PDA

View Full Version : Family Finder and Lactase Persistence



rms2
06-01-2013, 11:59 PM
FTDNA's Family Finder test includes rs4988235, which is the most common European SNP associated with lactase persistence. Once I downloaded 7-zip (which is free, btw) and figured out how to unzip my raw autosomal data, I discovered rs4988235 is there.

23andMe on rs4988235 and Lactose Intolerance (https://www.23andme.com/health/Lactose-Intolerance/)

I have "AA" there, which means I am lactase persistent and can drink milk and consume other dairy products without discomfort or ill effect. Since I am homozygous at rs4988235, that means I inherited lactase persistence from both my father and my mother.

I knew that I was lactase persistent from personal experience already, but I was always curious what dna testing would show in that regard.

Anyway, according to 23andMe, an "AG" or "AA" at rs4988235 makes one likely to be lactase persistent.

Rs4988235 is also sometimes called the "C/T13910 variant", where a "T" imparts lactase persistence.

There is yet another indicator of lactase persistence in FTDNA's Family Finder data: rs182549.

In this case a "CT" or "TT" result indicates lactase persistence. A "CC" would be indicative of lactose intolerance.

I have a "TT" at rs182549, so I got lactase persistence from both my parents on that one, as well.

This study (http://www.nature.com/ejhg/journal/v17/n3/full/ejhg2008156a.html) showed that lactase persistence in Britain increases as one moves north and west across the island.

Silesian
06-02-2013, 05:19 PM
^^^^

Your Ydna[R-DF41]+mtDna[U5a2]+blood type mutation[A-{p36.13-p34.3)}]+lactase persistence genes[C/T13910 +TT" at rs182549] In combination are only found in very specific areas geographically in Europe.

I have inherited the same mutations but with a little difference in paternal [R1b-Z-2103] and maternal lineage[U5b2a2].

Ydna[Z-2105{L23x51} ]+mtDna[U5b2a2]+blood type mutation[Ao-{p36.13-p34.3)}]+lactase persistence genes[C/T13910 +TT" at rs182549-AA]

Jean M
06-02-2013, 08:41 PM
Here's a thread that might interest you: http://www.anthrogenica.com/showthread.php?717-Lactase-Persistence-and-the-LCT-22018A-gene

rms2
06-05-2013, 11:56 AM
^^^^

Your Ydna[R-DF41]+mtDna[U5a2]+blood type mutation[A-{p36.13-p34.3)}]+lactase persistence genes[C/T13910 +TT" at rs182549] In combination are only found in very specific areas geographically in Europe.

I have inherited the same mutations but with a little difference in paternal [R1b-Z-2103] and maternal lineage[U5b2a2].

Ydna[Z-2105{L23x51} ]+mtDna[U5b2a2]+blood type mutation[Ao-{p36.13-p34.3)}]+lactase persistence genes[C/T13910 +TT" at rs182549-AA]

Can you provide any links to handy blood group and lactase persistence maps?

Jean M
06-05-2013, 12:16 PM
Global Geography of Milk Consumption and Lactose (In)Tolerance

http://geocurrents.info/cultural-geography/culinary-geography/global-geography-of-milk-consumption-and-lactose-intolerance

Silesian
06-05-2013, 03:32 PM
Can you provide any links to handy blood group and lactase persistence maps?

I have not found any really good maps, because these mutations are unique and found in pockets.


T−13910
http://pastmist.files.wordpress.com/2009/04/lp1.jpg


rh negative, cde
http://www.hgklein.de/romsem/propaedeutikum/grafiken/RHESUS.JPG
http://dublinsmick.files.wordpress.com/2012/08/rh-neg.jpeg


A frequency worldwide and Europe
http://www.naturalbuy.com/wp-content/uploads/2009/02/a-type-blood.gif

AJL
06-05-2013, 04:41 PM
For blood groups:

http://anthro.palomar.edu/vary/vary_3.htm

rms2
09-14-2013, 10:52 PM
^^^^

Your Ydna[R-DF41]+mtDna[U5a2]+blood type mutation[A-{p36.13-p34.3)}]+lactase persistence genes[C/T13910 +TT" at rs182549] In combination are only found in very specific areas geographically in Europe.

I have inherited the same mutations but with a little difference in paternal [R1b-Z-2103] and maternal lineage[U5b2a2].

Ydna[Z-2105{L23x51} ]+mtDna[U5b2a2]+blood type mutation[Ao-{p36.13-p34.3)}]+lactase persistence genes[C/T13910 +TT" at rs182549-AA]

Add at least one red hair variant to that, as well: rs1805008, also known as R160W or Arg160Trp :)

DebbieK
09-26-2013, 05:04 PM
Can you provide any links to handy blood group and lactase persistence maps?

UCL (University College London) maintain the Global Lactase Persistence Association Database and there are some very nice maps on their website:

http://www.ucl.ac.uk/mace-lab/resources/glad