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Thread: U1 General Thread

  1. #11
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    U1 showed up in the Complete Mitochondrial DNA Diversity in Iranians here: http://journals.plos.org/plosone/art...e-0080673-t002



    "Besides haplogroup U7, sub-haplogroups U1 and U3 exist at considerable levels in the Iranian populations studied, reaching their highest frequencies in Azeris (9%) and Qashqais (8%), respectively (Table 2). To further assess the variability of haplogroups U1 and U3 found in the mitochondrial gene pool of Iranians we reconstructed the complete mtDNA genome phylogeny based on our and all available published data (Figure S3). It is obvious that these haplogroups have a likely pre-LGM time depth characterized by an overall coalescence time estimates of 38–50 kya and 32–41 kya, respectively, and both have a very distinctive geographic distribution which might be highly informative about the demographic history of the Middle East. Haplogroup U1 presents two basal branches, named - U1a’c and U1b. The latter is found mostly among Europeans, and its estimated age of ∼9–14 kya indicates a postglacial or Late Glacial expansion. Sub-clade U1a’c, with coalescence age estimate of 29–44 kya, is the most represented of U1 clades, and it probably originated in Southwest Asia and split early into three branches. The first branch, U1a, comprises a series of sub-clades (U1a1, U1a2, U1a3, and U1a4) dating to 13–15 kya; it was found across Southwest and South Asia, the Caucasus region and Europe, but at least one lineage within U1a3, which we called here U1a3b, was restricted to Iran. It is characterized by coalescence age estimates of about 10–16 kya thus placing its origin to postglacial or Late Glacial time. It should be noted, that the Persian-specific U1a3a branch is also found in Sardinians, and its estimated age of 8–10 kya points to a long-standing link between them.















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  3. #12
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    Thank you so much, I hope even more research is done on U1 and its descendants in the future as well as more research on its presence in Kerala and South India.
    Last edited by Tirunelvi; 03-03-2018 at 05:39 AM.

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  5. #13
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    Quote Originally Posted by Tirunelvi View Post
    I hope even more research is done on U1 and its descendants in the future as well as more research on its presence in Kerala and South India.
    Me too. It's definitely an important part of the story of the entire U mtdna haplogroups. There is so much U2 that's showing up in many samples in Europe so there is an interesting angle there.

  6. #14
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  7. #15
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  8. #16
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    The spread of haplogroup U in west Eurasia with emphasis on branch U3

    MtDNA haplogroup U has a prominent West/Central Eurasian geographic range. Its first radiation seems to have occurred in the initial stable warm phase of the MIS 3 interstadial around 50 kya (Table ​(Table1).1). We situated its hypothetical center of expansion in the Dahoguz province of Turkmenistan (Table ​(Table1).1). Next expansions, at around 43 and 33 kya, involved branches U1, U2 and U8 and branches U3, U5 and U6 respectively, and occurred also in periods of relatively mild temperatures. A more recent radiation was dominated by branches U4, U7, U9, and K around 24 kya, just before the Last Glacial Maximum. All these dispersion waves had rather overlapping ranges and preferably southward expansions [42]. Most probably, U1, U3, and U9 went to the Middle East [43–46]; U2i and U7 mainly to South Asia [47–49]; U2e, U4, U5 and U8 to Europe [50–52], and U6 to North Africa and the Mediterranean basin [53–57]. The recent analysis of the mitogenome of a 35 ky-old modern human from Romania, resulted in being a basic U6* sequence, supporting a Paleolithic Eurasian origin for this African lineage [58]. Secondary branches of these haplogroups have revealed more recent and limited human migrations in all the regions mentioned above. Interesting examples are the expansions to the Volga-Ural and Siberian regions of numerous sub-branches of U1a, U2e, U3b, U4, U5b, U7a, U8a and K1a [59, 60], to India of U2i and U7 [61], to Europe of K [62], or in North Africa of U5b [63]. Advances in ancient DNA technology have also made diachronic studies of human populations possible. An outstanding case was the genome sequencing of a 45 ky-old modern human from western Siberia that already carried a basic mtDNA U* lineage [64]. Haplogroups U4, U5, and U8 were the most prominent U lineages in Paleolithic hunter-gatherers of North and Central Europe, but its frequencies drastically diminished with the Neolithic expansion into the area [65–69], while other U lineages as U2, U3, and K, drastically increased in subsequent periods [66, 70–73]. The fact that Neolithic and Bronze Age migrations introduced southern Siberian U5a1b1e and U5b2a2 lineages to Ireland is noteworthy too [74]. It has been also reported the presence of western U2e, U5a and U7 lineages in prehistoric remains as far as the Tarim Basin and Northeast Mongolia [75, 76].

    LINK : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442693/

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  10. #17
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    9 U1 samples showed up in the Central and South Asian DNA Paper:





    LINK: https://www.biorxiv.org/content/earl...1.figures-only

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  12. #18
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  13. #19
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    Upper Casts in South India Tamils have U1a in this paper: "Genetic variation in South Indian castes: evidence from Y-chromosome, mitochondrial, and autosomal polymorphisms"


    LINK: https://bmcgenet.biomedcentral.com/a...2156-9-86#Tab5




    Last edited by Johane Derite; 04-11-2018 at 04:44 PM.

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  15. #20
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    3 new U1's showed up in the "Genetic prehistory of the Greater Caucasus" paper.

    Its interesting because they are on the complete other side of the black sea to the Bulgarian U1 that showed up in the recent paper yet not too seperated in time.


    LINK: https://www.biorxiv.org/content/early/2018/05/16/322347





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