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View Full Version : Different methylation in different ethnic sub-groups



Saetro
08-20-2016, 04:45 AM
http://biorxiv.org/content/early/2016/07/29/036822
Galanter et al found differences in methylation between two different Latino groups - from Mexico and Puerto Rico

For example:


These results suggest that ethnic differences in methylation at loci known to be responsive to tobacco smoke exposure in utero may be explained in part by ethnic-specific differences in the prevalence of maternal smoking during pregnancy. We also found that CpG loci previously reported to be associated with diesel-exhaust particle (DEP) exposure were significantly enriched among the set of loci whose methylation levels varied between ethnic groups. Specifically, of the 101 CpG sites that were significantly associated with exposure to DEP and passed QC in our dataset, 31 were nominally associated with ethnicity (p < 0.05), and 5 were associated with ethnicity after adjusting for 101 comparisons (p < 0.005).