seferhabahir

03-21-2015, 03:32 AM

See the following paper (published today) on new rate constants for Y-SNPs based on NGS data

http://rjgg.molgen.org/index.php/RJG...e/view/151/175

I went and checked all of my FGC SNPs to see how many fell into the paper's combBED regions (defined in Table 1 of the paper's supplement) and came up with 28 of them. So, using their 160 years per SNP, this gives 4480 years ago, consistent with my previous statements that my particular lineage likely diverged from the rest of the Z251 cousins 4000-5000 years ago.

Those 28 included FGC11986 (in a combBED region) but not A555 (not in a combBED region). If I add SNPs we know are above FGC11986 (these would be S9294, S11556, Z251, DF13), there will be 32 SNPs to give 5120 years ago and is consistent with my thinking on DF13 and also consistent with YFull's estimate of 5200 years ago for DF13 and 5100 years ago for Z251.

Perhaps we are seeing the dots line up well enough to have a reasonable story. It would be interesting to see if these dates hold up for other Z251 Big Y results. You will need to take your list of unique SNPs and see how many are in their combBED regions (which totals about 7.6 Mbp). Note that most Big Y tests looked at more of the Y, up to perhaps 10.3 or 11.0 Mbp, in which case you would need to use a smaller number of years per BIG Y SNP than of 160. The paper states 118 years as a coefficient for 10.3 Mbp and 111 years for 11.0 Mbp. For FGC coverage which is much more than Big Y at 23 Mbp, they use 53 years per SNP as the rate.

http://rjgg.molgen.org/index.php/RJG...e/view/151/175

I went and checked all of my FGC SNPs to see how many fell into the paper's combBED regions (defined in Table 1 of the paper's supplement) and came up with 28 of them. So, using their 160 years per SNP, this gives 4480 years ago, consistent with my previous statements that my particular lineage likely diverged from the rest of the Z251 cousins 4000-5000 years ago.

Those 28 included FGC11986 (in a combBED region) but not A555 (not in a combBED region). If I add SNPs we know are above FGC11986 (these would be S9294, S11556, Z251, DF13), there will be 32 SNPs to give 5120 years ago and is consistent with my thinking on DF13 and also consistent with YFull's estimate of 5200 years ago for DF13 and 5100 years ago for Z251.

Perhaps we are seeing the dots line up well enough to have a reasonable story. It would be interesting to see if these dates hold up for other Z251 Big Y results. You will need to take your list of unique SNPs and see how many are in their combBED regions (which totals about 7.6 Mbp). Note that most Big Y tests looked at more of the Y, up to perhaps 10.3 or 11.0 Mbp, in which case you would need to use a smaller number of years per BIG Y SNP than of 160. The paper states 118 years as a coefficient for 10.3 Mbp and 111 years for 11.0 Mbp. For FGC coverage which is much more than Big Y at 23 Mbp, they use 53 years per SNP as the rate.