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Heber
12-02-2014, 10:06 AM
Has anyone tried the new Tribe code NGS DTC DNA Service. I has some impressive specifications as described in the comparison chart from their FAQ. It appears to be available in the US only for the moment. On sale for $75.

3087

https://www.tribecode.com/

Salkin
12-02-2014, 10:32 AM
Interesting. I thought I was finished sending samples all over the planet, but this looks really tempting. I hope they'll go international soon enough.

I'm not getting through to their site, though. It's timing out.

Dr_McNinja
12-02-2014, 01:18 PM
I'm not in the US right now otherwise I'd have volunteered to be the guinea pig. That's not a bad price for the ridiculous number of SNPs they're claiming (12 million SNPs apparently, that'd be amazing just for the raw data... assuming they give you your raw data).


TribeCode sequences at least 12 million markers in your genome, over 100 times more than any other ancestry test, you can examine your chromosome portrait in much finer detail. You can zoom into each segment of each of the 22 chromosomes. For fun you can even see which parts of the world, your ancestral heritage, could be influencing your capabilities, e.g. athletic potential.

bored
12-02-2014, 04:18 PM
Damn that looks amazing. 12 million SNPs :hail:

Wulf Warrior
12-02-2014, 04:37 PM
It looks promising, 62 population references and 12 million SNPS?

*drools*

Quick edit.

There features also look very interesting, the ethnicity composition and Haplogroup lineages specifically.

It needs to be available in the UK!

ArmandoR1b
12-02-2014, 05:05 PM
There is another thread on this at http://archiver.rootsweb.ancestry.com/th/read/GENEALOGY-DNA/2014-12/1417464395

ArmandoR1b
12-02-2014, 05:16 PM
In the About US link it says The explorers at Centrillion Biosciences® created the TribeCode DNA Ancestry Test.

There was a news story in July 2010 http://venturebeat.com/2010/07/13/centrillion-biosciences-brings-in-2m-to-analyze-dna/

The Centrillion Biosciences staff is listed at https://www.centrillionbio.com/biography/

They say they do whole genome sequencing http://services.centrillionbio.com/services/sequencing-services/whole-genome-sequencing/

ArmandoR1b
12-02-2014, 05:29 PM
Report examples can be seen at https://www.tribecode.com/product/tribecode-dna-ancestry-test/

I'm thinking the price is worth the Y-DNA and mtDNA SNP results. I think I am going to try it just for the Y-DNA.

vettor
12-02-2014, 05:29 PM
Does it state any cost on international freight?

vettor
12-02-2014, 05:32 PM
Report examples can be seen at https://www.tribecode.com/product/tribecode-dna-ancestry-test/

I'm thinking the price is worth the Y-DNA and mtDNA SNP results. I think I am going to try it just for the Y-DNA.

is this a one off special price of $74

Scarlet Ibis
12-02-2014, 05:36 PM
Looks nice, but too new for me to shake off all my suspicions.

Also, people who are interested in getting their raw data might find this post on their facebook page (https://www.facebook.com/tribecode) to be interesting.


TribeCode Full mitochondria sequencing is included with TribeCode Gold. It is not limited to sub-regions. Raw data download is feature under review. The data file is very large, much larger than what other companies generate. Users will also need to have the tools to process the data. Tribecode is considering releasing some of the tools for data/scientifically oriented customers.
Like · 2 · November 30 at 7:24pm

Scarlet Ibis
12-02-2014, 05:49 PM
It seems like they're not offering relative matching, either, or at least not in the manner of gedmatch, 23andme, Family Finder, AncestryDNA, etc. Personally, I wouldn't care about that, particularly since it would have a largely US-only customer base, but I thought others might be interested.


TribeCode The test for kindship is built in, but we currently do not specifically offer this because most of the other services offer relative finder that identifies dubious 4th or 5th cousin. We want to offer someting better However, you can already find people whose DNA is close to you at what we call diversity space or PCR. It is currently a fun 3D visualization of people's DNA similarity. We are testing new software that can do better job identifying distance relatives. For close relatives, it is quite easy to find. A user friendly relative finder may be in the next software release which include many more features. All customers will get updated reports.
Like · 1 · November 28 at 10:02pm

vettor
12-02-2014, 06:13 PM
would the proposed depth of testing mean this better than Yfull or bigY

Erik
12-02-2014, 09:04 PM
I think I'll buy this, thanks for posting.

ArmandoR1b
12-02-2014, 09:08 PM
is this a one off special price of $74

I have no idea. I took advantage of the $74 price just in case. I hope I haven't wasted my money on a deal too good to be true but at least it doesn't cost $475 dollars even if I have to wait a whole year like some BigY customers have had to.

ArmandoR1b
12-02-2014, 09:21 PM
would the proposed depth of testing mean this better than Yfull or bigY

YFull doesn't do testing. They analyze files from FullGenomes and BigY. From what Tribecode is claiming they can do better than FullGenomes and BigY but I won't believe it until the Tribecode files have been analyzed. The price is just too low to believe it. Dr. Doug McDonald has the same reservation http://archiver.rootsweb.ancestry.com/th/read/GENEALOGY-DNA/2014-12/1417535264

It's best that you save your money and let us guinea pigs tell you how we fare.

Erik
12-02-2014, 10:24 PM
I just bought the kit!

vettor
12-03-2014, 04:49 AM
I have no idea. I took advantage of the $74 price just in case. I hope I haven't wasted my money on a deal too good to be true but at least it doesn't cost $475 dollars even if I have to wait a whole year like some BigY customers have had to.

price went up to $89 , 12 hours after my previous comment

Il Papŕ
12-03-2014, 10:02 PM
https://www.tribecode.com/

By navigating on their website I saw that they are offering a 12 millions markers test with full mtdna coverage and ancestry composition with 62 populations who seems at first sight even better than any others.It also seems to offer precise and up to date y-dna compared to the 5yo outdated 23andme phylogeny tree and 20yo outdated STR test Ftdna has to offer.And all of this for only 99$(89$ for christmas sale)

Anybody plan to try it ?

Artmar
12-03-2014, 10:16 PM
I plan to order Tribecode as soon as they start shipping to Europe. So, in the first months of 2015.

Generalissimo
12-03-2014, 11:30 PM
The autosomal analysis with only 62 populations (presumably from the 1000 Genomes and HGDP) looks like crap. The ancestry painting design is very limited too.

But the Y-hg and mtDNA analyses might be useful.

Erik
12-03-2014, 11:41 PM
I've already ordered and I started an Ashkenazi group on their site.

Il Papŕ
12-03-2014, 11:44 PM
The autosomal analysis with only 62 populations (presumably from the 1000 Genomes and HGDP) looks like crap. The ancestry painting design is very limited too.

But the Y-hg and mtDNA analyses might be useful.

Even if the DNA interpretation doesn't seem so good(and for the moment it's just an impression).Just to know that they are analysing 12 million markers make it worth it in my opinion, 23andme offer only 600 000 markers for the same price. and About the Ancestry painting, the design looks almost the same as 23andme one.

Generalissimo
12-04-2014, 12:20 AM
Even if the DNA interpretation doesn't seem so good(and for the moment it's just an impression).Just to know that they are analysing 12 million markers make it worth it in my opinion, 23andme offer only 600 000 markers for the same price. and About the Ancestry painting, the design looks almost the same as 23andme one.

I doubt they can use 12 million makers in each analysis. It's just not economical to do that.

Also, their ancestry painting looks more like the chromosome paintings at GEDmatch.

There's really no need for any hype based on what they've put up on their website so far. The 23andME analysis seems better IMO.

Il Papŕ
12-04-2014, 12:25 AM
I doubt they can use 12 million makers in each analysis. It's just not economical to do that.

Also, their ancestry painting looks more like the chromosome paintings at GEDmatch.

There's really no need for any hype based on what they've put up on their website so far. The 23andME analysis seems better IMO.

Well they have an AP similar to gedmatch but also to 23andme one:

http://i.imgur.com/5bHd9ML.png
I just have a doubt on how precise and accurate their Ancestry composition can be.

And they does clearly state that they are testing for 12 million markers:


it’s a unique and individual portrait depicting the ancestral story woven into your DNA. Because TribeCode sequences at least 12 million markers in your genome, over 100 times more than any other ancestry test, you can examine your chromosome portrait in much finer detail

Generalissimo
12-04-2014, 12:47 AM
They sequence 12 million markers. They don't say how many they use. Fine print...

Generalissimo
12-04-2014, 12:49 AM
And it looks like they use Finnish samples from the 1000 Genomes to get the Scandinavian cluster. That'd be funny if true.

ZephyrousMandaru
12-04-2014, 02:39 AM
I'm skeptical, they claim to their DNA analysis scans 12 million SNPs, which if true would be a significantly higher coverage of your genome. However, what's important to remember is that just because they're genotyping more SNPs doesn't insinuate that every SNP that's being sequenced is ancestry informative nor do they specify whether every customer is going to have all 12 million SNPs analyzed. Which is likely not going to be the case for two reason.

1. Cost

2. Labor intensive

So in all likelihood, it's going to be an approximation, just like 23andMe when they claim to scan through 1 million SNPs, which in actuality most people only have about 800,000-900,000 data points scanned. Which only 100,000-200,000 of which the ADMIXTURE calculators use.

vettor
12-04-2014, 04:49 AM
I'm skeptical, they claim to their DNA analysis scans 12 million SNPs, which if true would be a significantly higher coverage of your genome. However, what's important to remember is that just because they're genotyping more SNPs doesn't insinuate that every SNP that's being sequenced is ancestry informative nor do they specify whether every customer is going to have all 12 million SNPs analyzed. Which is likely not going to be the case for two reason.

1. Cost

2. Labor intensive

So in all likelihood, it's going to be an approximation, just like 23andMe when they claim to scan through 1 million SNPs, which in actuality most people only have about 800,000-900,000 data points scanned. Which only 100,000-200,000 of which the ADMIXTURE calculators use.

this is tribecode
http://www.isogg.org/wiki/Centrillion_Biosciences

http://www.centrillionbio.com/

http://www.centrillionbio.com/biography/

http://services.centrillionbio.com/services/sequencing-services/whole-genome-sequencing/

The final result is, for who has been tested before is......will they find out any extra stuff for you, but, they seem to want to get info on the masses who care little once they are tested. It seems very likely they will squeeze out Natgeno in the market of genetics, something natgeno did not have their heart into

vettor
12-04-2014, 04:58 AM
And it looks like they use Finnish samples from the 1000 Genomes to get the Scandinavian cluster. That'd be funny if true.

sounds like they also got a foothold/start from an association with DNACousins............

Dr_McNinja
12-04-2014, 10:35 AM
I'm skeptical, they claim to their DNA analysis scans 12 million SNPs, which if true would be a significantly higher coverage of your genome. However, what's important to remember is that just because they're genotyping more SNPs doesn't insinuate that every SNP that's being sequenced is ancestry informative nor do they specify whether every customer is going to have all 12 million SNPs analyzed. Which is likely not going to be the case for two reason.

1. Cost

2. Labor intensive

So in all likelihood, it's going to be an approximation, just like 23andMe when they claim to scan through 1 million SNPs, which in actuality most people only have about 800,000-900,000 data points scanned. Which only 100,000-200,000 of which the ADMIXTURE calculators use.

We can make new calculators using new datasets of high SNP samples. If they give you the raw data (which I'm not sure they presently do), then it'd be worth it for that alone I think.

Admixture/Plink are relatively easy to use, one would just need a lot of user-submitted samples and a very fast computer. It would be interesting to at least start such an endeavor and compare initial results to the 100-200k SNP Admixture results.

dp
12-06-2014, 06:51 PM
I just bought the kit!
They did seem to emphasis AJ's and Far Easterners, so good luck :-) Got to save my Christmas money for Y-DNA deep clade testing.

PS: "Sooie" :-)
PPS: I don't know what noises guinea pigs make :biggrin1:

Isidro
12-07-2014, 08:44 PM
Ordered mostly for the Y and MT. Does anyone know what snp's are tested?.

Artmar
12-07-2014, 11:33 PM
Ordered mostly for the Y and MT. Does anyone know what snp's are tested?.
You can register on a Tribecode.com and then choose exemplary ancestry. After that, you will be able to find the haplotree.

ArmandoR1b
12-08-2014, 03:26 AM
You can register on a Tribecode.com and then choose exemplary ancestry. After that, you will be able to find the haplotree.

Thanks. It at least has P312 and DF27 which Geno 2.0 doesn't have. FTDNA doesn't have DF27 in it's tree either. This is a good test for 23andme people that are terminal for R1b1b2a1a. Most of them would be positive for both P312 and DF27.

Neacal
12-08-2014, 06:56 PM
I bought one of these last monday, but I'm still waiting for it to arrive. I can't wait to see the results. I've already tested with Ancestry and 23andme, so it will be interesting to see how the results differ. Does anyone know if the raw data (assuming it becomes available) will ever be compatible with third party calculators?

vettor
12-08-2014, 07:14 PM
Thanks. It at least has P312 and DF27 which Geno 2.0 doesn't have. FTDNA doesn't have DF27 in it's tree either. This is a good test for 23andme people that are terminal for R1b1b2a1a. Most of them would be positive for both P312 and DF27.

If what you say is correct then Tribecode will eventually replace 23andme for ancestral genetics in the USA as 23andme has no want in updating its 2008 tree. 23andme will be left with its medical arm which has been severed in the USA but allowed in Canada and the UK

Isidro
12-08-2014, 07:53 PM
I just saw one of their demos and looks promising:
3147

Neacal
12-08-2014, 08:08 PM
Overall, I'm very excited about this. I've been playing around with the features on the site and most of it looks very promising. However, I am slightly concerned about how accurately they can detect/interpret Iberian ancestry. There are two sample profiles with significant Amerindian (and "Hispanis looking") photos but both of them show primarily Italian ancestry (within the European category). I'm well aware that there was significant Italian immigration to Latin America, but it seems odd to me that one of the Latin American profiles shows no Iberian and the other vey little while both show a good amount of Italian.

Here are the profiles I was referring to if anyone is interested in seeing what the company's autosomal results look like:
http://i.imgur.com/N9Fzg7a.png
http://i.imgur.com/H3xGaCO.png

Wulf Warrior
12-08-2014, 08:27 PM
I can't wait to see the results of members who have ordered it. I still hope that it becomes available in the UK.

Erik
12-08-2014, 08:35 PM
Overall, I'm very excited about this. I've been playing around with the features on the site and most of it looks very promising. However, I am slightly concerned about how accurately they can detect/interpret Iberian ancestry. There are two sample profiles with significant Amerindian (and "Hispanis looking") photos but both of them show primarily Italian ancestry (within the European category). I'm well aware that there was significant Italian immigration to Latin America, but it seems odd to me that one of the Latin American profiles shows no Iberian and the other vey little while both show a good amount of Italian.

Here are the profiles I was referring to if anyone is interested in seeing what the company's autosomal results look like:
http://i.imgur.com/N9Fzg7a.png
http://i.imgur.com/H3xGaCO.png

What do they have for speculative?

Neacal
12-08-2014, 09:31 PM
What do they have for speculative?

Here are the speculative results for the same two individuals. To be honest, I found them even more confusing. They are a new service, tjough, and I'm sure they'll refine and modify the categories over time.

Also the self-declared tab just shows default values for every group. I can only imagine that once they get enough samples, they'll fix that and stat using that data to enhance their predictions.

http://i.imgur.com/mgm8HRK.png
http://i.imgur.com/mxoEVVq.png

cyna
12-09-2014, 03:18 AM
How does one see the other profiles?

The regional results look somewhat odd.

Isidro
12-09-2014, 05:34 AM
Well it looks like they are also testing for L238/S182, DF19/S232,DF99/S11987.

ArmandoR1b
12-09-2014, 12:48 PM
If what you say is correct then Tribecode will eventually replace 23andme for ancestral genetics in the USA as 23andme has no want in updating its 2008 tree. 23andme will be left with its medical arm which has been severed in the USA but allowed in Canada and the UK
I think they will still have a large share of the market due to their Ancestry Composition being the best Biographical Analysis on the market and the price being a flat $99. FTDNA was already better than 23andme for Y-DNA and FTDNA should be even better than Tribecode for Y-DNA SNPs once they release their SNP-packs. I don't know if FTDNA will offer the SNP-packs to people that haven't had an STR test though. The competition for autosomal DNA to 23andme is AncestryDNA. What I've seen so far of the Tribecode Biographical Analysis they are worse than 23andme and AncestryDNA.

ArmandoR1b
12-09-2014, 12:51 PM
Overall, I'm very excited about this. I've been playing around with the features on the site and most of it looks very promising. However, I am slightly concerned about how accurately they can detect/interpret Iberian ancestry. There are two sample profiles with significant Amerindian (and "Hispanis looking") photos but both of them show primarily Italian ancestry (within the European category). I'm well aware that there was significant Italian immigration to Latin America, but it seems odd to me that one of the Latin American profiles shows no Iberian and the other vey little while both show a good amount of Italian.

Here are the profiles I was referring to if anyone is interested in seeing what the company's autosomal results look like:
http://i.imgur.com/N9Fzg7a.png
http://i.imgur.com/H3xGaCO.png

You bring up a very good point. The Ethnicity Composition leaves a lot to be desired. The Y-DNA SNPs are the only good part of the test and only for certain haplogroups that haven't tested with Geno 2.0, BigY or FullGenomes.

Isidro
12-09-2014, 02:37 PM
I don't know what to make of the demo samples, just going by looks, there are two guys that could pass as Spaniards ( all of them could be of course) one is not available and the other is 100% European and 100% British.
If they are in touch with trends maybe a member rep will chime in to get their product into high gear...

Isidro
12-12-2014, 02:27 PM
Regarding my above post, it might be random pictures of people and random results.
6 days since I ordered the kit, so far no E-mails or any signs from Tribecode.I think I will keep my expectations low for now. :)

dp
12-12-2014, 10:10 PM
One of my concerns is how the raw data will be sent to the user, if allowed. IE. My version of Excel only allows 65,000 rows of data, so I have to split up the data into smaller files to use it in anyway. I'm not even sure my computer could load a file with xx million lines.
Also, I'd rather what upon purchasing a new product until their format has been submitted to GEDmatch, and conversion routines made --preferably prior to launch-- so users can see who they match on at least that platform.
dp :-)

Erik
12-12-2014, 10:56 PM
I just received the kit!

The spitting tube has a terrible design and giving my DNA sample was not a fun experience, just a warning.

Isidro
12-12-2014, 10:59 PM
Good questions David.
I should have spoken earlier, I just got my kit today. It took about a week. User friendly, very similar to 23andMe's kit. We do have to pay return postage, they recommend $2.07 in stamps.
One thing I noticed as I was registering the kit, and if I understood correctly they are actually sequencing the Full MtDNA, which it would be just wow.
I am still wondering how extense is the Y going to be.

dp
12-15-2014, 03:55 PM
One thing I noticed as I was registering the kit, and if I understood correctly they are actually sequencing the Full MtDNA, which it would be just wow.

For a complete mtGenome it could be worthwhile. That is if you can get the results separated from those of the auDNA and yDNA, an preferably into a .fasta file. Then the file might be aligned --if needed-- to match either of the standards and be submittable to GENBANK. I say aligned because the mitochondrion is circular, so where you start matters. Then there's a handful of places that may need N's inserted, to get the file into one of the standards --I prefer RSRS.
dp :-)

KCW
12-30-2014, 07:00 PM
Looks like they're sold out currently. I wonder how many kits were in the initial production run?

Isidro
12-30-2014, 11:36 PM
I am surprised they run out of kits. It could mean good news or not so good. If they run out because of great demand or it was just a one time limited testing. Let's hope for the best.

KCW
12-30-2014, 11:52 PM
Time will tell. I ordered one and just sent it back, went to order another and it was a no go.

ArmandoR1b
12-31-2014, 01:34 PM
I was finally able to talk to a rep a few weeks ago. They said that they weren't going to be able to define my subclade further than it's current position on the Y-DNA tree even though there are several SNPs below it defined at YFull and they wouldn't be able to find new SNPs or retest for SNPs once more are included on their tree. That means the test really isn't Next Generation Testing. Since Y-DNA and NGS testing was my only on interest in the test I cancelled my order. It is still good for those that have not had SNP testing or have only tested with 23andme. BritainsDNA is still better and BigY and FullGenomes are even better for Y-DNA testing.

KCW
01-09-2015, 06:36 PM
Checked again. Still sold out. Not a good sign, I was definitely in for one more kit...

Isidro
01-11-2015, 03:39 AM
Four days ago I got an E-mail upgrading from 40%-kit shipped out, to 60%-received; next mark will be 80%-analyzing.
I wonder where all this is going, the website is at stand still pretty much.Maybe there will be a gala display of results and website and tons of kits for sale.

KCW
01-11-2015, 04:29 AM
I received the same message too about my one kit, I guess we will see.

KCW
01-27-2015, 03:13 AM
Received an update message in status today but their kits are still sold out.

dp
01-27-2015, 06:50 PM
I just bought the kit!

Dear Erik,
Been nearly 50 days, any results yet...
dp :-)

Isidro
01-28-2015, 04:29 AM
Got mi update from 60% to 80% .
I wonder if everyone waiting is in the same schedule or there is an advanced group.

Neacal
02-02-2015, 04:56 PM
Got mi update from 60% to 80% .
I wonder if everyone waiting is in the same schedule or there is an advanced group.

I too am at 80%, hopefully we'll all reach 100 soon!

Ron from PA
02-04-2015, 02:27 PM
I'm at 80%.

Erik
02-04-2015, 08:37 PM
At 80% now

Sein
02-14-2015, 06:53 AM
Overall, I'm very excited about this. I've been playing around with the features on the site and most of it looks very promising. However, I am slightly concerned about how accurately they can detect/interpret Iberian ancestry. There are two sample profiles with significant Amerindian (and "Hispanis looking") photos but both of them show primarily Italian ancestry (within the European category). I'm well aware that there was significant Italian immigration to Latin America, but it seems odd to me that one of the Latin American profiles shows no Iberian and the other vey little while both show a good amount of Italian.

Here are the profiles I was referring to if anyone is interested in seeing what the company's autosomal results look like:
http://i.imgur.com/N9Fzg7a.png
http://i.imgur.com/H3xGaCO.png

For what it's worth, the pictures aren't of the actual individuals who were tested. They are just random photos.

I received my results a few days ago, and I'm not really sure as to how I should evaluate them. Here's my "Ethnicity Composition":

Baloch/Brahui/Makrani=27.39%
Pashtun=16.53%
Sindhi=11.54%
Burusho=10.13%
Italian=7.73%
Russian=6.43%
Uyghur=6.01%
Kalash=4.59%
Druze=4.11%
Scandinavian=3.21%
Caucasus=2.32%

To be honest, not too bad.

I can't really evaluate these estimates, mainly since this is the first time I've seen personal results that are supposedly based on "next-generation sequencing". I'm guessing no apples-to-apples comparison can be made until other similar services arise, and I see how I stack up with them.

I also checked the PCA. My results are quite unexpected, as I cluster with the Kalash, not with the HGDP Pashtuns, all of whom are quite distant from myself. Again, I don't know if this is more accurate than what I'm used to, since this is supposedly based on a much larger number of SNPs than anything I've seen before. Although, it's very irritating how the actual mechanics are shrouded in complete mystery, lol. There is just no technical explanation from the company as to what methods they've utilized for "Ethnicity Composition", how many actual SNPs we're dealing with, what read-depth is involved, etc. This is crucial information that needs to be presented.

Edit: I forgot to add my "Caucasus" score to the results.

Táltos
02-14-2015, 03:38 PM
For what it's worth, the pictures aren't of the actual individuals who were tested. They are just random photos.

I received my results a few days ago, and I'm not really sure as to how I should evaluate them. Here's my "Ethnicity Composition":

Baloch/Brahui/Makrani=27.39%
Pashtun=16.53%
Sindhi=11.54%
Burusho=10.13%
Italian=7.73%
Russian=6.43%
Uyghur=6.01%
Kalash=4.59%
Druze=4.11%
Scandinavian=3.21%

To be honest, not too bad.

I can't really evaluate these estimates, mainly since this is the first time I've seen personal results that are supposedly based on "next-generation sequencing". I'm guessing no apples-to-apples comparison can be made until other similar services arise, and I see how I stack up with them.

I also checked the PCA. My results are quite unexpected, as I cluster with the Kalash, not with the HGDP Pashtuns, all of whom are quite distant from myself. Again, I don't know if this is more accurate than what I'm used to, since this is supposedly based on a much larger number of SNPs than anything I've seen before. Although, it's very irritating how the actual mechanics are shrouded in complete mystery, lol. There is just no technical explanation from the company as to what methods they've utilized for "Ethnicity Composition", how many actual SNPs were dealing with, what read-depth is involved, etc. This is crucial information that needs to be presented.

Sein,
Thanks for sharing your admixture results. How was their breakdown of your Y DNA and mtDNA?

Sein
02-15-2015, 04:04 AM
Sein,
Thanks for sharing your admixture results. How was their breakdown of your Y DNA and mtDNA?

Hi Táltos,

My mtDNA haplogroup is apparently plain M30. My reported Y-HG is disappointing, R1a1a (M417), since I already knew that I'm positive for Z94, but negative for L657. I was expecting them to report something further down on the tree.

Kurd
02-15-2015, 05:03 AM
[B]Baloch/Brahui/Makrani=27.39%
Pashtun=16.53%
.
.
.
Kalash=4.59%


I also checked the PCA. My results are quite unexpected, as I cluster with the Kalash, not with the HGDP Pashtuns, all of whom are quite distant from myself.

Not bad indeed! Do you mean that you cluster with Baloch, since you have the greatest overlap with them?

Isidro
02-15-2015, 07:05 AM
I also got my results. It feels like the analysis is a basic software program with scores that remind me the old DNATribes. My Y DNA results is P312 and MTDNA HV0-195C. They added the 195C to the 23andMe HV0.
I hope those results including the Mt and Y are part of the analysis and the raw data shows more.

3783

Sein
02-16-2015, 04:22 AM
Not bad indeed! Do you mean that you cluster with Baloch, since you have the greatest overlap with them?

I also expected that to be the case (clustering with the Baloch), but apparently I cluster with the Kalash.

parasar
02-16-2015, 06:30 AM
Hi Táltos,

My mtDNA haplogroup is apparently plain M30. My reported Y-HG is disappointing, R1a1a (M417), since I already knew that I'm positive for Z94, but negative for L657. I was expecting them to report something further down on the tree.

Do you have the raw SNP data?

Sein
02-16-2015, 10:43 PM
Do you have the raw SNP data?

Unfortunately, they haven't provided the raw-data (yet). I really hope they do so.

ArmandoR1b
02-17-2015, 12:49 AM
I also got my results. It feels like the analysis is a basic software program with scores that remind me the old DNATribes. My Y DNA results is P312 and MTDNA HV0-195C. They added the 195C to the 23andMe HV0.
I hope those results including the Mt and Y are part of the analysis and the raw data shows more.


There aren't any Spaniards at 23andme that have shared their DNA with me that have any West Asian. Some of the people that have shared with me at 23andme are Basque.

The Y-DNA test really sucks if they didn't at least show you to be DF27 and Z195 which are above R1b-L176 and below P312. They even have DF27 in their phylogenetic tree.

I'm not liking what I'm seeing.

So others can see it here is a screenshot of the Tribecode tree with P312 and DF27 showing.

3792

http://i.imgur.com/9emh7tF.png

That's from https://www.tribecode.com/ancestry/paternal-lineage/#1

The YFull Tree is for DF27 is at http://www.yfull.com/tree/R1b1a2a1a2a/

rod
02-17-2015, 09:44 AM
mtDNA V9a1 - correct (better than 23andme)
yDNA - R1b-P311 (as out of date as 23andme) - they may have DF27 in their tree but it looks like they aren't testing for it.

Confident
100.00% European
6.66% Basque Country
46.12% British Isles
9.71% France
19.79% Italian Peninsula
7.26% Russia
10.47% Scandinavia

Speculative
98.49% European
6.02% Basque Country
47.84% British Isles
9.07% France
3.20% Iberian Peninsula
16.27% Italian Peninsula
6.52% Russia
9.58% Scandinavia

1.51% West Asian

Italian Peninsula has me baffled - maybe it's generic southern European.

They did deliver my results in the predicted time frame.

ArmandoR1b
02-17-2015, 01:09 PM
yDNA - R1b-P311 (as out of date as 23andme) - they may have DF27 in their tree but it looks like they aren't testing for it.

That's basically what I was pointing out with the results of Isidro. I had also forgotten to point out that he didn't show positive for Z195 either.

Are they showing negative results?

Isidro
02-17-2015, 11:43 PM
ArmandoR1b, I have very low West Asian in others analysis, some close to 0 like the Basques. The image you show of the Y-tree from Tribecode is like mine exactly and it ends in P312... Over the years after all tests I am L176/Z198+.

Well , I just got s prompt response today upon me requesting if the Y-Ch and Mt being smaller files could be available soon. Their response was:

"Fast Q files of raw data will be made available in the future. We are not currently offering this service."

Well, I mentioned the DNATribes similarity to these results by memory; I will try to pull the old file and compare scores.

Isidro
02-18-2015, 12:24 AM
Here is an image of my Tribecode and DNATribes World and regional (2012) results.

3800

ArmandoR1b
02-18-2015, 08:15 AM
ArmandoR1b, I have very low West Asian in others analysis, some close to 0 like the Basques.
That is what I fully expected and was inferring would be the case. I have seen more people state that 23andme Ancestry Composition is more accurate than from other companies.


The image you show of the Y-tree from Tribecode is like mine exactly and it ends in P312
Yes, that is exactly what I understood from your first post. That is why I had stated it was for others to see.


... Over the years after all tests I am L176/Z198+.
I already knew that. R1b-L176 is in your signature and I'm pretty sure you used to be in the DF27 and/or SRY2627/L176.2 DNA projects. That means that the Tribecode test sucks for the Y-DNA test because it should have shown you to be positive for DF27 and for Z195 which are both in the Tribecode tree. In post #75 rod shows to be DF27** in his signature and he doesn't even show to be P312 much less DF27. That is a huge fail on the part of Tribecode. I give Tribecode an F for the Y-DNA test and since that test will cause a lot of confusion for people without an understanding that it isn't accurate and that they need to get SNP tests from other companies I give Tribecode an F for the whole test. I don't want my distant relatives, that are descendants of my ancestors, spreading misinformation about their Y-DNA SNP because of a bad test.


Well , I just got s prompt response today upon me requesting if the Y-Ch and Mt being smaller files could be available soon. Their response was:

"Fast Q files of raw data will be made available in the future. We are not currently offering this service."
That is another reason not to use Tribecode. I am extremely happy that I had canceled my order once I spoke with a rep. It took forever to get a hold of one.

Isidro
02-18-2015, 01:53 PM
ArmandoR1b, I fought common sense and common sense won... LOL.

I agree that as we stand with these analysis results it's worse than useless because it misleads with totally off the wall analysis.

There are 2 possible redemption points for the 100 bucks. One, the possible access to raw data which is personal property in my view.Second, and right now, possible mining of the chromosome browser, I am not expert enough to decipher that one. Here is a detailed shot of the browser:

3803

KCW
02-23-2015, 07:59 PM
Looks like you can now order kits again but there is a strange message on the main site:

We have very limited inventory now. If you'd like to order one, please send your request to [email protected] Let us know why you want it and we'll review your request ASAP.

Does this seem strange to anyone else? I'd like to order another kit but I am unsure where this company is going.

Scarlet Ibis
02-23-2015, 11:09 PM
Looks like you can now order kits again but there is a strange message on the main site:

We have very limited inventory now. If you'd like to order one, please send your request to [email protected] Let us know why you want it and we'll review your request ASAP.

Does this seem strange to anyone else? I'd like to order another kit but I am unsure where this company is going.

Yeah, I'm not impressed, to say the least. I don't know what they're trying to get at with that kind of a statement. Enter your email address, your name, and include a brief essay on why you want to buy a product, then maybe they'll consider taking your money, and delivering the consumer product?? If it didn't have its own webpage, I'd actually wonder if you quoted some Craigslist college scholarship essay "offer." Absurd.

Isidro
02-24-2015, 12:56 AM
I've read the order page. Unusual for sure.It could be poorly translated instructions, I see those errors often in the Spanish in USA product labels .
And it kind of makes sense with the E-mail responses in the past.

Petr
02-24-2015, 08:34 AM
The page about the raw data download: https://www.tribecode.com/help/raw-data-download/ disappeared, Google cache still contains the statement:
We're not ready to offer raw data in any form just yet, but we are considering the best ways to provide this information to our customers.The same here: https://www.tribecode.com/help/sequencing-information/

Sequencing information
Hi I am a graduate researcher and am interested in obtaining a kit from tribecode. I still have some questions which are not really answered on your website. 1) what is the average coverage? 2) what is the average read length? 3) how many base pairs is covered? 4) will I be able to download FASTQ files? I have purchased 23andMe V4 and found the data to be quite noisy. Many disease risk SNVs were not called. I am intrigued with your service, but would like to expand on your analysis with my own. Thank you for your time.
Asked on Dec 5, 2014 at 16:53
Dan Anta

Hello Dan,

Our coverage for the autosomes and sex chromosomes is approximately 0.1x coverage of over 3.2 billion base pairs. For the maternal haplogroup, we sequence virtually all the mitochondrial DNA.

The TribeCode test doesn’t use individual markers or SNPs. Instead, the algorithm uses “blocks” of DNA sequence that distinguishes more than 60 different populations worldwide. Our method is based on an algorithm developed and published by Stanford genetics and statistics professor Dr. Hua Tang.

We are not currently providing raw data information to our customers, but we are planning to develop and release this feature as soon as we figure out the logistics. We realize that raw data is of great interest to genealogists and are working hard to find the best way to supply it to you.
Posted by TribeCode
Answered On Dec 9, 2014 at 17:39



Maybe they stopped their plans?

KCW
02-24-2015, 05:22 PM
While I was interested in buying another kit I think it's safe to say that I'm not going to unless things change. Too bad, I had hoped this might lead somewhere interesting. I guess there's always a chance something might change though.

vettor
02-24-2015, 05:30 PM
I wonder if tribe code was in union with DnaTribes..........who recently had their owner die and that is why DnaTribes has not produced anything in the last 3 months

Ron from PA
02-27-2015, 01:36 PM
Got my results and they're useless. Self estimate i'm 65-70% PA Dutch/German. I was concerned when I looked at the demo results and saw no German. So I emailed the day I ordered, and they assured me they had German samples. Got my results two days ago and lo and behold no German. Emailed them and they admitted they have no German at this time but plan too in the future. Honestly its fraud to market this in the USA. The largest self reported group in this country is German as of now. I also asked about raw data have'nt heard back yet.

Salkin
02-27-2015, 01:45 PM
They lied about having German reference data? WTF? Scammers!

Scarlet Ibis
02-27-2015, 08:50 PM
Yep. Saw this a while back.

Huntergatherer1066
02-28-2015, 03:19 AM
Sounds like they really got the cart before the horse

Ron from PA
02-28-2015, 03:19 AM
They replied today and said they don't have a date on a German sample, but will be in next few months. Ignored my question about raw data.

Petr
03-01-2015, 11:00 PM
Really disappointg. They claimed:

100 times more data than any other test
Reality: No data available

Most detailed ethnicity composition
Reality: Really strange results

Maternal ancestry fully decoded (Mitochondrial DNA fully sequenced)
Reality: just about 50 % of mtDNA sequenced, many markers missing, in my case, I'm J1c1 + 6 extra markers, they did not reported any of these 6 extra markers. 2 markers reported incorrectly.

Paternal ancestry (Y chromosome haplogroup) included
Reality: just few of hundreds SNP tested. In my case just 6 markes reported:
A0-T - L1085
...
BT: V202, L971
...
K: P128/PF5504
...
R: no result
R1: P286/PF6136, remaining 10 markers no result
R1b: no result
R1b1: no result
R1b1a: no result
R1b1a2: M269, remailning 6 markers no result
R1b1a2a: no result
R1b1a2a1: no result
R1b1a2a1a: no result
R1b1a2a1a2: no result
R1b1a2a1a2b: no result
R1b1a2a1a2b1: no result
R1b1a2a1a2b1c: no result
R1b1a2a1a2b1c1: no result

Salkin
03-02-2015, 10:06 AM
Yep. Saw this a while back.

Their inability to spell "German" is not reassuring, either. :)

vettor
03-02-2015, 06:23 PM
Their inability to spell "German" is not reassuring, either. :)

maybe they are using this word, Germen in USA ( american slang) , they ( americans ) do spell many words very differently to what is true English, like centre , they have center and many, many, many other words

Táltos
03-03-2015, 04:22 AM
maybe they are using this word, Germen in USA ( american slang) , they ( americans ) do spell many words very differently to what is true English, like centre , they have center and many, many, many other words

Nope. We spell German with an "A" here in the USA. Not sure why Tribe Code has a problem spelling it. But sure there are subtle differences. Color vs colour, gray vs grey. Never would we spell German like they did though!

Artmar
04-09-2015, 07:27 PM
I have heard that some people have received another portion of some Y-SNPs after few weeks. Can you confirm that?

Petr
04-09-2015, 07:57 PM
In my case the number of positive SNPs increased from 6 to 20:

A0-T: L1085, L1105, L1130
A1: L1013
...
BT: V202, PF1408/V29, PF1410/V235, L1062/P302, M94/PF1081, L971
CT: M168/PF1416
...
F: P145/PF2617, P14/PF2704, P148/PF2734
...
K: P128/PF5504
...
P: P281/PF5941, M45/PF5962, remaining 25 markers no result
R: no result
R1: P286/PF6136, remaining 10 markers no result
R1b: no result
R1b1: no result
R1b1a: no result
R1b1a2: M269, remaining 6 markers no result
R1b1a2a: no result
R1b1a2a1: no result
R1b1a2a1a: L151/PF6542, remaining 3 markers no result
R1b1a2a1a2: no result
R1b1a2a1a2b: no result
R1b1a2a1a2b1: no result
R1b1a2a1a2b1c: no result
R1b1a2a1a2b1c1: no result

dp
04-09-2015, 08:06 PM
I wonder if tribe code was in union with DnaTribes..........who recently had their owner die and that is why DnaTribes has not produced anything in the last 3 months

I too have wondered what are the origins for their business.
dp :-)

dp
04-09-2015, 08:08 PM
Well I guess they are proving a backbone haplogroup assignment. How did your autosomal results compare to other companies and tests you have had?
dp :-)

In my case the number of positive SNPs increased from 6 to 20:

A0-T: L1085, L1105, L1130
A1: L1013
...
BT: V202, PF1408/V29, PF1410/V235, L1062/P302, M94/PF1081, L971
CT: M168/PF1416
...
F: P145/PF2617, P14/PF2704, P148/PF2734
...
K: P128/PF5504
...
P: P281/PF5941, M45/PF5962, remaining 25 markers no result
R: no result
R1: P286/PF6136, remaining 10 markers no result
R1b: no result
R1b1: no result
R1b1a: no result
R1b1a2: M269, remaining 6 markers no result
R1b1a2a: no result
R1b1a2a1: no result
R1b1a2a1a: L151/PF6542, remaining 3 markers no result
R1b1a2a1a2: no result
R1b1a2a1a2b: no result
R1b1a2a1a2b1: no result
R1b1a2a1a2b1c: no result
R1b1a2a1a2b1c1: no result

KCW
06-12-2015, 02:48 PM
Any news on this company?

Bleuteufel
08-27-2015, 07:46 PM
The European for me is a bit inflated from my 23andme results, and I am probably at most only about 1-2% British/Irish in ancestry so the British and Irish results are definitely off in my case and seem to be substituting for my NW German Ancestry.

confident

44.43% African
12.41% Luhya
32.02 % West African
5.59% Mandinka
26.44% Yoruba
55.57% European
27.34% British Isles
4.89% France
5.02% Italian Peninsula
4.03% Russia
14.29% Scandinavia

European Panel
European 51.66%
7.36% Netherlands / Austria
3.93% Eastern Europe
8.62% Northern Europe
6.74% Northeast Europe
4.84% Ireland
20.18% UK
48.34% Others

Standard

44.43% African
1.39% Bayaka
11.53% Luhya
31.50% West African
5.50% Mandinka
26.01% Yoruba
55.57 European
3.01% Basque
26.23% British Isles
4.39% France
3.84% Italian Peninsula
3.91% Russia
14.19% Scandinavia

European Panel
European 51.72%
6.90% Netherlands/Austria
3.25% Eastern Europe
8.47% Northern Europe
6.41% Northeast Europe
1.90% Southeast Europe
1.29% France
4.07% Ireland
19.43% UK
48.28% Others

vettor
08-27-2015, 08:10 PM
http://www.thegeneticgenealogist.com/2015/08/01/a-review-of-tribecode-by-centrillion-biosciences/

cyna
04-22-2016, 08:10 PM
My Tribecode results in the regular mode aren't terrible, but their Euro panel for me is way way off. Ironically, I get better results with the standard euro panel than their experimental, as supposedly more accurate panel. The regional proportions are way off, and I get a much lower European ancestry than I have seen anywhere else. Looks like Tribecode is headed in the wrong direction.

AnnieD
04-23-2016, 06:58 PM
TribeCode was my 5th major DNA test (becoming an addict? :)) and reported some interesting findings such as a North-South cline for certain European populations: Belgian paired with Swiss (my result) vs. Holland paired with Austria. I also noted that they highlighted “Finland” on the map to apparently illustrate Scandinavian results, perhaps an illustration that shouldn't be taken too literally.

As an American of assumed mostly British diaspora, my overall results between Standard and Experimental were interesting for differences in minor admixture but consistent with NW Euro results that I generally get. I posted my big 3 DNA test results on this thread for anyone interested in comparing mostly British heritage in an admixed individual with this newer test:

http://www.anthrogenica.com/showthread.php?3920-Post-Ancestry-com-23andme-and-MyOrgins-for-the-same-person&p=126966#post126966

Ethnicity Composition – Overview (Confident mode):


100.00% European

47.26% British Isles
7.30% France
7.80% Iberian Peninsula
16.18% Italian Peninsula
6.38% Russia
15.08% Scandinavia



Ethnicity Composition – European (Confident mode):


100.00% European

8.29% Eastern Europe
4.68% Northeast Europe
15.59% Switzerland/Belgium
19.40% France
7.63% Germany
22.34% Ireland
4.97% Portugal
11.08% Spain
6.02% United Kingdom



TribeCode states that it does not report trace admixture under 1%. What is least consistent with these results is the higher Italian score in General and Ireland score in European modes. I score 0% to 1.5% South Euro on the big 3 DNA tests but over 14% at DNA.Land (SW Euro). While I may have hidden Irish ancestors in my family tree, I score only 5% Irish at Ancestry.com and 60% British / Irish at 23andMe (most Irish born or mostly Irish report > 70% from what I’ve seen). Therefore, I was surprised that the United Kingdom score was not higher than Ireland. Possibly France and UK cluster closely with this tool, however. Overall, I am excited by this new methodology and eager to see the results from less admixed, Diaspora such as myself to discover how reliable it might be.

If interested in reviewing TribeCode’s response to some of my results inquiries, I have posted it below:
______________
Hello Annie,

Thank you for your patience while we looked into your inquiry. Based on the information provided, I believe you are referring to our Principal Component Analysis (PCoA).

Starting with individuals in the reference populations, Principal Component Analysis transforms the allele differences at the SNP sites into sets of points along dimensions (known as components) that reveal the greatest variances between the data points for individuals represented in the reference database. It is a statistical procedure that is mostly used as a tool in exploratory data analysis and for making predictive models.

PCoA is used to convert a set of observations of possibly correlated variables into a set of values of linearly uncorrelated variables called principal components. The first principal component has the highest possible variance and thus will introduce the greatest distances. The graphical representation is meant to be viewed as a 3-D plot, therefore two data points which may appear closely related in one plane may actually be separated when viewed along a second plane. A simple analogy for visualizing in 3D plot is looking into a fish bowl from the side, where two fish may appear close to each other versus peering down from the top and realizing that they are separated by a greater distance than anticipated by the first view. In the analysis of your TribeCode DNA data we ran a PCoA analysis with thousands samples from around the globe and included your sample in the analysis.

Regarding your self-reported Belgian ancestry, the posted results are derived from your DNA data, our algorithms and our reference databases. We don't include your self-reported information, but we do love it when we hear of nice agreement!

Finally, in Map View of our Ethnicity Composition feature, our inclusion of Finland with the three Scandinavian kingdoms of Norway, Sweden, and Denmark is based on its geographical location and the reference database which doesn't power distinguishing these, as you suggested. We are aware of the strong association of Finns with the Ugric peoples, particularly in Hungary and Iceland due to population migration, and are proud to base our findings on the high-confidence reference data used in the analysis.

I hope that helps!
All the best,
Tribecode Customer Care

stev0
03-20-2017, 04:26 PM
Hi, does anyone know if Tribecode has gone out of business?

Exosuits
03-29-2017, 01:14 AM
One guy did reveal his results around September last year on Tribecode's facebook page. But they don't seem to be responding to emails and private messages/posts anymore. Last time I checked their website, they were out of stock.

EDIT: I just checked their website. It's saying there's an announcement coming soon "offering expanded genome services".

stev0
04-01-2017, 07:52 PM
I wonder what exactly "expanded genome services" means and why they seemingly have abandoned the test.

tomz
08-20-2017, 10:35 PM
Still says the same thing that there will soon be an announcement regarding expanded genome services. So much for "soon".

kostoffj
08-21-2017, 02:10 PM
It seems their sites are zombies now. I logged into their website a few months ago, and was surprised I could get in, as otherwise everything else is silence on the net. Someone must be paying to keep all that running, but since they don't seem to be otherwise active, I don't see why.

I did get very detailed uniparentals from them, but otherwise they didn't have much to offer.