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utR!
12-24-2012, 07:15 AM
Diabetes mellitus is quite common here and USA. This research is a new one. There are plenty others done.

I have many relatives who had or have it and I have a risk.

http://www.sciencedaily.com/releases/2012/12/121223152412.htm

tuuli

AJL
12-24-2012, 07:57 PM
This is of personal interest because the disease occurs in both my mother's father's family, and on my father's mother's side.

There's quite a rise in Type-2 diabetes in the US, and worst, among children. It's tied up in a lot of issues, many of them discussed in this short series:

http://theweightofthenation.hbo.com/

There are some clear genetic predisposing factors. For instance, not far from me, this Aboriginal population has a mutation in the HNF1α gene:

http://www.ncbi.nlm.nih.gov/pubmed/12726923

A lot of it is environmental/lifestyle, too. Lack of exercise and poor diet, obviously, but some work is being done examining the potential contribution of air pollution to diabetes risk.

DMXX
12-24-2012, 10:22 PM
From memory, the HNF1α gene mutation predisposes to one of the 4-odd types of Maturity-Onset Diabetes of the Young (MODY).

Most causes of diabetes are the result of sedentary lifestyles combined with non-complimenting eating habits (i.e. eating pasta like you're Michael Phelps despite working a 9-5 office job. :D )

It's important to note that some people do have diabetes as a result of other health problems, such as Cushing's, which is when you have too much steroid (cortisol) circulating in your body.

AJL
12-25-2012, 12:54 AM
From memory, the HNF1α gene mutation predisposes to one of the 4-odd types of Maturity-Onset Diabetes of the Young (MODY).

Ah yes, I think you're right. Perhaps I was thinking of one of the mitochondrial mutations that are linked to diabetes? I'm not sure.

MJost
12-25-2012, 12:54 AM
A lot of it is environmental/lifestyle, too. Lack of exercise and poor diet, obviously, but some work is being done examining the potential contribution of air pollution to diabetes risk.

Only one of my six half siblings and I have Type2, but my late mother did as well.
> Lack of exercise and poor diet

Hey I eat great (not right - I am sure), must be the former.....

MJost

utR!
12-25-2012, 07:32 AM
Ah yes, I think you're right. Perhaps I was thinking of one of the mitochondrial mutations that are linked to diabetes? I'm not sure.

I think as far as I know old age diabetes occurs only in my mother's side. Quite many of her close relatives had it. So it may be linked to the mitochondrial mutatations. I do not know for sure but I do assume it.

My mother's diabetes went worser and worser. Last thing were the wounds which did not get anymore closed. It was already terminal state because she refused to intake the pills anymore. I was with my sister when she died. She got nearly to the end still injektions of insulin but it got up and up. All it made me thinking a lot of my future with the weakness of the genetics to have diabetes 2.


tuuli

utR!
01-05-2013, 01:13 PM
Because of my new haplogroup I found this page which may significant at least for me hope for someone else too:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434112/

tuuli

utR!
01-07-2013, 06:17 PM
Do you have any idea how much there is corn syrup in different kind of soft drinks? I do drink quite occasionally soft drinks.

For me this article was something to do with diabetes too:

http://blogs.scientificamerican.com/observations/2013/01/01/how-corn-syrup-might-be-making-us-hungry-and-fat/

tuuli

:faint:

authun
08-11-2013, 06:58 PM
You'll find this article in MedScape interesting. Roy Taylor is Professor of Metabolism and Medicine at Newcastle University and is widely published on diabetes research. You may have to register to see the artcle but it's free and when they ask you for your profession, you can just select 'other'.

Type 2 Diabetes: Etiology and Reversibility (http://www.medscape.com/viewarticle/781719)

Topics include:

Introduction
Reversal of Type 2 Diabetes by Bariatric Surgery
Reversal of Type 2 Diabetes by Diet Alone
New Perspectives on Insulin Resistance
New Perspectives on the β-cell Defect
The Time Course to Development of Type 2 Diabetes
The Twin Cycle Hypothesis of Etiology of Type 2 Diabetes
Implication for Management of Type 2 Diabetes

He also has a page on the department's website:

Reversing Type 2 Diabetes (http://www.ncl.ac.uk/magres/research/diabetes/reversal.htm)