Men with haplogroup I of Y chromosome have 50% greater risk of developing heart disea

[gravetti]

http://www.news-medical.net/news/20130618/Men-with-haplogroup-I-of-Y-chromosome-have-5025-greater-risk-of-developing-heart-disease.aspx

A team of researchers including clinicians and scientists have made an important step forward in search of the mechanisms underlying increased risk of coronary artery disease in men who carry a particular type of the Y chromosome (haplogroup I).

Specifically, men with haplogroup I were shown to have decreased expression of 2 genes: the ubiquitously transcribed tetratricopeptide repeat, Y-linked gene (UTY) and protein kinase, Y-linked, pseudogene (PRKY) in macrophages.

[Augustus]

These studies linking Y-Dna HGs to anything medical are pseudo-science at best. If you look hard enough you can probably find correlations between y-dna and smoking, sex habits, video game habits, junk food habits.

Academics should seek to establish causality, not correlation between variables that are unlikely to have a concrete relationship. I guess that scholarly standards have dropped so much in contemporary times, that professors sit around doing nothing and come up with superficial papers just to get their paycheck.

[Ann Turner]

23andMe attempted to replicate this finding but failed:

http://blog.23andme.com/news/second-opinion-haplogroup-i-likely-not-linked-to-heart-disease/

[Megalophias]

Academics should seek to establish causality, not correlation between variables that are unlikely to have a concrete relationship.

Difference in gene expression *is* a causal mechanism. That's the point.