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RobertCasey
05-09-2016, 04:10 PM
I am trying to learn how to interpret the NGS summary reports by others and need some clarifications of what is required to declare the discovery of a new branch. I do not want to use the ISOGG rules since their qualifications are too conservative: 1) requiring genetic diversity between two positive results ignores all the genealogical branches that are the most interest to me and increases testing costs of getting a second person to test positive; 2) excluding indels and "unstable" YSNPs may avoid dropping a few branches in the future, but these omissions of branches drive up testing costs by removing consistent testing results of "unstable" YSNPs. We have around 50 NGS tests and approaching another 50 SNP panel/pack tests under L226 with consistent testing results for six "unstable" YSNPs. These "unstable" YSNPs are mainly major branching YSNPs that really break up L226.


Here is one example of what I think are two valid new branches under FGC12290:

This pair creates the branch FGC12296 under FGC12290:
69433 FGC12290+ FGC12296- FGC12294-
B7244 FGC12290+ FGC12296+ FGC12294-

This pair creates the branch FGC12294 under FGC12296
B7244 FGC12290+ FGC12296+ FGC12294-
25505 FGC12290+ FGC12296+ FGC12294+

I think it only takes one positive AND one negative to create a new branch
(and the testing has to be consistent above and below the new father/son
as well).



Another issue what separates a possible branch from confirmed branch:

If one tester is positive for a particular YSNP and no other testers have
tested at all, there is no new branch until another tester tests negative.
This would be a possible new branch that is not confirmed to date. All the
other testers could be positive which only defines an equivalent branch.

Another issue what separates an equivalent branch from confirmed branch:

If one tester is positive for a particular YSNP and a second tester tests
positive, there is no new branch until another tester tests negative. At
this point in time this second positive test reveals a new equivalent YSNP
of the existing branch not a new branch.


Thanks in advance for helping me getting up to speed on what is branch.

PS. Sorry about the typos in the thread title (can not edit those apparently).