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Humanist
02-18-2013, 08:47 AM
If you have one, please share your "Minor Allele Program Report."


The program finds about 50 'rare/uncommon' SNPs from the 900,000+ tested by 23andMe.

There are 2 homozygous-recessive results:

'CC' rs17366686 Intergenic -
'CC' rs4899491 ALDH6A1 aldehyde dehydrogenase 6 family, member A1 - synonymous V138V

but neither is significant as one is an Intergenic region and the other causes a synonymous change.

The only other SNP of interest is:

'AG' rs34301344 ARL11 ADP-ribosylation factor-like 11 - missense W149X

where you are heterozygous for a 'truncation' of the protein ARL11.

(Note: Tiago Espinha [Portuguese] has 'AA' here - but it woud be interesting to speculate a link between the pair of you.)

The ancestry is European.

Humanist
02-23-2013, 01:51 AM
Regarding the Portuguese reference. :) A possibility?

http://mapcollection.files.wordpress.com/2012/06/greek-phoenician-colonies.jpg?w=645&h=475

MikeWhalen
02-24-2013, 12:07 AM
never heard of that program before..where does one find it to try out?

Mike



If you have one, please share your "Minor Allele Program Report."

AJL
02-24-2013, 11:16 PM
There's a sample report here (http://www.ianlogan.co.uk/23andme/open/hans-rudolf-schaer.htm), but I'm not sure how you go about getting one?

Ann Turner
02-25-2013, 02:36 PM
I haven't run this myself, but the introductory page is here:

http://www.ianlogan.co.uk/23andme/23andMe_index2.htm

AJL
02-25-2013, 07:52 PM
Thanks, Ann!

Here's mine for chromosomes 4-7, with comments from http://www.ianlogan.co.uk/23andme/the_results_chr4.htm (etc.) though the comments in the square brackets are mine:

rs36207100 at Chr4:2927646 gave 'CT
' The minor allele is 'T' with a MAF = 0.00685
Appears 8% in Europe, 1% in Africa and absent from Asia.

rs11573780 at Chr4:70713767 gave 'CT
' The minor allele is 'T' with a MAF = 0.00685.
Appears 8% in Europe, 1% in Africa and absent from Asia.

rs6887007 at Chr5:18154011 gave 'AC
' The minor allele is 'A' with a MAF = 0.00731
Maybe 1% in Europe and absent elsewhere.

rs2069700 at Chr5:75914003 gave 'CT
' The minor allele is 'C' with a MAF = 0.00868.
Possibly 3% in Europe and absent elsewhere.

rs9267814 at Chr6:32130320 gave 'AG
' The minor allele is 'G' with a MAF = 0.00594
Appears 1% in Europe.

rs1883852 at Chr6:46560051 gave 'CT
' The minor allele is 'T' with a MAF = 0.00000
[No info. This is very rare -- maybe a misread or de novo mutation?]

rs2235076 at Chr6:102516260 gave 'AG
' The minor allele is 'A' with a MAF = 0.00959
Probably 1% in Europe, and probably absent elsewhere.

rs2232106 at Chr7:43916973 gave 'CT
' The minor allele is 'C' with a MAF = 0.00548.
The 1000 Genome Project gives 5 per 1000.
The change T<>A is common and unlikely to be significant.

rs17336988 at Chr7:55238147 gave 'AG
' The minor allele is 'A' with a MAF = 0.00868
Appears 2% worldwide, but up to 6% in Italy.

rs12721631 at Chr7:99355427 gave 'AG
' The minor allele is 'A' with a MAF = 0.00228.
[No info.]

rs34048349 at Chr7:100197642 gave 'AG
' The minor allele is 'A' with a MAF = 0.00731
Appears about 7% in Europe and less elsewhere.

rs5763 at Chr7:139715645 gave 'AA
' The minor allele is 'A' with a MAF = 0.00594
Possibly 5% in Europe and lower elsewhere.
The change T<>N is uncommon, but the amino acids are similar. Possibly significant.

The selected level was 0.01