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Awale
06-25-2015, 09:32 PM
I'm not much of a Haplogroup-man and need to brush up on my knowledge of them but there's a pretty great new paper out on Haplogroup E that was brought to my attention on another forum & I thought it might be of some interest to all of you here:



Haplogroup E, defined by mutation M40, is the most common human Y chromosome clade within Africa. To increase the level of resolution of haplogroup E, we disclosed the phylogenetic relationships among 729 mutations found in 33 haplogroup DE Y-chromosomes sequenced at high coverage in previous studies. Additionally, we dissected the E-M35 subclade by genotyping 62 informative markers in 5,222 samples from 118 worldwide populations. The phylogeny of haplogroup E showed novel features compared to the previous topology, including a new basal dichotomy. Within haplogroup E-M35, we resolved all the previously known polytomies and assigned all the E-M35* chromosomes to 5 new different clades, all belonging to a newly identified subhaplogroup (E-V1515), which accounts for almost half of the E-M35 chromosomes from the Horn of Africa. Moreover, using a Bayesian phylogeographic analysis and a SNP-based approach we localized and dated the origin of this new lineage in the northern part of the Horn, about 12 kya. Time frames, phylogenetic structuring and socio-geographic distribution of E-V1515 and its subclades are consistent with a multi-step demic spread of pastoralism within north-eastern Africa and its subsequent diffusion to sub-equatorial areas. In addition, our results increase the discriminative power of the E-M35 haplogroup for use in forensic genetics through the identification of new ancestry-informative markers.

Link (http://gbe.oxfordjournals.org/content/early/2015/06/23/gbe.evv118.abstract)


https://scontent-vie1-1.xx.fbcdn.net/hphotos-xta1/v/t1.0-9/11403032_10204811298863922_3519285756620290012_n.j pg?oh=f6df664bad04ffc33e477d3422627eba&oe=55F21AF4

Some extra useful info:

Improved resolution of E-M215 (aka E3b / E1b1b), Ethiohelix Blog (http://ethiohelix.blogspot.ae/2015/06/improved-resolution-of-e-m215-aka-e3b.html)

For those of you interested; enjoy discussing this new paper. :)

Lank
06-27-2015, 08:55 PM
All of the former paragroup E-M35* East African lineages, and the supposedly "basal" East African M35 lineages have been assigned to a new East African subclade, V1515, that's merely ~12,000 years old. Several steps in the updated M35 phylogeny appear rooted in North Africa. This study seems to establish with fairly high probability that E-M35 originated in North Africa, not East Africa.

Agamemnon
06-30-2015, 10:07 PM
Nothing about E-M35.1's linguistic implications for Afroasiatic, it's almost criminally inaccurate at this point!

brownar
08-18-2016, 12:32 PM
Several steps in the updated M35 phylogeny appear rooted in North Africa. This study seems to establish with fairly high probability that E-M35 originated in North Africa, not East Africa.

I think it has always been assumed that the origin of E-M35 was eastern North Africa. We're still a bit low of good research from Egypt, Libya, and Sudan even with this study. Once we get enough in-depth research from those population, I think you'll get a very clear picture. Most studies study populations surrounding these regions.