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Thread: Determining genetic distance

  1. #1
    Junior Member
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    Determining genetic distance

    i guess this question may have been asked several times, but here goes, how does one determine genetic distance and is it possible to determine in a time lines, as in number of years?
    A member on ysearch has a very close match with my 67 marker results, is it possible to determine how many years ago those couple of markers that make the difference may have changed??

  2. #2
    Registered Users
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    131
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    Location
    England
    Nationality
    British
    Y-DNA (P)
    Z253 >S841 >FGC8551
    mtDNA (M)
    T2b6

    Ireland United Kingdom
    Without getting into the complexity of multiple step mutations, Genetic Difference between two Haplotypes can be determined by summing the difference in values of the 2 profiles being considered. If you are referring to your own profile recently posted on a different thread - Ysearch ref W25R4 compared to Irvine Ysearch ref H7JJM, 64 of the values on your 67 markers match Irvine's. The 3 markers that don't match have a difference in value of 1 so the Genetic Difference (GD) between yourself and Irvine is regarded as 3 on 67 markers.

    Both of you have a high probability of belonging to the R1b-U106 Haplogroup. I suggest you go to Ysearch and look for matches to yourself using 67 markers and look for matches using the option with say 57 matches. You will find a number of matches including N5PA5, the U106 Modal. If you compare the three haplotypes you can print them or preferably copy/paste them into Excel where you can identify the differences with coloured cells.

    Comparing you and Irvine with the U106 Modal you will see that you and Irvine share 5 or 6 differences with the U106 Modal. It is highly unlikely that these ''off modal mutations'' occurred independently and it is much more likely that you and Irvine share a much more recent common ancestor who also had these values. It is probable that one of you have 2 mutations from you common ancestor and the other has 1 i.e. genetic difference = 3. As a rule of thumb if you can consider that a mutation will occur on a 67 marker profile on average every 6 generations suggesting that your common ancestor lived approximately 12 generations ago.

  3. #3
    Junior Member
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    Hi, thanks for this, helps quite a lot

  4. #4
    Registered Users
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    1,051
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    Location
    Central United States
    Ethnicity
    Celtic, Goidelic
    Y-DNA (P)
    DF13>FGC5494>FGC5496
    mtDNA (M)
    H11a2a>C12014T

    United States of America Netherlands Isle of Man Scotland Poland Northern Ireland
    A GD of three between two people is the sum of mutation between the two back to a common ancestor. A 67 marker GD3 divided by two equals 1.5 gd's times 172 years per mutation (MarkoH 2012 rates) is about 258 years before the current generation, about 8.6 generation back to a most recent common ancestor. Reconsider any difference with Multi-copy marker allele values that have a greater than one and treat it as only one GD ( infinite alleles model)

    MJost
    148326, FGC-0FW1R, YSID6 & YF3272 R-DF13>FGC5494>*7448>*5496>*5521>*5511>*5539>*5538>* 5508>*5524
     
    Watterson USA GD1/67 & GD3/111, *5508+. GD1ís fatherís sister-23andme pred. 3rd Cous w/ 0.91% DNA shared-3 seg. Largest on Chr1 w/non-Euro admix affirms my NPE paternal Watterson line via aDNA & YDNA. A 2nd pred. 4th cous has same DKA b. 1840's Georgia and MDKA d 1703 IOM. 3rd Cousin FtDNA FF is from the Watterson Ala. *5538+ b. IOM w/ GD6/67 & GD8/111 -SGD3. FGC5539+ a Scot-Ross GD13/111 -SGD8

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