rms2
06-01-2013, 11:59 PM
FTDNA's Family Finder test includes rs4988235, which is the most common European SNP associated with lactase persistence. Once I downloaded 7-zip (which is free, btw) and figured out how to unzip my raw autosomal data, I discovered rs4988235 is there.
23andMe on rs4988235 and Lactose Intolerance (https://www.23andme.com/health/Lactose-Intolerance/)
I have "AA" there, which means I am lactase persistent and can drink milk and consume other dairy products without discomfort or ill effect. Since I am homozygous at rs4988235, that means I inherited lactase persistence from both my father and my mother.
I knew that I was lactase persistent from personal experience already, but I was always curious what dna testing would show in that regard.
Anyway, according to 23andMe, an "AG" or "AA" at rs4988235 makes one likely to be lactase persistent.
Rs4988235 is also sometimes called the "C/T13910 variant", where a "T" imparts lactase persistence.
There is yet another indicator of lactase persistence in FTDNA's Family Finder data: rs182549.
In this case a "CT" or "TT" result indicates lactase persistence. A "CC" would be indicative of lactose intolerance.
I have a "TT" at rs182549, so I got lactase persistence from both my parents on that one, as well.
This study (http://www.nature.com/ejhg/journal/v17/n3/full/ejhg2008156a.html) showed that lactase persistence in Britain increases as one moves north and west across the island.
23andMe on rs4988235 and Lactose Intolerance (https://www.23andme.com/health/Lactose-Intolerance/)
I have "AA" there, which means I am lactase persistent and can drink milk and consume other dairy products without discomfort or ill effect. Since I am homozygous at rs4988235, that means I inherited lactase persistence from both my father and my mother.
I knew that I was lactase persistent from personal experience already, but I was always curious what dna testing would show in that regard.
Anyway, according to 23andMe, an "AG" or "AA" at rs4988235 makes one likely to be lactase persistent.
Rs4988235 is also sometimes called the "C/T13910 variant", where a "T" imparts lactase persistence.
There is yet another indicator of lactase persistence in FTDNA's Family Finder data: rs182549.
In this case a "CT" or "TT" result indicates lactase persistence. A "CC" would be indicative of lactose intolerance.
I have a "TT" at rs182549, so I got lactase persistence from both my parents on that one, as well.
This study (http://www.nature.com/ejhg/journal/v17/n3/full/ejhg2008156a.html) showed that lactase persistence in Britain increases as one moves north and west across the island.