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Thread: Hemocromatosis (The Celtic Disease)

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    Hemocromatosis (The Celtic Disease)

    I just found out I am a carrier of Hemocromatosis. Thankfully I don't have the two copies needed to cause problems but I carry one copy and because of that am getting both of my parents tested. It is said to have a high prevalence in people of Celtic ancestry. Does anyone have this or know anything about it?

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    Ditto, but "Not a H63D hemochromatosis carrier." according to Promethease.
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    Quote Originally Posted by AmieLynn101 View Post
    I just found out I am a carrier of Hemocromatosis. Thankfully I don't have the two copies needed to cause problems but I carry one copy and because of that am getting both of my parents tested. It is said to have a high prevalence in people of Celtic ancestry. Does anyone have this or know anything about it?
    I'm not sure if I'm a carrier, but my great-grandfather's brother and his brother's son had hemochromatosis.

    A number of relatives died of cirrhosis, whether it was alcohol induced or a mix of both scenarios I don't know.

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    Quote Originally Posted by AmieLynn101 View Post
    I just found out I am a carrier of Hemocromatosis. Thankfully I don't have the two copies needed to cause problems but I carry one copy and because of that am getting both of my parents tested. It is said to have a high prevalence in people of Celtic ancestry. Does anyone have this or know anything about it?
    One of the Early Bronze Age indivuals buried at Rathlin Island, Co. Antrim, Northern Ireland (2026–1534 cal BC), whose DNA has been tested carried the C282Y hemochromatosis mutation, which has its highest frequencies in Ireland today.

    See Lara M. Cassidy et al., Neolithic and Bronze Age migration to Ireland and establishment of the insular Atlantic genome, PNAS, vol. 113 no. 2 (January 2016), 368–373.
    http://www.pnas.org/content/113/2/368.abstract

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    ^^ My West Midlands ancestry ^^
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    I'm a C282Y carrier. I don't think you need to worry even if you have two copies, as it doesn't necessarily lead to iron overload. It wouldn't hurt to get iron levels blood tested if you do have two copies though, or are heterozygous for different mutations. Age, diet and alcohol consumption are some factors that can affect your ferritin levels.

    The mutation is thought to have been beneficial as it would have helped our ancestors when food was scarce. Nowadays, carrier or two copies, it helps stave off iron deficiency anaemia and is said to aid athletic performance. I believe it also promotes absorption of some other minerals.

    It would probably be cheaper to get your parents ferritin levels checked, rather than buying more DNA kits.
    Last edited by ollie444; 10-15-2017 at 05:04 PM.
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    My mother has it (hemochromatosis), and unfortunately liver damage that happened before anyone knew she had it. I assume this means I am at least a carrier -- all they told us is that it's genetically-linked and to get iron tested regularly. Never heard it was a Celtic thing before, interesting.

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    Quote Originally Posted by AmieLynn101 View Post
    I just found out I am a carrier of Hemocromatosis. Thankfully I don't have the two copies needed to cause problems but I carry one copy and because of that am getting both of my parents tested. It is said to have a high prevalence in people of Celtic ancestry. Does anyone have this or know anything about it?
    My aunt has this. Not surprisingly we are Irish. Her father, my grandfather, died of cirrhosis of the liver at a relatively young age.

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    Some friends have it.
    Some of them find that blood donation helps reduce iron levels.
    I don't have it, but when I stopped donating blood, my own iron content rose and my doctor tested for haemochromatosis - the first DNA test I ever took!

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    My mother has it.
    ᾽Άλλο δέ τοι ἐρέω, σὺ δ᾽ ἐνὶ φρεσὶ βάλλεο σῇσιν:
    κρύβδην, μηδ᾽ ἀναφανδά, φίλην ἐς πατρίδα γαῖαν
    νῆα κατισχέμεναι: ἐπεὶ οὐκέτι πιστὰ γυναιξίν.


    -Αγαμέμνων; H Οδύσσεια, Ραψωδία λ

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    Quote Originally Posted by AmieLynn101 View Post
    I just found out I am a carrier of Hemocromatosis. Thankfully I don't have the two copies needed to cause problems but I carry one copy and because of that am getting both of my parents tested.
    Like you I have just one copy of the C282Y mutation and no problems.

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