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geneticexplorer
03-16-2016, 05:07 PM
What has been your experience with parent-child mutations on 23andMe?

Wonder, because when comparing my raw genotyped DNA to my parent, I find several SNPs on almost every chromosome where there appears to be a mutation.

Example:

On Chromosome 1 at 155205634 (i5007553) my parent has TT.
At the same spot I have have CC.

Wonder if these are more likely to be measurement errors or if it's typical to have mutations on almost all chromosomes? If so, this might explain my mutant superpowers. :)

AJL
03-16-2016, 05:39 PM
We're all mutants.

Probably some of the mismatches are misreads; some are germline mutations (a mutation you have which occurred in transmission of DNA to your egg, and which your mother does not herself have); and some are somatic mutations that occurred in your mother's DNA after you were conceived. You might also have a few somatic mutations in your own DNA but probably not as many as your mother, since these increase with age.

geneticexplorer
03-16-2016, 05:49 PM
If anyone computed their numbers, how many mutations did you see?

AnnieD
03-17-2016, 04:43 AM
Example:

On Chromosome 1 at 155205634 (i5007553) my parent has TT.
At the same spot I have have CC.

My family always claimed that they didn't know where I came from! ;) I was going to look for evidence of serious genetic mutations by comparing my father's results to mine, but my father was only genotyped at FTDNA which does not appear to have a call for RS155205634. At 23andMe I did have a call for it (TT). If there are other significant SNP that might be worthwhile to explore between FTDNA and 23andMe, I'll give it a try.

AJL
03-17-2016, 02:51 PM
Incidentally you can use this handy tool to compare mismatches:

http://www.math.mun.ca/~dapike/FF23utils/pair-discord.php

geneticexplorer
03-17-2016, 04:39 PM
Thanks AGL! What's the number of mismatches you get?

AJL
03-17-2016, 04:43 PM
I got 87.