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Huntergatherer1066
08-17-2015, 10:53 PM
I thought I would create a new thread to continue the discussion of my S11601 uncle and fellow S11601 men in a new thread separate from the general Z18 thread as more BigY results have come in. I have been able to get in touch with almost all BigY S11601+ men so far. A new close match with my uncle has turned two of his previously private SNPs into potentially a new twig. The new match is distant enough to not be an STR match. Below is the current S11601 haplotree leading to my uncle, who is 323104 Richards in the relevant projects. Some other twigs may be able to added for others, this is just a starting point. 13819020 A>G is a novel variant that was recently named FGC35830, however I am reluctant to ascribe much phylogenetic reliability to it due to it being in an STR. For now though, my uncle and three others have been positive for it. My uncle and the new S11601 man share the as yet unnamed SNPs 17894572 G>A and 21810990 T>G in common. I haven't been able to find him in the U106 or Z18 projects so I will see if I can recruit him. I have also been trying to gather information on the geographic distribution of S11601 and downstream clades for mapping purposes.


http://i.imgur.com/dBIm7jc.png

I look forward to more S11601 BigY results coming in. I'll update this thread with further diagrams and maps as possible.

Cofgene
08-18-2015, 12:37 AM
Look at your INDEL's as one of them could be useful. If you have a FGC report that is a great way to locate the 0-2 new INDELs / Big-Y that are worth researching. There is a decent LD relationship between the appearance of an INDEL and a corresponding SNP.

Huntergatherer1066
08-24-2015, 10:26 PM
I heard back from my uncle's newest BigY match and he has origins going back to Wiltshire. He is in the U106 project now as well. Looks like another branch has been identified under S19726 so I'll add that to the diagram when I get a chance. I believe there is some question about whether S19726 really is below S11601 and not equivalent, so that is something to keep an eye on. There is one Z18 guy my uncle matches on 33/37 STRs who is also from Devon that I really wish would do further testing. It isn't certain that he is S11601 but he very well could be.

Huntergatherer1066
08-30-2015, 08:22 PM
Here is a MDKA map I've created for all individuals who have been able to trace their origins back to Europe. I hope this number grows as the M343 Panel and Z18 panels start sorting a few more people into S11601. NGS results are really necessary though in order to learn much more. The lone continental sample appears to be from the timeframe when Gdansk was Prussian Danzig, which makes more sense than being of Polish origin.

http://i.imgur.com/HN5PahQ.jpg


FGC35830 (located within an STR) is not seeming to be reliable, it is leading to contradictory results when you map S11601 individuals on a haplotree. If you desregard FGC35830, the S11601 haplotree now looks like this:

http://i.imgur.com/3u8P1L1.png

Huntergatherer1066
02-04-2016, 01:40 AM
It's been awhile since I've updated this thread, since August there have been a number of new S11601+ samples with documented European origins and new NGS results as well. Two individuals were able to push their genealogies further back, relocating their MDKA locations. I am looking forward to the BAM file being analyzed for the most recent BigY as it will likely be another new branch of S11601.
Here is the most up to date map and haplotree I've made:

http://i.imgur.com/CoLfe6F.jpg

http://i.imgur.com/yprZQQp.png

Tomas455
03-05-2016, 11:56 PM
It Zp141 on this chart somewhere? That's the next SNP test they suggest for me

Huntergatherer1066
03-06-2016, 12:29 AM
ZP141 is further downstream on another branch downstream of Z18 than S11601. Are you in the Z18 and subgroups project?

Tomas455
03-13-2016, 01:53 AM
Yes, did't look at a big chart for the other branches oops!

Huntergatherer1066
03-13-2016, 09:14 PM
This may be a good time for a S11601 map update post, note the new Swedish addition.

http://i.imgur.com/nI2Ul4u.jpg


I've also be working on creating a more aesthetically pleasing map of British Isles S11601 people, here is an early draft version.


http://i.imgur.com/CFPqFTJ.png

Huntergatherer1066
05-08-2016, 02:45 PM
Here is the latest S11601 haplotree, it has been growing thanks to BigY results. The Z18 SNP Pack has also helped break up the cluster of SNPs at the S11601 level.

http://i.imgur.com/MhOwphX.png

COEH
05-30-2016, 11:54 AM
Hello,
I am new to this forum and recently received Big-Y results for my 3rd cousin who is a BRYAN with ancestor in North Carolina born 1759. It is thought his ancestral home is East Anglia based on similar SNP results. The best Big-Y match he has is sharing 28 novel variants and has a Swedish ancestor. He shares SNP ZP143 with him and some others in the Z-18 project. However, I do not see ZP143 on the latest S11601 haplotree. I would be very interested in knowing where ZP143 fits. My cousin is negative for SNP S17548 based on Z-18 SNP Pack results. He is positive for SNPs S11601 and S19726. I would also be interested in knowing if S19726 is downstream from S11601. The reason I ask is that I see one member of the Z-18 project that is positive for S11601 yet negative for S19726.

Huntergatherer1066
05-30-2016, 01:21 PM
Hello,
I am new to this forum and recently received Big-Y results for my 3rd cousin who is a BRYAN with ancestor in North Carolina born 1759. It is thought his ancestral home is East Anglia based on similar SNP results. The best Big-Y match he has is sharing 28 novel variants and has a Swedish ancestor. He shares SNP ZP143 with him and some others in the Z-18 project. However, I do not see ZP143 on the latest S11601 haplotree. I would be very interested in knowing where ZP143 fits. My cousin is negative for SNP S17548 based on Z-18 SNP Pack results. He is positive for SNPs S11601 and S19726. I would also be interested in knowing if S19726 is downstream from S11601. The reason I ask is that I see one member of the Z-18 project that is positive for S11601 yet negative for S19726.

Hi, welcome to the forum. I noticed your cousin amongst my uncle's (Richards) new BigY matches, it's great to see more S11601 BigY results. ZP143 (also known as FGC35830 ) has proven to be somewhat unstable as it is located in an STR, so that is why it does not appear in haplotrees. S19726 is somewhat uncertain as well, from what I recall the person who is negative for it actually just has a no-call there, so may really be positive. I'm not sure what novel variants the Swede-descendant has as he has yet to share them with myself or the Z18 project, I have emailed with him some though. It would be great to be able to make a new branch on the S11601 tree with any new shared SNPs between your cousin and him.

COEH
05-30-2016, 02:31 PM
Thanks for the status on ZP143. I was hoping it might be a stable SNP. I just compared my novel variants I have with the Swede. I believe every one of them is upstream of ZP30 because I also share them with a Venier and he appears to be negative for ZP30. There is one position that seems interesting but I don't know much about it or whether it is stable. It is at 22,240,888. Let me know what you think.

Huntergatherer1066
05-30-2016, 05:46 PM
Thanks for the status on ZP143. I was hoping it might be a stable SNP. I just compared my novel variants I have with the Swede. I believe every one of them is upstream of ZP30 because I also share them with a Venier and he appears to be negative for ZP30. There is one position that seems interesting but I don't know much about it or whether it is stable. It is at 22,240,888. Let me know what you think.

Yeah I am not sure about that one, it is listed on http://l257.groenebeverbv.nl/index.php?option=com_content&view=article&id=15&Itemid=121 as an invariant so may not be useful. If you haven't already I definitely recommend sending your VCF file to the Z18 administrator and/or the U106 administrators just to keep all interested parties informed on the latest results; they will be able to compare your results with the other results they have. It may be the case that you are another new branch beneath ZP30. You might email the Swede as well and see if he can send his VCF file to a project administrator for easier comparison.

COEH
05-31-2016, 03:55 PM
I sent my vcf to the U106 admin. I contacted the Z-18 admin but he hasn't replied.
I'm not really sure what an "invariant" is but it looks like some of the people that have it are also negative for ZP30 so I'm guessing it won't matter to me. I'm still trying to understand what the Big-Y is telling me. I think what I am seeing now is that none of my cousin's matches are downstream of ZP30 and upstream of the SNP he is negative on (S17548). I am thinking if I was able to get one of his close 111 STR matches to do the Big-Y I might see some SNPs he has in common that are real.