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Thread: New U5 sequences

  1. #1
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    New U5 sequences

    I'll use this thread for updates on new U5 sequences, starting with the results from the new Li et al study on diabetes in Denmark. The study has 2000 full mtDNA sequences, including 160 in haplogroup U5, or 8%. The sequencing is of uneven quality with some samples having large numbers of no calls, but I was able to place all but 1 in subclades of U5, listed below.

    It is interesting that Denmark is nearly 73% U5a and 27% U5b. The U5b samples are heavily concentrated in U5b2. In constrast, the recent 13 U5 samples from northwest Spain (Zamorra Province) were 31% U5a and 69% U5b.

    Some notable finds were new U5a1*, U5b1* and U5b3* samples.

    For two of the subclades found often in Finland, U5b1b1a and U5b1b2, there were no U5b1b1a samples, and there were 3 U5b1b2 samples. I've speculated that U5b1b1a arrived in Finland via an eastern European route, and U5b1b2 via a western European route, and these results seem consistent with that theory.


    U5a1 = 51%
    N = 84
    U5a1* = 1
    U5a1a1 = 31
    U5a1a2 = 5
    U5a1b = 22
    U5a1c2a = 9
    U5a1d = 3
    U5a1e = 1
    U5a1f = 4
    U5a1g = 4
    U5a1h = 4
    U5a1*i1 = 1

    U5a2 = 21%
    N = 34
    U5a2a = 13
    U5a2b = 10
    U5a2c = 5
    U5a2d = 3
    U5a2e = 1
    U5a2*g =1


    U5b1 = 7.6%
    N = 12
    U5b1* = 1
    U5b1b2 = 3
    U5b1c2 = 1
    U5b1c2b = 3
    U5b1d2 = 2
    U5b1e = 2


    U5b2 = 17%
    N = 27
    U5b2a1a1 = 3
    U5b2a1a1*C = 2
    U5b2a1a1*C2 = 2
    U5b2a2a1 = 4
    U5b2a2b = 1
    U5b2a2b1 = 3
    U5b2a2c = 1
    U5b2a4a = 1
    U5b2a5 = 1

    U5b2b* = 1
    U5b2b1a = 1
    U5b2b4 = 3
    U5b2b4*B = 2
    U5b2b4*B1 = 1

    U5b2c2b = 1


    U5b3 = 1.3%
    N = 2
    U5b3* = 1
    U5b3e = 1
    Last edited by GailT; 10-08-2013 at 05:35 PM. Reason: added 1 sequence

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    Why is my U5b2b2 so elusive?

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    Would you please elaborate on what differentiates U5b2a1a1, U5b2a1a1*C, and U5b2a1a1*C2? Also, why haven't these sub-groups been officially designated?

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    Interesting, seems U5a1b is fairly common there, or the second largest group among the U5a.
    Y-DNA: I1* (Ware, Hertfordshire)
    MT-DNA: U5a1b4 (Boughton Aluph, Kent)
    Father's MT-DNA: J1c8 (Wolverhampton, Staffordshire)
    Grandfather's MT-DNA: H1b (Littlehampton, Sussex)

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    Quote Originally Posted by rbstens View Post
    Would you please elaborate on what differentiates U5b2a1a1, U5b2a1a1*C, and U5b2a1a1*C2? Also, why haven't these sub-groups been officially designated?
    Here are the mutations I used to define these:

    U5b2a1a1*C: 16239 and 16192!
    U5b2a1a1*C2: 13708, 16269


    It require a certain number of samples, and diversity of samples, for a new subclade name to be included in Phylotree. And updates have been slow. Perhaps it will make it into the next update.

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    May I ask that how do you draw a conclusion that the haplogroup U5b1b2 arrived to Finland via Western Europe route?

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    Quote Originally Posted by annika View Post
    May I ask that how do you draw a conclusion that the haplogroup U5b1b2 arrived to Finland via Western Europe route?
    This is speculative, but there are several U5b1b2 samples from Denmark, Germany, UK and Ireland, but none from eastern Europe. There are quite a few U5b1b1a samples from eastern Europe, but it is rare in western Europe. So I'm guessing that U5b1b1a and U5b1b2 arrived in Finland by different routes.
    Last edited by GailT; 01-25-2014 at 06:30 AM.

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    There are 1292 FMS samples just published in a study by Raule et al. on Longevity (link). First, thanks to Ian Logan for sorting these into haplogroups.

    By country, the number of samples are:
    Denmark 854
    Finland 292
    Italy 125
    Greece 21

    There are 112 U5 samples, with totals and percentage by country:
    Denmark 59 (6.9%)
    Finland 48 (16.1%)
    Italy 5 (4%)
    Greece none

    The Li et al study had 2000 Danish samples, with 170 U5, or 8.5%.

    The distribution by subclade is similar to the Li et al study and the U5 project results with very few U5b1 samples in Denmark and a large number of U5b1 samples in Finland.

    Denmark % of U5
    U5a1 32 54%
    U5a2 10 17%
    U5b1 3 5%
    U5b2 10 17%
    U5b3 4 7%

    Finland % of U5
    U5a1 11 23%
    U5a2 8 17%
    U5b1 25 52%
    U5b2 4 8%
    U5b3 0 0%
    Last edited by GailT; 01-25-2014 at 06:29 AM.

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    My U5b2a1a has a marker 16185T which cannot be found in this group, except to the Z haplogroup.
    Please advise if possible, thanks.

  13. #10
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    Quote Originally Posted by tuuli View Post
    My U5b2a1a has a marker 16185T which cannot be found in this group, except to the Z haplogroup.
    Please advise if possible, thanks.
    Did you test at FTDNA or 23andMe? If 23andMe, you can use mthap to possibly identify a subclade of U5b2a1a. There is one person in U5b2a1a1 (GQ853200) who also has 16185.

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