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Krefter
03-31-2015, 04:19 AM
I'm interested in seeing member's Hirisplex results to test its accuracy in predicting hair and eye color, especially for Middle Easterns and south-central Asians. Here's the Online Predictor (http://www.erasmusmc.nl/47743/3604975/HIris?lang=en).

It takes awhile to get a accustomed to the Online predictor. So here's a Guide for how to plug in the #s correctly.

Guide for plugging in #s into Online Hirisplex Predictor. (https://docs.google.com/spreadsheets/d/15Tfc7Ghv6tvl-czwXLL1UvCcFdnCqMnuDkH5Rb2D1ts/edit)

EDIT, 3/31/2015: I'd rather have people post their calls(alleles) in each Hirisplex SNP. I've used the predictor many times and will be able to post your results quickly. IF you haven't used the predictor before you'll probably plug in wrong #s and get strange results.

Some useful links related to Hirisplex.

Study which created the predictor. (http://www.fsigenetics.com/article/S1872-4973(12)00181-0/fulltext)

Hirisplex results for Pre-Historic Europeans. (https://docs.google.com/document/d/1PVpN5zC3vW-FC_IUzFMaf6JI2XezGooJgsoIRagKyy8/edit)

The study linked above used the calls of around 1200 individuals from Greece, Poland, and Ireland in the 24 Hirisplex SNPs to create the predictor. They then tested the accuracy of the predictor by predicting hair-eye color of about 300 other individuals from Greece, Poland, and Ireland.

The Hirisplex system was correct 69.5% of the time for blond, 78.5% of the time for brown, 80% of the time for red and 87.5% of the time for black hair

When the samples got calls in every hair color SNP the predictions were much more accurate: 93% for red, 87% for black, 82% for brown, and 81% for blonde.

Hirisplex predicted brown vs blue eyes correctly 88% of the time.

In Table 3. (http://www.fsigenetics.com/cms/attachment/2022359633/2042116586/gr2.jpg) of the study linked above they show the affect 2 minor alleles of the 22 Hirisplex SNPs has on hair color prediction.

Here's a map showing Hirisplex results for 51 populations and 945 HGDP-CEPH individuals from around the world.
http://www.fsigenetics.com/cms/attachment/2022359633/2042116582/gr5.jpg

Everyone knows ~70% of French, North Italians, and Orcadians don't have blonde hair. I've noticed that 1 minor allele in rs12913832 or rs16891982 or rs28777 makes the biggest difference between being predicted to have blonde-brown hair or black-brown hair. There's a lot of dark haired people with rs16891982 GG who I think are often wrongly being predicted to have blonde hair.

Stephen1986
03-31-2015, 11:02 AM
For eyes, my brother and myself have almost identical results which don't have an effect on the predictions. I have dark blue eyes with green in the middle, whilst my brother has slightly lighter blue eyes. 23andMe predicts that we have a 72% chance of blue eyes, 27% chance of green eyes and 1% chance of brown eyes.

blue eye 0.884
intermediate eye 0.083
brown eye 0.033

Here's my hair predictions -

blond hair 0.007
brown hair 0.056
red hair 0.935
black hair 0.002
light hair 0.824
dark hair 0.176

And my brother's hair predictions, which are slightly different -

blond hair 0
brown hair 0.001
red hair 0.999
black hair 0
light hair 0.981
dark hair 0.019

I'm not sure how to interpret the hair results, they look a bit odd to me.


There's a lot of dark haired people with rs16891982 GG who I think are often wrongly being predicted to have blonde hair.

Yeah, both myself and my brother have GG there, my hair is dark brown and his is medium brown. The only relatives I know who have naturally blonde hair are children, and they'll probably be dark-haired once they grow up.

jeanL
03-31-2015, 03:44 PM
Here are my maternal's grandfather younger sister results:

4218

It is worth noting that she is heterozygous for the EDAR mutation(rs3827760 AG), yet she doesn't have thick hair nor does she have shovel-shaped incisors. Here are some pictures of her when she was younger(she is turning 95 this year!).

http://www.anthrogenica.com/showthread.php?4077-Guess-Ancestral-Origin&p=75407&viewfull=1#post75407

Here are her K36 scores:

http://www.anthrogenica.com/showthread.php?4077-Guess-Ancestral-Origin&p=75432&viewfull=1#post75432

vettor
03-31-2015, 05:29 PM
I'm interested in seeing member's Hirisplex results to test its accuracy in predicting hair and eye color, especially for Middle Easterns and south-central Asians. Here's the Online Predictor (http://www.erasmusmc.nl/47743/3604975/HIris?lang=en).

It takes awhile to get a accustomed to the Online predictor. So here's a Guide for how to plug in the #s correctly.

Guide for plugging in #s into Online Hirisplex Predictor. (https://docs.google.com/spreadsheets/d/15Tfc7Ghv6tvl-czwXLL1UvCcFdnCqMnuDkH5Rb2D1ts/edit)

Some useful links related to Hirisplex.

Study which created the predictor. (http://www.fsigenetics.com/article/S1872-4973(12)00181-0/fulltext)

Hirisplex results for Pre-Historic Europeans. (https://docs.google.com/document/d/1PVpN5zC3vW-FC_IUzFMaf6JI2XezGooJgsoIRagKyy8/edit)

The study linked above used the calls of around 1200 individuals from Greece, Poland, and Ireland in the 24 Hirisplex SNPs to create the predictor. They then tested the accuracy of the predictor by predicting hair-eye color of about 300 other individuals from Greece, Poland, and Ireland.

The Hirisplex system was correct 69.5% of the time for blond, 78.5% of the time for brown, 80% of the time for red and 87.5% of the time for black hair

When the samples got calls in every hair color SNP the predictions were much more accurate: 93% for red, 87% for black, 82% for brown, and 81% for blonde.

Hirisplex predicted brown vs blue eyes correctly 88% of the time.

In Table 3. (http://www.fsigenetics.com/cms/attachment/2022359633/2042116586/gr2.jpg) of the study linked above they show the affect 2 minor alleles of the 22 Hirisplex SNPs has on hair color prediction.

Here's a map showing Hirisplex results for 51 populations and 945 HGDP-CEPH individuals from around the world.
http://www.fsigenetics.com/cms/attachment/2022359633/2042116582/gr5.jpg

Everyone knows ~70% of French, North Italians, and Orcadians don't have blonde hair. I've noticed that 1 minor allele in rs12913832 or rs16891982 or rs28777 makes the biggest difference between being predicted to have blonde-brown hair or black-brown hair. There's a lot of dark haired people with rs16891982 GG who I think are often wrongly being predicted to have blonde hair.

it seems not to work for me.......it runs for 30 minutes without ending
Do you do the manual input or the CSV file input at bottom of each test?

maybe you can do it from mine below and advise what else I have missing

http://i103.photobucket.com/albums/m153/vicpret/slc24a5_zps476c113a.jpg (http://s103.photobucket.com/user/vicpret/media/slc24a5_zps476c113a.jpg.html)

rs12913832 = GG

Jusarius
03-31-2015, 07:00 PM
Mine:

blue eye 0.972 0
intermediate eye 0.025 0
brown eye 0.002 0

blond hair 0 0
brown hair 0 0
red hair 1 0
black hair 0 0
light hair 0.989 0
dark hair 0.011 0



I have brown hair in reality:

http://i112.photobucket.com/albums/n178/Jusarius/hiukset_zpsd6d8713d.jpg



Eyes:

http://i112.photobucket.com/albums/n178/Jusarius/munsilma_zpsb4e8c30f.jpg

SwampThing27
03-31-2015, 07:14 PM
Here are my results and a picture of my eyes and hair. The hair result is a bit off as you can see.
http://i60.tinypic.com/11jvxw9.jpg

fil
03-31-2015, 07:57 PM
4221
4223

I have no idea why in the second one my scores are so different for eye color. Maybe I made a mistake but I double checked and couldn't find anything wrong.

SwampThing27
03-31-2015, 08:28 PM
4221
4223

I have no idea why in the second one my scores are so different for eye color. Maybe I made a mistake but I double checked and couldn't find anything wrong.

You probably have at least one T allele for the Herc2 snp, but on the second one you put that you have 0. That is the major eye color snp.

Edit: Yeah on the first one you put that you have 2 T's.

Humanist
03-31-2015, 08:34 PM
Perhaps I entered the wrong values, but what is the deal with the "red hair" value?

I have green eyes and light brown hair (dark/dirty blond as a child (http://www.anthrogenica.com/showthread.php?1513-Photos-From-Your-Childhood&p=17574&viewfull=1#post17574)).

http://i1096.photobucket.com/albums/g326/dok101/dok101050/hirisplex.jpg

Krefter
03-31-2015, 08:51 PM
EDIT, 3/31/2015: I'd rather have people post their calls(alleles) in each Hirisplex SNP. I've used the predictor many times and will be able to post your results quickly. IF you haven't used the predictor before you'll probably plug in wrong #s and get strange results.

Krefter
03-31-2015, 08:54 PM
4221
4223

I have no idea why in the second one my scores are so different for eye color. Maybe I made a mistake but I double checked and couldn't find anything wrong.

You got differnt eye color scores because for one you plugged in "0" for rs12913832(meaning you have GG, for light eyes) and the other you plugged in "2" for rs12913832(meaning you have AA, for dark eyes). So, the predictor seems to be accurate for you.

Krefter
03-31-2015, 09:01 PM
For eyes, my brother and myself have almost identical results which don't have an effect on the predictions. I have dark blue eyes with green in the middle, whilst my brother has slightly lighter blue eyes. 23andMe predicts that we have a 72% chance of blue eyes, 27% chance of green eyes and 1% chance of brown eyes.

blue eye 0.884
intermediate eye 0.083
brown eye 0.033

Here's my hair predictions -

blond hair 0.007
brown hair 0.056
red hair 0.935
black hair 0.002
light hair 0.824
dark hair 0.176

And my brother's hair predictions, which are slightly different -

blond hair 0
brown hair 0.001
red hair 0.999
black hair 0
light hair 0.981
dark hair 0.019

I'm not sure how to interpret the hair results, they look a bit odd to me.



Yeah, both myself and my brother have GG there, my hair is dark brown and his is medium brown. The only relatives I know who have naturally blonde hair are children, and they'll probably be dark-haired once they grow up.

Unless you have a derived allele in two MCR1 SNPs, Hirisplex won't predict you and your brother to have red hair. If you don't and plugged in the wrong numbers it'll probably predict you to have blonde or brown hair(because of GG in rs16891982 and rs12913832). There's isn't a clear divide between Brown and Blonde hair, so I guess that's accurate.

Krefter
03-31-2015, 09:09 PM
Here are my maternal's grandfather younger sister results:

4218

It is worth noting that she is heterozygous for the EDAR mutation(rs3827760 AG), yet she doesn't have thick hair nor does she have shovel-shaped incisors. Here are some pictures of her when she was younger(she is turning 95 this year!).

http://www.anthrogenica.com/showthread.php?4077-Guess-Ancestral-Origin&p=75407&viewfull=1#post75407

Here are her K36 scores:

http://www.anthrogenica.com/showthread.php?4077-Guess-Ancestral-Origin&p=75432&viewfull=1#post75432

She has two calls associated with blonde hair. 2 "minor"(not always derived for Hirisplex, just what's least popular in Euros) alleles in rs4959270 and one derived allele in rs1393350(doesn't make a big effect in the predictor though). I can see she also has GG in rs16891982 and rs12913832, which adds more than anyothers to the blonde category.

But in reality she had dark hair. I'm not surprised. There's a lot of dark haired West Eurasians with blue eyes and or GG in rs16891982, but this predictor will usually predict them to have blonde hair. This is evident when ~20% of West Asians are predicted to have blonde hair.

Krefter
03-31-2015, 09:13 PM
it seems not to work for me.......it runs for 30 minutes without ending
Do you do the manual input or the CSV file input at bottom of each test?

maybe you can do it from mine below and advise what else I have missing

http://i103.photobucket.com/albums/m153/vicpret/slc24a5_zps476c113a.jpg (http://s103.photobucket.com/user/vicpret/media/slc24a5_zps476c113a.jpg.html)

rs12913832 = GG

No I don't use the CSV thing. If you plug in your #s it should take a few moments to load.

You're missing most of them. Here's a spreadsheet with the SNPs. Maybe you can copy and paste it to a spreadsheet, post that spreadsheet, than I'll put in your #s.

Krefter
03-31-2015, 09:19 PM
Here are my results and a picture of my eyes and hair. The hair result is a bit off as you can see.
http://i60.tinypic.com/11jvxw9.jpg

You have pretty much every marker associated with blonde hair, except for a few. Obviously those markers don't necessarily result in blonde hair. I'd say this predictor is mostly only useful for predicting red vs non-red hair and predicting whether someone is European or not. If you have CC in rs16891982 and AA in rs12913832(most brown eyed Euros have AG) you're probably from Asia or Africa.

SwampThing27
03-31-2015, 09:30 PM
You have pretty much every marker associated with blonde hair, except for a few. Obviously those markers don't necessarily result in blonde hair. I'd say this predictor is mostly only useful for predicting red vs non-red hair and predicting whether someone is European or not. If you have CC in rs16891982 and AA in rs12913832(most brown eyed Euros have AG) you're probably from Asia or Africa.

I don't know which parent i got the blonde alleles from, but niether had blonde hair.

jeanL
03-31-2015, 09:31 PM
She has two calls associated with blonde hair. 2 "minor"(not always derived for Hirisplex, just what's least popular in Euros) alleles in rs4959270 and one derived allele in rs1393350(doesn't make a big effect in the predictor though). I can see she also has GG in rs16891982 and rs12913832, which adds more than anyothers to the blonde category.

But in reality she had dark hair. I'm not surprised. There's a lot of dark haired West Eurasians with blue eyes and or GG in rs16891982, but this predictor will usually predict them to have blonde hair. This is evident when ~20% of West Asians are predicted to have blonde hair.

Everybody in my family has rs4959270 AA, except for my paternal grandfather who is AC. Are you sure AA is the minor allele?

Per http://snpedia.com/index.php/Rs4959270 AA is more common in Europeans(CEU, TSI) and European admixed populations(MEX) than in nonEuropeans.

As for rs1393350, she has AG, what is crazy is that according to:

http://snpedia.com/index.php/Rs1393350

Both AA and AG are extremely uncommon, with A/A surpassing 5% in CEU. Out of the 6 23andme profiles I manage, 4 are AG, then other 2(me and my dad) are A/A.

Do you know what the allele calls for rs1393350 are for ancient Europeans?

Also, I should mentioned that my aunt didn't have dark hair, she had medium brown. You can see it in a couple of the pictures:

4224

4225


If you have CC in rs16891982 and AA in rs12913832(most brown eyed Euros have AG) you're probably from Asia or Africa.

Not if you are from Spain, there was one guy or girl from the 1000 genome project IBS population that was both CC in rs16891982 and AA in rs12913832, I remember because I noted how similar he/she was to Stuttgart who was also CC and AA in those loci. But you are right most brown eyed Euros are AG. Amongst my 23andme profiles I have 4 GG and 2-AG, one of the AG has hazel eyes, the other has brown eyes.

Krefter
03-31-2015, 09:47 PM
I don't know which parent i got the blonde alleles from, both niether had blonde hair.

The allele may not have much to do with blonde hair. Hirisplex may be almost completely useless for predicting anything but red hair and non-red hair.

Krefter
03-31-2015, 09:59 PM
Not if you are from Spain, there was one guy or girl from the 1000 genome project IBS population that was both CC in rs16891982 and AA in rs12913832, I remember because I noted how similar he/she was to Stuttgart who was also CC and AA in those loci. But you are right most brown eyed Euros are AG. Amongst my 23andme profiles I have 4 GG and 2-AG, one of the AG has hazel eyes, the other has brown eyes.

All Pre-Historic Euros except for SHG, EHG, and LN/BA has similar rs16891982 alleles as west and south-central Asians. I'm curious whether selection for the derived allele in that SNP in the last 5,000 years helped make Euros lighter skinned than other west Eurasians. Sardinians have the highest amount of the ancestral dark-allele in rs16891982 for Europeans and have fairly dark skin.

The people to study to see what SNPs cause light vs dark skin are Latinos/Hispanics, because they're mostly a mixture of Spanish and Native American.

fil
03-31-2015, 10:53 PM
You got differnt eye color scores because for one you plugged in "0" for rs12913832(meaning you have GG, for light eyes) and the other you plugged in "2" for rs12913832(meaning you have AA, for dark eyes). So, the predictor seems to be accurate for you.

Thanks! Corrected values

Predicted phenotype
p-value AUC Loss
blue eye 0 0
intermediate eye 0.003 0
brown eye 0.997 0
blond hair 0.003 0.004
brown hair 0.181 0.001
red hair 0 0.011
black hair 0.816 0
light hair 0.003 0
dark hair 0.997 0

vettor
04-01-2015, 06:25 AM
No I don't use the CSV thing. If you plug in your #s it should take a few moments to load.

You're missing most of them. Here's a spreadsheet with the SNPs. Maybe you can copy and paste it to a spreadsheet, post that spreadsheet, than I'll put in your #s.

ok, manual input ......

HERC2 rs12913832 T
OCA2 rs1800407 A
SLC24A4 rs12896399 T
SLC45A2 rs16891982 C
TYR rs1393350 T
IRF4 rs12203592 T



Predicted phenotype
p-value AUC Loss
blue eye 0.858 0
intermediate eye 0.081 0
brown eye 0.061 0

I have GG for every one except #2 and last which are CC

Real life ...I have mid-green coloured eyes with barely any brown in them


................

other test below

p-value AUC Loss
blue eye 0.858 0
intermediate eye 0.081 0
brown eye 0.061 0
blond hair 0.752 0.007
brown hair 0.217 0.002
red hair 0.007 0.027
black hair 0.024 0.002
light hair 0.965 0
dark hair 0.035 0

Tolan
04-01-2015, 10:01 AM
If I don't make any mistakes

blue eye 0.075 0
intermediate eye 0.136 0
brown eye 0.788 0

blond hair 0.386 0.007
brown hair 0.386 0.002
red hair 0.213 0.027
black hair 0.015 0.002

light hair 0.961 0
dark hair 0.039 0

Ignis90
04-01-2015, 01:38 PM
My results:
MCR1 rs86insA NA
MCR1 rs11547464 GG (CC) 0
MCR1 rs885479 GG (CC) 0
MCR1 rs1805008 CC (GG) 0
MCR1 rs1805005 GG (GG) 0
MCR1 rs1805006 CC (GG) 0
MCR1 rs1805007 CC (GG) 0
MCR1 rs1805009 NA
MCR1 Y152OCH NA
MCR1 rs2228479 GG (CC) 0
MCR1 rs1110400 TT (AA) 0
SLC45A2 rs28777 CT 1
SLC45A2 rs16891982 CG 1
KITLG rs12821256 TT (AA) 0
EXOC2 rs4959270 CC (GG) 0
IRF4 rs12203592 CC (GG) 0
TYR rs1042602 AC (TG) 1
OCA2 rs1800407 CC (GG) 0
SLC24A4 rs2402130 AG (TC) 1
HERC2 rs12913832 AA (TT) 2
ASIP rs2378249 AA (TT) 0
SLC24A4 rs12896399 GT (CA) 1
TYR rs1393350 GG (CC) 0
TYRP1 rs683 AA (TT) 0


Predicted phenotype

p-value AUC Loss
blue eye 0 0
intermediate eye 0.007 0
brown eye 0.993 0
blond hair 0.031 0.007
brown hair 0.431 0.002
red hair 0.001 0.027
black hair 0.538 0.002
light hair 0.045 0
dark hair 0.955 0


I do have regular brown eyes and dark brown/black hair.

Jusarius
04-01-2015, 02:49 PM
EDIT, 3/31/2015: I'd rather have people post their calls(alleles) in each Hirisplex SNP.Here are my alleles:

http://i112.photobucket.com/albums/n178/Jusarius/Jusarius_Hplex_zpsc4foe3ui.jpg


My real colors:

http://i112.photobucket.com/albums/n178/Jusarius/hiukset_zpsd6d8713d.jpg



Eyes:

http://i112.photobucket.com/albums/n178/Jusarius/munsilma_zpsb4e8c30f.jpg

Salkin
04-01-2015, 05:25 PM
My alleles:

http://i.imgur.com/cxXV2AJ.png

Results:

p-value AUC Loss
blue eye 0.384 0
intermediate eye 0.104 0
brown eye 0.512 0
blond hair 0.206 0.007
brown hair 0.455 0.002
red hair 0.001 0.027
black hair 0.338 0.002
light hair 0.554 0
dark hair 0.446 0

Actual eye:

http://i.imgur.com/9S3h0nO.jpg

Actual hair: medium brown (blond in childhood)

This is actually different from what I got when I first played around with this predictor. Maybe I made a mistake with allele equivalences or somesuch. Anyway, this result obviously makes a great deal more sense than the original "almost certainly blond & blue-eyed" I got then.

Krefter
04-01-2015, 09:02 PM
I can see with posters results and HGDP-CEPH that Hirisplex is pretty much useless at predicting Brown vs Blonde hair, but nearly perfect at predicting red hair. All the Neolithic farmers predicted to have blonde hair(~35%), I bet actually had brown hair. It's close to perfect at predicting brown vs blue eyes, but horrible at predicting green, etc. eyes.

sqwelchy
01-02-2016, 07:49 PM
I can see with posters results and HGDP-CEPH that Hirisplex is pretty much useless at predicting Brown vs Blonde hair, but nearly perfect at predicting red hair. All the Neolithic farmers predicted to have blonde hair(~35%), I bet actually had brown hair. It's close to perfect at predicting brown vs blue eyes, but horrible at predicting green, etc. eyes.

Did you use the prediction guide or simply the probabilities? Dark blond also means light brown in some predictions, hence the person may not be light blond or wrong like you think! your statement is quite harsh.

Passa
01-02-2016, 08:40 PM
My results:
7148

My hair colour (golden blond in childhood):
7149

I've got blue eyes.

Krefter
01-02-2016, 09:02 PM
Did you use the prediction guide or simply the probabilities? Dark blond also means light brown in some predictions, hence the person may not be light blond or wrong like you think! your statement is quite harsh.

You're right. I didn't know there was a prediction guide. Most "Blond" results would be predicted as Brown or Light Brown. I got results for entire populations and they were consistent with reality.


My results:
http://www.anthrogenica.com/attachment.php?attachmentid=7148&stc=1

My hair colour (golden blond in childhood):
http://www.anthrogenica.com/attachment.php?attachmentid=7149&stc=1

I've got blue eyes.

According to the prediction guide, you probably have Light Brown or Blond hair. Looks like that is correct.

psaglav
01-02-2016, 09:21 PM
7151
7152

I'm not good at reading these. My eyes are green and my hair is medium brown (lightish auburn as a child).

psaglav
01-02-2016, 09:24 PM
I'm not good at reading these. My eyes are green and my hair is medium brown (lightish auburn as a child).

OK, that's weird, all my p-values show as 0.

Mestace
01-02-2016, 09:31 PM
http://s29.postimg.org/sjm6vrdgn/Hiris_P1.png

I have blue eyes and dark brown hair. Father, same hair/eyes, mother blonde with blue eyes (same than sisters)

MatAust21
01-02-2016, 09:52 PM
My results are correct. I have light eyes (blue-green) and brown hair. Let me try to attach the screencaps to this post.

lemon
01-02-2016, 10:02 PM
I had ginger hair when I was a child but darker now.

http://i.imgur.com/JMUaf5B.jpg

khanabadoshi
01-02-2016, 10:10 PM
p-value
AUC Loss


blue eye
0.384
0


intermediate eye
0.104
0


brown eye
0.512
0


blond hair
0.153
0.007


brown hair
0.422
0.002


red hair
0.002
0.027


black hair
0.423
0.002


light hair
0.287
0


dark hair
0.713
0

evon
01-02-2016, 10:44 PM
http://i412.photobucket.com/albums/pp207/vulcanphoto/Screenshot%20from%202016-01-02%20233927.png

I got blue eyes and mixed hair colour, black, brown, blond and red strains all mixed into each other (Mostly black on the sides and back, while front and top is more mixed, 23andme predicted me to be red haired).. I was bright blond until about 4-5, then I turned black and now in later life the red has become more prominent..

evon
01-02-2016, 10:45 PM
OK, that's weird, all my p-values show as 0.

I got the same when I used chrome, so I used Vivaldi and it worked...

Krefter
01-02-2016, 10:49 PM
All new predictions are accurate so far. Results for my Dad and Grandpa are accurate. It predicates me as Brown/Light Brown, but I have a rare MC1R variant they don't take into account, and when that is taken into account my prediction would be Red. Two of brothers have Brown/Light Brown, so that could be why.

psaglav
01-02-2016, 11:01 PM
I got the same when I used chrome, so I used Vivaldi and it worked...


What is Vivaldi?

evon
01-02-2016, 11:15 PM
What is Vivaldi?

https://vivaldi.com

khanabadoshi
01-02-2016, 11:30 PM
I got the same when I used chrome, so I used Vivaldi and it worked...


OK, that's weird, all my p-values show as 0.

Same thing happened to me, it worked when I refreshed the page and re-entered the values though.

SwampThing27
01-03-2016, 01:04 AM
There seems to be some new snps used for this calculator, but its still off IMO.
phenotype
p-value AUC Loss
blue eye 0.187 0
intermediate eye 0.151 0
brown eye 0.662 0
blond hair 0.474 0
brown hair 0.473 0
red hair 0.004 0
black hair 0.048 0
light hair 0.863
dark hair 0.137

Picture if my eye and hair is attached.

Krefter
01-03-2016, 01:12 AM
There seems to be some new snps used for this calculator, but its still off IMO.
phenotype
p-value AUC Loss
blue eye 0.187 0
intermediate eye 0.151 0
brown eye 0.662 0
blond hair 0.474 0
brown hair 0.473 0
red hair 0.004 0
black hair 0.048 0
light hair 0.863
dark hair 0.137

Picture if my eye and hair is attached.

It's acurate for you if you use this method (http://www.fsigenetics.com/cms/attachment/2022359633/2042116583/gr4.jpg). I use my own predicting critera that's a little differnt. If I saw your results and not your picture, I'd say you definitly have Brown hair, and that it can be anything from Light to Dark Brown, but probably basic Brown.

Mellifluous
01-03-2016, 01:16 AM
Delete

SwampThing27
01-03-2016, 01:34 AM
It's acurate for you if you use this method (http://www.fsigenetics.com/cms/attachment/2022359633/2042116583/gr4.jpg). I use my own predicting critera that's a little differnt. If I saw your results and not your picture, I'd say you definitly have Brown hair, and that it can be anything from Light to Dark Brown, but probably basic Brown.

Interesting thanks

Mellifluous
01-03-2016, 01:59 AM
Oops.

Did mine incorrectly, so I'm posting my results again.

p-value AUC Loss
blue eye 0.057 0
intermediate eye 0.077 0
brown eye 0.866 0
blond hair 0.175 0.007
brown hair 0.641 0.002
red hair 0.064 0.027
black hair 0.119 0.002
light hair 0.69 0
dark hair 0.31 0

Edited it once again. This time I'm pretty sure it's accurate. The last time it said I'm probably blonde, which is incorrect.

Star93
01-03-2016, 02:11 AM
I only entered eye colour.

blue eye 0.917
intermediate eye 0.052
brown eye 0.031

Mellifluous
01-03-2016, 02:29 AM
p-value
AUC Loss


blue eye
0.384
0


intermediate eye
0.104
0


brown eye
0.512
0


blond hair
0.153
0.007


brown hair
0.422
0.002


red hair
0.002
0.027


black hair
0.423
0.002


light hair
0.287
0


dark hair
0.713
0



Seems like you have some recessive alleles for blue eyes! Cool. :)

khanabadoshi
01-03-2016, 02:57 AM
Seems like you have some recessive alleles for blue eyes! Cool. :)

Yeah, I wasn't expecting that. I should do this for all my family members and compare, but it's so much work to put in all the SNPs. I will do it in a bit.

Mellifluous
01-03-2016, 03:00 AM
Yeah, I wasn't expecting that. I should do this for all my family members and compare, but it's so much work to put in all the SNPs. I will do it in a bit.

You should post your SNPs! It would be interesting to see them. I'm heterozygous for blue eyes but I get a different probability. Maybe you have more homozygous alleles?

khanabadoshi
01-03-2016, 04:01 AM
Myself


I



Sister


DID



Grandmother (M)


THEM ALL WRONG






SNP
Myself
Sister
Grandmother (M)


rs86insA
NA
NA
NA


rs11547464
G / G
G / G
G / G


rs885479
G / G
G / G
G / G


rs1805008
C / C
C / C
C / C


rs1805005
G / G
G / T
T / T


rs1805006
C / C
C / C
C / C


rs1805007
C / C
C / C
C / C


rs1805009
NA
NA
NA


Y152OCH
NA
NA
NA


rs2228479
G / G
G / G
G / G


rs1110400
T / T
T / T
T / T


rs28777
C / C
C / C
C / C


rs16891982
C / C
C / C
C / C


rs12821256
T / T
T / T
T / T


rs4959270
A / C
A / A
A / A


rs12203592
C / C
C / C
C / C


rs1042602
A / C
A / C
A / C


rs1800407
C / C
C / C
C / C


rs2402130
A / A
A / A
A / A


rs12913832
A / A
A / A
A / A


rs2378249
A / G
A / G
A / A


rs12896399
G / G
G / G
T / T


rs1393350
G / G
G / G
A / G


rs683
A / C
A / C
A / C




Half done.....

khanabadoshi
01-03-2016, 04:37 AM
Grandmother (M) Brother


I



Uncle (P)


DID



Grandfather (M) Sister


THEM ALL WRONG






SNP
Grandmother (M) Brother
Uncle (P)
Grandfather (M) Sister


rs86insA
NA
NA
NA


rs11547464
G / G
G / G
G / G


rs885479
G / G
G / G
G / G


rs1805008
C / C
C / C
C / C


rs1805005
G / T
G / G
G / G


rs1805006
C / C
C / C
C / C


rs1805007
C / C
C / C
C / C


rs1805009
NA
NA
NA


Y152OCH
NA
NA
NA


rs2228479
G / G
G / G
G / G


rs1110400
T / T
T / T
T / T


rs28777
C / C
A / C
A / C


rs16891982
C / C
C / G
C / G


rs12821256
T / T
T / T
T / T


rs4959270
C / C
A / C
A / C


rs12203592
C / C
C / C
C / C


rs1042602
A / C
C / C
C / C


rs1800407
C / T
C / C
C / C


rs2402130
A / A
A / A
A / A


rs12913832
A / G
A / A
A / G


rs2378249
A / A
A / G
A / A


rs12896399
T / T
G / G
G / G


rs1393350
G / G
G / G
G / G


rs683
A / C
A / C
C / C

khanabadoshi
01-03-2016, 05:12 AM
SNP
Aunt (M)
1/2 Leghari Cousin
Mohmand Pashtun - Pakistan


rs86insA
NA
NA
NA


rs11547464
G / G
G / G
G / G


rs885479
G / G
G / G
A / G


rs1805008
C / C
C / C
C / C


rs1805005
G / T
G / G
G / G


rs1805006
C / C
C / C
C / C


rs1805007
C / C
C / C
C / C


rs1805009
NA
NA
NA


Y152OCH
NA
NA
NA


rs2228479
G / G
G / G
G / G


rs1110400
T / T
T / T
T / T


rs28777
C / C
A / A
A / C


rs16891982
C / C
C / G
C / G


rs12821256
T / T
T / T
T / T


rs4959270
A / A
C / C
C / C


rs12203592
C / C
C / C
C / C


rs1042602
A / C
C / C
A / C


rs1800407
C / C
C / C
C / C


rs2402130
A / A
A / A
A / A


rs12913832
A / A
A / A
A / G


rs2378249
A / A
A / A
A / A


rs12896399
G / T
G / T
G / T


rs1393350
G / G
G / G
G / G


rs683
A / C
A / C
A / C



If someone can run these for me.... my fingers are killing me after Ctrl + Ving my life away.

surbakhunWeesste
01-03-2016, 05:35 AM
^ :nono:

ashwinb
01-04-2016, 06:02 PM
Here are mine, it would be great if anyone could use them for me.

SNP
rs86insA NA
rs11547464 G / G
rs885479 G / G
rs1805008 C / C
rs1805005 G / G
rs1805006 C / C
rs1805007 C / C
rs1805009 NA NA NA
Y152OCH NA NA NA
rs2228479 G / G
rs1110400 T / T
rs28777 C / C
rs16891982 C / C
rs12821256 T / T
rs4959270 C / C
rs12203592 C / C
rs1042602 C / C
rs1800407 C / C
rs2402130 A / G
rs12913832 A / G
rs2378249 A / G
rs12896399 G / G
rs1393350 G / G
rs683 A / C

Dorkymon
01-05-2016, 12:24 AM
That was an interesting calculator.

http://puu.sh/mjRtw/2e37376311.jpg

http://puu.sh/mjRzp/3442c0ff4d.png

Krefter
01-05-2016, 01:10 AM
Here are mine, it would be great if anyone could use them for me.

SNP
rs86insA NA
rs11547464 G / G
rs885479 G / G
rs1805008 C / C
rs1805005 G / G
rs1805006 C / C
rs1805007 C / C
rs1805009 NA NA NA
Y152OCH NA NA NA
rs2228479 G / G
rs1110400 T / T
rs28777 C / C
rs16891982 C / C
rs12821256 T / T
rs4959270 C / C
rs12203592 C / C
rs1042602 C / C
rs1800407 C / C
rs2402130 A / G
rs12913832 A / G
rs2378249 A / G
rs12896399 G / G
rs1393350 G / G
rs683 A / C

I don't need to plug those numbers in. Your result will be Black hair and Brown eyes.