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View Full Version : Anyone have AA on rs1015362? Whats your ethnic background?



SwampThing27
12-04-2014, 11:23 PM
Just curious because according to SNPedia it is pretty rare in European populations. I am AA on it and of European descent. Wondering what others are?

MikeWhalen
12-05-2014, 12:36 AM
hmm, says you can have versions C or T and I have CT-so how do you have an AA?
..I triple checked that it is the SNP you noted, in fact, I copied and pasted but something seems off

edit-so converted I am AG with 2-4 x's the risk for sun sensitivity (according to bored's chart)

Mike

PS
I was blonde as a kid and brown haired as an adult...I have no freckles and am blue eyed and very 'fair' or 'white' , but like many of Irish decent, I burn easily, especially if I hav'nt had much sun lately...when I was a kid out at camps on Lake Superior, I got some pretty bad sunburns several times, bad enough to get big blisters, which I think means a 2nd degree burn

SwampThing27
12-05-2014, 01:01 AM
Sometimes 23andme reports things differently than other databases. In this case A=T and C=G, so in my case I have TT. Thanks for the reply.

leonardo
12-05-2014, 01:30 AM
I am CC, but tan nicely. I don't burn and I don't have freckles.

J Man
12-05-2014, 01:36 AM
I have CT at rs1015362 and my dad and uncle have TT while my paternal grandfather has CT. My mother and relatives on her side all seem to have CC.

bored
12-05-2014, 02:00 AM
I am CC according to 23andme so GG I guess. I'm South Asian. As per SNPedia, alleles at this SNP have the following significance.

http://i.imgur.com/jGqQSKm.png

I don't really have any problem with sunlight sensitivity though. I tan quite easily.

MJost
12-05-2014, 02:08 AM
I think there are forward and reverse readings. fwd/T A/G and rev/B C/T but not sure why build changes aren't archived info.

I have CT at rs1015362. I see its the same risk with Rs4911414 with fwd/B G/T where I am GT.
Rs4911414
G;G) 0 normal
(G;T) 2 2-4x higher risk of sun sensitivity if part of risk haplotype
(T;T) 2 2-4x higher risk of sun sensitivity if part of risk haplotype


My Promethease latest run of my 23andme data shows:

2-4x higher risk of sun sensitivity if part of risk haplotype
Magnitude: 2
Frequency: 45.1%
Repute:Bad
References:12

As per dbSNP:
"rs4911414 is a SNP near the ASIP (agouti signaling protein) gene on chromosome 20.
This SNP is one of a tightly-linked pair that increases the likelihood of an individual being prone to sun sensitivity, in other words, freckles and sunburn, based on a study of 6,000+ Caucasians (5,000+ Icelanders + 1,000+ Dutch). The odds ratios, presumably on a dominant basis, and at least in the largest population (Icelanders) for "freckles and burns vs. no freckles and tans" for the haplotype pair rs1015362(G) - rs4911414(T) is 3.91 (CI: 2.54-6.03) for males and 2.42 (CI: 1.52-3.86) for females, with an overall p=0.051.[PMID 18488028]

Based on a study by the same authors of 4,000+ skin cancer patients, this haplotype was seen to confer significant increased risk for cutaneous malignant melanoma (odds ratio 1.45, p = 1.2 x 10-9) as well as basal cell carcinoma (odds ratio 1.33, p = 1.2 x 10-6).[PMID 18488027] "

Man I don't know why I haven't got issues late in life because I always got sunburned as a kid swimming all the time.

MJost

bored
12-05-2014, 02:57 AM
On rs4911414 I am GG. That explains it.

kenji.aryan
12-05-2014, 03:16 AM
I'm CT at rs1015362 and GT at rs4911414

SwampThing27
12-05-2014, 03:33 AM
So I'm the only AA or TT so far for the SNP. I am also TT for Rs4911414. I don't have freckles, red hair or pale skin.

Salkin
12-05-2014, 09:35 AM
I am CC (GG), probably typical for a Swede. I've certainly gotten a few nasty sunburns in my time, but yeah, probably not maxed on sensitivity.

I was careless sunbathing near Rome when I was about 18, and I ended up with such a bad sunburn that lots of skin sloughed off my legs. I worry about that sometimes, since I gather melanoma can turn up quite a while after the sunburn incident itself.

And on rs4911414 I am GG (CC).

Tolan
12-05-2014, 10:48 AM
i have CC (GG) for rs1015362 and GG (CC) for rs4911414.
I always have sunburn and my skin does not tan.
I avoid prolonged exposure to the sun...

leonardo
12-05-2014, 04:08 PM
On rs4911414 I am GG. That explains it.

As am I. As I posted, I tan quickly and very seldom burn. My tan lasts past summer, and I have never used a sunscreen (I guess this is my bad).

rick_r
12-06-2014, 01:48 AM
I am CC for rs1015362 and GG for rs4911414. I tan perfectly, and often. No freckles. Or sunburn, despite being in the sun. I am more olive complected, and that is probably due to having folks from Croatia area.

Táltos
12-06-2014, 02:44 AM
I am CT at rs1015362, and GT at rs4911414. I tan easily, and have no freckles. I'm pretty much olive complected year round. I even had been called a "different species" by a really catty girl in college because of my overall coloring.

ilmari
12-06-2014, 12:25 PM
In 23andMe results, I am CC
In 23andNe results, mom is CT

John Doe
12-06-2014, 01:04 PM
hmm, says you can have versions C or T and I have CT-so how do you have an AA?
..I triple checked that it is the SNP you noted, in fact, I copied and pasted but something seems off

edit-so converted I am AG with 2-4 x's the risk for sun sensitivity (according to bored's chart)

Mike

PS
I was blonde as a kid and brown haired as an adult...I have no freckles and am blue eyed and very 'fair' or 'white' , but like many of Irish decent, I burn easily, especially if I hav'nt had much sun lately...when I was a kid out at camps on Lake Superior, I got some pretty bad sunburns several times, bad enough to get big blisters, which I think means a 2nd degree burn

I'm CT or GA. I'm Ashkenazi Jewish with roots in Germany, Poland and Ukraine. Shaten (dark blonde) hair, green grey eyes, fair skin.

Little bit
12-06-2014, 01:45 PM
Opensnp is showing 8% are TT for rs1015362 so definitely less common but not rare:
https://opensnp.org/snps/rs1015362#users

In my group of 8 interrelated profiles at 23andme:
rs1015362/rs4911414
7 CC/GG
1 CT/GT

I am CC/GG and pretty sun sensitive and have a fair amount of freckles and other sun spots. My skin tone is very fair and ruddy.

rms2
12-06-2014, 02:17 PM
I have TT at rs1015362, or AA when viewed from the other side of the double helix. I have Family Finder results only and no 23andMe results, so I can't report anything for rs4911414.

I sunburn pretty easily and only begin to acquire a bit of a tan by the end of the summer, just in time to lose it in the fall. I have freckles all over my shoulders. When I was a kid, I had them on my face, especially across the bridge of my nose and on my cheeks. My complexion is ruddy, so an AA at rs1015362 isn't doing much for me.

My dad also has TT or AA at rs1015362.

SwampThing27
12-06-2014, 04:29 PM
I have TT at rs1015362, or AA when viewed from the other side of the double helix. I have Family Finder results only and no 23andMe results, so I can't report anything for rs4911414.

I sunburn pretty easily and only begin to acquire a bit of a tan by the end of the summer, just in time to lose it in the fall. I have freckles all over my shoulders. When I was a kid, I had them on my face, especially across the bridge of my nose and on my cheeks. My complexion is ruddy, so an AA at rs1015362 isn't doing much for me.

My dad also has TT or AA at rs1015362.

Interesting, thanks! Do you have red hair?

Kurd
12-06-2014, 10:52 PM
Rs1015362 was not sampled by my testing service, Ancestry DNA. My raw results have RS10153622, which is a base pair on chromosome 2, but no RS1015362. I guess I should have used 23andme.

My raw data did contain rs4911414. The alleles were G G. As per SNPedia:


rs4911414 is a SNP near the ASIP (agouti signaling protein) gene on chromosome 20.
This SNP is one of a tightly-linked pair that increases the likelihood of an individual being prone to sun sensitivity, in other words, freckles and sunburn, based on a study of 6,000+ Caucasians (5,000+ Icelanders + 1,000+ Dutch). The odds ratios, presumably on a dominant basis, and at least in the largest population (Icelanders) for "freckles and burns vs. no freckles and tans" for the haplotype pair rs1015362(G) - rs4911414(T) is 3.91 (CI: 2.54-6.03) for males and 2.42 (CI: 1.52-3.86) for females, with an overall p=0.051.[PMID 18488028]


Geno Mag Summary
(G;G) 0 normal
(G;T) 2 2-4x higher risk of sun sensitivity if part of risk haplotype
(T;T) 2 2-4x higher risk of sun sensitivity if part of risk haplotype

My rs2228479 SNP was also sampled and the alleles were GG. As per SNPedia:

rs2228479, known as Val92Met or V92M, is one of several SNPs in the MC1R gene commonly associated with red (or blond) hair and poor tanning, but note its high presence in one Asian population [PMID 7581459, PMID 16463023]

The risk allele is rs2228479(A), compared with the wild-type rs2228479(G) allele

rms2
12-06-2014, 11:52 PM
Interesting, thanks! Do you have red hair?

No, but I carry the red hair variant Arg160Tryp. I did have red hair in my moustache and beard before they started going white, and I was told I had "red highlights" in my otherwise dark head hair (before that started going gray). I was blond as a little boy and into my teenaged years.

ViktorL1
12-08-2014, 08:50 AM
rs1015362-- CC

I always tan. I have never burned, thankfully.

Kurd
12-08-2014, 01:28 PM
Oh, forgot to mention, I am olive complected, and don't have issues with sun sensitivity. I tan easily.

Mamluk
12-09-2014, 02:04 AM
On rs1015362-
My father: CC
My wife: CC
My mother: CT
Me: CT

On rs4911414-
My father: GG
My wife: GG
My mother: GT
Me: GT

My father has olive skin, and he tans easily, and can withstand being in the sun for extended periods.
My wife has "white" skin, and she has never been in the sun long enough to know whether she tans or burns.
My mother has "Asian white" skin (like a fair-skinned Japanese or Korean), but she also has light rosy cheeks; she always gets sunburnt without sunscreen, and by the end of summer she has freckles on her cheeks and arms.
I have the same skin complexion as my mother, and if I'm without sunscreen, the first 2-3 exposures to the sun in summer results in getting burnt, and peeling like an onion for a few days. After that I'm able to get tanned pretty well, but I haven't done that in at least 18 years!