View Full Version : Scientists discover how to ‘switch off’ autoimmune diseases

Jean M
09-04-2014, 10:49 AM

This is huge.

Scientists have made an important breakthrough in the fight against debilitating autoimmune diseases such as multiple sclerosis by revealing how to stop cells attacking healthy body tissue. Rather than the body’s immune system destroying its own tissue by mistake, researchers at the University of Bristol have discovered how cells convert from being aggressive to actually protecting against disease. The study, funded by the Wellcome Trust, is published today [03 September] in Nature Communications.

It’s hoped this latest insight will lead to the widespread use of antigen-specific immunotherapy as a treatment for many autoimmune disorders, including multiple sclerosis (MS), type 1 diabetes, Graves’ disease and systemic lupus erythematosus (SLE). MS alone affects around 100,000 people in the UK and 2.5 million people worldwide.

Scientists were able to selectively target the cells that cause autoimmune disease by dampening down their aggression against the body’s own tissues while converting them into cells capable of protecting against disease.

The paper itself is open access: Bronwen R. Burton et al., Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy, Nature Communications. http://www.nature.com/ncomms/2014/140903/ncomms5741/full/ncomms5741.html

09-08-2014, 02:12 AM
That is good to hear. There have been some such autoimmune diseases like MS and ME in my wider family. There are hard hearted idiots out there that doubt ME but when you see the effect on someone you know you just know its real and there are slowly emerging scientific tests that prove its a real physical autoimmune disease.

09-09-2014, 08:47 AM
Great news indeed! There are remedy now for people who have this kind of disease.

Jean M
09-09-2014, 09:58 AM
Great news indeed! There are remedy now for people who have this kind of disease.

It is not immediately available. Therapies are under development by http://www.apitope.com/ .

Apitope is an European biotech company focused on the discovery and development of revolutionary disease modifying therapies for autoimmune and allergic diseases, including multiple sclerosis, Graves’ disease and uveitis. Apitope peptide therapies are identified using our patented discovery platform. This has allowed us to build an impressive pipeline of candidate therapeutics, the most advanced of which is currently undergoing early clinical trials in patients as a treatment for multiple sclerosis.

09-23-2014, 04:06 AM
Yes this is good news for a terrible debilitating disease.

I have an interest in an Australian company working on antisense therapy. http://en.wikipedia.org/wiki/Antisense_therapy
Yesterday, hopeful clinical trial results were published in Neurology.

But it is a long road to patient treatment, I have been with this company for 20 years ! only now is it starting to look promising.

09-24-2014, 01:02 PM
That's great news and everything but hold your horses guys. First they must make sure that clinical tests are indeed promising and then we should pray that pharmaceutical companies also find it as a good idea and not classify as something they can't make money off.