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Solothurn
03-29-2015, 03:25 PM
Hi L2 cousins :)

I want to 'Wish a SNP' for L2 at Yseq for anybody who needs confirmation, due to 23s inferior chip!

I selected 'other' from the list.

Then I got

"Then enter the name of your desired SNP, its position (hg19) on ChrY, the ancestral/derived mutation bases and the haplogroup where it’s been observed in the “Add Comments About Your Order” field."

Any advice on what to put please?

Thanks

Huntergatherer1066
03-29-2015, 03:43 PM
I'm surprised L2 isn't already in their catalog. It's a C>T mutation at 5755550.

Solothurn
03-29-2015, 03:54 PM
Thanks

5755550 and got "There is no product that matches the search criteria."

So if I Wish 5755550 (R1b-L2) do you think this will suffice?

Thanks


I'm surprised L2 isn't already in their catalog. It's a C>T mutation at 5755550.

Salkin
03-29-2015, 04:19 PM
Thanks

5755550 and got "There is no product that matches the search criteria."

So if I Wish 5755550 (R1b-L2) do you think this will suffice?

Thanks

Based on my previous wishes, I would put: L2, 5755550 (anc: C der: T), R1b-L2

or possibly the longhand haplogroup name if available.

mafe
03-29-2015, 06:03 PM
It looks like L2 is now available, good work :thumb:

Solothurn
03-30-2015, 11:14 AM
Direct link to order L2 :)

http://www.yseq.net/product_info.php?products_id=10945

If the L2 'no-calls' at 23 order this and get a +, maybe they can order the 12 STRs via FTDNA and expand the project :)


It looks like L2 is now available, good work :thumb:

Solothurn
05-26-2015, 12:23 PM
Thanks

If L2+ what SNP would be the best to test for next at Ysearch?

R.Rocca
05-26-2015, 08:06 PM
Thanks

If L2+ what SNP would be the best to test for next at Ysearch?

If YSeq has it, then Z49 is the most logical choice.

Solothurn
05-26-2015, 10:47 PM
Thanks Rich :)


If YSeq has it, then Z49 is the most logical choice.

anglesqueville
06-06-2015, 07:32 AM
Just back from the Orkneys. Thanks very much to Richard and Solo. I have asked YSeq to include z49 in the tested snps.

Solothurn
06-06-2015, 01:27 PM
It only takes a few days (usually) so it should be available soon :)

mafe
06-06-2015, 01:39 PM
Perhaps we should create a U152-panel at YSEQ?

Solothurn
06-06-2015, 02:59 PM
How does a panel work?


Perhaps we should create a U152-panel at YSEQ?

mafe
06-06-2015, 03:23 PM
How does a panel work?

I think they are normal Sanger SNP tests (like the individual SNP tests.) But depending on the number of SNPs that are on it, you can get to a "terminal" SNP without ordering all SNPs individually and it might even be cheaper. I don't know if the phylogeny of U152 is suited for this kind of panel. Here an example of a panel, it's the "L21 Super Clade orientation panel" that is priced at $88,- http://www.yseq.net/product_info.php?cPath=25&products_id=4321

mafe
06-06-2015, 05:08 PM
The "R-U152 orientation panel for 23andMe participants" could look like this; (I haven't added all "round 3" SNPs yet)

4703

MitchellSince1893
06-07-2015, 12:08 AM
Looking at the two big L2 branches, L2> Z258,Z367,Z384, and L2> Z49,Z68; there are no differences in their modal values.

Currently the Z258,Z367,Z384 branch is much larger than Z49,Z68; so it may be wise to recommend testing for this branch first, followed by Z49, then PF6658,Z193.

Solothurn
06-07-2015, 11:06 AM
I suspect Rich could help with this (time and energy permitting :))

For one branch of Z193 my signature SNPs down to Z10676 should help :)





The "R-U152 orientation panel for 23andMe participants" could look like this; (I haven't added all "round 3" SNPs yet)

http://www.anthrogenica.com/attachment.php?attachmentid=4703&stc=1

Solothurn
06-07-2015, 11:45 AM
I have emailed Yseq and asked :)


I don't know if the phylogeny of U152 is suited for this kind of panel

MitchellSince1893
06-08-2015, 04:27 AM
Looking at the two big L2 branches, L2> Z258,Z367,Z384, and L2> Z49,Z68; ...

I went back and looked this again and noticed I had a spreadsheet problem when I first did the comparison.

There are actually a couple of markers with different modal values.

DYS460 = 10: 88% of Z258,Z367,Z384
DYS460 = 11: 83% of Z49

DYS456 = 15: 86% of Z258,Z367,Z384
DYS456 = 16: 62% of Z49

76% of Z258, Z367, Z384 had DYS460 = 10 and DYS456 = 15; while none of Z49 kits had this combination.

So these two STRs could be used when guiding L2 types on what to test for next...not guaranteed but better than flipping a coin.

Probably the simplest thing would be to use the DYS460 value for guidance.

anglesqueville
06-08-2015, 08:02 AM
I've received the response of Yseq:
06/06/2015 Pending Z49 R1b1a2a1a2b1c position: 28462237 G-_T
06/08/2015 Delivered Z49 is located on a segment which is very similar to chromosome 1 (98.4% Chr1: 202432497..202433211).
We recommend the phylo-equivalent marker Z68 which is available at http://www.yseq.net/product_info.php?products_id=6304

mafe
06-08-2015, 12:19 PM
I have emailed Yseq and asked :)

Do you know of more 23andMe participants that are interested in further testing? If noone is interested there is also no need to create a panel.

Solothurn
06-11-2015, 05:10 PM
No I don't as yet, but think it is only $2 to create the panel :)


Do you know of more 23andMe participants that are interested in further testing? If noone is interested there is also no need to create a panel.

mafe
06-11-2015, 05:44 PM
No I don't as yet, but think it is only $2 to create the panel :)

The number of SNPs on the panel and the number of SNPs in each round will affect the price, the cheapest panels I've seen are $88,- but there are also a few expensive ones. Key is to have all important SNPs on a panel so every "23andme U152" can benefit from it.

Solothurn
06-20-2015, 02:55 AM
Z68: C-

He also has a G for L20 at 23andMe so what would be the next logical SNP at Yseq: Z367 or?

Thanks
If YSeq has it, then Z49 is the most logical choice.

R.Rocca
06-20-2015, 03:04 AM
Z68: C-

He also has a G for L20 at 23andMe so what would be the next logical SNP at Yseq: Z367 or?

Thanks

Correct, Z367 is the next logical SNP.

Solothurn
06-20-2015, 03:29 AM
Thanks Rich

Q. Can somebody have a no-call for L2 but have a L20+ result at 23andMe?

I only ask as anglesqueville (http://www.anthrogenica.com/member.php?2385-anglesqueville) was given a no-call for L2, but a G for L20 instead of a no-call!
http://www.anthrogenica.com/images/AegeanE/statusicon/user-offline.png

Member
Correct, Z367 is the next logical SNP.

R.Rocca
06-20-2015, 04:13 AM
Thanks Rich

Q. Can somebody have a no-call for L2 but have a L20+ result at 23andMe?

I only ask as anglesqueville (http://www.anthrogenica.com/member.php?2385-anglesqueville) was given a no-call for L2, but a G for L20 instead of a no-call!
http://www.anthrogenica.com/images/AegeanE/statusicon/user-offline.png

Member

A no-call simply means that the L2 test failed to produce results, so "yes" it is possible.

Solothurn
06-25-2015, 04:52 AM
Z367+ for anglesqueville and he is L20- at 23andMe :)

I know it is very difficult without STRs and here are some Z367+ L20-. They may not mean much, but what is his next logical SNP to test for?


Eustatius de Wijs
Terheijden, Nederland

Nils Nilsson
Brännarebygden, Jämshög, Sweden

3x Blair UK

Thomas Blayston
South Dalton, E Yorks, ENG

Jan van Huchtenburg b.1647,
Haarlem, N. Holland

Jacques Demeulemeester,
Gijzelbrechtegem, Belgium

Daniel DuVal b.c.1675,
Normandy, France

Joseph DAWSON/NEWBY (npe) Starston, Norfolk

Thomas Godden
Portesham, Dorset England

Pieter Pollepel
Petten, Netherlands

Alberto matiz y Prado
Gran Canaria, Spain