View Full Version : COMT Gene Allele Associated with Risk of Schizophrenia with Marijuana/Cannabis Use

10-13-2012, 11:42 PM
From snpedia (http://www.snpedia.com/index.php/Rs4680) and pubmed (http://www.ncbi.nlm.nih.gov/pubmed/15866551?dopt=Abstract):
"Adolescent cannabis use was associated with increased risk of schizophreniform disorder in adulthood among Val/Val (i.e. rs4680 (https://www.23andme.com/you/explorer/snp/?snp_name=rs4680)(G;G)) individuals (OR = 10.9, 95% CI: 2.2–54.1) and, to a lesser extent, among Met/Val individuals (rs4680(A;G)); OR = 2.5, 95% CI: .78 – 8.2), but not among Met/Met (rs4680(A;A)) individuals (OR = 1.1, 95% CI: .21–5.4)." (link to 23andme provided on SNP ID) Other interesting information available at snpedia (link above).