As mentioned in J Man's thread on hazel eyes, I am pleased to announce my project on eye colour genetics is active once more.
For those who are unfamiliar with it, or wish to learn what happened to the project since its' inception, please view the Spoiler below.
Several users here on Anthrogenica were participants in my project. I have listed all previous participants below. If those users could kindly inform me (publicly or privately) whether or not they are interested in remaining in the project, that would be much appreciated. All data belonging to previous users who haven't made contact will remain unused indefinitely and in their entirety.
I should also take this opportunity to state that, if sufficient users (at least n=50) are participating by August 15th 2013, it is my intention to formally write up and publish the results and subsequent analysis (for more information on this please view "Project Assurances and Terms" below). Participation in this project is therefore automatically taken as unwritten permission to include your eye colour SNP's for my research. This was stated toward the end of the original project and remains the case now.
Project Aims
Based on the 23andMe chip, ascertain...
- Which SNP's predominantly control brown vs. light eye phenotype.
- Which SNP's for the cohort are involved in additional variation.
- Successfully predict the phenotype from five examples of genotype data.
- Contrast with existing conclusions in several studies.
- Whether 23andMe's standard v2 chip has the capacity to support more detailed eye colour prediction assays.
How Can Users Participate?
- Please inspect the SNP panel below.
Code:rs12913832 rs1800407 rs12896399 rs16891982 rs1393350 rs12203592 rs7495174 rs7183877 rs4778232 rs1408799 rs8024968 rs683 rs4778138 rs4778241 rs1667394 rs26722 rs1015362 rs4911414 rs1540771 rs12821256 rs885479 rs1805008 rs1805005 rs3829241- Search your 23andMe Raw Data for all the SNP's in this panel (currently accessed by logging into your profile, highlighting the cogwheel on the top left hand side, selecting "BROWSE RAW DATA").
- List your SNP genotypes in the order shown in the panel.
- Information on eye colour phenotype is also crucial to the project. Pictures are ideal, descriptions of phenotype are acceptable. Additional information (i.e. heritage) is welcomed but not mandatory. For a guide on how to describe your eyes, please refer to the image below (add your observations as appropriate):
Modified and taken from Beleza et al.'s Genetic Architecture of Skin and Eye Color in an African-European Admixed Population and Ruiz et al.'s Further development of forensic eye color predictive tests.- Share the essential data (genotype and phenotype information) with the project creator (myself, DMXX) either publicly on this thread or privately by PM.
- Participants are sent a unique ID (IDnnn) by PM to confirm their information is stored on an offline spreadsheet.
How Do Participants Benefit?
- Receive deeper analysis into genotype data provided from markers validated in current scientific literature. This will be delivered via an online spreadsheet which differs from the offline hard copy. In it, user ID's are listed alongside the inferences made from their genotypes.
- Opportunity to discuss findings or queries concerning the inheritance of eye colour via personal data.
- Real-time updates concerning what the project has discovered and how this relates to you.
Project Assurances and Terms
- All communications and data between the project creator and participants (user ID's, genotypes, pictures) will remain confidential unless users choose to publicly post these.
- At no point will user data of the sort described above be passed onto third parties.
- Incomplete participant information (i.e. half of SNP genotypes, no picture/description) will not be included in the project.
- If a formal report is composed, no personal genotype data or user ID's will be published. The only planned exception will be of the five predictions from genotype data. If I feel any of the pictures are worth including in the report, I will seek permission from those who provided them.
- Updates on findings will be posted in this thread only.
- It is worth stating that eye colour genotypes are highly unlikely to convey sensitive information concerning health traits as they tend to come from genes which regulate pigmentation. The first version of the project also revealed that a partial distinction between West Eurasians and other world groups could be gleamed from eye colour genotypes in a rudimentary and non-specific manner. Therefore, it is also highly unlikely any specific information pertaining to ancestry will be inferred.
- As unlikely as it is, any changes made to the project's methodology or approach will be announced here.
Updated List of Citations
Will be completed in the next week.
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Originally Posted by DMXX
