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MacUalraig
10-23-2015, 03:08 PM
I've now stumbled across a second Italian academic paper finding H5r, my mtDNA hg, in northern Italy. The one I had already seen was Santoro et al 2010 'Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer’s Disease'. The second is a Ph. D. by Capocasa whose work seems to have been mentioned in several places here. What is interesting is that his sole H5r find was in a Cimbrian Lessinia person and I understand from wikipedia that this language is thought to have moved down to Italy from Bavaria.

http://padis.uniroma1.it/bitstream/10805/2590/1/Marco_Capocasa_PhD_Dissertation.pdf

My mitochondrial MDKA is from villages adjacent to Sleaford which was a well known Roman settlement in Lincolnshire and has a significant Roman cemetery. On the other hand my sole commercial hg match is a woman in Poland (who doesn't reply, or understand English!).

Earlier Santoro paper is

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012037

I haven't yet read the Ph. D. in full so apologise if I have misunderstood it...

vettor
10-23-2015, 06:13 PM
I've now stumbled across a second Italian academic paper finding H5r, my mtDNA hg, in northern Italy. The one I had already seen was Santoro et al 2010 'Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer’s Disease'. The second is a Ph. D. by Capocasa whose work seems to have been mentioned in several places here. What is interesting is that his sole H5r find was in a Cimbrian Lessinia person and I understand from wikipedia that this language is thought to have moved down to Italy from Bavaria.

http://padis.uniroma1.it/bitstream/10805/2590/1/Marco_Capocasa_PhD_Dissertation.pdf

My mitochondrial MDKA is from villages adjacent to Sleaford which was a well known Roman settlement in Lincolnshire and has a significant Roman cemetery. On the other hand my sole commercial hg match is a woman in Poland (who doesn't reply, or understand English!).

Earlier Santoro paper is

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012037

I haven't yet read the Ph. D. in full so apologise if I have misunderstood it...

Take note , that there where no Austrians before 998AD, they where all bavarians.............austrian language is a bavarian dialect.

So I can easily see why this marker = bavarian

MacUalraig
10-23-2015, 06:30 PM
Take note , that there where no Austrians before 998AD, they where all bavarians.............austrian language is a bavarian dialect.

So I can easily see why this marker = bavarian

Thanks for your comment. I did see a bit later that Eupedia maps show a bit of a hotspot for H5 in the Italian alps so this might be a case where language and mtdna didn't travel together.

http://www.eupedia.com/europe/Haplogroup_H_mtDNA.shtml

MacUalraig
10-23-2015, 06:39 PM
There is an amusing update to the Polish angle. I had another look at the match details and saw that she was using what looked like a personal email domain so I googled the domain and account name and she is quite well known! Of course I won't say any more but I can maybe understand why she didn't want to respond...

MacUalraig
09-26-2016, 01:56 PM
H5r now has two sub-branches on the latest tree H5r1 and H5r2, it appears that I should now call myself H5r* as I'm not in either. H5r2 may be showing more of a western slant but H5r* seems to be concentrated in central/eastern Europe.

MacUalraig
03-25-2017, 04:58 PM
The current hotspot for H5r* appears to be Slovenia followed by the Czech Republic. Rummaging for some Slovenian studies I came across this rather old article

http://link.springer.com/article/10.1007/s00414-003-0394-3

Sequence polymorphism of the mitochondrial DNA control region in the Slovenian population

The coverage isn't that great but I believe that the combination of 16304C and 16311C uniquely prove H5<rst> (rCRS tree). The dataset has 2 rows with both these but sadly none of them has 207A which is a prerequisite to be H5r and the markers that define H5s and H5t weren't tested.

If an mtDNA wizard would like to verify this that would be great.

If anyone has any links to Slovenian mtDNA studies please post, thanks.

vettor
03-25-2017, 05:43 PM
The current hotspot for H5r* appears to be Slovenia followed by the Czech Republic. Rummaging for some Slovenian studies I came across this rather old article

http://link.springer.com/article/10.1007/s00414-003-0394-3

Sequence polymorphism of the mitochondrial DNA control region in the Slovenian population

The coverage isn't that great but I believe that the combination of 16304C and 16311C uniquely prove H5<rst> (rCRS tree). The dataset has 2 rows with both these but sadly none of them has 207A which is a prerequisite to be H5r and the markers that define H5s and H5t weren't tested.

If an mtDNA wizard would like to verify this that would be great.

If anyone has any links to Slovenian mtDNA studies please post, thanks.

you might find more information on the marker in this article or the many data info

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081704

all the K-M9 in Luserna Cimbrians are ydna L1b

all the K-M9 in Sole Valley are ydna T-L131

There is a L1a ydna and a T-L131 in Lessinia Cimbrians

Fiemme Valley K-M9 are all L1a ydna

C J Wyatt III
03-25-2017, 05:47 PM
The current hotspot for H5r* appears to be Slovenia followed by the Czech Republic. Rummaging for some Slovenian studies I came across this rather old article

http://link.springer.com/article/10.1007/s00414-003-0394-3

Sequence polymorphism of the mitochondrial DNA control region in the Slovenian population

The coverage isn't that great but I believe that the combination of 16304C and 16311C uniquely prove H5<rst> (rCRS tree). The dataset has 2 rows with both these but sadly none of them has 207A which is a prerequisite to be H5r and the markers that define H5s and H5t weren't tested.

If an mtDNA wizard would like to verify this that would be great.

If anyone has any links to Slovenian mtDNA studies please post, thanks.

Finding an H5r is difficult. I do not see any in the mtDNA projects.

I wonder if the mtDNA experts are trying to extend the subclades too far.

Anyhow, I was curious to take a look at your GEDmatch kit, but the kit number which you give in the message footer is no longer there (or private).

Jack

MacUalraig
03-25-2017, 06:09 PM
Finding an H5r is difficult. I do not see any in the mtDNA projects.

I wonder if the mtDNA experts are trying to extend the subclades too far.

Jack

There are I believe a few internally, as well as the few in the Italy study and on genbank. But in truth, a rare breed :-) Yet to see one in the UK I think, apart from mine.

MacUalraig
06-22-2017, 05:04 PM
My sample is now on GenBank:

https://www.ncbi.nlm.nih.gov/nuccore/KY849397

Latest picture seems to be a focus around Slovenia. A number of H5r2s are also circulating but as I'm H5r* its unclear what I can learn from them.

cyndcoffee
11-25-2017, 07:19 PM
I am H5r2, and I am having a tough time finding out much of anything about this haplogroup. My mom was adopted from Bradenton, FL, in 1928, and I know absolutely nothing about her birth parents. I've had my dna done at Family Tree (that's where I got the H5r2 designation), and Ancestry. I am a complete novice as far as figuring out my mom's origins, and finding my haplogroup has only made it more of a fog. There seem to be VERY few of us H54r2's! Wow, I feel lost!

MacUalraig
11-25-2017, 07:36 PM
I am H5r2, and I am having a tough time finding out much of anything about this haplogroup. My mom was adopted from Bradenton, FL, in 1928, and I know absolutely nothing about her birth parents. I've had my dna done at Family Tree (that's where I got the H5r2 designation), and Ancestry. I am a complete novice as far as figuring out my mom's origins, and finding my haplogroup has only made it more of a fog. There seem to be VERY few of us H54r2's! Wow, I feel lost!

The H5r2 branch is a relatively new discovery and it isn't clear how informative it is. H5r seems to spread around central/eastern Europe. I thought at first there might be a Roman settlement angle to my line but I've gone off that theory a bit.

Are you in the big (million plus) autosomal dbs? You're more likely to crack the mystery that way.

Also, have you done a genbank submission of your mtDNA? Very important to do so to help build the tree (identify new branches).

MacUalraig
09-19-2018, 08:22 AM
Interestingly the only H5r* sample I have seen emerge this year so far has a solid trail to Sicily. That bucks the trend which had been veering off to central/eastern Europe. Sicily is the most southerly data point I have.