is also linked to more efficient information processing (executive cognitive function) under most conditions (including under stress). Individuals with the AA genotype (worriers) have also been shown to exhibit greater attentional focus when aware of having made an error during tests based on learning tasks. Some research has also suggested that this genotype has a lower pain threshold although results are mixed. The warrior phenotype is associated with a lower susceptibility to stress, but it’s also linked to moderately reduced information processing (executive cognitive processing) under most conditions. Warrior genotypes (GG genotype) and heterozygotes (AG) do not exhibit the same increased attentional focus after errors as the worrier genotype (AA). Some studies have indicated greater levels of cooperativity in individuals with the warrior genotype. The COMT gene codes for an enzyme that degrades a family of molecules that includes dopamine, an important neurotransmitter. Dopamine regulation is important for a wide variety of personality traits. The worrier genotype is associated with lower COMT enzyme activity, which leads to higher dopamine levels. The warrior genotype is associated with higher COMT enzyme activity which leads to lower dopamine levels.

Petr
08-09-2015, 07:30 PM
Felix's tool shows wrong results.

cybele
09-28-2015, 05:02 AM
I'm G;G... but regarding my family, i'm not surprised at all.

Richard Nixon
10-18-2015, 03:44 PM
rs909525 GG (warrior) MAOA 3 repeats
rs6323 GG (Increased monoamine oxidase A activity)

... How am I supposed to interpret that?

Darko
11-05-2015, 11:36 PM
yesterday i upload my family finder raw data to promethease and i have this result:

rs4680(G;G)
(warrior) multiple associations, see details You have the VAL/VAL version of the snp discussed in this news article. It is able to perform better in a test where the optimal strategy changes. Placebo is less effective for you http://www.nytimes.com/2013/02/10/ma...pagewanted=all
rs4680 (Val158Met) is a well studied SNP in the COMT gene. 23andMe blog summarizes them as *rs4680(A) = Worrier. Met, more exploratory, lower COMT enzymatic activity, therefore higher dopamine levels; lower pain threshold, enhanced vulnerability to stress, yet also more efficient at processing information under most conditions *rs4680(G) = Warrior. Val, less exploratory, higher COMT enzymatic activity, therefore lower dopamine levels; higher pain threshold, better stress resiliency, albeit with a modest reduction in executive cognition performance under most conditions Roughly speaking, the predominant wisdom (known colloquially as the warrior/worrier hypothesis; summary at ) posits that people with Val alleles have increased COMT activity and lower prefrontal extracellular dopamine compar...
more info

The Illyrian Warrior
04-29-2017, 07:27 PM
rs909525 CC
rs6323 GG

Score warrior on both snps.

Kelmendasi
04-29-2017, 10:12 PM
CC GG Warrior Gene on both SNPs

rockman
06-15-2017, 06:03 PM
Got my Promethease results:
rs909525(G;G)
rs6323(G;G)

This is what's written:
Perhaps MAOA 3 repeats: Warrior Gene? People with this SNP may also have the 3 repeat version of MAOA, known as the Warrior Gene. It makes people more aggressive and antisocial. If you are male, you inherited this from your mother and your sons won't get it from you. Do not confuse this with the completely different warrior/worrier COMT gene.

I wonder if this makes me a "warrior" haha. I am rather averse and not comfortable with confrontational situations so it would come as a shock to me. Reminds me of the National Geographic Doc on MAOA where the violent guys and MMA fighters did not have MAOA yet all the Buddhist Monks had it. Perhaps it is a pacifist gene instead (hopefully)?

Nachobou
07-31-2017, 06:38 PM
not me

Grimbold
02-25-2019, 07:53 PM
Hello!

I'm:
rs909525 C
rs6323 G
rs2064070 A

What does it mean according to "warrior gene"?

Magnetic
02-25-2019, 09:23 PM
I have :

Rs909525 Genotype: C
Rs6323 Genotype: G

explain please ?

halfalp
02-25-2019, 09:42 PM
I just discovered the Genes and SNP's on 23andMe with that topic, cool to know.

But i dont seem to have the rs6323 and rs6909525 under the MAOA gene of chromosome X. Any clue? As for the COMT genes, rs4680 i'm A/G. So i guess not very warriorish.

Petr
02-25-2019, 09:57 PM
The only way to know if you have Warrior Gene is this test: https://www.familytreedna.com/landing/warrior-gene.aspx - I found no relation between this test and rs6323 and rs6909525.

Magnetic
02-27-2019, 11:28 AM
I have :

Rs909525 Genotype: C
Rs6323 Genotype: G

explain please ?

so what does it mean ? can anybody help ?

Nino90
02-27-2019, 11:43 AM
You can check if you are a "Worrier" or a "Warrior" on www.Yourdnaportal.com

Magnetic
02-27-2019, 11:56 AM
You can check if you are a "Worrier" or a "Warrior" on www.Yourdnaportal.com

it says "People with your genotype fall into the "worrier" category, which is an advantage in memory and attention tasks"

weird because I have been in a lot of fights when I was a child and teenager . have a high pain tolerance . have trained in boxing for years where I had heavy sparring wars with all kind of people including good tournament fighters where I even had my eye socket broken and had several concussions . I can lift up one of my best friends who is 189cm and 102kg like a baby . I am also a hard hitter and am even known by many people/gyms here for my punching power etc.

but at the same time I do worry often about things . I have anxiety and bad hypochondria and think too much about certain things

hmm

Censored
03-02-2019, 01:52 AM
I am heterozygous for it so I am both. It makes sense given what I know about myself.

LePrieur
03-11-2019, 05:32 AM
I am Heterozygous for it, so both.

tamandua
03-16-2019, 05:40 PM
There are two different genetic sequences referred to as "warrior genes"

1. The warrior/worrier distinction.(The rs4680 SNP in the COMT gene) This is about responding to stress and uncertainty - flying through without worry vs getting anxious, it has nothing to do with aggression.
See: NYT articles https://www.nytimes.com/2013/02/10/magazine/why-can-some-kids-handle-pressure-while-others-fall-apart.html
https://well.blogs.nytimes.com/2015/11/02/while-waiting-for-test-results-worrying-may-help-in-the-long-run/
and
https://www.snpedia.com/index.php/Rs4680

2. The MAOA sequence on the X chromosome. Here the number of repeats in a promoter area may/or may not be meaningful. Few repeats (say 1 or 2) may correlate with aggression if one's childhood is problem filled? or if one drinks? etc. etc. The nature of the environmental component is unclear. Though 3 repeats is sometimes called "warrior", in terms of population frequencies it is really as normal as having 3.5, 4 or 5 repeats.
Find a copy of the old National Geographic documentary "Born to Rage" You may have increased likelihood of becoming a Buddhist monk.
See this: https://geneticliteracyproject.org/2016/07/29/does-the-human-warrior-gene-make-violent-criminals-and-what-should-society-do/
and this
https://ghr.nlm.nih.gov/gene/MAOA#resources

Magnetic
03-17-2019, 06:08 PM
There are two different genetic sequences referred to as "warrior genes"

1. The warrior/worrier distinction.(The rs4680 SNP in the COMT gene) This is about responding to stress and uncertainty - flying through without worry vs getting anxious, it has nothing to do with aggression.
See: NYT articles https://www.nytimes.com/2013/02/10/magazine/why-can-some-kids-handle-pressure-while-others-fall-apart.html
https://well.blogs.nytimes.com/2015/11/02/while-waiting-for-test-results-worrying-may-help-in-the-long-run/
and
https://www.snpedia.com/index.php/Rs4680

2. The MAOA sequence on the X chromosome. Here the number of repeats in a promoter area may/or may not be meaningful. Few repeats (say 1 or 2) may correlate with aggression if one's childhood is problem filled? or if one drinks? etc. etc. The nature of the environmental component is unclear. Though 3 repeats is sometimes called "warrior", in terms of population frequencies it is really as normal as having 3.5, 4 or 5 repeats.
Find a copy of the old National Geographic documentary "Born to Rage" You may have increased likelihood of becoming a Buddhist monk.
See this: https://geneticliteracyproject.org/2016/07/29/does-the-human-warrior-gene-make-violent-criminals-and-what-should-society-do/
and this
https://ghr.nlm.nih.gov/gene/MAOA#resources

I have found this regarding MAOA : https://selfhacked.com/blog/about-mao-a-and-what-to-do-if-you-have-the-warrior-gene/

and I do have the warrior gene(s) according to the site

Goodman
03-18-2019, 01:42 AM
What are the statistics regarding these mutations for people incarcerated in jail.
I seem to be noticing certain types of people (mainly men) who I’d bet have the warrior gene, who seem to be getting into trouble or are causing others trouble. Hear me out; these people are prone to violence, tailgating, car crashes, getting women pregnant and leaving them, don’t like taking orders, cocaine use (often making symptoms worse), bullying and a lot of basically poor behavioural conditions. I’m sure I’ve read that the warrior gene is over represented in prisons. Anyone care to share a bit of knowledge on this or impart some views on these types of people who I believe are responsible for causing a hell of a lot of problems. I’m not discriminating but I think if we could test these people (all people so we can find the ones who’ve got it) when younger, then we could avoid by nurturing them, a whole load of problems if they’ve had a bad upbringing. Apologies to anyone with this gene as I know that most are thoroughly decent and law abiding citizens.

tamandua
03-20-2019, 03:53 PM
If you take your raw data file from wherever and submit it to Promethease you will get your genotype for warrior/worrier rs4680 (G;G is homozygous "test-taking warrior")

- - - and for rs909525 (G;G is homozygous "possible warrior") which may, or may not, correlate with the number of "warrior" promoter MAOA repeats. You can also get an actual reading of the number of repeats, not a questionable proxy, by ordering the specific test from ftdana. Pricey but precise.

Promethease will also have links to credible (for the most part) literature. There is a lot of junk information out there, please try to stick to reputable studies.

FionnSneachta
04-28-2019, 02:08 PM
I'm AA so I don't have the warrior gene apparently making me less aggressive and less anti-social. No surprise there.