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Thread: Y-chromosomal analysis identifies skeletal remains of Swiss national hero Jenatsch

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    Y-chromosomal analysis identifies skeletal remains of Swiss national hero Jenatsch

    C. Haas, N. Shved, F. R¨uhli, C. Papageorgopoulou, J. Purps,
    M. Geppert, S.Willuweit, L. Roewer,M. Krawczak, Y-chromosomal analysis identifies
    the skeletal remains of Swiss national hero J¨org Jenatsch (1596-1639), Forensic Science
    International: Genetics (2013), http://dx.doi.org/10.1016/j.fsigen.2013.08.006

    Abstract

    Jörg Jenatsch was a Swiss defender of independence and a fighter for liberty in the 17th century. With the help of three living male members of the Jenatsch family, we successfully identified a skeleton exhumed from Chur cathedral as the remains of Jörg Jenatsch. Our conclusion was based upon complete Y-STR and Y-SNP profiles that could be generated by replicate analyses of a bone sample available to us. The skeleton and the three living family members carried the same Y-SNP-haplogroup, but were discordant at three of 23 Y-STR loci. This notwithstanding, conservative biostatistical evaluation of the data suggests that the Chur skeleton is at least 20 times more likely than not to be Jörg Jenatsch.

    http://www.sciencedirect.com/science...72497313001804

    The skeleton and the three living family members carried the same Y-SNPhaplogroup,
    R1b1b2a2g. In YHRD, R1b1b2a2g occurs in 132 of 2357 Western- or
    Middle-Europeans (frequency: 5.610-2), meaning that this haplotype is quite
    common in the target area. Therefore the match on its own did not provide sufficient
    evidence to allow reliable identification of the skeleton. Comparison of the PowerPlex
    Y23 profiles of the skeleton and the three living family members revealed three
    discrepancies and 20 matches. Bearing in mind that, under the hypothesis that the
    skeleton is that of Jörg Jenatsch, each of these mutations would have occurred in
    one of 12 meioses, such an observation may well have been compatible with the
    presumed identity. Indeed, conservative biostatistical evaluation of the data
    suggested that it was at least 20 times more likely than not that the Chur skeleton is
    Jörg Jenatsch. In addition, our calculations were based upon the 17 loci of the Yfiler
    kit only, due to the scarcity of population data, and did not allow for the fact that the
    profiles under study matched for six additional STRs. If the conservative assumption
    was made that the probability of observing exactly three mismatches between two
    unrelated Western-European Y-chromosomal haplotypes is the same for the
    PowerPlex Y23 kit as for the 17 Yfiler loci, a likelihood ratio of 36 would emerge.
    Finally, two of the additional markers, DYS570 and DYS576, are rapidly mutating
    with mutation rates >10-2 [24, 25]. The fact that we did not find a mutation at any of
    these loci argues further for the presumed relationship. Since no other male relative
    has ever been connected to the find, our analysis therefore strongly suggests that the
    Chur skeleton is that of Jörg Jenatsch.
    Our study highlights the power of Y-chromosomal

  2. The Following 4 Users Say Thank You to RCO For This Useful Post:

     Alpine Hominin (09-06-2013),  Humanist (07-22-2014),  rms2 (09-06-2013),  Scarlet Ibis (09-06-2013)

  3. #2
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    Wales Ireland Scotland France Bretagne England Switzerland
    "R1b1b2a2g" is an old longhand for U152, correct?

  4. The Following User Says Thank You to rms2 For This Useful Post:

     Alpine Hominin (09-06-2013)

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    Yes, I think so ! It's a nice little article.

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