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Thread: Southeast Asian Haplogroup E

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    Southeast Asian Haplogroup E

    Here is a great study in regards of South Asian peoples, specifically highlighting Haplogroup E

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1204787/

    "Human mitochondrial DNAs (mtDNAs) from 153 independent samples encompassing seven Asian populations were surveyed for sequence variation using the polymerase chain reaction (PCR), restriction endonuclease analysis and oligonucleotide hybridization. All Asian populations were found to share two ancient AluI/DdeI polymorphisms at nps 10394 and 10397 and to be genetically similar indicating that they share a common ancestry. The greatest mtDNA diversity and the highest frequency of mtDNAs with HpaI/HincII morph 1 were observed in the Vietnamese suggesting a Southern Mongoloid origin of Asians. Remnants of the founding populations of Papua New Guinea (PNG) were found in Malaysia, and a marked frequency cline for the COII/tRNA(Lys) intergenic deletion was observed along coastal Asia. Phylogenetic analysis indicates that both insertion and deletion mutations in the COII/tRNA(Lys) region have occurred more than once."


    Phylogenetic analysis: A tree generated using a
    hypothesized ancestor (haplotype HYPANC) is presented
    in Figure 2. The two branches of this tree are
    defined by the DdeI and AluI sites at nps 10394 and
    10397, respectively. The majority of the deletion
    haplotypes cluster together (groups D* and C) except
    for haplotypes 2 1, 43 and 61. Most of the distinct
    branches within the tree encompass multiple populations,
    indicating that some haplotype groups (A-E
    and G) may represent common ancient Asian lineages.
    Overall there are few population-specific groupings
    of haplotypes within the network. One exception is
    haplotype group I in which five Malay aboriginal
    haplotypes (73, 75, 78, 81, 82) are associated.
    Combining the Southeast Asian mtDNA data with
    that of PNG indicates that specific haplotype groupings
    are more characteristic of isolated populations. A
    tree of both populations (STONEKING et al. 1990) is
    presented in Figure 3. Two additional haplotype
    grbups now stand out, group S, defined by the HZncIIl
    HpaI np 207 site gain, and group U, a subgroup of F.
    Like the Orang Asli group I, groups S and U are
    isolated, occurring predominately in highland PNG.
    Other PNG haplotypes are dispersed within the other
    Southeast Asian haplotype groups. These include type
    P150 which falls within group A and deletion types
    P 1 19-P130 which fall within group D*,

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