View Full Version : Chemists offer more evidence of RNA as the origin of life

05-13-2016, 05:58 PM
(Phys.org)—A team of chemists at Ludwig Maximilian University of Munich has shown how the purines adenine and guanine can be synthesized easily and in reasonable yields, offering more evidence that RNA could have served as the origin of life on Earth. In their paper published in the journal Science, the team describes the process they took in looking for evidence that RNA could have been the first self-replicating molecule that eventually led to all life on our planet and what they found.

For several years many scientists have supported the idea that life got its start on our planet due to a series of events that led to the creation of RNA molecules—it seems like a strong candidate because it is able to both store information and act as a catalyst. To bolster the theory, scientists have been trying to show under what conditions RNA might have come about based on the conditions that existed on early Earth. In the early going, researchers found it relatively easy to show how two of the four main building blocks in RNA, uracil and cytosine, could have come about, but showing how the other two, adenine and guanine, might have come about has been problematic. In this new effort the research team describes a scenario under with both might have come about given conditions at the time that life is believed to have got its start.

The team started by extending prior research that had shown that a molecule called formamidopyrimidine can react under certain conditions to form purines—they discovered that adding acid to an amine (which the team showed could have come about very easily from plentiful carbon, nitrogen and hydrogen) allowed for a reaction that led to the formation of a purine and that it would easily bond with formic acid, which recent research has shown is plentiful on comets—that means it could have met with existing purines if a comet crashed into the planet at the right place. Once that happened, the resultant reactions would have led to forging bonds with sugars which would have resulted in the creation of large amounts of purines, including adenine and guanine—thus all of the necessary ingredients would have been in place for the creation of RNA molecules, setting the stage for the development of living organisms.